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Mechanism of Ginkgo biloba *** in the treatment of ischemic stroke based on network pharmacology,bioinformatics and molecular docking

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Asian Journal of Traditional Medicines 2022年第6期17卷 259-274页

作者： Hanxiao Shang Fei Zhai Ya Zeng Yanjie cao Xiaohui Han rongwu xiang Jingyu Yang Department of Pharmacology Shenyang Pharmaceutical UniversityShenyangChina Department of Clinical Pharmacy Shenyang Pharmaceutical UniversityShenyangChina Department of Pharmaceutical Information Shenyang Pharmaceutical UniversityShenyangChina

Ginkgo biloba ***(GBL)has been reported to protect against ischemic stroke(IS),one of the leading causes of death and longterm disability worldwide,while there is a lack of systematic study on the exact ***,network pharmacology and bioinformatics were used to predict the active components,important targets,and potential mechanisms of GBL in the treatment of *** compounds of GBL were screened based on drug-like index and oral bioavailability,key target genes were screened based on network pharmacology and gene chip,downstream pathways for the regulation of key target genes were predicted based on gene set enrichment analysis,and the interaction between key targets and active compounds was verified based on molecular *** results showed that GBL played a protective role in cerebral ischemia with mainly 14 active compounds,such as isoquercitrin,luteolin-4’-glucoside,beta-sitosterol,campesterol,diosmetin,ginkgolide B,ginkgolide C,ginkgolide J,ginkgolide M,isogoycyrol,laricitrin,luteolin,sesamin,and *** studies revealed that GBL played important role in immunomodulation and inflammation inhibition after cerebral ischemia by acting on its peripheral targets ARG1 and MMP9 to regulate Toll-like receptor,Chemokine and Notch signaling ***,GBL played important role in reducing neuroinflammation and blood-brain barrier damage after cerebral ischemia by acting on its central targets,CCL2,PTGS2,IL6,IL1B and MMP9 to regulate the Cytokine-cytokine receptor interaction,Jak-STAT,and Toll-like receptor signaling ***,molecular docking verified that the active compounds mentioned above could bind to ARG1,MMP9,CCL2,PTGS2,IL6,and *** present study shows the multicomponent,multitarget and multichannel pharmacological effects of GBL on cerebral ischemia and provides a new strategy for the treatment of IS.

关键词： Ginkgo biloba L. ischemic stroke network pharmacology bioinformatics molecular docking

Advance in Operator Theory and Jiang's Seven Questions

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Communications in Mathematical Research 2023年第2期39卷 287-295页

作者： Chunlan Jiang Yang cao Department of Mathematics Hebei Normal UniversityShijiazhuangHebei 050016China School of Mathematics Jilin UniversityQianjin Street 2699Changchun130021China

In this paper we review the seven questions posed by Professor Jiang Zejian and summarize the progress of ***,we introduce those applications of tools developed in studying Jiang's questions,especially in dealing with... 详细信息

关键词： BIR operator geometric operator Halmos'third question

Advances in depressants used for pyrite fotation separation from coal/minerals

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International Journal of Coal Science & Technology 2022年第4期9卷 29-48页

作者： Yulong Li Gan Cheng Mengni Zhang Yijun cao Ee Von Lau College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000China Henan Key Laboratory of Coal Green Transformation Henan Polytechnic UniversityJiaozuo 454000China Collaborative Innovation Center of Coal Work Safety and Clean High Efciency Utilization Henan Polytechnic UniversityJiaozuo 454000China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450000China School of Engineering Monash University MalaysiaSelangor 47500Malaysia

Pyrite is separated from other minerals mainly by ***,the hydrophilicity of pyrite is afected by many factors,causing it to easily enter the concentrate and consequently reduce the quality of *** efcient pyrite depressants can be selectively adsorbed on the surface of pyrite to improve its hydrophilicity,thereby increasing the fotation separation *** the fundamental inhibition mechanism of depressants on pyrite is a prerequisite to improve the fotation desulfurization *** inhibition ability and mechanism of diferent types of pyrite depressants are reviewed in this *** recent years,molecular simulation has increasingly become a powerful tool to study the interaction between reagents and minerals,shedding new light on the adsorption mechanisms of reagents on mineral surfaces at the atomic and electronic *** properties of sulfde mineral and fotation reagents as well as the microscopic adsorption mechanistic studies of reagents on mineral surfaces based on quantum chemistry and molecular simulation are also reviewed.

关键词： Pyrite Flotation Depressant Coal Mineral

Automation and Orchestration of Zero Trust Architecture:Potential Solutions and Challenges

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Machine Intelligence Research 2024年第2期21卷 294-317页

作者： Yang cao Shiva Raj Pokhrel Ye Zhu Robin Doss Gang Li Centre for Cyber Resilience and Trust Deakin UniversityBurwood 3125Australia School of Information Technology Deakin UniversityGeelong 3216Australia

Zero trust architecture(ZTA)is a paradigm shift in how we protect data,stay connected and access *** is non-perimeter-based defence,which has been emerging as a promising revolution in the cyber security *** can be used to continuously maintain security by safeguarding against attacks both from inside and outside of the network ***,ZTA automation and orchestration,towards seamless deployment on real-world networks,has been limited to be reviewed in the existing *** this paper,we first identify the bottlenecks,discuss the background of ZTA and compare it with traditional perimeter-based security *** importantly,we provide an in-depth analysis of state-of-the-art AI techniques that have the potential in the automation and orchestration of ***,in this review paper,we develop a foundational view on the challenges and potential enablers for the automation and orchestration of ZTA.

关键词： Zero trust architecture cyber security artificial intelligence access control authentication

Carbon Dots Intensified Mechanochemiluminescence from Waterborne Polyurethanes as Tunable Force Sensing Materials

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Chinese Journal of Polymer Science 2021年第11期39卷 1403-1411页

作者： Bo-Han cao Wu Chen Wan-Yuan Wei Yu-Lan Chen Yuan Yuan Tianjin Key Laboratory of Molecular Optoelectronic Science Department of ChemistryTianjin UniversityTianjin 300354China

1,2-Dioxetane is a well-known chemiluminescent mechanophore allowing real-time monitoring of polymer chain scission,but usually suffers from fluorescence quenching in polar ***,a series of mechanochemiluminescent waterborne polyurethanes/carbon dots composites(WPU-CDs)have been synthesized by incorporating fluorescent CDs to promote the energy transfer process in different *** resulting bulk WPUs,and in particular,their swollen films filled with a large amount of polar solvents(water and ionic liquid)emit intense *** force-induced covalent bond scission and stress distribution within these different WPU-CDs films can be sensitively ***,the ionic liquid containing films exhibited both electrical and luminescent signal changes under stretching,which offer a new kind of force sensor responsive at a broad detecting strain range and for multi-mode strain *** study is expected to stimulate new research endeavors in mechanistic insight on waterborne polyurethanes and the corresponding stretchable sensing devices.

关键词： Polymer mechanochemistry Mechanochemiluminescence Waterborne polyurethane Carbon dots Force sensing

FISS GAN:A Generative Adversarial Network for Foggy Image Semantic Segmentation

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IEEE/CAA Journal of Automatica Sinica 2021年第8期8卷 1428-1439页

作者： Kunhua Liu Zihao Ye Hongyan Guo Dongpu cao Long Chen Fei-Yue Wang School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Automotive Simulation and Control and the Department of Control Science and Engineering Jilin University(Campus Nanling)Changchun 130025China Mechanical and Mechatronics Engineering Department at the University of Waterloo 200 University Avenue West WaterlooON N2L 3G1Canada State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China

Because pixel values of foggy images are irregularly higher than those of images captured in normal weather(clear images),it is difficult to extract and express their *** method has previously been developed to directly explore the relationship between foggy images and semantic segmentation *** investigated this relationship and propose a generative adversarial network(GAN)for foggy image semantic segmentation(FISS GAN),which contains two parts:an edge GAN and a semantic segmentation *** edge GAN is designed to generate edge information from foggy images to provide auxiliary information to the semantic segmentation *** semantic segmentation GAN is designed to extract and express the texture of foggy images and generate semantic segmentation *** on foggy cityscapes datasets and foggy driving datasets indicated that FISS GAN achieved state-of-the-art performance.

关键词： Edge GAN foggy images foggy image semantic segmentation GAN semantic segmentation

Vanadium Haloperoxidases Model Compounds: Synthesis, Structural Characterization and Mimic Catalytic Bromination Activity of [VO(C_2O_4)(2,2′-bipy)(H_2O)]·C_2H_5OH and VO(C_2O_4)(phen)(H_2O)

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Chemical Research in Chinese Universities 2012年第5期28卷 768-774页

作者： REN Dong-xue cao Yun-zhu CHEN Chen XING Yong-heng College of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 116029R R.China

Two oxo-vanadium（IV） complexes, [VO（C2O4）（2,2′-bipy）（H2O）]·C2H5OH（1） and VO（C2O4）（phen）（H2O）（2）, where 2,2′-bipy=2,2′-bipyridyl, phen=1,10-phenanthroline, were synthesized as potential functional models of vanadium haloperoxidases（VHPOs） in mixed solvent of ethanol and water at room temperature. The complexes were characterized by elemental analysis, infrared（IR）, UV-Vis and X-ray crystallography. Structural analyses showed that vanadium atom was coordinated by a terminal oxygen, one oxygen atom from coordinated water, two oxygen atoms from the carboxylate group of oxalic acid, and two nitrogen atoms（N1 and N2） from 2,2′-bipy/phen. Central vanadium atoms in complexes 1 and 2 were both in a distorted-octahedral environment, and some intermolecular hydrogen bonding linkages were also observed in each complex. Bromination reaction activity of the two complexes was evaluated with phenol red as organic substrate in the presence of H2O2, Br-and phosphate buffer, indicating that they can be considered as a potential functional model of VHPO. In addition, thermal analysis was also performed and discussed in detail.

关键词： Oxo-vanadium complex Bromination reaction activity Vanadium haloperoxidase

Concentrating partially entangledW-class states on nonlocal atoms using low-Q optical cavity and linear optical elements

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Science China(Physics,Mechanics & Astronomy) 2016年第10期59卷 42-48页

作者： Cong cao Xi Chen YuWen Duan Ling Fan Ru Zhang TieJunWang Chuan Wang State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications School of Ethnic Minority Education Beijing University of Posts and Telecommunications School of Science Beijing University of Posts and Telecommunications

Entanglement plays an important role in quantum information science, especially in quantum communications. Here we present an efficient entanglement concentration protocol(ECP) for nonlocal atom systems in the partially entangled W-class states, using the single-photon input-output process regarding low-Q cavity and linear optical elements. Compared with previously published ECPs for the concentration of non-maximally entangled atomic states, our protocol is much simpler and more efficient as it employs the Faraday rotation in cavity quantum electrodynamics(QED) and the parameter-splitting method. The Faraday rotation requires the cavity with low-Q factor and weak coupling to the atom, which makes the requirement for entanglement concentration much less stringent than the previous methods, and achievable with current cavity QED techniques. The parameter-splitting method resorts to linear-optical elements only. This ECP has high efficiency and fidelity in realistic experiments, and some imperfections during the experiment can be avoided efficiently with currently available techniques.

关键词： entanglement concentration W-class states cavity QED linear optical elements

Changes in thyroid function in patients with liver failure and their clinical significance:A clinical study of non-thyroidal illness syndrome in patients with liver failure

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 561-566页

作者： Hong-Ling Feng Qian Li Wu-Kui cao Ji-Ming Yang Intensive Care Unit Tianjin Second People’s HospitalTianjin 300192China

Background:Non-thyroidal illness syndrome(NTIS)develops in a large proportion of critically ill patients and is associated with high risk for *** aimed to investigate the correlation between NTIS and liver failure,and the short-term mortality of patients with these ***:The clinical data of 87 patients with liver failure were collected retrospectively,73 of them were randomly selected for an observational study and to establish prognostic models,and 14 for model *** 73 sex-and age-matched patients with mild chronic hepatitis were randomly selected as a control *** free triiodothyronine(FT3),free thyroxine(FT4),and thyroid-stimulating hormone(TSH)were *** clinical characteristics of patients with liver failure and NTIS were *** follow-up of patients lasted for 3 ***,the values for predicting short-term mortality of model for end-stage liver disease(MELD),Child-Turcotte-Pugh(CTP),chronic liver failure-sequential organ failure assessment(CLIF-SOFA)scores,FT3-MELD model,and FT3 were ***:The observation group had significantly lower FT3(2.79±0.71 vs.4.43±0.75 pmol/L,P<0.001)and TSH[0.618(0.186-1.185)vs.1.800(1.570-2.590)mIU/L,P<0.001],and higher FT4(19.51±6.26 vs.14.47±2.19 pmol/L,P<0.001)than the control *** was diagnosed in 49 of the patients with liver failure(67.12%).In the observation group,patients with NTIS had a higher mortality rate than those without(63.27%vs.25.00%,P=0.002).Across the whole cohort,the 3-month mortality was 50.68%.The international normalized ratios(INR)were 2.40±1.41 in survivors and 3.53±1.81 in deaths(P=0.004),the creatinine(Cr)concentrations were 73.27±36.94μmol/L and 117.08±87.98μmol/L(P=0.008),the FT3 concentrations were 3.13±0.59 pmol/L and 2.47±0.68 pmol/L(P<0.001),the MELD scores were 22.19±6.64 and 29.57±7.99(P<0.001),the CTP scores were 10.67±1.53 and 11.78±1.25(P=0.001),and the CLIF-SOFA scores were 8.42±1.68 and 10.16±2.03(P<0.001),resp

关键词： Liver failure Non-thyroidal illness syndrome Free triiodothyronine Prognosis