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Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

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Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： Javier Romero Otero Borja Garcia Gomez Jose Medina Polo carlos Pascual Mateoe Silvia Garcia Barreras Eduard Garcia cruz Javier de la Riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

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Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros Lima Antonio Jose Goncalves cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

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An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros Lima Wu Hong Kwong Antonio José Goncalves cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

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Comparison of six human anti-transglutaminase ELISA-tests in the diagnosis of celiac disease in the Saharawi population

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World Journal of Gastroenterology 2005年第24期11卷 3762-3766页

作者： Eloy Fernández Sabino Riestra Luis Rodrigo carlos Blanco Antonio López-Vázquez Dolores fuentes Maria Moreno carlos López-Larrea Biochemistry Service Gastroenterology Service Immunology Service

AIM: Celiac disease (CD) is an enteropathic disorder very prevalent in Saharawi people. Our aim was to investigate the diagnostic accuracy of six human tissue transglutaminase (tTG) based ELISA tests in Saharawi CD patients. METHODS: Fifty-two CD patients and 23 controls were selected from the Saharawi refugee camps in Tinduf. CD patients were divided into two groups according to their anti-endomysium (EmA) status: 41 EmA positive and 11 EmA negative. Sera from patients and controls were tested for human tTG using six commercial ELISA kits. We used receiver operating characteristics (ROC) curves and areas under the curve to compare the diagnostic accuracies of the six assays. RESULTS: In general, there are differences in the sensitivity and specificity of the human tTG ELISA assays used. Diagnostic accuracy of tests was significantly improved by adjusting the cut-off thresholds according to ROC plot analysis; the correction of the cut-off with the employment of the ROC curve analysis modifies the decision limit in more than 50% in five of the six kits evaluated. CONCLUSION: Some of the human tTG ELISAs used in this study have a diagnostic accuracy similar to EmA determination for diagnosis of CD in Saharawi people. However, it is necessary to select the assay with a higher sensitivity and specificity, and recalculate the cut-off threshold using samples from the referral population.

关键词： Anti-transglutaminase tests Comparative study Celiac diagnosis Saharawi population

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Full Euclidean Algorithm by Means of a Steady Walk

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Applied Mathematics 2021年第4期12卷 269-279页

作者： carlos M. Falcon Rodriguez Maria A. Garcia cruz Claudia Falcon Grupo de Investigación de Análisis Matemático Instituto de Formación docente Salomé Ure&#241 a Santo Domingo D.N. República Dominicana Wake Forest University Winstom-Salem NC USA

Let x and y be two positive real numbers with x y. Consider a traveler, on the interval [0, y/2], departing from 0 and taking steps of length equal to x. Every time a step reaches an endpoint of the interval, the traveler rebounds off the endpoint in order to complete the step length. We show that the footprints of the traveler are the output of a full Euclidean algorithm for x and y, whenever y/x is a rational number. In the case that y/x is irrational, the algorithm is, theoretically, not finite;however, it is a new tool for the study of its irrationality.

关键词： Extended Euclidean Algorithm Greatest Common Divisor Incommensurable Numbers Steady Walk Diophantine Equation

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Design and Construction of an Equipment for the Radiochemistry Process of Molecules Marked for the Sector Health

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Journal of Environmental Science and Engineering(A) 2015年第4期4卷 196-202页

作者： Jose Alanis Hector Flores Simon de la cruz Jose carlos Vazquez Department of Radioactive Waste Nuclear Center of Mexico ININ Oeoyoacac Edo. de Mexico 52 750 Mexico Department of Chemical Analyses Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico Department Manufacture of Prototypes Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico Department of A utomation Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico

At the Plant of Production of Radioisotopes part of Nuclear Center of Mexico （ININ）, weekly radiofarmaceutics of sodium iodohippurate and meta-iodobenzyl-guanidine are prepared, these compounds are known as marked molecules with iodine-131. Currently the processes for the preparation of these compounds are carried out individually and in manual form, in box of gloves, presenting radiological risks. To avoid these risks, this work, shows equipment that is inside a warm cell with the finality of minimizing the radiological risks. Also, this semi-automated equipment has the purpose of to reduce the radiation exposure of personnel involved in the process of marking molecules. The routine industrial production with this equipment starts with the preparation of 9 marked doses of sodium iodohippurate of 2.73 mCi of iodine-131, each of the vials with saline solution of 4.5 mL and the product that containing the marked molecules of 0.5 mL with a percentage of marked of 95.6%. The innovation of this work consists in presenting a new design of equipment, for marked molecules, formed by electrical, mechanical, vacuum systems, and air extraction system.

关键词： Construction equipment molecules marked sector health

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Interaction of piRNA-like sequences from the 3′-UTR of SARS-CoV-2 with mRNA regions

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Genes & Diseases 2023年第6期10卷 2282-2284页

作者： Laura Pérez-Campos Mayoral María Teresa Hernández-Huerta carlos Romero Díaz carlos Alberto Matias-Cervantes Eduardo Pérez-Campos Mayoral Margarito Martínez cruz Juan de Dios Ruiz-Rosado Edgar Gustavo Ramos Martínez Marco Antonio Sánchez Medina Eduardo Pérez-Campos Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico CONACyT Faculty of Medicine and Surgery.Autonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico National Technology of Mexico(TecNM)/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico The Research Institute at Nationwide Children's Hospital Columbus 43205USA Facultad de Química Universidad Nacional Autónoma de MéxicoCoyoacán 04510Mexico

Piwi-interacting RNAs(piRNAs of 26-32 nt in length)regulate gene expression,epigenetics,and transcriptional and post-transcriptional processes.1 In humans,piRNAs are expressed in germline and somatic tissues,and generally have a uracil at the 5'-end(position+1),an adenine at the+10 position,and are 2'-0 methylated at the 3'-end.2 Onice piRNAs form the RNA-induced silencing complex(RISC)with PIWl proteins,they serve as guides to find their complementary sequences of the target mRNA,thus initiating their *** Wuhan patient's genome is approximately 265 nucleotides(nts)in its 3'-UTR;piRNAs-like sequences have been reported in this region.3 Our objective was to search,through bioinformatics,for mRNA sequences that were homologous to the reverse complementary of the previously reported piRNA-like sequences from the 3'-UTR of SARS-Cov-2,3 and identify the possible interaction between them.

关键词： sequences complementary initiating

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Posterior quadrant epilepsy surgery: case series of a South American hospital

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Acta Epileptologica 2022年第4期5卷 227-232页

作者： Mario Velasco Andrés Felipe Cárdenas-cruz María Paula Aguilera-Pena Alejandro Vargas-Moreno Daniel Nariño Juan carlos Pérez Oscar Zorro Pontificia Universidad Javeriana Cr16#75-32 apt 203BogotaColombia110221 Neuroscience Department Hospital Universitario San IgnacioCr16#75-32 apt 203BogotaColombia110221

Background Posterior quadrant epilepsy(PCE)is a type of focal epilepsy that originates in the parietal lobe,occipital lobe,and the parietal-occipital border of the temporal lobe,or in any combination of these *** has a low incidence,but it can cause a great burden in disability-adjusted life *** this retrospective cohort,patients of all ages with a diagnosis of PCE between 2006 and 2019 were evaluated in a referral center in Bogotá,Colombia.A descriptive analysis of demographic data,clinical history,imaging findings,type of surgery,histopathological diagnosis,outcome,and follow-up was performed using the Engel *** This study included refractory PCE patients of all ages who were evaluated by the epilepsy surgery group of the Hospital Universitario San Ignacio from 2006 to ***,imaging and surgical variables were obtained from the medical records and *** Thirteen patients were included in the study,including 8 males and 5 *** mean age of diagnosis was 8.8 years,while the mean age of surgery was 25 *** most frequent clinical finding was intellectual *** most common findings on magnetic resonance imaging were encephalomalacia and *** 61.5%of the patients,the lateralization of video-EEG matched with brain magnetic resonance imaging *** most frequent types of surgery performed were lobectomies,lesionectomies and cortical ***-freedom was achieved in approximately one third of the patients;however,more than half of the patients were free of disabling seizures or had significant improvement after *** PCE surgery is scarcely performed worldwide,therefore the effectiveness and outcomes are quite variable in the reported *** this study,we show that patients with PCE can obtain great benefits in terms of reduction of seizures with a low risk of surgical complications,encouraging the use of this type of procedure in carefully selected patients.

关键词： Posterior cortex Epilepsy surgery Posterior quadrant epilepsy

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Stereological Evaluation of Precipitates within Ferrite Grains in Heat-Treated 1.25Cr0.5Mo Steel Previously Exposed to Service

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Journal of Metallic Material Research 2019年第2期2卷 1-8页

作者： Rafael Fernandez-fuentes Americo Scotti Amado cruz-Crespo Roberto Silva Gonzalez Rafael Ariza Nelson Guedes de Alcantara Universidad Central Marta Abreu de Las Villas–UCLV Cuba Universidade Federal de Uberlandia–UFU Brazil Universidade Federal de Sao carlos-UFSCar Brazil University of West Department of Engineering ScienceTrollhattanSweden

The objective of this work was to study the effect of the heat treatment and further operation aging on the stereological parameters(size,quantity and volume fraction)of precipitates within ferrite grains of a creep-resistant 1.25Cr0.5Mo steel after long-term *** heat treatment was similar to the treatment that is carried out in industrial steam pipelines after welding(post weld heat treatment-PWHT)during installation and/or *** operation aging corresponds to a subsequent long in-service operation after *** determine the stereological parameters,SEM digital images were taken from samples of this material after conditions of in-service-aged(after long-term operation),in-service-aged and heat-treated(simulating repairing)and in-service-aged,heat-treated and in-laboratory aged(simulating subsequent long-term operation after repairing).The results indicate that the changes in the stereological parameters of the precipitates within ferrite grains after PWHT is associated with the coarsening process of the within-ferrite-grain precipitates as well as stabilizing the microstructure,since the material aging after PWHT of an in-serviced aged material would not change the stereological parameters.

关键词： Creep-resistant 1.25Cr0.5Mo Steel Repairing PWHT Precipitation coarsening

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Localized Plasmon in Silver Nanoparticles Synthesized by Microwave Radiation

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材料科学与工程（中英文A版） 2017年第2期7卷 97-109页

作者： Juan Sebastian Pelaez Garzon, Ricardo E. Baez cruz carlos Vargas Hemandez Laboratorio de Propiedades Opticas de Materiales (POM) Universidad Nacional de Colombia Sede Manizales 170-003 Caldas-Colombia

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