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Aberrant DNA repair as a potential contributor for the clonal evolution in subsets of anaplastic thyroid carcinomas arising through dedifferentiation: implications for future therapeutic algorithms?

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Cancer Drug Resistance 2020年第4期3卷 992-1000页

作者： carl Christofer Juhlin Department of Oncology-Pathology Karolinska InstitutetStockholm SE-17176Sweden Department of Pathology and Cytology Karolinska University HospitalStockholm SE-17176Sweden

Well-differentiated thyroid carcinoma(WDTC,including papillary thyroid carcinoma and follicular thyroid carcinoma)are fairly slow-growing tumors with an overall low mortality due to the efficacy of combinatory surgery and postoperative radioiodine *** of WDTCs may dedifferentiate into poorly differentiated thyroid carcinoma(PDTC)and anaplastic thyroid carcinoma(ATC),of which especially the latter has an exceptionally poor patient *** underlying genetics responsible for this tumor progression is only partly understood,and is complicated by the fact that subgroups of ATCs are thought to arise de novo without a demonstrable,pre-existing *** so,recent advances using next generation sequencing(NGS)techniques have identified a genetic link between WDTCs and ATCs,suggesting a step-wise accumulation of mutations driving the loss of differentiation for most *** this Commentary,recent findings from an NGS study on synchronous FTC,PDTC,and ATC tumor components from the same patient are *** using whole-genome data,clonality analyses identified a chief ancestral clone carrying mutations in TP53-associated signaling networks regulating genes involved in DNA repair,with sub-clones in each tumor component that were identified also in the less differentiated,neighboring ***,mutational signatures suggested a general mismatch repair(MMR)deficiency along with microsatellite *** findings support the chained progression model of dedifferentiation in thyroid cancer,and pinpoint a central role for defective DNA *** effective treatment modalities for ATCs are urgently needed,studies regarding therapeutic agents specifically targeting defective MMR in dedifferentiated thyroid carcinoma could be pursued.

关键词： DNA repair mismatch repair P53 thyroid carcinoma dedifferentiation anaplastic thyroid carcinoma clone treatment

NUMERICAL SIMULATION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAL JET

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： carl L. Gardner Steven J. Dwyer School of Mathematical and Statistical Sciences Arizona State University Tempe AZ 85287 USA

Computational gas dynamical simulations using the WENO-LF method are applied to modeling the high Mach number astrophysical jet XZ Tauri, including the effects of radiative cooling. Mach 55 simulations of the pulsed proto-jet are presented and analyzed in terms of interacting nonlinear waves： terminal Mach disks, bow shocks, and Meshkov-Richtmyer instabilities of the leading jet contact boundary.

关键词： astrophysical jets ENO. method gas dynamics

Quality Assurance in Toxicology Studies in Developing Countries

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Biomedical and Environmental Sciences 1989年第1期2卷 44-47页

作者： carl R.MORRIS International Chemical Consultants 4600 Pinecrest Office Park Drive Alexandria Virginia 22312

As developing countries become more involved in the international chemical trade, they must adhere to certain requirements for importation of their chemicals into foreign countries. These developing countries will be required to provide basic safety information on their chemical products, including data developed from chemical and toxicologic testing. These data must be developed in accordance with the national requirements of the importing country. Many importing countries have adopted the OECD Test Guidelines and the OECD Principles of Good Laboratory Practice (GLP) as primary guidance to assure the quality of laboratory data. These procedures provide a basis for internationally acceptable data. Several countries have incorporated many of these provisions into their national laws or administrative procedures. These procedures describe the process of documenting the conduct of laboratory studies, including recording of data, reporting of study results, and storage of data gathered. This process is intended to assure the quality and integrity of the data so that, if required, the study can be reconstructed by an auditor or an inspector. Details of these procedures and their applicability to the international chemical trade are discussed. 1989 Academic Press, Inc.

关键词： As Co Quality Assurance in Toxicology Studies in Developing Countries

HALONICKEL 2,4-DI-t-BUTYL-6-(QUINOLIN-8-YLIMINOMETHYL)PHENOLATES:SYNTHESIS,CHARACTERIZATION AND ETHYLENE REACTIVITY

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Chinese Journal of Polymer Science 2013年第5期31卷 769-777页

作者： Qi-song Shi Xiang Hao carl Redshaw 孙文华 College of Materials Science and Engineering Beijing Institute of Petrochemical Technology Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of Sciences Department of Chemistry University of Hull

A series of nickel halides bearing 2,4-di-t-butyl-6-（quinolin-8-yliminomethyl） phenolate ligands was synthesized and characterized by IR spectroscopy and elemental analysis. Molecular structures of C1 （R = H, X = Br） and C2 （R = H, X = C1） were further confirmed by single-crystal X-ray crystallographic studies, and revealed a distorted square planar geometry at nickel. Upon activation with diethylaluminum chloride （Et2AlCl）, all nickel pre-catalysts displayed good catalytic activity [up to 9.3 × 10^5 g mol-1（Ni） h-1] for ethylene oligomerization with major dimerization. In the presence of methylaluminoxane （MAO）, the nickel complex C1 was capable of ethylene polymerization under 3 MPa, and produced polyethylene products with narrow polydispersity （1.16-1.73） and molecular weights in the range of 2.6-4.95 kg/mol.

关键词： Nickel 2,4-Di-t-butyl-6-(quinolin-8-yliminomethyl)-phenolates Ethylene oligomerization Polymerization.

On the road towards the global analysis of human synapses

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Neural Regeneration Research 2017年第10期12卷 1586-1589页

作者： G.Aleph Prieto carl W.Cotman Institute for Memory Impairments and Neurological Disorders University of CaliforniaIrvineCAUSA

Synapses are essential units for the flow of information in the *** the last 70 years,synapses have been widely studied in multiple animal models including worms,fruit flies,and *** comparison,the study of human synapses has evolved significantly slower,mainly because of technical ***,three novel methods allowing the analysis of molecular,morphological,and functional properties of human synapses may expand our knowledge of the human ***,we briefly describe these methods,and evaluate how the information provided by each unique approach may contribute to the functional and anatomical analysis of the synaptic component of human brain *** particular,using tissue from cryopreserved human brains,synaptic plasticity can be studied in isolated synaptosomes by fluorescence analysis of single-synapse long-term potentiation（FASS-LTP）,and subpopulations of synapses can be thoroughly assessed in the ribbons of brain tissue by array tomography（AT）.Currently,it is also possible to quantify synaptic density in the living human brain by positron emission tomography（PET）,using a novel synaptic ***,data provided by FASS-LTP,AT,and PET may significantly contribute to the global understanding of synaptic structure and function in both healthy and diseased human brains,thus directly impacting translational research.

关键词： fluorescence analysis of single-synapse long-term potentiation array tomography positron emission tomography synaptosomes flow cytometry microscopy [11C]UCB-J[(R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3 4 5-trifluorophenyl)pyrrolidin-2-one]

Coupling Alfvénic and Ion-Acoustic Solitons

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Chinese Physics Letters 1996年第8期13卷 594-597页

作者： WU De-jin WANG De-yu carl-Gunne Fälthammar Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008*Department of Plasma PhysicsRoyal Institute of TechnologyStockholmSweden

An exact nonlinear equation governing the coupling Alfvénic and ion-acoustic solitons and criterion for their existence are *** the case of low-β plasmas,the two modes *** the small amplitude limit,the analytical re... 详细信息

关键词： solitons exact criterion

Production of the Cancer-Preventive Glucoraphanin in Tobacco

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Molecular Plant 2010年第4期3卷 751-759页

作者： Michael Dalgaard Mikkelsen carl Erik Olsen Barbara Ann Halkier University of Copenhagen Faculty of Life Sciences Department of Plant Biology Plant Biochemistry Laboratory VKR Research Centre for Pro-Active Plants 40 Thorvaldsensvej DK-1871 Frederiksberg C Copenhagen Denmark University of Copenhagen Faculty of Life Sciences Department of Basic Sciences and Environment/Bioorganic Chemistry 40 Thorvaldsensvej DK-1871 Frederiksberg C Copenhagen Denmark

Epidemiological studies have demonstrated reduced risk of developing cancer upon consumption of diets rich in cruciferous vegetables. This chemoprevention has been largely attributed to the presence of the natural products glu- cosinolates, particularly the methionine-derived glucoraphanin from broccoli. Improved nutrition by functional foods or health-promoting dietary supplements is an attractive means for prevention of lifestyle-based diseases. Towards this goal, we have engineered the glucoraphanin pathway into tobacco. First, we engineered elongation of the side chain of methionine to produce the key intermediate dihomo-methionine. This process is catalyzed through two cycles in a chain-elongation pathway that takes place partly in the cytosol and partly in the chloroplast. Second, by coupling the five enzymes of the chain-elongation pathway to eight enzymes of the glucosinolate pathway, we show production of glucoraphanin together with other glucosinolates derived from chain-elongated isoleucine and/or leucine. The conver- sion of methionine to glucoraphanin is obtained via 14 intermediates. Demonstrating the production of the high-value glucoraphanin in a heterologous host has great potential in the food and medicinal industry as a means to generate a stable, rich source of glucoraphanin for the benefit of human health.

关键词： Compartmentation secondary metabolism/natural products Agrobacterium Arabidopsis tobacco glucosinolates metabolic engineering.

Multi-affine registration using local polynomial expansion

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第7期11卷 495-503页

作者： Yuan-jun W'ANG Guimar FARNEBACK carl-Fredrik WESTIN Digital Medical Research Center Shanghai Medical School Fudan University Shanghai 200032 China Lab of Mathematics in Imaging Brigham and Women's Hospital Harvard Medical School Boston 02115 MA USA

In this paper, we present a non-linear (multi-affine) registration algorithm based on a local polynomial expansion model. We generalize previous work using a quadratic polynomial expansion model. Local affine models are estimated using this generalized model analytically and iteratively, and combined to a deformable registration algorithm. Experiments show that the affine parameter calculations derived from this quadratic model are more accurate than using a linear model. Experiments further indicate that the multi-affine deformable registration method can handle complex non-linear deformation fields necessary for deformable registration, and a faster convergent rate is verified from our comparison experiment.

关键词： Deformable registration Polynomial expansion Least squares Multi-affine Normalized convolution

Comparison of Adult Defendants' Forensic Psychiatric Evaluation in Criminal Courts between China' Mainland and Taiwan region:From Law to Clinical Practice

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Journal of Forensic Science and Medicine 2022年第1期8卷 32-40页

作者： Wai-Cheong carl Tam Department of Psychology Chung Yuan Christian UniversityTaoyuan CityTaiwanChina

The defendant’s mental capacity is often crucial in criminal procedure,and an expert witness may be requested to conduct a forensic psychiatric *** paper analyzes the law and clinical practice of adult defendants’forensic psychiatric evaluation in criminal courts between China' Mainland and Taiwan *** indicated that the law in Taiwan region explicitly mentioned more mental illness and mental capacity than the law in China' Mainland regarding forensic psychiatric *** expert witnesses,China' Mainland has established a registration and management system,but in Taiwan region,the judge decides the expert witness’s ***,clinical evaluation guidelines have been promulgated in China' Mainland,while none in Taiwan *** of the findings were discussed.

关键词： Criminal responsibility expert witness forensic assessment legal competence