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Chinese Journal of Structural Chemistry 2020年第3期39卷 535-542,379页

作者： CHEN Ru-Ru YANG Wei-Guang cao min-na LI Hong-Fang College of Chemistry Fuzhou UniversityFuzhou 350002China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

A new supramolecular self-assembly [Li(H2 O)2]2[(H2 O@Me10 CB[5])][PtC l6]·7 H2 O(1, Me10 CB[5] = decamethylcucurbit[5]uril), has been successfully constructed with Me10 CB[5] and [PtCl6]^(2-) anion in the presence of lithium cation(Li+). Single-crystal X-ray diffraction study reveals that compound 1 crystallizes in monoclinic space group P21/n with a = 11.1681(18), b = 28.5425(4), c = 18.9342(3) ?, β = 99.0143(15)°, V = 5961.02(16) ?~3, Z = 4, F(000) = 3224, μ = 2.714 mm^(-1), R = 0.0470 and wR = 0.1076(I > 2σ(I)). In the supramolecular self-assembly, two of the portal carbonyl oxygen atoms of Me10 CB[5] are coordinated to Li+ cation, yielding a "half-open" molecular capsule. Then adjacent molecular capsules are connected with each other through hydrogen-bonding to form a one-dimensional(1 D) supramolecular chain structure. The [PtCl6]^(2-) anions are fixed on one side of the 1 D supramolecular chain through supramolecular interactions. The thermal stability, electronic valence and morphology of compound 1 are also investigated.

关键词： decamethylcucurbituril noble metal supramolecular self-assembly crystal structure

Nitrogen Doped Carbon as Efficient Catalyst toward Oxygen Reduction Reaction

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Chinese Journal of Structural Chemistry 2020年第2期39卷 287-293,186页

作者： YANG Wei-Guang GONG Zhi-Wei CHEN Yan-Ning CHEN Ru-Ru MENG Dong-Li cao min-na College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

A kind of nitrogen-doped carbon(NC) nanomaterials was prepared via calcining the nitrogen-rich organic molecular glycoluril under nitrogen atmosphere. Elemental analysis result indicates the N content of the obtained NC is 13.9 wt.%. Electrochemical measurement demonstrated that the obtained NC catalyst is an efficient ORR electrocatalyst in alkaline electrolyte. The process of ORR is dominated by a four-electron transfer pathway with the most efficient catalytic activity. In addition, the NC catalyst exhibits excellent stability and good resistance to methanol poisoning. After 10000 s of chronoamperometric durability test, the relative current of NC catalyst retained as high as 95%. This work provides a new strategy for the preparation of cost-effective ORR catalysts with high catalytic performance.

关键词： nitrogen-doped carbon oxygen reduction reaction electrochemical catalysis

一个新的双核锌配合物Zn_2(dhaash)_2(py)_4的合成及晶体结构

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无机化学学报 2006年第5期22卷 925-929页

作者：胡宗球丁瑜加兵施少敏程翠霞曹敏纳华中师范大学化学学院武汉430079 湖北孝感学院化学系孝感432000

The crystal of binuclear zinc complex Zn2(dhaash)2(py)4 was obtained in DMF and pyridine, where H2dhaash is 2,4-dihydroxy-5-acetylacetophenone-N-salicylhydrazone. It has been characterized by IR, UV, element analysis and X-ray single crystal diffraction. The crystallographic data were as follows: monoclinic system, space group P21 / c, a=1.108 98(11) nm, b=1.640 84(16) nm, c=1.445 14(14) nm, β=108.617(2)°, Z=2, V=2.492 1(4) nm3, Dc=1.466 g·cm-3, Mr=1 099.74, μ=1.031 mm-1, F(000)=1 136 and the final R=0.044 8 and wR=0.105 8 for 4 143 observed reflections with I≥2σ(I), respectively. The X-ray crystal structure analysis revealed that, in the centrosymmetric binuclear complex molecule, two zinc髤 centers are linked by two oxygen atoms (O(3) and O(3A)), respectively. Zn(1)...Zn(1A) distance is 0.314 81(6) nm, O(3)...O(3A) distance is 0.270 4(2) nm. Every zinc髤 ion has an elongated octahedral coordination. For example, the two pyridine nitrogen atoms, one oxygen atom and one nitrogen atom from salicylhydrazone, one oxygen atom from 2,4-dihydroxy-5-acetylacetophenone in one dhaash2- ligand and one oxygen atom from 2,4-dihydroxy-5-acetylacetophenone in another dhaash2- ligand coordinated to zinc髤 ion, respectively. Two zinc髤 ions and all the 72 non-hydrogen atoms in the two dhaash2- ligands are in the same plane. CCDC: 261929.

关键词： 2,4-二羟基-5-乙酰苯乙酮缩水杨酰肼 Zn2(dhaash)2(py)4 晶体结构

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纸木蜂窝板面外静态压缩有限元仿真分析

包装工程 2023年第9期44卷 199-205页

作者：曹敏娜杨国超张求慧北京林业大学木质材料科学与应用教育部重点实验室北京100083 北京林业大学木材科学与工程北京重点实验室北京100083

目的探究纸木蜂窝板的压溃模式和单个蜂窝单元的变形失效模式,为纸木蜂窝板内部失效机制提供一定的理论基础。方法通过有限元仿真模拟,分析面外静态压缩得到变形云图、应力–应变云图和应力–应变曲线。结果纸木蜂窝板的受压过程分为4... 详细信息

目的探究纸木蜂窝板的压溃模式和单个蜂窝单元的变形失效模式,为纸木蜂窝板内部失效机制提供一定的理论基础。方法通过有限元仿真模拟,分析面外静态压缩得到变形云图、应力–应变云图和应力–应变曲线。结果纸木蜂窝板的受压过程分为4个阶段,应力集中分布在蜂窝芯层,最外侧的蜂窝最早出现变形且变形较大,随后中间区域的蜂窝逐步变形增大。蜂窝芯层在受压时存在至多1个应力峰,蜂窝壁弯曲折叠了1~2次,产生了1~2个塑性铰,并在此过程中吸收能量。结论纸木蜂窝板的压溃失效趋势为由外侧蜂窝向内部蜂窝,由单层壁向双层壁,由最弱的压溃点向其余位置。

关键词：纸木蜂窝板蜂窝芯层面外静态压缩有限元

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基于多尺度脑网络局部特征的抑郁症分类

计算机工程与设计 2018年第12期39卷 3712-3716页

作者：曹敏娜陈俊杰郭浩太原理工大学计算机科学与技术学院山西晋中030600

为克服传统使用单一尺度的脑网络特征进行精神疾病分类的局限性,提升抑郁症临床诊断率,对使用静息态功能磁共振成像数据得到的多尺度脑网络局部特征分类进行研究。通过将影像划分为不同规模的区域,构建不同尺度的脑网络;在利用统计分析... 详细信息

为克服传统使用单一尺度的脑网络特征进行精神疾病分类的局限性,提升抑郁症临床诊断率,对使用静息态功能磁共振成像数据得到的多尺度脑网络局部特征分类进行研究。通过将影像划分为不同规模的区域,构建不同尺度的脑网络;在利用统计分析对不同尺度网络下的局部属性进行特征选择的基础上,用支持向量机对抑郁症患者与正常被试进行分类并验证尺度的影响因素。实验结果表明,小尺度脑网络的分类准确率高于大尺度分类准确率,尺度减小带来有效特征数的提升会影响分类结果,进一步验证了尺度划分在脑网络数据分类中的重要性。

关键词：抑郁症功能磁共振成像脑网络多尺度特征选择支持向量机

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing cao Chenglin Cai Guangming Wang min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

镉诱导鲫肝细胞内Ca2+-ATP酶与金属硫蛋白的表达

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水产学报 2011年第6期35卷 824-830页

作者：吴婷婷魏华郭敏曹娜李国鹏上海海洋大学水产与生命学院

研究了镉诱发鲫肝细胞相关的胞内游离钙离子变化,以及Ca2+-ATP酶及金属硫蛋白表达量的变化。试验分为对照组、5、10、15、20μmol/L CdCl25个组。Ca2+用Fura-2/AM方法检测,试验后24 h用荧光倒置显微镜观察细胞内游离钙离子变化;分光光... 详细信息

研究了镉诱发鲫肝细胞相关的胞内游离钙离子变化,以及Ca2+-ATP酶及金属硫蛋白表达量的变化。试验分为对照组、5、10、15、20μmol/L CdCl25个组。Ca2+用Fura-2/AM方法检测,试验后24 h用荧光倒置显微镜观察细胞内游离钙离子变化;分光光度法检测Ca2+-ATP酶;石墨炉—原子分光光度法检测了细胞内镉离子浓度;免疫酶联法(ELISA)检测了金属硫蛋白(MT)含量。结果显示,镉可导致细胞存活率下降,具有一定的毒性。镉离子引起胞内Ca2+荧光强度和Ca2+-ATP酶活性增加(P<0.01)。随镉浓度升高,处理组Ca2+-ATP酶浓度活性分别是对照组的4.52、6.73、6.68、7.19、6.18倍;暴露24 h后各组细胞内镉离子均有上升,其中5μmol/L组最高,达(2.045±0.322)μmol/L;各处理组金属硫蛋白(MT)含量增高(P<0.01),且5μmol/L低浓度组MT增幅最大,达17.15%。结果提示,镉诱导下细胞内Ca2+升高,MT表达量上升,且MT可螯合进入细胞内的镉离子,这种螯合可能是降低镉毒理作用的机制之一。

关键词：肝细胞镉 Ca2+-ATP酶金属硫蛋白

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洛莫司汀脂质体包封率的测定

沈阳药科大学学报 2009年第6期26卷 447-450页

作者：王娜邓英杰王敏曹金娜张睿智刘颜沈阳药科大学药学院辽宁沈阳110016

目的对洛莫司汀脂质体进行质量评价，建立洛奠司汀脂质体包封率的测定方法。方法采用微柱离心法分离洛莫司汀脂质体与游离药物，采用HPLC法测定洛莫司汀含量。结果微柱离心法对洛莫司汀游离药的吸附率在97．25％～98．36％内，空白脂质... 详细信息

目的对洛莫司汀脂质体进行质量评价，建立洛奠司汀脂质体包封率的测定方法。方法采用微柱离心法分离洛莫司汀脂质体与游离药物，采用HPLC法测定洛莫司汀含量。结果微柱离心法对洛莫司汀游离药的吸附率在97．25％～98．36％内，空白脂质体回收率在98．60％-100．5％内，洛莫司汀脂质体和游离洛莫司汀得到良好的分离；在选定色谱条件下，洛莫司汀与脂质体分离良好，辅料不干扰测定，洛莫司汀质量浓度在0．5—50．0mg·L^-1内与峰面积呈良好的线性关系（r=0．9999），日内和日间RSD均小于2％（n=5），加样回收率在97．96％-98．79％内。结论微柱离心-HPLC法可用于洛莫司汀脂质体包封率的测定。

关键词：洛莫司汀脂质体高效液相色谱法微柱离心法包封率

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原料对胶粉沥青储存稳定性的研究

合成材料老化与应用 2016年第4期45卷 65-69页

作者：李国峰曹敏娜陈梅新疆应用职业技术学院石油与化学工程系新疆奎屯833200 新疆大学石油天然气精细化工教育部重点实验室新疆乌鲁木齐830046

以克拉玛依石化AH-110沥青和塔河石化AH-110沥青作为沥青原料,以湖北合得利橡胶粉有限公司和天津天元亨橡胶制品厂的两种废橡胶粉作为改性剂,研究原料对改性沥青储存稳定性能的影响。结果表明：不同的原料会对改性沥青的性能产生一定的... 详细信息

以克拉玛依石化AH-110沥青和塔河石化AH-110沥青作为沥青原料,以湖北合得利橡胶粉有限公司和天津天元亨橡胶制品厂的两种废橡胶粉作为改性剂,研究原料对改性沥青储存稳定性能的影响。结果表明：不同的原料会对改性沥青的性能产生一定的影响,胶粉改性沥青性能除了与沥青轻组分量有重要关系外,还与胶质和沥青质的量有一定的关系。

关键词：基质沥青废橡胶粉改性储存稳定性

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning