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Dynamic impact properties of deep sandstone under thermal-hydraulicmechanical coupling loads

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Journal of Mountain Science 2024年第6期21卷 2113-2129页

作者： cao Chunhui DING Haonan ZOU Baoping School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China Zhejiang-Singapore Joint Laboratory for Urban Renewal and Future City Hangzhou 310023China

The deep rock mass within coal mines situated in a challenging environment are characterized by high ground stress,high geotemperature,high osmotic water pressure,and dynamic disturbances from mechanical *** investigate the impact of this complex mechanical environment on the dynamic characteristics of roof sandstone in self-formed roadways without coal pillars,standard specimens of deep sandstone from the 2611 upper tunnel working face of the Yongmei Company within the Henan Coal Chemical Industry Group in Henan,China were prepared,and an orthogonal test was *** a self-developed geotechnical dynamic impact mechanics test system,triaxial dynamic impact tests under thermal-hydraulicmechanical coupling conditions were conducted on deep *** results indicate that under high confining pressure,deep sandstone exhibits pronounced brittle failure at low temperatures,with peak strength gradually decreasing as temperature and osmotic water pressure ***,under low confining pressure and low temperature,the brittleness of deep sandstone weakens gradually,while ductility ***,sandstone demonstrates higher peak strength at low temperatures under high axial pressure conditions,lower peak strength at high temperatures,and greater strain under low axial pressure and high osmotic water *** in impact air pressure and osmotic water pressure have proportionally greater effects on peak stress and peak *** 50%of the input strain energy is utilized as effective energy driving the sandstone fracture *** analysis identifies the optimal combination of factors affecting the peak stress and peak strain of *** the coupling effect,intergranular and transgranular fractures occur within the *** images illustrate that the damage forms range from minor damage with multiple fissures to extensive fractures and severe *** study elucidates the varied dynamic impact me

关键词： Deep sandstone Thermal-hydraulicmechanical coupling Dynamic impact Stress-strain Failure Modes Polar analysis

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“砍”字出现时代考

贺州学院学报 2013年第2期29卷 64-67页

作者：曹小云甘小明合肥师范学院中文系安徽合肥230601 上海师范大学天华学院上海201815

出现在唐以前文献里的"砍"字不可信,"砍"字当是宋代出现的新字。

关键词：砍出现时代读音来源

Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism

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Zoological Research 2024年第5期45卷 1048-1060页

作者： xiao-xiao Li Dan-Chen Zhang Yan Wang Jian Wen Xing-Ju Wang Yu-Lu cao Ru Jiang Jia-Rui Li Yi-Nuo Li He-He Liu Wen-Hai Xie Zheng-Feng Xu Ping Hu Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Stem Cell Research and Translation Center Nanjing Agricultural UniversityNanjingJiangsu 210095China School of Life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Department of Prenatal Diagnosis Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Extracellular membrane proteins are crucial for mediating cell attachment,recognition,and signal transduction in the testicular microenvironment,particularly germline stem *** 18(CDH18),a type Ⅱ classical cadherin,is primarily expressed in the nervous and reproductive ***,we investigated the expression of CDH18in neonatal porcine prospermatogonia(ProSGs)and murine spermatogonial stem cells(SSCs).Disruption of CDH18 expression did not adversely affect cell morphology,proliferation,self-renewal,or differentiation in cultured porcine ProSGs,but enhanced cell adhesion and prolonged cell *** analysis indicated that the down-regulation of CDH18 in ProSGs significantly up-regulated genes and signaling pathways associated with cell *** further elucidate the function of CDH18 in germ cells,Cdh18 knockout mice were generated,which exhibited normal testicular morphology,histology,*** analysis showed increased expression of genes associated with adhesion,consistent with the observations in porcine *** interaction of CDH18withβ-catenin and JAK2 in both porcine ProSGs and murine SSCs suggested an inhibitory effect on the canonical Wnt and JAK-STAT signaling pathways during CDH18 ***,these findings highlight the crucial role of CDH18 in regulating cell adhesion in porcine ProSGs and mouse *** this regulatory mechanism provides significant insights into the testicular niche.

关键词： Extracellular signal Fertility Quiescency Wnt signaling pathway

A Support Data-Based Core-Set Selection Method for Signal Recognition

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China Communications 2024年第4期21卷 151-162页

作者： Yang Ying Zhu Lidong cao Changjie National Key Laboratory of Wireless Communications(University of Electronic Science and Technology of China) Chengdu 611731China College of Computer Science and Cyber Security(Chengdu University of Technology) Chengdu 610059China College of Mathmatics and Physics(Chengdu University of Technology) Chengdu 610059China

In recent years,deep learning-based signal recognition technology has gained attention and emerged as an important approach for safeguarding the electromagnetic ***,training deep learning-based classifiers on large signal datasets with redundant samples requires significant memory and high *** paper proposes a support databased core-set selection method(SD)for signal recognition,aiming to screen a representative subset that approximates the large signal ***,this subset can be identified by employing the labeled information during the early stages of model training,as some training samples are labeled as supporting data *** support data is crucial for model training and can be found using a border sample *** results demonstrate that the SD method minimizes the impact on model recognition performance while reducing the dataset size,and outperforms five other state-of-the-art core-set selection methods when the fraction of training sample kept is less than or equal to 0.3 on the RML2016.04C dataset or 0.5 on the RML22 *** SD method is particularly helpful for signal recognition tasks with limited memory and computing resources.

关键词： core-set selection deep learning model training signal recognition support data

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《长阿含经》同素异序词研究

安徽理工大学学报（社会科学版） 2013年第3期15卷 61-65页

作者：曹小云潘晓柒合肥师范学院中文系合肥230601

《长阿含经》是研究东晋时期汉语现象的重要语料。共有47组同素异序双音词。从语法分布看,动词最多,有24组;从词义分布看,意义完全相同的占绝大所数,有34组;从发展变化看,现代汉语中只保留了一种词形占一半以上,达25组;从历时分析看,多... 详细信息

《长阿含经》是研究东晋时期汉语现象的重要语料。共有47组同素异序双音词。从语法分布看,动词最多,有24组;从词义分布看,意义完全相同的占绝大所数,有34组;从发展变化看,现代汉语中只保留了一种词形占一半以上,达25组;从历时分析看,多为共时产生,有31组。

关键词：《长阿含经》词语同素异序词

Enzymatic C1 reduction using hydrogen in cofactor regeneration

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 33-40页

作者： Ruishuang Sun Chenqi cao Qingyun Wang Hui cao Ulrich Schwaneberg Yu Ji Luo Liu Haijun Xu Beijing Bioprocess Key Laboratory Beijing University of Chemical TechnologyBeijing 100029China Institute of Biotechnology Rheinisch-Westfälische Technische Hochschale(RWTH)AachenAachen 52074Germany

Carbon dioxide fixation presents a potential solution for mitigating the greenhouse gas *** carbon dioxide fixation,C1 compound reduction requires a high energy *** calculations suggest that the energy source for cofactor regeneration plays a vital role in the effective enzymatic C1 *** utilizes renewable hydrogen to achieve the regeneration and supply cofactor nicotinamide adenine dinucleotide(NADH),providing a driving force for the reduction reaction to reduce the thermodynamic barrier of the reaction cascade,and making the forward reduction pathway thermodynamically *** on the regeneration of cofactor NADH by hydrogenase,and coupled with formaldehyde dehydrogenase and formolase,a favorable thermodynamic mode of the C1 reduction pathway for reducing formate to dihydroxyacetone(DHA)was designed and *** resulted in accumulation of 373.19μmol·L^(-1) DHA after 2 h,and conversion reaching 7.47%.These results indicate that enzymatic utilization of hydrogen as the electron donor to regenerate NADH is of great significance to the sustainable and green development of bio-manufacturing because of its high economic efficiency,no by-products,and environment-friendly ***,formolase efficiently and selectively fixed the intermediate formaldehyde(FALD)to DHA,thermodynamically pulled formate to efficiently reduce to DHA,and finally stored the low-grade renewable energy into chemical energy with high energy density.

关键词： [NiFe]-hydrogenase SH formolase NADH regeneration C1 compound reduction thermodynamic calculation

Impacts of pancreatic exocrine insufficiency on gut microbiota

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin GUO Feng cao Fei LI Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical University Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and *** main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion *** studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement *** studies have also confirmed the association between PEI and the dysbiosis of gut *** exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut *** turn,the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional *** forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota Gut microbiome Pancreatic enzyme replacement therapy

Taphonomy and Paleoecology of Lycoptera: A Case Study from the Lower Jehol Group in Western Liaoning, Northeastern China

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Journal of Earth Science 2024年第3期35卷 737-746页

作者： Zhongwu Lan Rong cao Shujing Zhang State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430078China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geology Trinity CollegeDublin 999015Ireland

Taphonomy and paleoecology(biological behavior)of the Early Cretaceous fish fossils are poorly *** study reports for the first time a detailed taphonomical and paleoecological study on Lycoptera in the Mesozoic strata of western Liaoning Province,NE *** XRD analysis shows that gismondine is the dominant clay minerals that could have contributed to the preservation of Lycoptera fossils and microbial mat fragments in the fossil-bearing *** may have formed under volcanism-related hydrothermal regime that was transformed from crystal and lithic ***μ-XRF imaging analysis shows a dominant chemical composition of Al,Si,P,S,Rh,K,Ca,Ti,C,Cr,Mn,Fe,Ni,among which P,Ca,C and S are enriched in the fish skeleton in comparison to the *** suggests a dominant apatite composition for the fish *** influence did not smear off these organic signals probably because of protection of *** coexistance of C and S with Ni is assumed to represent recovered primary productivity following volcanic explosions and toxic gas *** head of juvenile fish stays close to the body of adult *** further discoveries,such phenomenon is interpreted to suggest that adult fish actively protected juvenile fish in the presence of environmental pressures such as anoxia and deterioration of water quality induced by *** acidification and hypoxia in association with volcanism created a harmful environment causing mass extinction of *** adult Lycoptera protected their juveniles by its body at the moment before *** biological behavior will be increasingly reported given the wide occurrence of Lycoptera in Mesozoic strata.

关键词： Lycoptera taphonomy paleoecology fish Jehol Group NE China.

维持性血液透析患者血流感染病原菌与耐药基因分析

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中华医院感染学杂志 2021年第12期31卷 1835-1839页

作者：曹小云曹花云陈群菊彭俊琼谢霜孙丰芹江南大学附属医院血液净化中心江南大学附属医院心脏内科江苏无锡214000 泰兴市第一人民医院产科江苏泰兴225400 解放军960医院泰安院区肾病内科山东泰安271000

目的探究维持性血液透析患者血流感染病原菌、分子流行学及主要病原菌耐药基因类型。方法选取2014年1月-2019年8月江南大学附属医院血液净化中心收治的合并血流感染的维持性血液透析患者118例,另招募同期无血流感染的维持性血液透析患... 详细信息

目的探究维持性血液透析患者血流感染病原菌、分子流行学及主要病原菌耐药基因类型。方法选取2014年1月-2019年8月江南大学附属医院血液净化中心收治的合并血流感染的维持性血液透析患者118例,另招募同期无血流感染的维持性血液透析患者95例,分析维持性血液透析患者发生血流感染的影响因素;统计血流感染患者病原菌分布及药敏试验结果,分离耐甲氧西林金黄色葡萄球菌(MRSA)菌株,采用多重聚合酶链式反应(PCR)技术对MRSA中盒式染色体基因(SCCmec)进行分型,并分析SCCmec基因型菌株耐药情况。结果年龄、合并糖尿病、透析龄、置管时间是导致维持性透析患者发生血流感染的影响因素(P<0.05);合并血流感染患者共培养分离病原菌149株,其中革兰阳性菌95株占63.76%,革兰阴性菌46株占30.87%,以金黄色葡萄球菌、表皮葡萄球菌、鲍氏不动杆菌为主;金黄色葡萄球菌和表皮葡萄球菌对利奈唑胺、万古霉素和利福平耐药率<15.00%,鲍氏不动杆菌对阿米卡星、哌拉西林舒巴坦、美罗培南、亚胺培南较敏感;41株金黄色葡萄球菌中检出MRSA 15株(36.59%),其中携带SCCmec基因型的MRSA菌株9株(60.00%),以SCCmecⅢ型基因为主,检出率为53.33%;携带SCCmecⅢ型基因和SCCmecⅡ型基因MRSA菌株对利奈唑胺、万古霉素和利福平耐药率相对较低。结论维持性血液透析患者血流感染病原菌分布具有一定特征,主要病原菌金黄色葡萄球菌对多种抗菌药物耐药率较高,分离MRSA基因型以SCCmecⅢ型为主,临床应合理选用敏感药物。

关键词：维持性血液透析血流感染耐甲氧西林金黄色葡萄球菌 SCCmec基因耐药性