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Heparan sulfate proteoglycans as possible diagnostic molecular tools with therapeutic potential in Alzheimer′s disease

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neural Regeneration Research 2021年第7期16卷 1404-1405页

作者： Iván Fernández-Vega Laura Lorente-Gea carla martín Luis M.Quirós Department of Pathology Hospital Universitario Central de Asturias/Biobank of Principality of AsturiasHealth Research Institute of the Principality of AsturiasOviedoSpain Department of Pathology Hospital Universitario de Araba-Txagorritxu/Biobanco Vasco para la Investigación(O+eHun)Brain BankHospital UniversitarioVitoriaSpain Instituto Universitario Fernández-Vega OviedoSpain Department of Functional Biology University of OviedoSpain

Importance of dementia and Alzheimer's disease(AD): On Earth, there is a "country" that we call Dementia with around 50 million inhabitants and an estimated global economic cost of US $1 trillion(Wimo et al., 2017).AD may contribute to 60–70% of cases, with other major forms of dementia being vascular dementia, dementia with Lewy bodies and a group of diseases that contribute to frontotemporal ***, the boundaries between different forms of dementia are indistinct and mixed forms often co-exist, which are only confirmed after postmortem neuropathological studies(Fernandez-Vega et al., 2015).

关键词： al. diseases Alzheimer

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Heparan sulfate proteoglycans and heparanases in Alzheimer's disease:current outlook and potential therapeutic targets

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neural Regeneration Research 2017年第6期12卷 914-915页

作者： Laura Lorente-Gea Beatriz García carla martín Luis M.Quirós Iván Fernández-Vega Department of Pathology Hospital Universitario de Araba-Txagorritxu Department of Functional Biology University of Oviedo Instituto Universitario Fernández-Vega Department of Pathology Hospital Universitario Central de Asturias Biobanco Vasco para la Investigación (O+e Hun) Brain Bank Hospital Universitario Araba

Relevance of Alzheimer’s disease（AD）：AD is one of the greatest health-care challenges of the 21^st *** is known to be the most common neurodegenerative disease and,in the United States,the sixth most common cause ... 详细信息

关键词： outlook amyloid pathogenesis prion greatest sixth gression challenges neuronal brains

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Towards neurotoxicity testing in the 22nd century:a vision,a taste or a smell?

Towards neurotoxicity testing in the 22nd century:a vision,a...

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neurotoxicity and neurodegeneration:Local Effect and Global Impact--13th International neurotoxicology Association Meeting & 11th International Symposium on neurobehavioral Methods and Effects in Occupational and Environmental Health

作者： Jordi Llorens carla Soler-martín Blanca Cutillas Lara Sedó Sandra Saldaa-Ruiz Departament de Ciencies Fisiologiques Ⅱ Universitat de Barcelona - IDIBELLHospitalet de LlobregatSpain

The report "Toxicity testing in the 21 century:A vision and a strategy"（nRC,US nAS）,advocates for a toxicity testing strategy that relies on high throughput in vitro tests sensitive to key effects on "toxicity pathw... 详细信息

关键词： Towards neurotoxicity testing in the 22 century:a vision,a taste or a smell

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APRI as a predictor of early viral response in chronic hepatitis C patients

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世界胃肠病学杂志：英文版 2009年第39期15卷 4923-4927页

作者： José A Mata-Marín José L Fuentes-Allen Jesús Gaytán-martínez Bulmaro Manjarrez-Téllez Alberto Chaparro-Sánchez carla I Arroyo-Anduiza Infectious Diseases Department Hospital de Infectología"La Raza"National Medical CenterIMSS Clinical Pathology Department Hospital General "La Raza"National Medical CenterIMSS

AIM:To evaluate the aspartate aminotransferase(AST) to platelet ratio index(APRI) as a predictive factor of early viral response in chronic hepatitis C naive ***:We performed an ambispective case-control *** enrolled chronic hepatitis C naive patients who were evaluated to start therapy with PEGylated interferon α-2b(1.5 μg/kg per week) and ribavirin(>75 kg:1200mg and nts were allocated into two groups,group 1:Hepatitis C patients with early viral response(EVR),group 2:Patients without *** ratio(OR) and 95% confi dence interval(CI) were calculated to assess the relationship between each risk factor and the EVR in both ***:During the study,80 patients were analyzed,45 retrospectively and 35 *** mean ± SD age of our subjects was 42.9 ± 12 years;weight 70 kg(±11.19),AST 64.6 IU/mL(±48.74),alanine aminotransferase(ALT) 76.3 IU/mL(±63.08) and platelets 209000 mill/mm3(±84 429).Fifty-five(68.8%) were genotype 1 and 25(31.3%) were genotype 2 or 3;the mean hepatitis C virus RnA viral load was 2 269 061 IU/mL(±7220266).In the univariate analysis,APRI was not associated with EVR [OR 0.61(95% CI 0.229-1.655,P=0.33)],and the absence of EVR was only associated with genotype 1 [OR 0.28(95% CI 0.08-0.94,P=0.034)].After adjustment in a logistic regression model,genotype 1 remains signifi ***:APRI was not a predictor of EVR in chronic hepatitis C;Genotype 1 was the only predictive factor associated with the absence of EVR in our patients.

关键词：丙型肝炎预测应答病毒患者慢性早期

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Genetic Diversity of Great Dane Breed Using Ten Microsatellites: Impact of Breeding Control over the Breeding Line

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Open Journal of Genetics 2014年第2期4卷 78-86页

作者： Gino noris carla Santana Mariana Herrán-Aguirre Marco Antonio Meraz-Ríos Mario Pérez-martínez Carlos Esquivel-Lacroix Leonor C. Acosta-Saavedra Eduardo Rodríguez María de la Paz Juaréz Emma S. Calderón-Aranda Rocío Gómez BIMODI (Biología Molecular Diagnóstica) Querétaro Qro. México Departamento de Biomedicina Molecular Cinvestav-IPN México D.F. México Departamento de Morfología Facultad de Medicina Veteri-naria y Zootecnia Universidad Nacional Autónoma de México México D.F. México Departamento de Reproducción Facultad de Medicina Vete-rinaria y Zootecnia Universidad Nacional Autónoma de México México D.F. México Departamento de Toxicología Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508 Col. San Pedro Zacatenco México D.F. México

The American Kennel Club and the Fédération Cynologique Internationale recognize two phenotypic variants of Great Dane breed denominated American and European varieties. Historically, these varieties have been segregated according to morphological characteristics. In an attempt to obtain a better characterization, breeders have been interested in the genetic parameters that could evaluate the within-breed diversity. In this document, we studied the genetic structure of Great Dane breed with 10 STR markers in 88 dogs using capillary electrophoresis. Cluster analysis, population differentiation and phylogenetic analyses revealed that American and European varieties are genetically independent. nevertheless, within the American variety a genetic stratification was found. Additionally, a high misclassification (28%) was detected, which could be due to wrong registration or false paternity. Our results support the importance to deem genetic markers as useful tools in breeding control. Similarly, these studies serve as an accurate reference to establish standards by dog breeding associations and for choosing among dogs for inter-breeding. nevertheless, genetic tools are only a complement of morphological methods, since both are reshuffling the control over the breeding line. notwithstanding, this database provides an overall and scape concerning the impact of genetic diversity within-breed. Unmistakably, more databases are needed to increase the quality of the breeding line as well as the number of STR in order to study, with more detail, the genetic structure in the Great Dane race.

关键词： Genetic Structure Great Dane Varieties Microsatellites Population Genetics Population Stratification

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