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英国政府新计划仍无法解决空气污染问题无助于缓解英国城镇空气污染与气候变化的危机

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英国医学杂志中文版 2017年第11期20卷 621-622页

作者： David McCoy Alice Munro carla Stephan Jonathan Grigg 邓晓春莫云凌 Barts and LondonSchool of Medicineand Dentistry QueenMary UniversityLondon Sandwell Metropolitan Borough Council professor o fpaediatrie respiratory and environmental medicine Medact 航空医学研究所附属医院

经过多次拖延，最终在法院下达命令之后，英国政府7月26日才公布了一项计划，以处理国内肮脏空气违法丑闻。由于交通，特别是柴油动力汽车，造成的空气污染，英国城市的空气质量现在经常超过安全标准。因为柴油车的温室气体排放率低于... 详细信息

经过多次拖延，最终在法院下达命令之后，英国政府7月26日才公布了一项计划，以处理国内肮脏空气违法丑闻。由于交通，特别是柴油动力汽车，造成的空气污染，英国城市的空气质量现在经常超过安全标准。因为柴油车的温室气体排放率低于汽油车，随着前几届政府不断鼓励消费者购买，柴油车的数量和比例近年来不断增长。

关键词：英国空气污染环境保护环境管理

Bladder cancer exosomes: Getting the message across

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World Journal of Clinical Urology 2016年第1期5卷 18-23页

作者： Claudia Berrondo Thomas Osinski carla J Beckham Department of Urology University of Rochester School of Medicine and Dentistry University of Rochester

Bladder cancer is the seventh most common cancer in men and the seventeenth most common in women. It is also the most expensive cancer to treat over the lifetimeof a patient, partially due to the necessity of frequent cystoscopy to monitor for tumor recurrence. There have also been no new developments for the treatment of bladder cancer in the last several decades. Exosomes are small, secreted, membrane-bound vesicles representative of the donor cell. Increasing understanding of the role of exosomes in cancer biology has inspired interest in their potential use as a non-invasive diagnostic tool, prognostic markers and/or indicator of recurrence of bladder cancer, and even for use in the treatment of bladder cancer. Exosomes can be readily isolated from urine. Several groups have already demonstrated differences in the protein and micro RNA content of exosomes in bladder cancer patients compared to normal healthy volunteers. Furthermore, cancer cellderived exosomes mediate tumor progression through the delivery of their biologically active content to recipient cells. Exosomes may be useful for the delivery of targeted molecules for the treatment of bladder cancer.

关键词： Bladder cancer Cystoscopy Exosome Biomarker Urine

Clinical Application of Dynamic Gait Index-Brazilian Brief Version

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Advances in Aging Research 2018年第6期7卷 113-118页

作者： Carlos Kazuo Taguchi élida Pinto Costa Lucas Vieira Alves Larissa Karoline Santos Erbson Rodrigues de Oliveira Silva Brenda carla de Lima Araújo Fabíola Andréa Andrade dos Santos Allan Robert da Silva Audiology Departament Federal University of Sergipe S&atilde o Cristóvã o Brazil Federal University of Sergipe S&atilde o Cristóvã o Brazil Education Coordinator of Sergipe State Aracaju Brazil Speech Therapist and Audiology Departament Federal University of Sergipe S&atilde o Cristóvã o Brazil University Hospital Board Federal University of Sergipe S&atilde o Cristóvã o Brazil Statistical Departament Federal University of Sergipe S&atilde o Cristóvã o Brazil

Introduction: In elderly, the progressive degenerations in the nervous system and vestibular system compromise the human body balance leading to a greater risk of falls. The Dynamic Gait Index is a protocol that predicts risks to falls in seniors. Objective: To analyze the results of the application of the Dynamic Gait Index (DGI)-Brazilian brief proposal and establish correlation with the original version. Methods: Study approved by the Ethics and Research Committee of Federal University of Sergipe (number 0197.0.107000.09). We analyzed 223 files of socially active elderly, female gender, aged ranged 60 to 85 years, mean 68.54 (±7.61) years since 2014. The volunteers were evaluated by the DGI-Brazil. For the statistical analysis, the Pearson Correlation Momentum Correlation Test with Spearman Correlation was used, with p ≤ 0.05 and r = 1.0. Results: Sixty-three (27.8%) of the volunteers presented an altered DGI scores. The statistical analysis indicated that Task 1 and Task 2 did not contribute to decrease the total score in the test. The worst performances occurred in Tasks 3, 5 and 6. There was founded a positive correlation between Tasks 1 and 2;1 and 8;3 and 4;3 and 5;4 and 5;2 and 4;2 and 7. Negative correlation occurred between Tasks 4 and 8, and 6 was not correlated with another Task. Conclusion: The DGI-Brazilian brief version presented an excellent correlation with the original proposal and may be useful in clinical practice as a tool to evidence future risks of falls in the elderly people.

关键词： Aged Postural Balance Accidental Falls Clinical Protocols

Indolbutyric Acid and Time of the Year Influence on Rooting of Chrysanthemum Cuttings

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American Journal of Plant Sciences 2018年第3期9卷 507-516页

作者： Marina Romano Nogueira Marcos Vieira Ferraz Amanda Kelly Dias Bezerra Renata Bachin Mazzini-Guedes carla Rafaele Xavier Costa Lívia Caroline Praseres de Almeida Suzana Targanski Sajovic Pereira Kathia Fernandes Lopes Pivetta Department of Plant Production Sao Paulo State University (Unesp) Jaboticabal Brazil Federal University of Paraná (UFPR) Jandaia do Sul Brazil

The objective of this study was to analyze the effect of the seasons and indol butyric acid (IBA), as well as the preparation of IBA solutions on rooting growth of “Fine Time” chrysanthemum cuttings. The first experiment was arranged in a 4 × 2 factorial scheme: IBA concentrations (0, 1000, 2000 and 3000 mg·L-1) during summer and winter with 4 replicates of two pots and six cuttings per pot. In the second experiment, the storage of IBA solution (1000 mg·L-1) at 15°C was studied with four replicates of 10 cuttings per plot in a period of four weeks. In the third experiment, dilution and supply of IBA (1000 mg·L-1 or 1000 mg·kg-1) were studied;there were eight treatments: (1) IBA mixed with industrial talc;(2) IBA diluted in 50% alcohol and oven dried at 30°C;(3) IBA diluted in 50% alcohol and oven dried at 70°C;(4) IBA diluted in NaOH and supplied via aqueous solution;(5) IBA diluted in acetone and supplied via aqueous solution;(6) IBA diluted in alcohol 92.8% and supplied via alcoholic solution;(7) IBA diluted in alcohol 50% and supplied via alcoholic solution;(8) IBA mixed and supplied via lanolin;with four replicates of 10 cuttings per plot. Twenty-one days after cutting implementation, the following variables were evaluated: rooting percentage, number, average length and root dry mass. Statistical analysis and time-of-year averages were compared using the Tukey test at 5%;polynomial regression for IBA concentration and preparation data. The means of dilution and delivery were compared by the Scott-Knott test. Treatment with IBA at a concentration of 3000 mg·kg-1 resulted in 90% rooting in the winter and 100% in the summer for all treatments. Results suggest the concentration of 2000 mg·L-1 in the summer and 2000 and 3000 mg·L-1 during the winter provided better quality for the root system. Cuttings treated with IBA diluted in 50% alcohol and oven dried at 30°C showed higher number, length and vigor of the roots.

关键词： Dendranthema grandiflora Cutting Asexual Propagation

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爪哇的精神疾病早期病程

爪哇的精神疾病早期病程

Sensory Profile of Fermented Arabica Coffee in the Perception of American Cupping Tasters

第四届泛亚太地区心理卫生学术研讨会

作者： carla Marchira Nida Ul Hasanat Muhana Sofiati Utami Vista Pradanita Byron Good Gadjah Mada University Yogyakarta Indonesia Gadjah Mada University Yogyakarta Indonesia Gadjah Mada University Yogyakarta Indonesia Gadjah Mada University Yogyakarta Indonesia Gadjah Mada University Yogyakarta Indonesia

＜正＞调查者报告了精神分裂症发病国际试验研究（IPSOS）在印尼的日惹开展后的一些初步发现。日惹是爪哇中部一个大约有 120万人口的城市。病人来自一个大学的附属医院和一个私立医院,包括城市、市郊和农村的病人。本研究的设计是来探...

＜正＞调查者报告了精神分裂症发病国际试验研究（IPSOS）在印尼的日惹开展后的一些初步发现。日惹是爪哇中部一个大约有 120万人口的城市。病人来自一个大学的附属医院和一个私立医院,包括城市、市郊和农村的病人。本研究的设计是来探讨精神疾病的早期过程、评估精神疾病未经治疗的时间（DUP）以及探讨与未治时间相关的地方因素。还有一个假设要特别探讨,该假设来自于研究小组早先在日惹的一个研究。本研究还

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Agricultural Sciences 2019年第3期10卷 321-329页

作者： Lucas Louzada Pereira Rogério Carvalho Guarconi Tais Rizzo Moreira Dério Brioschi Jr. Joao Paulo Pereira Marcate Luiz Henrique Bozzi Pimenta de Sousa Aldemar Polonini Moreli Danieli Grancieri Debona carla Schwengber Ten Caten Federal Institute of Education Science and Technology of Espírito Santo Venda Nova do Imigrante CampusFood Science and Technology ProgramRua Elizabeth Minete PerimVitóriaBrazil Capixaba Institute for Technical Assistance Research and ExtensionINCAPERDepartment of StatisticsDomingos MartinsBrazil Department of Forest Sciences and Wood Federal University of Espirito SantoCenter for Agrarian Sciences and EngineeringJeronimo MonteiroBrazil Department of Production and Transportation Engineering Federal University of Rio Grande do SulPorto AlegreBrazil

The consumption of specialty coffees has been growing year after year, indicating that several niches and market forms according to the sensorial orientation of the consumers, as well as the cupping tasters and agents are responsible for the composition of blends, and for the physical and sensory classification of the coffees in the industry. This study presented 5 methods of spontaneous and induced fermentation to different North American cupping tasters, in order to evaluate coffee quality potential, based on the Specialty Coffee Association (SCA) protocol. During the months of May to July of 2017, 150 coffee samples were evaluated. Initial results indicate that North American cupping tasters evaluated dry fermented coffees using yeast culture as superiors, in the sensorial aspect, than the more conventional methods in Brazil. Such indication opens new discussions on the acceptance of a determined product, followed by the potential for modification of the sensory route as of the fermentation that will affect the attributes.

关键词： Arabica Coffee Fermentation Acceptance Cupping Tasters

Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: An overview of the possible applications

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World Journal of Virology 2015年第2期4卷 124-133页

作者： Alba Grifoni carla Montesano Vittorio Colizzi Massimo Amicosante Department of Biology University of Rome "Tor Vergata" Department of Biomedicine and Prevention University of Rome "Tor Vergata"

Host and viral factors deeply influence the human immunodeficiency virus(HIV) disease progression. Among them human leukocyte antigen(HLA) locus plays a key role at different levels. In fact, genes of the HLA locus have shown the peculiar capability to modulate both innate and adaptive immune responses. In particular, HLA class Ⅰmolecules are recognized by CD8+ T-cells and natural killers(NK) cells towards the interaction with T cell receptor(TCR) and Killer Immunoglobulin Receptor(KIR) 3DL1 respectively. Polymorphisms within the different HLA alleles generate structural changes in HLA classⅠpeptide-binding pockets. Amino acid changes in the peptide-binding pocket lead to the presentation of a different set of peptides to T and NK cells. This review summarizes the role of HLA in HIV progression toward acquired immunodeficiency disease syndrome and its receptors. Recently, many studies have been focused on determining the HLA binding-peptides. The novel use of immune-informatics tools, from the prediction of the HLA-bound peptides to the modification of the HLAreceptor complexes, is considered. A better knowledge of HLA peptide presentation and recognition are allowing new strategies for immune response manipulation to be applied against HIV virus.

关键词： Human immunodeficiency virus progression Human leukocyte antigen Epitope Immunoinformatics CD8+T lymphocytes

Immunoglobulin G Specific Antibody Level against Ebola Viral Glycoprotein and Nucleoprotein in Ebola Virus Disease Survivors and Their Relatives

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Journal of Biosciences and Medicines 2021年第4期9卷 179-196页

作者： Nadège Goumkwa Mafopa Raoul Emeric Guetiya Wadoum Marta Giovanetti Antonella Minutolo Béatrice Dambaya Claude Kwe Yinda Gianluca Russo Georges Teto Georgia Ambada Patrick Turay Judith Torimiro Alexis Ndjolo Jules Roger Kuate Vittorio Colizzi carla Montesano Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management Yaoundé Cameroon University of Roma “Tor Vergata” Rome Italy Department of Biochemistry University of Dschang Dschang Cameroon Departement of Public Health University of Makeni Makeni Sierra Leone National Institute of Health—ISS Rome Italy Faculty of Science University of Yaoundé I Yaoundé Cameroon Intramural Research Program National Institute of Health Bethesda Maryland USA University di Roma “Sapienza” Rome Italy Holy Spirit Hospital Makeni Makeni Sierra Leone Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Ebola virus disease is a complex zoonosis that is highly virulent in humans. Despite its sorely pathogenic and lethal nature, survivors of this infection and even asymptomatic cases are able to develop both humoral and cellular immunity against several Ebola virus (EBOV) proteins. We aimed at determining immunoglobulin G (IgG) antibodies level against two Ebola viral antigens, the glycoprotein and the nucleoprotein in Ebola survivors and their relatives. Anti-EBOV glycoprotein (GP) and nucleoprotein (NP) IgG antibodies were quantified using ELISA. We enrolled 199 participants in two different sites as follow: 91 survivors at the Loreto clinic and 70 survivors with 38 relatives of Sierra Leone Association of Ebola Survivors Bombali Branch (SLAESB) tested for anti-EBOV NP and anti-EBOV GP IgG antibodies. Our findings revealed that the median anti-EBOV IgG level among survivors was 5.7128 U/ml [IQR: 2.793 - 7.783] for anti-EBOV GP IgG and 4.431 U/ml [IQR: 2.083 - 7.696] for anti-EBOV NP IgG. Survivors relatives had a median anti-EBOV GP IgG level of ?0.7128 U/ml [IQR: -0.903 to -0.04327] and -2.711 U/ml [IQR: -4.01 to -1.918] for anti-EBOV NP IgG. We observed that IgG levels in survivors were higher than in relatives with a significant difference of about 0.0001. The median value of anti-EBOV IgG level among seropositive relatives was 0.7043 U/ml [IQR: 0.5686 to 3.716] for anti-EBOV GP IgG and 4.05 U/ml [IQR: 0.2765 to 7.759] for anti-EBOV NP IgG respectively. Interestingly, we observed that 3.30% of Loreto clinic survivors did not developed anti-EBOV NP IgG antibodies;also about 10% survivors of the SLAESB were not reactive to anti-EBOV NP IgG and 1.43% of these survivors did not express antibodies against the Ebola viral glycoprotein. Our work is consistent with previous published studies showing heterogeneity in both survivors and asymptomatic cases of Ebola infection developing adaptive immunity against EBOV proteins.

关键词： Immunoglobulin IgG Level Ebola Survivors and Relatives Glycoprotein and Nucleoprotein

Characteristics of Students in Three Schools of General Education and Council of Christian Churches of Angola in the City of Huambo-Angola on Sexuality for Educational Intervention

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Open Journal of Obstetrics and Gynecology 2016年第10期6卷 572-587页

作者： Natércia Paulina S. de Almeida Carolina Lino da Silva José R. Molina Garcia Alberto Capoco Sachiteque Welema Cipriano da Fonseca carla Ramalho Frederico João Carlos Juliana Cezaltina Naduva Kahuli Hamilton dos Prazeres Tavares Central Hospital of Huambo Huambo Angola Medical School University of Porto Porto Portugal Huambo Provincial Department of Health Huambo Angola Medical School UniversityJose Eduardo dos Santos Huambo Angola Municipal Hospital of Caála Medical School University José Eduardo dos Santos Huambo Angola

Sexual education is a social responsibility and is a part of the coherent strategy referred to the introduction in schools in Angola. It was made of a prospective, descriptive and longitudinal study that has been characterized the knowledge of sexual education of students in general education in three schools and the Council of Christian Churches in Huambo-Angola in July 2015. The sample consisted of 386 students chosen randomly;there are no sexual education programs in the education system, there are taboos on sexuality, the respondents do not know the sexual organs and much less contraceptive methods, there are still taboos in sexuality theme approach with adolescents, the results showed.

关键词： Characterization Students Schools Knowledge Sexuality