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Gouty destruction of a patellar tendon reconstruction and novel revision reconstruction technique: A case report

World Journal of Orthopedics 2024年第7期15卷 675-682页

作者： carl c edge Jonathan Widmeyer Omar Protzuk Maya Johnson Robert O’connell Department of Orthopaedic Surgery Division of Sports MedicineVirginia Commonwealth University Health SystemRichmondVA 23298-0153United States Division of Sports Medicine OrthowestCarroltonGA 30117United States

BAcKGROUND Gout is a disease characterized by hyperuricemia,and resultant deposition of uric acid crystals in *** typically manifested as intraarticular crystals or tophi,gout can also cause pathology at *** deposition within tendinous structures put them at risk for traumatic and degenerative ***,allografts can also be at risk of rupture in the setting of severe *** present the case of a 56-year-old female with severe gouty disease who sustained a re-rupture of a patellar tendon allograft *** SUMMARY A 56-year-old female presented to clinic after feeling her left knee pop and collapse beneath her while descending *** had a history of tophaceous gout and left patellar tendon rupture with reconstruction and multiple revisions over the course of 19 *** patient presented with pain and extensor lag.A magnetic resonance image demonstrated a ruptured patellar tendon allograft reconstruction and avulsion fracture at the tibial *** patient was treated with a novel intervention of Achilles allograft with bone block in a unique configuration with a dermal allograft incorporated into the *** was made non-weight bearing in the operative extremity in extension for the first four weeks postoperatively and was then progressed to active flexion over the course of eight *** twelve weeks,she was able to fully extend her operative knee and at five months she was resuming her normal activities and *** Failed patellar tendon reconstruction due to gouty infiltration is treated with dermal allograft augmented Achilles tendon reconstruction with bone block.

关键词： Gout Patella Reconstruction Dermal allograft Revision case report

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Progress on the antiferromagnetic topological insulator MnBi2Te4

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National Science Review 2024年第2期11卷 33-49页

作者： Shuai Li Tianyu Liu chang Liu Yayu Wang Hai-Zhou Lu X.c.Xie Department of Physics Harbin Institute of Technology Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and Technology(SUSTech) Quantum Science center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen Key Laboratory of Quantum Science and Engineering International Quantum Academy Beijing Academy of Quantum Information Sciences Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of Physics Renmin University of China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua University Frontier Science center for Quantum Information Hefei National Laboratory International center for Quantum Materials School of Physics Peking University Institute for Nanoelectronic Devices and Quantum computing Fudan University

Topological materials, which feature robust surface and/or edge states, have now been a research focus in condensed maTher physics. They represent a new class of materials exhibiting nontrivial topological phases,and provide a platform for exploring exotic transport phenomena, such as the quantum anomalous Hall effect and the quantum spin Hall effect. Recently, magnetic topological materials have attracted considerable interests due to the possibility to study the interplay between topological and magnetic *** particular, the quantum anomalous Hall and axion insulator phases can be realized in topological insulators with magnetic order. MnBi2Te4, as the first intrinsic antiferromagnetic topological insulator discovered, allows the examination of existing theoretical predictions; it has been extensively studied, and many new discoveries have been made. Here we review the progress made on MnBi2Te4from both experimental and theoretical aspects. The bulk crystal and magnetic structures are surveyed first, followed by a review of theoretical calculations and experimental probes on the band structure and surface states, and a discussion of various exotic phases that can be realized in MnBi2Te4. The properties of MnBi2Te4thin films and the corresponding transport studies are then reviewed, with an emphasis on the edge state transport. Possible future research directions in this field are also discussed.

关键词： MnBi2Te4 magnetic topological insulator antiferromagnetic quantum anomalous Hall effect axion insulator

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mRNA vaccines:a new era in vaccine development

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Oncology Research 2024年第10期32卷 1543-1564页

作者： SHUBHRA cHANDRA JENNIFER c.WILSON DAVID GOOD MING Q.WEI School of Pharmacy&Medical Sciences Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia School of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,particularly through the development of mRNA cancer vaccines,has ushered in a new era in the field of *** article provides a concise overview of the key principles,recent advancements,and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer *** cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune *** vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens,prompting the immune system to recognize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vaccines holds immense potential for addressing the heterogeneity of cancer and tailoring treatments to individual *** breakthroughs in the development of mRNA vaccines,exemplified by the success of cOVID-19 vaccines,have accelerated their application in *** mRNA platform’s versatility allows for the rapid adaptation of vaccine candidates to various cancer types,presenting an agile and promising avenue for therapeutic *** trials of mRNA cancer vaccines have demonstrated encouraging results in terms of safety,immunogenicity,and *** candidates,such as BioNTech’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outcomes in targeting melanoma and solid tumors,*** successes underscore the potential of mRNA vaccines to elicit robust and durable anti-cancer immune *** the field holds great promise,challenges such as manufacturing complexities and cost considerations need to be addressed for widespread *** development of scalable and cost-effective manufacturing processes,along with ongoing clinical research,will be pivotal in realizing the full potential of mRNA cancer ***,mRNA cancer vaccines represent a cutting-edge therapeutic approach that holds the promise of transforming cancer treatment.

关键词： cancer immunotherapy Immune checkpoint Preventive&therapeutic vaccine Delivery system mRNA

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Multichannel coupling induced topological insulating phases with full multimerization

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Photonics Research 2024年第3期12卷 491-498页

作者： JUN LI YAPING YANG c-M.HU MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics and Astronomy University of ManitobaWinnipegManitoba R3T 2N2Canada

We propose and experimentally realize a class of quasi-one-dimensional topological lattices whose unit cells are constructed by coupled multiple identical resonators,with uniform hopping and inversion *** the presence of coupling-path-induced effective zero hopping within the unit cells,the systems are characterized by complete multimerization with degenerate-1 energy edge states for open boundary condition.

关键词： symmetry topological coupling

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Atomistic Investigation of Shock-Induced Amorphization within Micro-shear Bands in Hexagonal close-Packed Titanium

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： Z.c.Meng K.G.Wang T.Ali D.Li c.G.Bai D.S.Xu S.J.Li A.H.Feng G.J.cao J.H.Yao Q.B.Fan H.Wang R.Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Interdisciplinary centre for Additive Manufacturing(IcAM) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Tongji UniversityShanghai 201804China Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of Science and Technology on Materials Under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology chongqing Innovation center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated using molecular dynamics ***,non-uniform plastic deformation was observed in the *** high strain rates,amorphization occurred near the edge of the contact region where severe shear strain induced a large number of stacking faults(SFs)and *** contrast,the central part of the contact region underwent less deformation with significantly fewer ***,instead of amorphization by consuming SFs and dislocations,there was a gradual increase in the density of dislocations and SFs during the process of *** local amorphous regions eventually grew into shear bands.

关键词： Shock compression Amorphization Shear band Titanium Molecular dynamics

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A Secure Framework for WSN-IoT Using Deep Learning for Enhanced Intrusion Detection

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computers, Materials and continua 2024年第1期81卷 471-501页

作者： Kumar c.O. Gajendran S. Marappan S. Zakariah M. Almazyad A.S. School of computer Science & Engineering Vellore Institute of Technology Chennai Campus Chennai 600127 India School of Electronics & Engineering Vellore Institute of Technology Chennai Campus Chennai 600127 India Department of computer Sciences and Engineering College of Applied Science King Saud University Riyadh 11543 Saudi Arabia Department of computer Engineering College of Computer and Information Sciences King Saud University Riyadh 11543 Saudi Arabia

The security of the wireless sensor network-Internet of Things (WSN-IoT) network is more challenging due to its randomness and self-organized nature. Intrusion detection is one of the key methodologies utilized to ensure the security of the network. conventional intrusion detection mechanisms have issues such as higher misclassification rates, increased model complexity, insignificant feature extraction, increased training time, increased run time complexity, computation overhead, failure to identify new attacks, increased energy consumption, and a variety of other factors that limit the performance of the intrusion system model. In this research a security framework for WSN-IoT, through a deep learning technique is introduced using Modified Fuzzy-Adaptive DenseNet (MF_AdaDenseNet) and is benchmarked with datasets like NSL-KDD, UNSWNB15, cIDDS-001, edge IIoT, Bot IoT. In this, the optimal feature selection using capturing Dingo Optimization (cDO) is devised to acquire relevant features by removing redundant features. The proposed MF_AdaDenseNet intrusion detection model offers significant benefits by utilizing optimal feature selection with the cDO algorithm. This results in enhanced Detection capacity with minimal computation complexity, as well as a reduction in False Alarm Rate (FAR) due to the consideration of classification error in the fitness estimation. As a result, the combined cDO-based feature selection and MF_AdaDenseNet intrusion detection mechanism outperform other state-of-the-art techniques, achieving maximal Detection capacity, precision, recall, and F-Measure of 99.46%, 99.54%, 99.91%, and 99.68%, respectively, along with minimal FAR and Mean Absolute Error (MAE) of 0.9% and 0.11. © 2024 The Authors.

关键词： accuracy Deep learning false alarm rate feature selection fuzzy rules intrusion detection wireless sensor networks

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Oxygen Radical Generation as an Index of Neurotoxic Damage

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Biomedical and Environmental Sciences 1991年第1期4卷 217-223页

作者： STEPHEN c.BONDY carl P.LEBEL Department of community and Environmental Medicine University of california Irvine CA Arthur D. Little Inc. Chemical and Life Sciences Acorn Park Cambridge 92717 Massachusetts 02140

Biochemical, anatomical, and physiological characteristics of the brain make it especially vulnerable to insult. Specifically, some of these characteristics such as myelin and a high energy requirement provide for the introduction of free radical-induced insult. Recently, the biochemistry of free radicals has received considerable attention. It also has become increasingly suggestive that many drug and chemical-induced toxicities may be evoked via free radicals and oxidative stress. Major points addressed in this work are the regulation of neural-free radical generation by antioxidants and protective enzymes, xenobiotic-induced disruption of cerebral redox status, and specific examples of neurotoxic agent-induced alterations in free radicals as measured by the fluorescent probe dichlorofluorescein. This article considers that free radical mechanisms may contribute significantly to the properties of several diverse neurotoxic agents and proposes that free radicals may be common phenomena of neurotoxicity.

关键词： Oxygen Radical Generation as an Index of Neurotoxic Damage

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Seismic attribute and well-log analysis for channel characterization in the upper San Andres and Grayburg formations of the Midland Basin,Texas

Energy Geoscience

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Energy Geoscience 2024年第2期5卷 263-278页

作者： Sumit Verma Esra Yalçın Yılmaz Laura Ortiz Sanguino Justin Yandell Miles A.Henderson Robert c.Trentham Department of Geosciences The University of Texas Permian BasinOdessaTXUSA School of Geosciences The University of OklahomaNormanOKUSA

The Permian Basin is one of the most prolific,and currently one of the most active,oil and gas basins in the *** Lower Permian strata in the Permian Basin have produced more than 14 billion barrels of oil(BBO),making it the largest volume of hydrocarbon in the *** in the Midland Basin during late Leonardian through early Guadalupian(ca.272-269 Ma)resulted in progradation of shelf edge and ultimately closure of the basin by Middle Permian *** analyzed a merged seismic survey covering parts of the Permian Basin(i.e.,central Basin Platform and Midland Basin)in Andrews,Ector,and Midland counties,*** seismic survey and well logs show the presence of gently dipping(ca.1°)clinoforms in the Upper San Andres and Grayburg Formations on the eastern edge of the central Basin Platform and western Midland *** seismic attributes,curvature,and spectral decomposition identify low sinuosity slope channels oriented north-south,but such channels do not appear beyond the *** shelf edge shifts from north to south during deposition of the Upper San Andres and Grayburg *** identify five basinward shifts noted by the migration of the shelf edge toward the basin center and the presence of channel features along the depositional *** petrophysical analysis indicates that channels cut into carbonate rocks and are filled by siliciclastic sediments;this interpretation is supported by the most negative curvature anomalies along the channel axes caused by the differential compaction between the carbonate and siliciclastic *** are a few channels with a northwest-southeast strike,which matches the direction of the concho Lineament observed by satellite *** observations are consistent with previous interpretations of the northern Midland Basin closure during Middle-Late Permian time.

关键词： Permian shelf carbonate

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Implications of cMS analysis of photon-photon interactions for photon PDFs

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chinese Physics c 2018年第11期42卷 1-7页

作者： Pazilet Obul Mamut Ababekri Sayipjamal Dulat Joshua Isaacson carl Schmidt c.-P. Yuan School of Physics Science and Technology Xinjiang University Urumqi Xinjiang 830046 China center for Theoretical Physics Xinjiang University Urumqi Xinjiang 830046 China Department of Physics and Astronomy Michigan State University East Lansing MI 48824 USA Fermi National Accelerator Laboratory Batavia IL 60510 USA

As part of a recent analysis of exclusive two-photon production of W＋W- pairs at the LHc, the cMS experiment used di-lepton data to obtain an ＂effective＂ photon-photon luminosity. We show how the cMS analysis on their 8 TeV data, along with some assumptions about the likelihood for events in which the proton breaks up to pass the selection criteria, can be used to significantly constrain the photon parton distribution functions, such as those from the cTEQ, MRST, and NNPDF collaborations. We compare the data with predictions using these photon distributions, as well as the new LUXqed photon distribution. We study the impact of including these data on the NNPDF2.3QED, NNPDF3.0QED and cT14QEDinc fits. We find that these data place a useful and complementary cross-check on the photon distribution, which is consistent with the LUXqed prediction while suggesting that the NNPDF photon error band should be significantly reduced. Additionally, we propose a simple model for describing the two-photon production of W^＋W^- at the LHc. Using this model, we constrain the number of inelastic photons that remain after the experimental cuts are applied.

关键词： applications of electroweak models to specific processes summation of perturbation theory inclusive production with identified leptons photons or other nonhadronic particles

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Developments in Humidity Standards and the Psychrometer Equation

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chinese Journal of chemical Engineering 2004年第6期12卷 792-800页

作者： Ian c.Kemp carl-Gustav Berg Hyprotech UK Aspen Technology Gemini Building Fermi Avenue Harwell Business Centre Didcot Oxfordshire OX11 0QR U.K.Process Design Laboratory Faculty of Chemical Engineering Abo Akademi University Biskopsgatan 8 FIN-20500 Abo FINLAND

Determination of the wet-bulb temperature at the surface of a material is the basis of one class ofhumidity measuring instruments, and is important in industrial applications such as dryer modelling and simula-tion. The psychrometer equation is a frequently used method of estimating wet-bulb temperature, and contains apsychrometer 'constant'. Analysis shows that this is in fact a variable coefficient affected by temperature, pressure,radiation and conduction effects, and the identity of the gas and vapour. Radiation and conduction affect the dif-ference between adiabatic saturation temperature and indicated wet-bulb temperature. Inconsistencies in currentlyrecommended values for the psychrometer coefficient, including published international standards, are identifiedand explained. Particular problems arise when the enhancement factor is applied to vapour pressure to accountfor non-ideality of gases. Special considerations are also needed for wet-bulb temperatures approaching the boilingpoint, where the psychrometer coefficient tends to zero. Self-consistent recommendations recently published in thenew British Standard BS1339 are given, which cover both the air-water system and a general vapour-gas system.

关键词： psychrometry humidity standards convection diffusion enhancement factor

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