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An approach to explore the eddy currents of the new type divertor for EAST device using ANSYS code

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Science China(Technological Sciences) 2014年第1期57卷 9-13页

作者： LIU ChangLe YAO DaMao DOODY Jeffrey LIPSCHULTZ Bruce ZHOU LiHua LIANG Chao ZHOU ZiBo cao lei XU TieJun Institute of Plasma Physics Chinese Academy of Sciences Plasma Science and Fusion Center Massachusetts Institute of Technology 190 Albany StreetCambridge MA 02139 USA

An effective method for eddy current calculation has been developed for EAST’s new divertor by using ANSYS.A 3D model of a double null divertor for the EAST device was built to evaluate eddy currents and electromagnetic(EM)forces on these *** main input to the model is the plasma current and poloidal field coil currents,which are loaded into the model using experimental data measured from the EAST *** currents generate magnetic fields that match those producing an EAST discharge,and the time variation of these fields produces the eddy currents in the divertors,along with from the resulting EM *** addition,the first 10 time steps were discussed for the eddy current generation and changing *** indicates that a static analysis before a transient mode start can solve the eddy current origination in the initial time *** this method,the EM transient response of EAST’s new divertor can be predicted based on ANSYS ***,the method is also an effective approach to estimate the EM results for the in-vessel components of a fusion reactor during a disruption.

关键词： eddy current divertor plasma disruption EAST (Experimental Advanced Superconducting Tokamak) device ANSYS

Integrated biomarker response to assess toxic impacts of iron and manganese on deep-sea mussel Gigantidas platifrons under a deep-sea mining activity scenario

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Journal of Oceanology and Limnology 2024年第2期42卷 522-532页

作者： Li ZHOU Mengna LI Zhaoshan ZHONG Minxiao WANG Hao CHEN Chao LIAN Hao WANG Huan ZHANG lei cao Chaolun LI Center of Deep Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Deep-sea mining activities can potentially release metals,which pose a toxicological threat to deep-sea ***,due to the remoteness and inaccessibility of the deep-sea biosphere,there is insufficient knowledge about the impact of metal exposure on its *** this study,deep-sea mussel Gigantidas platifrons,a commonly used deep-sea toxicology model organism,was exposed to manganese(100,1000μg/L)or iron(500,5000μg/L)for 7 d,*** and iron were chosen for their high levels of occurrence within deep-sea *** accumulation and a battery of biochemical biomarkers related to antioxidative stress in superoxide dismutase(SOD),catalase(CAT),malondialdehyde(MDA);immune function in alkaline phosphatase(AKP),acid phosphatase(ACP);and energy metabolism in pyruvate kinase(PK)and hexokinase(HK)were assessed in mussel *** showed that deep-sea mussel *** exhibited a high capacity to accumulate Mn/*** addition,most tested biochemical parameters were altered by metal exposure,demonstrating that metals could induce oxidative stress,suppress the immune system,and affect energy metabolism of deep-sea *** integrated biomarker response(IBR)approach indicated that the exposure to Mn/Fe had a negative impact on deep-sea mussels,and Mn demonstrated a more harmful impact on deep-sea mussels than ***,SOD and CAT biomarkers had the greatest impact on IBR values in Mn treatments,while ACP and HK were most influential for the low-and high-dose Fe groups,*** study represents the first application of the IBR approach to evaluate the toxicity of metals on deep-sea fauna and serves as a crucial framework for risk assessment of deep-sea mining-associated metal exposure.

关键词： mussel metal deep-sea mining biomarker environmental monitoring

Backstepping Adaptive Controller of Electro-Hydraulic Servo System of Continuous Rotary Motor

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Journal of Harbin Institute of Technology(New Series) 2014年第3期21卷 111-116页

作者： Xiao-Jing Wang Chang-Fu Xian cao-lei Wan Jin-Bao Zhao Li-Wei Xiu An-Cai Yu School of Mechanical and Power Engineering Harbin University of Science and Technology School of Mechanical and Electrical Engineering Harbin Institute of Technology Tianjin Research Institute of Construction Machinery

In order to consider the influence of the continuous rotary motor electro-hydraulic servo system parameters change on its performance,the design method of backstepping adaptive controller is put *** mathematical model of electro-hydraulic servo system of continuous rotary motor is established,and the whole system is decomposed into several lower order subsystems,and the virtual control signal is designed for each subsystem from the final subsystem with motor angular displacement to the subsystem with system control input voltage. Based on Lyapunov method and the backstepping theory,an adaptive backstepping controller is designed with the changed parameters adaptive law. It is proved that the system reaches the global asymptotic stability,and the system tracking error asymptotically tends to zero. The simulation results show that the backstepping adaptive controller based on the adaptive law of the changed parameters can improve the performance of continuous rotary motor,and the proposed control strategy is feasible.

关键词： continuous rotary motor low speed performance backstepping adaptive control

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超临界CO_2萃取青皮挥发油的工艺研究

化学工程 2007年第9期35卷 75-78页

作者：曹蕾曹纬甘肃农业大学生命科学技术学院甘肃兰州730070 兰州石油机械研究所甘肃兰州730050

采用正交实验法对超临界CO2萃取中药青皮挥发油的最佳工艺条件进行优选。以挥发油得率为考察指标,探讨了萃取压力、萃取温度、萃取时间三因素在不同水平下对青皮挥发油得率的影响,并与水蒸气蒸馏法进行了比较。研究表明,萃取压力对挥发... 详细信息

采用正交实验法对超临界CO2萃取中药青皮挥发油的最佳工艺条件进行优选。以挥发油得率为考察指标,探讨了萃取压力、萃取温度、萃取时间三因素在不同水平下对青皮挥发油得率的影响,并与水蒸气蒸馏法进行了比较。研究表明,萃取压力对挥发油得率有显著影响,萃取温度及时间影响不显著,各因素作用主次关系为:压力>温度>时间。优选得到的最佳工艺为:萃取压力25 MPa,萃取温度35℃,萃取时间1.5 h,得率为1.3197%,比水蒸气蒸馏法提高2.4倍,时间减少78.57%。超临界CO2萃取收率高、耗时短、品质好。

关键词：超临界流体萃取二氧化碳青皮挥发油提取工艺

Cases of Residual Paralysis in an Acute Flaccid Paralysis Surveillance System--China,2001−2010

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China CDC weekly 2020年第50期2卷 962-967页

作者： Ning Wen Qiru Su Chunxiang Fan Haibo Wang Yong Zhang lei cao Wei Xia Zhijie An Huiming Luo Chinese Center for Disease Control and Prevention BeijingChina Shenzhen Children’s hospital ShenzhenGuangdongChina Clinical Research Institute Peking UniversityBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Background:China has been polio-free since 2000 and maintains an acute flaccid paralysis(AFP)surveillance *** paralysis(RP)in children with acute flaccid paralysis can be caused by Sabinstrain poliovirus(PV)and non-polio enteroviruses(NPEV).Methods:The national AFP surveillance data was analyzed to describe AFP cases with RP in the mainland of China during 2001 to *** patterns and virus detection of AFP cases with RP were ***:Annual incidence of AFP with RP among children aged<15 years old ranged between 0.22-0.35 cases per 100,*** peak age for AFP with RP and PV was 2 to 4 *** cases with viral Sabinstrain viral isolates,types Ⅱ and Ⅲ were the most common.A summer season peak in RP cases was similar to cases with NPEV *** and Implications for Public Health Practice:The first ten years after polio eradication of AFP surveillance data for the occurrence of RP can serve as a baseline rate for poliovirus vaccine changes in the routine immunization system to help detect vaccine safety signals in a timely manner and to support the routine polio immunization program switch in China.

关键词： routine vaccine acute

The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding

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Cellular & Molecular Immunology 2020年第7期17卷 741-752页

作者： Xuan Zhong Lu Feng Wen-Hua Xu Xin Wu Yi-Di Ding Yan Zhou cao-Qi lei Hong-Bing Shu College of Life Sciences Wuhan UniversityWuhan 430072China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Medical Research Institute Wuhan UniversityWuhan 430072China

Recognition of viral dsRNA by Toll-like receptor 3(TLR3)leads to the induction of downstream antiviral effectors and the innate antiviral immune ***,we identified the zinc-finger FYVE domain-containing protein ZFYVE1,a guanylate-binding protein(GBP),as a positive regulator of TLR3-mediated *** of ZFYVE1 promoted the transcription of downstream antiviral genes upon stimulation with the synthetic TLR3 ligand poly(I:C).Conversely,ZFYVE1 deficiency had the opposite ***1^(−/−) mice were less susceptible than wild-type mice to inflammatory death induced by poly(I:C)but not ***1 was associated with TLR3,and the FYVE domain of ZFYVE1 and the ectodomain of TLR3 were shown to be responsible for their ***1 was bound to poly(I:C)and increased the binding affinity of TLR3 to poly(I:C).These findings suggest that ZFYVE1 plays an important role in the TLR3-mediated innate immune and inflammatory responses by promoting the ligand binding of TLR3.

关键词： TLR3 ZFYVE1 ligand binding immune response

Hydraulic design and pre-whirl regulation law of inlet guide vane for centrifugal pump

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Science China(Technological Sciences) 2010年第8期53卷 2142-2151页

作者： TAN lei ,cao ShuLiang&GUI ShaoBo State Key Laboratory of Hydroscience and Engineering,Department of Thermal Engineering,Tsinghua University,Beijing 100084,China State Key Laboratory of Hydroscience and Engineering Department of Thermal Engineering Tsinghua University Beijing China

A new hydraulic design method of three-dimensional guide vane for centrifugal pump is proposed on the assumption that the fluid at the outlet of guide vane satisfies the uniform velocity moment *** geometry of blade is controlled by the distributed rule of blade angles along the meridional streamline which is described by a fourth-order *** results demonstrate that the designed guide vane can overcome the drawback of two-dimensional guide vane,enlarge the high efficiency scope and improve the hydraulic performance of centrifugal pump on the off-design operation *** comparison with the performance of the centrifugal pump without inlet guide vane,the peak value of efficiency can be enhanced by 2.13% after the three-dimensional guide vane was being *** three-dimensional entire flow field of the centrifugal pump with inlet guide vane is simulated,and the basic principle and mechanism of inlet guide vane pre-whirl regulation are *** validity of design method has been proved.

关键词： centrifugal pump inlet guide vane pre-whirl regulation hydraulic design method experiment numerical simulation

Post-Marketing Surveillance of Adverse Events Following Immunization with Haemophilus Influenzae Type b Conjugate Vaccine—China,2010–2021

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China CDC weekly 2024年第33期6卷 834-840页

作者： Minrui Ren Keli Li Yan Li Chunxiang Fan Yuyang Xu Lina Zhang Yuan Li lei cao Wenzhou Yu Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) National Immunization ProgrammeChinese Center for Disease Control and PreventionBeijingChina Department of Expanded Programme on Immunization Hangzhou Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina

Introduction The Haemophilus influenzae type b(Hib)conjugate vaccine is widely administered in *** We extracted data on Hib vaccine doses administered and adverse events following immunization(AEFI)reported between 2010 and 2021 from the Chinese National Immunization Information System(CNIIS).A descriptive analysis was conducted to examine the characteristics and incidence rates of AEFI with the Hib *** In China,between 2010 and 2021,a total of 52,910 AEFIs with the Hib vaccine were reported,resulting in an overall AEFI reporting rate of 38.10 per 100,000 ***(typically minor)and rare(potentially serious)vaccine reactions occurred at rates of 34.71 and 2.78 per 100,000 doses,*** the common vaccine reactions,the incidences of fever(axillary temperature≥38.6℃),injection site redness and swelling(>2.5 cm in diameter),and injection site induration(>2.5 cm in diameter)were 11.93,9.69,and 3.38 per 100,000 doses,*** vaccine reactions included anaphylactic rash,angioedema,and febrile convulsion with reported incidences of 2.42,0.10,and 0.05 per 100,000 doses,*** incidence of serious rare vaccine reactions was 0.16 per 100,000 *** The reported incidence of AEFI with the Hib vaccine was low,with the occurrence of serious rare adverse reactions also being markedly low throughout the period 2010–2021 in China.

关键词： doses markedly injection

Biosorption effects of copper ions on Candida utilis under negative pressure cavitation

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Journal of Environmental Sciences 2006年第6期18卷 1254-1259页

作者： ZU Yuan-gang ZHAO Xiu-hua HU Mao-sheng REN Yuan XIAO Peng ZHU lei cao Yu-jie ZHANG Yao Key Laboratory of Forest Plant Ecology Northeast Forestry University Ministry of Education Harbin 150040 China

Under the optimal condition of copper ions adsorption on yeast,we found some different effects among static adsorption, shaking adsorption and negative pressure cavitation adsorption, and the methods of yeast with different pretreatments also affect adsorption of copper ions. At the same time, the change of intercellular pH before and after adsorption of copper with BCECF was studied. The copper distribution was located by using PhenGreen （dipotassium salt and diacetate）, and the surface of yeast was observed by an atomic force microscope. The results showed that negative pressure cavitation can improve bioadsorption capacity of copper ions on yeast. However, the yeasts＇ pretreatment has a higher effect on bioadsorption. It indicates that heavy metal bioadsorption on yeast has much relation with its cellular molecule basis. With the adsorping, the intercellular pH of yeast increased gradually and changed from acidity to alkalescence. These results may suggest that negative pressure cavitation can compel heavy metals to transfer from the cell surface into inside cell and make the surface of yeast coarse.

关键词： negative pressure cavitation Candida utilis biosorption copper ion adsorption mechanism