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Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

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老城之光葡萄牙Farmácia Lordelo药店

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室内设计与装修 2014年第9期 72-77页

作者： JOSé carlos cruz-ARQUITECTO 和维

Farmacia Lordelo药店位于葡萄牙的古镇雷阿尔，并且已经在这里开办了25年。当店主人决定将这家药店进行全方位的更新升级时，她有了更大胆地思考，她需要一个非传统的药店来为自己的品牌争取更多的客人与信任。

关键词：建筑设计室内设计室内装修装修材料

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Mechanosynthesis as a Simple Method to Obtain a Magnetic Composite (Activated Carbon/Fe₃O₄) for Hyperthermia Treatment

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Journal of Biomaterials and Nanobiotechnology 2016年第1期7卷 19-28页

作者： Jorge carlos Ríos-Hurtado Elia Martha Múzquiz-Ramos Alejandro Zugasti-cruz Dora Alicia Cortés-Hernández Facultad de Ciencias Químicas Universidad Autónoma de Coahuila Saltillo México Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Saltillo Ramos Arizpe México

A large number of magnetic nanomaterials have been studied for their hyperthermic potential, such as iron oxide based materials. These are embedded in different matrices to improve their properties. In this paper magnetite was synthesized by the coprecipitation method and an activated carbon/magnetite composite was obtained by mechanosynthesis (400 rpm, 3 h). The samples were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), IR-FT spectroscopy and Scanning Electron Microscopy (SEM). Furthermore, composite heating curves as well as hemolysis tests were performed. The composite showed a superparamagnetic behavior due to its low coercivity index (8.92 Oe) and a high saturation magnetization (40.12 emu/g). SEM images showed that the magnetite was observed on the surface of activated carbon and also the IR-FT spectra indicated that oxygenated groups on the activated carbon surface were responsible for the anchoring of magnetite in the surface, with particle sizes between 9 and 14 nm. Heating results indicated that a composite mass of 18 mg reach a temperature of 45.6°C in a low frequency magnetic field (10.2 kA and 200 kHz). Hemolysis tests indicated that the composite is a non-hemolytic material (4.7% hemolysis). These results demonstrate that the material can be used in magnetic hyperthermia techniques for cancer treatment.

关键词： Mechanosynthesis Hyperthermia Magnetite Activated Carbon Composite

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Nonlinear Coefficient Determination of Au/Pd Bimetallic Nanoparticles Using Z-Scan

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Advances in Nanoparticles 2013年第3期2卷 223-228页

作者： José Luis Jiménez Pérez Rubén Gutiérrez-fuentes José Francisco Sánchez Ramírez Omar Uriel García Vidal Daniel Erick Téllez-Sánchez Zormy Nacary Correa Pacheco Alfredo cruz Orea Jesús Antonio fuentes García Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada México D.F. México Departamento de Física Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional México D.F. México Unidad Profesional Interdisciplinaria en Ingeniería y Tecnologías Avanzadas del IPN México D.F. México

In this paper we present the nonlinear optical characterization of Au/Pd nanoparticles in order to obtain the nonlinear refractive indices using the Z-scan technique. The experiments were performed using a 514 nm laser beam Ar+, with 14 Hz of modulation frequency, as excitation source. By using a lens the excitation beam was focused to a small spot and the sample was moved across the focal region along the z-axis by a motorized translation stage. Seven samples with different concentration ratio of Au/Pd nanoparticles were prepared by simultaneous reduction of gold and palladium ions in presence of poly (N-vinyl-2-pirrolidone) (PVP) using ethanol as a reducing agent. In this work, we report the application of the Z-scan technique, to generate optical transmission of laser light as a function of the z position for solutions containing bimetallic nanoparticles of Au (core)/Pd (shell) with average sizes ranging from 3 to 5 nm. The magnitude of the obtained nonlinear refractive index was in the order of 10?8 cm2/W. Our results show that the nonlinear refractive index has a nonlinear behavior when the (Au/Pd) ratio was increased.

关键词： Nanofluids Nanoparticles Nonlinear Refractive Indices Z-Scan

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The COVID-19 Pandemic:Global Asymmetries and Challenges for the Future of Health

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China CDC weekly 2021年第7期3卷 140-141页

作者： Nísia Trindade Lima carlos Grabois Gadelha Oswaldo cruz Foundation-Fiocruz

The coronavirus disease 2019(COVID-19)pandemic reveals economic,social,and environmental trends that have been present since the last two decades,and it is characterized as a new phenomenon that qualitatively alters contemporary global and national dilemmas—not only because it was caused by a hitherto unknown virus,but by the magnitude of the crisis and the transformations that shape the *** marks a disruptive and threatening historical period in the face of the foundations of modern sociability built during the post-war period.

关键词： COV demic contemporary

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Ab Initio Study of Aluminum-Phosphorus Co-doped Graphene

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Journal of Physical Science and Application 2017年第1期7卷 1-7页

作者： Victor Eduardo Comparan Padilla Maria Teresa Romero de la cruz carlos Eduardo Rodriguez Garcia ReyesGarcia Diaz Gregorio Hernandez Cocoletzi Facultad de Ciencias Quimicas Universidad Autonoma de Coahuila Blvd. Venustiano Carranza C.P. 25280 Saltillo CoahuilaMexico Facultada de Ciencias Fisico Matematica Universidad Autonoma de Coahuila Blvd. Venustiano Carranza C.P. 25280 SaltilloCoahuila Mexico Instituto de Fisica Luis Rivera Terrazas Benemerita Universidad Autonoma de Puebla Av. San Claudio y Blvd. 18 Sur C.P.72570 Puebla Puebla Mexico

In the present work it is studied the phosphorus-aluminum co-doping effect on the electronic and structural graphene properties using ab initio calculations in the framework of DFT （density functional theory）. The doping of graphene with substituent heteroatoms can modify the band structures as well as the electron transfer, improving the electronic performance that could enhance the sensing ability in gas sensor devices. The incorporation of heteroatoms in the graphene monolayer alters the unit cell. The alteration degree depends on the dopant concentration. Furthermore, the electronic properties were modified by opening the gap up to 0.61 eV produced by the combination of phosphorus and aluminum as dopants. The dopant concentration can be controlled, which causes different degrees of semiconductor behavior on the co-doped graphene.

关键词： Density functional theory graphene co-doping band gap aluminum phosphorus.

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Evaluation of the Antiviral Activity of Propolis from Native Bees (<i>Plebeia frontalis</i>) against Canine Distemper Virus

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Open Journal of Veterinary Medicine 2020年第12期10卷 207-218页

作者： Olga Valeria Domínguez Jiménez Betsabé Rodríguez Pérez Tonatiuh Alejandro cruz Sánchez carlos Gerardo García Tovar José Luis Nieto Bordes carlos Ignacio Soto Zárate Laboratorio 4 de Morfología Veterinaria y Biología Celular Unidad de Investigación Multidisciplinaria (UIM) Facultad de Estudios Superiores Cuautitlán UNAM Cuautitlán Izcalli México Laboratorio 6 de Bioprospección Microbiológica Unidad de Investigación Multidisciplinaria (UIM) Facultad de Estudios Superiores Cuautitlán UNAM Cuautitlán Izcalli México

Propolis is a natural substance made from resins collected from trees and plants, and which bees combine with pollen, wax, and their own enzymes. It has a complex chemical composition that varies with the harvest season, vegetation type, bee species, and geographical region. Thanks to its components, it has valuable biological properties such as antifungal, antibacterial, anticancer, antiviral, and immunomodulatory activity. For this study, a sample of propolis harvested in April 2019 was used, which came from a bee native to Mexico (Plebeia frontalis) in whose geographical environment there are seven other native species. Canine distemper virus is an RNA virus that causes a systemic infection with high fatality rates in guests without protective immunity. In this work, the antiviral effect of Plebeia frontalis propolis on canine distemper virus was tested, administering it one hour before and simultaneously to infection. The antiviral effect was evaluated by determining cellular viability with the MTT assay. The results obtained show that this propolis has a statistically significant antiviral effect on both treatments, although it is slightly better when applied one hour before viral infection, so we can recommend it as an antiviral treatment in both domestic animals and human beings. There are currently few studies of the antiviral effect of propolis, this being the first study of a melliponium propolis in veterinary medicine.

关键词： Propolis Vero Cells Antiviral Effect Meliponines

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Novel contributions of multimodality imaging in hypertension:A narrative review

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World Journal of Hypertension 2015年第2期5卷 28-40页

作者： Erick Alexanderson-Rosas Enrique Berríos-Bárcenas Aloha Meave Juan carlos de la Fuente-Mancera Mariano Oropeza-Aguilar Alejandro Barrero-Mier Andrea de Guadalupe Monroy-González Raul cruz-Mendoza Gerardo Yoshiaki Guinto-Nishimura Nuclear Cardiology Department National Institute of Cardiology Ignacio ChávezMexico City 14080Mexico Cardiac Magnetic Resonance Department National Institute of Cardiology Ignacio ChávezMexico City 14080Mexico

Hypertension is currently one of the most prevalent il nesses worldwide,and is the second most common cause of heart failure,only behind ischemic *** development of novel multimodality imaging techniques in recent years has broadened the diagnostic methods,risk stratification and monitoring of treatment of cardiovascular diseases available for *** magnetic resonance(CMR) has a great capacity to evaluate cardiac dimensions and ventricular function,is extremely useful in ruling-out ischemic cardiomyopathy,the evaluation of the vascular system,in making the differential diagnosis for resistant hypertension and risk stratification for hypertensive cardiomyopathy and constitutes today,the method of choice to evaluate left ventricular systolic *** tomography(CT) is the method of choice for the evaluation of vascular anatomy,including coronary arteries,and is also able to provide both functional and structural ***,nuclear cardiology studies have been traditionally used to evaluate myocardial ischemia,along with offering the capacity to evaluate ventricular,endothelial and cardiac innervation function;information that is key in directing the treatment of the *** this narrative review,the most recent contributions of multimodality imaging to the patient with hypertension(CMR,CT and nuclear cardiology) will be reviewed.

关键词： Cardiac imaging techniques Multimodality imaging Magnetic resonance imaging Multidetector computed tomography Cardiac-gated single photon emission computed tomography Positron emission tomography Hypertension

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Immunotherapy combinations and chemotherapy sparing schemes in first line non-small cell lung cancer

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World Journal of Clinical Oncology 2021年第12期12卷 1182-1192页

作者： María Sereno Oliver Higuera Patricia cruz Castellanos Sandra Falagan Xabier Mielgo-Rubio Juan carlos Trujillo-Reyes Felipe Couñago Medical Oncology Department Hospital Universitario Infanta SofíaSan Sebastián de los Reyes 28702MadridSpain Medical Oncology Department Hospital Universitario La PazMadrid 28046Spain Medical Oncology Department Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029CataloniaSpain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029CataloniaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

In recent years,studies have explored different combinations of immunotherapy and *** rationale behind these is the improved survival outcomes of new immunologic therapies used in first-line-treatment of advanced non-small cell lung ***,for the most-studied combinations of anti-programed death-1(PD-1)/programed death ligand-1(PD-L1)with the addition of platinumbased chemotherapy,recent research is investigating whether combining different immunologic antitumoral mechanisms of action,such as anti-PD-1/PD-L1 and anti-CTLA-4,or anti-PD-L1 and anti-TIGIT,with or without chemotherapy,can improve efficacy outcomes compared with more classical combinations,or compared with standard chemotherapy ***,we present the data of the main randomized studies that have evaluated these combinations,focusing on the basic rationale behind the different combinations,and the efficacy and tolerability data available to date.

关键词： Immunotherapy combinations Anti-programmed cell death protein Antiprogrammed cell death ligand 1 anti-TIGIT anti-CTLA-4 Combo Non-small cell lung cancer

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Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis

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World Journal of Hepatology 2021年第12期13卷 2052-2070页

作者： Larisse Longo Pabulo Henrique Rampelotto Eduardo Filippi-Chiela Valessa Emanoele Gabriel de Souza Fernando Salvati carlos Thadeu Cerski Themis Reverbel da Silveira Cláudia P Oliveira Carolina Uribe-cruz Mário ReisÁlvares-da-Silva Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Graduate Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Rio Grande do SulBrazil Experimental Research Center Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil School of Medicine Instituto Meridional de Educação-IMEDPasso Fundo 99070-220Rio Grande do SulBrazil Unit of Surgical Pathology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Cardiovascular disease is the main cause of death in metabolic-associated fatty liver disease,and gut microbiota dysbiosis is associated with both of *** To assess the relationship between gut dysbiosis and cardiovascular risk(CVR)in an experimental model of *** Adult male Sprague-Dawley rats were randomized to a control group(n=10)fed a standard diet and an intervention group(n=10)fed a high-fat choline-deficient diet for 16 ***,molecular,hepatic,and cardiac *** microbiota variables were *** The intervention group had a significantly higher atherogenic coefficient,Castelli’s risk index(CRI)-I and CRI-II,interleukin-1β,tissue inhibitor of metalloproteinase-1(all P<0.001),monocyte chemoattractant protein-1(P=0.005),and plasminogen activator inhibitor-1(P=0.037)than the control *** expression of miR-33a increased(P=0.001)and miR-126(P<0.001)decreased in the intervention *** with fibrosis was seen in the intervention group,and heart computerized histological imaging analysis showed a significant decrease in the percentage of cardiomyocytes with a normal morphometric appearance(P=0.007),reduction in the mean area of cardiomyocytes(P=0.037),and an increase of atrophic cardiomyocytes(P=0.007).There were significant correlations between the cardiomyocyte morphometry markers and those of progression and severity of liver disease and *** intervention group had a lower Shannon diversity index and fewer changes in the structural pattern of gut microbiota(both P<0.001)than *** microbial families that are involved in lipid metabolism were differentially abundant in intervention group and were significantly correlated with markers of liver injury and *** The study found a link between gut dysbiosis and significant cardiomyocyte abnormalities in animals with steatohepatitis.

关键词： Animal model Cardiovascular diseases Gut microbiota Metabolic-associated fatty liver disease Predicted lipid metabolism Risk cardiovascular Steatohepatitis

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