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Crystal-phase-controlled PtSn intermetallic nanowires for efficient methanol oxidation

Science china Chemistry 2024年

作者： Siyu cao Mengfan Li Zihan Guo Li Gong Yangfan Lu Wenhua Zhang Yu Ni Lei Gao Chao Ma Hongwen Huang College of Materials Science and Engineering Changsha University of Science and Technology College of Materials Science and Engineering Hunan University zhejiang Provincial Engineering Research Center of Oxide Semiconductors for Environmental and Optoelectronic Applications Institute of Wenzhou Zhejiang University State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University department of Chemical Physics University of Science and Technology of China china Power Engineering Consulting Group Co. LTD Shenzhen Research Institute of Hunan university

Developing highly efficient Pt-based methanol oxidation reaction（MOR） catalysts is pivotal for direct methanol fuel cells. Phase engineering of nanomaterials offers a promising strategy to improve their catalytic performance, yet achieving phase modulation in one-dimensional nanowires（NWs） remains a great challenge. Herein, we report a facile and one-pot synthesis approach for the crystal-phase-controlled Pt-Sn intermetallic nanowires（NWs）, realizing the crystal-phases regulation of face-centered cubic Pt3Sn intermetallic NWs（FCC-Pt3Sn INTNWs） and hexagonal close-packed PtSn intermetallic NWs（HCP-PtSn INTNWs） by adjusting the amounts of Sn precursors. Notably, the FCC-Pt3Sn INTNWs exhibit high mass and specific activities of6.4 A mg-1Pt and 11.8 m A cm–2. respectively, surpassing its counterparts, the HCP-PtSn INTNWs and commercial Pt/C *** a 10,000 s durability test, the FCC-Pt3Sn INTNWs still maintain a mass activity of 5.6 A mg-1Pt, which is 2..3 times higher than that of commercial Pt/C catalyst. This dramatic enhancement of MOR performance is primarily attributed to the phasecontrolled structure and accelerated removal of CO intermediates（CO*）. Theoretical calculations and CO stripping experiments demonstrate that the FCC-Pt3Sn INTNWs lower the energy barrier for converting CO* into COOH* by reducing CO* binding and enhancing OH adsorption, thus significantly improving the MOR activity, CO tolerance, and stability.

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自拟癣良方对咪喹莫特诱导小鼠银屑病的治疗作用及机制研究

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军事医学 2024年第3期48卷 219-224页

作者：李金隆曹德森曹岗浙江中医药大学药学院杭州310053 解放军总医院医学工程科北京100853

目的观察自拟癣良方对咪喹莫特诱导小鼠类银屑病的治疗作用并探讨其作用机制。方法BALB/c小鼠随机分为正常组、模型组及口服外涂组,每组10只。采用背部涂布5%咪喹莫特乳膏诱导建立BALB/c小鼠银屑病模型,考察自拟癣良方对银屑病的治疗作... 详细信息

目的观察自拟癣良方对咪喹莫特诱导小鼠类银屑病的治疗作用并探讨其作用机制。方法BALB/c小鼠随机分为正常组、模型组及口服外涂组,每组10只。采用背部涂布5%咪喹莫特乳膏诱导建立BALB/c小鼠银屑病模型,考察自拟癣良方对银屑病的治疗作用。于咪喹莫特乳膏诱导前,以及诱导后第3、7、10及12.,通过光声成像技术,观察小鼠皮肤血管分布和迂曲变化,评价自拟癣良方对血管异常新生的影响。采用苏木素-伊红染色,评价实验小鼠皮肤局部病理变化。采用酶联免疫吸附试验检测小鼠皮肤组织及血清中肿瘤坏死因子α(TNF-α)、白细胞介素-17(IL-17)及白细胞介素-6(IL-6)等细胞因子含量变化。通过流式细胞术,考察小鼠脾脏中Treg、Th1、Th17等细胞因子含量。结果与模型组相比,口服外涂组银屑病面积与严重性指数(PASI)评分显著下降(P1),口服外涂组皮肤中TNF-α、IL-17及IL-6含量显著下调(P1),口服外涂组Treg、Th17及Th1细胞比例明显下降(P<0.05),口服外涂组小鼠皮肤组织病理学(Baker法)评分明显降低(P<0.05)。结论自拟癣良方对银屑病具有良好治疗作用,可通过免疫抑制作用抑制银屑病皮损。

关键词：银屑病小鼠中药光声成像免疫抑制

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Vc与Cu^(2.)的耦合氧化对桑葚花色苷的降解作用

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食品科技 2011年第5期36卷 194-198页

作者：刘亮何雄施能进曹少谦浙江医药高等专科学校应用生物系宁波315100 浙江万里学院生物与环境学院宁波315100

研究通过构建含Vc和Cu2.的桑葚汁模拟体系,研究这两个内源因子对花色苷的降解作用。研究表明Vc能显著促进花色苷的降解,而在果汁所含Cu2.浓度下,Cu2.对花色苷具有一定的保护作用,但当在体系中与Vc共存时,则能大大促进花色苷的降解。因此... 详细信息

研究通过构建含Vc和Cu2.的桑葚汁模拟体系,研究这两个内源因子对花色苷的降解作用。研究表明Vc能显著促进花色苷的降解,而在果汁所含Cu2.浓度下,Cu2.对花色苷具有一定的保护作用,但当在体系中与Vc共存时,则能大大促进花色苷的降解。因此,可以得出一个花色苷被Vc和Cu2.耦合氧化的降解机制:低浓度时,Cu2.自身不催化花色苷的降解,但当有Vc存在时,它能先通过促进Vc的氧化降解,使Vc转化为对花色苷降解有显著促进作用的氢过氧化物,从而加速花色苷的降解。

关键词：桑葚花色苷 Vc 耦合氧化热降解

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Grifolin,secondary metabolite from the mushroom Albatrellus confluens,a potential ERK1/2.kinase inhibitor

Grifolin,secondary metabolite from the mushroom Albatrellus ...

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2.08年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Xiang-jian Luo~1 Mao Ye~2.Su-fang Liu~1 Xue-chi Lin~1 Li-li Li~1 Yan-feng Liu~1 Zi-jian Li~1 Ji-kai Liu~(3*) Ya cao~(1*) ~1 Cancer Research Institute,Xiangya School of Medicine,Central South university,Changsha,Hunan 410078,P.R.{2. ~2.School of Ophthalmology and Optometry,Wenzhou Medical College,Wenzhou,,zhejiang 32.02.,P.R.{2. ~3 department of Phytochemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan 6502.4,P.R.{2.

Grifolin,a secondary metabolite isolated from the fresh fruiting bodies of the mushroom Albatrellus confiuens,has shown various pharmacological and microbiological *** this study,we investigated the mechanism of tumor cells proliferation inhibition by *** findings suggested that grifolin could downregulate the phosphorylation level of ERK1/2.protein as well as its kinase activity and may act as an ERK1/2.kinase inhibitor in some types of human *** of the important role of the ERK1/2.pathway in cancer biology,the discovery of potent inhibitors of the important enzymes in this pathway is a highly attractive endeavor both scientifically and commercially.

关键词： Grifolin ERK1/2 Kinase inhibitor

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Interferon-y is an autocrine mediator for dendritic cell maturation

Interferon-y is an autocrine mediator for dendritic cell mat...

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浙江省免疫学会第五次学术研讨会

作者： Jianping Pan, Minghui Zhang, Jianii Wang, Qingqing Wang, Dajing Xia, Wenji Sun, Lihuang Zhang, Hai Yu, Yongjun Liu, Xuetao cao (Institute of Immunology, zhejiang university, {2. 310031, P.R. china Institute of Immunology, Second Military Medical university, Shanghai 2.0433, P.R. china department of Immunology, university of Texas, MD Anderson Cancer Center, Texas 77030, USA)

Maturation of dendritic cells (DC) is critical for efficient antigen presentation and initiation of an immune response. Interferon-γ(IFN-γ) is an important Thl cytokine. In this study, we investigated the role of IFN-γin DC maturation using either IFN-γreceptor deficient- or IFN-γoverexpression-models. We showed that immature DC generated in vitro from bone marrow progenitor cells produced low level of IFN-γ. After LPS stimulation, DC produced more IFN-γ, and IFN-γproductions were at comparable levels among C57BL/6 mice-derived DC (C57BL/6 DC), wild-type 12. mice-derived DC (12. DC) and IFN-y receptor deficient 12. mice-derived DC (IFN-γR-/-DC) . We found that IFN-γR-/-DC exhibited decreased expression of CD54, CD86, reduced capacity to secrete IL-1βand IL-12.70, and impaired capacity to stimulate alloreactive T cells and to drive Thl differentiation. Transfection of IFN-y gene into DC promoted DC to express higher CD40, CD54, CD80, CD86, CCR7 and I-Ab, secrete more IL-1βand IL-12.70, and more potently activate both CD4 and CDS T cells. These data suggest that IFN-γsignaling pathway is important for the maturation of DC in an autocrine fashion.

关键词： Interferon-γ Dendritic cells Interferon-γ receptor deficiency Antigen presentation Interleukin-12

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Effects of Shikonin Isolated from Zicao on Lupus Nephritis in NZB/W F1 Mice

Effects of Shikonin Isolated from Zicao on Lupus Nephritis i...

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2.09中国中西医结合系统性红斑狼疮研究学术会议

作者： Xin Chang WANG,~(a,c) Jian FENG,~(*,b) Feng HUANG,~(*,a) Yong Sheng FAN,~c Yan Yan WANG,~(a,c) Ling Yong cao,~c and Cheng Pin WEN~c a department of Rheumatology,Chinese PLA General Hospital No.2. Road Fuxing,Beijing 100089,{2.:b department of Pharmaceutics,zhejiang Chinese Medical university and c School of Basic Medical Sciences,zhejiang Chinese Medical university No.548 Road Binwen,District Binjiang,hangzhou 310053,{2..

The present study was performed to evaluate the potential protective effects of Shikonin extracted from Zicao on lupus nephritis(LN) using NZB/W F1 *** administration of Shikonin(2.,40 mg/kg body weight/d) or vehicle was applied to sixty female NZB/W F1 mice of 2.-week-old with *** with Shikonin for 14 weeks suppressed proteinuria dose-dependently with the mean proteinuria of 2.4.0 mg/dl and 160.3 mg/dl for low-dose and high-dose Shikonin groups,respectively,compared to 499.2.g/dl for the ***,Shikonin was observed to reduce circulating adhesion molecules significantly and down-regulate intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) mRNA expression in ***, anti-double stranded(ds)DNA antibody in mice with low or high Shikonin dose administration both exhibited no significant elevation,differing from vehicle *** histological examination showed that renal glomerular lesions were alleviated after Sbikonin *** results suggest that Shikonin has therapeutic effects on LN in NZB/W F1 mice,to which inhibition of anti-dsDNA may be potential contribution,and its part mechanism is related to suppression of mRNA expression of cell adhesion molecules(CAMs) in the kidney.

关键词： Shikomin lupus nephritis Zicao NZB/WF1 mouse

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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min Hu Yuehua Liu Yan Liu Jie Guo Fang Jin Yang cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang Li Rui Zou Yulou Tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&department of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~2.0 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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预应力混凝土连续梁的非线性分析

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绍兴文理学院学报（自然科学版） 2003年第9期23卷 63-67页

作者：沈湧王卫平曹立勇楼文娟浙江省财政投资工程预决算评审中心，浙江杭州310006 绍兴中兴工程建设监理有限公司，浙江绍兴312.00 浙江绿城控股集团有限公司，浙江杭州310012 浙江大学建筑工程学院，浙江杭州3.002.

采用分层法对预应力混凝土梁进行了非线性有限元分析，利用计算机数值计算方法，模拟预应力混凝土多跨连续梁的加载试验全过程，分析预应力混凝土梁的非线性特性，通过各层单元引入对应材料的非线性模型，并采用离散裂缝模型，能较正确... 详细信息

采用分层法对预应力混凝土梁进行了非线性有限元分析，利用计算机数值计算方法，模拟预应力混凝土多跨连续梁的加载试验全过程，分析预应力混凝土梁的非线性特性，通过各层单元引入对应材料的非线性模型，并采用离散裂缝模型，能较正确地模拟预应力混凝土梁从弹性状态到极限状态的受力特性，算例表明该方法既能使混凝土非线性分析的结构模型得到简化，又能较好地预测预应力混凝土梁的开裂荷载、极限荷载、正截面裂缝开展、荷载挠度曲线关系和钢筋及混凝土的应力变化过程，计算结果与试验结果吻合较好。

关键词：预应力混凝土连续梁非线性有限元分析分层法离散裂缝模型加载试验

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DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2774-2790页

作者： Mingjing Yan Junpeng Gao Ming Lan Que Wang Yuan cao Yuxuan Zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu Junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin Liu Weiqing tang Xiyue Zhang Yong Man Liang Sun Jianping Cai Qing He Fuchou tang Jian Li Tao Shen The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China Peking university Fifth School of Clinical Medicine Beijing 100730China department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China department of Health Care Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China department of Pathology and Pathophysiology and department of Cardiology at Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China department of Cardiovascular Surgery Peking University Shenzhen HospitalShenzhen 518036China Experimental Technology Center for Life Sciences at Beijing Normal university Beijing 100875China

DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor *** DDX17 is abundantly expressed in the myocardium,its role in heart is not fully *** generated cardiomyocyte-specific Ddx17-knockout mice(Ddx17-cKO),cardiomyocyte-specific Ddx17 transgenic mice(Ddx17-Tg),and various models of cardiomyocyte injury and heart failure(HF).DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte ***-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis,leading to progressive cardiac dysfunction,maladaptive remodeling and progression to heart *** of DDX17 expression in cardiomyocytes protects cardiac function under pathological *** studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6(BCL6)and inhibit the expression of dynamin-related protein 1(DRP1).When DDX17 expression is reduced,transcriptional repression of BCL6 is attenuated,leading to increased DRP1 expression and mitochondrial fission,which in turn leads to impaired mitochondrial homeostasis and heart *** also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart *** findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.

关键词： DDX17 homeostasis cardiac

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成年女性舌骨位置与牙颌面相关指标的三维分析

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山东大学学报（医学版） 2018年第5期56卷 85-90页

作者：李丁洋曹闪闪郭泾山东大学口腔医学院山东大学口腔医院正畸科山东济南250012 山东省口腔生物医学重点实验室山东济南250012 杭州口腔医院正畸科浙江杭州310002

目的探讨成年女性牙颌面复合体的相关指标与舌骨位置的关联性,依据牙颌面相关因素回归分析得到较为敏感的指标。方法选取成年女性患者53例,18.4~30.7岁,平均2..7岁。拍摄自然头位下头颅侧位片和锥形束CT(CBCT)。应用Dolphin软件定点测... 详细信息

目的探讨成年女性牙颌面复合体的相关指标与舌骨位置的关联性,依据牙颌面相关因素回归分析得到较为敏感的指标。方法选取成年女性患者53例,18.4~30.7岁,平均2..7岁。拍摄自然头位下头颅侧位片和锥形束CT(CBCT)。应用Dolphin软件定点测量分析牙颌面以及舌骨位置的相关指标,采用SPSS 2..0软件进行分析。结果上颌第一磨牙中央窝之间的水平距离(U6CW)及上颌第一磨牙根分叉点之间的水平距离(U6FW)与舌骨点到下颌平面的水平距离(H-MP)呈负相关关系(r=-0.2.2.P=0.02.;r=-0.313,P=0.02.);下颌下角(FMA)与舌骨点到下颌平面的水平距离(H-MP)呈正相关关系(r=0.2.8,P=0.030);矢状向上,骨性Ⅱ类的舌骨位置低于骨性Ⅲ类(P=0.017);垂直向上、垂直生长型患者的舌骨位置比水平生长型以及平均生长型更低(P=0.016;P=0.014);舌体长度(TT-Eb)越长,则舌体位置越低,舌骨位置也越低(P=0.007)。结论成年女性舌骨位置与牙颌面复合体具有相关性,垂直生长型、牙弓狭窄及舌位置靠下的患者舌骨位置更靠下。

关键词：舌骨位置牙颌面颌骨软组织上颌宽度

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