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What we have learned from urinary bladder cancer models

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 51-58页

作者： carina bernardo Céu Costa Carlos Palmeira Rosário Pinto-Leite Paula Oliveira Rui Freitas Francisco Amado Lúcio L.Santos Experimental Pathology and Therapeutics Group-Research Center Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal Mass Spectrometry Group QOPNADepartment of ChemistryUniversity of AveiroCampus Universitário de Santiago3810-193 AveiroPortugal Department of Immunology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal School of Health Sciences Fernando Pessoa University4249-004 PortoPortugal Genetic Service Cytogenetic LaboratoryHospital Center of Trás-os-Montes e Alto Douro5000-508 Vila RealPortugal Department of Veterinary Sciences CITABUniversity of Trás-os-Montes e Alto Douro5001-801 Vila RealPortugal Department of Urology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal Department of Surgical Oncology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal

Urinary bladder cancer(UBC)is a heterogeneous disease with highly variable clinical outcomes and responses to *** some advances in the molecular understanding of UBC,this knowledge still has not been translated to the clinic in terms of improvements in the prognosis and treatment of *** urinary bladder tumor models representative of the human disease in terms of histology and behavior are needed to study factors involved in tumor initiation,progression and ***,accurate model systems would facilitate identification of new therapeutic targets and predictive markers that could lead to optimization of existing therapies and development of new *** established cancer cell lines derived from human urinary bladder tumors representing different grades and stages have been used as experimental models for UBC *** cell lines reflect some of the genetic and morphologic alterations observed in human urothelial carcinoma and serve as simplified models to study the behavior of cancer cells in ***,their translational potential is limited due to the artificial conditions,in which the cells are maintained,grown and *** models offer a more complex and realistic model for the establishment,development,and progression of tumors as well as to evaluate new therapeutic *** the years,the authors'group has worked with several UBC cell lines,established and characterized chemically induced UBC models,and patient-derived xenografts *** this study,the authors will provide a summary of the UBC models developed by their group,analyze their translational potential and weaknesses,and define areas that remain to be explored.

关键词： Animal models cell lines tumor behavior urothelial bladder cancer xenografts

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Using detection dogs and genetic analyses of scat to expand knowledge and assist felid conservation in Misiones, Argentina

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Integrative Zoology 2014年第5期9卷 623-639页

作者： Karen E.DeMATTEO Miguel A.RINAS carina F.ARGÜELLES bernardo E.HOLMAN Mario S.DI BITETTI Barbara DAVENPORT Patricia G.PARKER Lori S.EGGERT Department of Biology University of MissouriSt.LouisUSA WildCare Institute at the Saint Louis Zoo St.LouisUSA Ministerio de Ecología y Recursos Naturales Renovables Argentina Instituto de Biología Subtropical(IBS)-nodo Posadas Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional de Misiones(UNaM)Argentina Facultad de Ciencias Exactas Químicas y NaturalesUNaMArgentina IBS-nodo Puerto Iguazú CONICET-UNaMArgentina Asociación Civil Centro de Investigaciones del Bosque Atlántico Argentina PackLeader Dog Training LLC Division of Biological Sciences University of MissouriColumbiaUSA

Many carnivores require large ranges to meet their ecological and energetic needs;however,anthropogenic changes threaten species and their *** traps have been used to effectively collect data on carnivores in a variety of habitat types;however,a single survey effort is typically limited to species that have similar body size,habitat use and movement patterns,and individual identification of animals is not always pos*** evaluated whether scat detection dogs could effectively survey for 4 wide-ranging felids that vary in these characteristics:jaguars(Panthera onca),pumas(Puma concolor),ocelots(Leopardus pardalis)and oncillas(Leopardus tigrinus).From June to October 2009 and May to August 2011,a detection dog-handler team detected 588 scats,from which 176 unique genotypes were *** assigned sex to 84.7%of the genotyped scats and identified 55 individuals multiple *** effectiveness of these noninvasive techniques(detection dogs and genetic analyses of scat)not only opens the door for additional studies in areas that were previously difficult or impossible with standard survey techniques,but also provides conservationists with a set of tools that overcome some of the limitations associated with the use of camera traps alone.

关键词： conservation detection dogs felids genetics noninvasive techniques

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菲律宾及其邻近地区的地磁场模型研究

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地球物理学报 2011年第8期54卷 2085-2092页

作者：狄传芝顾左文 bernardo M.Soriano 陈斌 carina G.Lao 张毅辛长江高金田中国地震局地球物理研究所北京100081 菲律宾大气和地球物理与空间科学处安徽省地震局工程院合肥230031 甘肃省地震局兰州观象台兰州730046

根据2001～2007年期间在菲律宾境内测量的74个点的地磁场数据,利用球冠谐和、泰勒多项式两种方法建立了2005.0菲律宾及周边地区地磁基本场模型,得到了菲律宾地区X、Y、Z、D、I、H、F七个分量的分布.两种模型反映的同一地区的地磁场分布... 详细信息

根据2001～2007年期间在菲律宾境内测量的74个点的地磁场数据,利用球冠谐和、泰勒多项式两种方法建立了2005.0菲律宾及周边地区地磁基本场模型,得到了菲律宾地区X、Y、Z、D、I、H、F七个分量的分布.两种模型反映的同一地区的地磁场分布形态基本类似,只在拐点的舒缓度、等值线平滑度等方面存在区别.在8°N左右,X、H、F出现系统的拐点,同纬度的X、H、F东低西高.D、y零线分布于8°N左右呈东西展布,北侧为负,南侧为正,等值线沿经度分布的同时,在纬度上有不同程度的小起伏.Z、I空间分布呈现更加规则均匀的东西向分布特征.零线分布在7.5°N左右,零线北部是正值区域,南部是负值区域.两种模型与IGRF的差值的分布形态有很大的不同,球冠谐模型与IGRF模型差值的正负异常区域呈现正负异常相间的分布特征,且各分量的正负异常最大值分布在低纬度地区.而泰勒多项式与IGRF差值的正负异常分布却相对完整.

关键词：菲律宾地区地磁场球冠谐模型泰勒多项式模型

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