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Environmental enrichment as a promising strategy for aiding multiple sclerosis treatment

Neural Regeneration Research 2020年第9期15卷 1660-1661页

作者： Berenice Anabel Silva carina cintia ferrari Instituto de Medicina Translacional e Ingenieria Biomedica del Hospital italiano(IMTIB-CONICET) Leloir Institute Foundation Institute for Biochemical InvestigationsIIBBA-CONICETBuenos AiresArgentina

Multiple sclerosis(MS)is a complex chronic disease of the central nervous system(CNS)which includes three main anatomopathological characteristics:inflammation,demyelination,*** pathology induces many clinical symptoms,depending on the site of the lesions,such as motor,sensitive,visual,urinary and cognitive *** addition,MS is a very heterogeneous disease that displays different clinical courses or phenotypes(relapsing/remitting MS,primary progressive MS(PPMS)and secondary progressive MS(SPMS).Both neurodegeneration and inflammation are present along the natural history of the ***,the balance of both phenomena varies according to the course of the *** relapsing/remitting MS form,the acute inflammation,mainly adaptive immunity,predominates over the neurodegeneration,being the main cause of the *** SPMS and PPMS,the neurodegeneration predominates over the inflammation,which appears as chronic inflammation,being innate immunity(microglia and astroglia)the main feature in the neurodegenerative process.

关键词： inflammation immunity sclerosis

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Neuroinflammation in cortical and meningeal pathology in multiple sclerosis:understanding from animal models

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Neuroimmunology and Neuroinflammation 2021年第3期8卷 174-184页

作者： Berenice Anabel Silva Esteban Miglietta carina cintia ferrari Instituto de Medicina Traslacional e Ingeniería Biomédica(IMTIB)-CONICET Buenos Aires C1181ACHArgentina Leloir Institute Foundation Institute for Biochemical InvestigationsIIBBA-CONICETPatricias Argentinas 435Buenos AiresC1405BWEArgentina.

Multiple sclerosis(MS)is a neurodegenerative and inflammatory disease usually presenting with acute demyelinating events that can start as,or progress to,chronic *** development of animal experimental models,specific for each stage of MS will aid in the design of new drugs specific for the different forms of the *** models of experimental autoimmune encephalomyelitis successfully reflect the pathophysiological mechanisms of the early phases of ***,few models resemble the features of the progressive forms of MS such as cortical demyelination and meningeal ***,a few auspicious animal models recapitulating many of the characteristics of progressive MS,aimed at a better understanding of the pathology of these forms of the disease,have been *** this review,we will summarize the latest developments in animal models reflecting the cortical and meningeal pathological features of progressive MS,as well as their response to drugs specifically targeting these forms.

关键词： Progressive multiple sclerosis experimental autoimmune encephalomyelitis cortex grey matter meningeal inflammation adaptive immune response

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