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sICAM-1和miR-155与miR-141对糖尿病肾病血液透析并发血流感染的预测价值

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中华医院感染学杂志 2024年第8期34卷 1168-1172页

作者：严文静曹小云彭俊琼薛金凤王若愚江南大学附属医院血液净化中心江苏无锡214122 江南大学附属医院肾脏内科江苏无锡214122

目的研究血清可溶性细胞间黏附分子-1(sICAM-1)、外周血微小核糖核酸-155(miR-155)、微小核糖核酸-141(miR-141)对糖尿病肾病(DN)血液透析并发血流感染的预测价值及患者感染病原菌分布情况。方法选取2018年6月-2022年9月江南大学附属医... 详细信息

目的研究血清可溶性细胞间黏附分子-1(sICAM-1)、外周血微小核糖核酸-155(miR-155)、微小核糖核酸-141(miR-141)对糖尿病肾病(DN)血液透析并发血流感染的预测价值及患者感染病原菌分布情况。方法选取2018年6月-2022年9月江南大学附属医院收治的119例DN血液透析并发血流感染患者作为B组,收集同期在医院接受治疗的132例DN血液透析未并发血流感染患者作为A组,统计两组一般资料,比较两组血清sICAM-1、外周血miR-155、miR-141表达情况,采用受试者工作特征(ROC)曲线分析血清sICAM-1、外周血miR-155、miR-141单独及联合对DN血液透析患者并发血流感染的预测价值,统计DN血液透析并发血流感染患者感染病原菌分布情况。结果B组血清sICAM-1、外周血miR-155、miR-141表达水平高于A组(P<0.05);血清sICAM-1、外周血miR-155、miR-141联合预测DN血液透析患者并发血流感染的曲线下面积(AUC)值高于三者单独预测(P<0.05),敏感度高于血清sICAM-1、外周血miR-141(P<0.05),特异度低于血清sICAM-1、外周血miR-141(P<0.05);DN血液透析并发血流感染患者革兰阴性菌占比63.71%,革兰阳性菌占比33.06%,真菌占比3.23%。结论血清sICAM-1、外周血miR-155、miR-141联合对DN血液透析患者并发血流感染具有较好的预测价值,同时DN血液透析并发血流感染患者主要感染病原菌种类较多。

关键词：糖尿病肾病血液透析血流感染可溶性细胞间黏附分子-1 微小核糖核酸-155 微小核糖核酸-141 病原菌

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我国医疗废物处理处置技术发展与创新

中国环保产业 2024年第1期 46-53页

作者：曹云霄于晓东岳佳妮张雪张广鑫陈刚沈阳环境科学研究院沈阳110167 国家环境保护危险废物处置工程技术(沈阳)中心沈阳110167 中国科学院生态环境研究中心北京100085

文章详细分析了医疗废物处理处置管理要求和技术现状,确定了焚烧处置和消毒处理的行业主导地位,并分别对两类技术中代表性技术的原理、适用性和特点进行了对比分析。在此基础上,对医疗废物处理处置创新技术进行了探索,确定了创新技术的... 详细信息

文章详细分析了医疗废物处理处置管理要求和技术现状,确定了焚烧处置和消毒处理的行业主导地位,并分别对两类技术中代表性技术的原理、适用性和特点进行了对比分析。在此基础上,对医疗废物处理处置创新技术进行了探索,确定了创新技术的三种分类,包括原理创新型、应用创新型和集成创新型技术,并对每一类别典型技术进行了详细阐述。最后,基于当前我国的标准政策要求,为创新技术的应用推广提出了建议。

关键词：医疗废物处理处置技术评价成果转化

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酒精依赖患者认知损害的磁共振波谱研究

中国药物依赖性杂志 2024年第2期33卷 131-135页

作者：陈倩曹潇云唐楚文罗颖周旭辉湖南中医药大学临床医学院长沙410007 湖南省脑科医院长沙410007 郴州市精神卫生中心湖南郴州423002

目的采用磁共振波谱(Magnetic Resonance Spectrum,MRS)技术研究酒精依赖患者代谢物变化特点,并探讨其与认知损害之间的关系,以期发现酒精依赖患者认知损害的神经生物学机制。方法使用重复性成套神经心理状态测验(Repeatable Battery fo... 详细信息

目的采用磁共振波谱(Magnetic Resonance Spectrum,MRS)技术研究酒精依赖患者代谢物变化特点,并探讨其与认知损害之间的关系,以期发现酒精依赖患者认知损害的神经生物学机制。方法使用重复性成套神经心理状态测验(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)对60例住院酒精依赖患者和40例健康志愿者的认知功能进行评估,采用MRS观测酒精依赖者额叶、杏仁核关键脑区代谢物变化,并分析MRS与RBANS之间的相关性。结果与正常对照组比较,酒精依赖组在左侧额叶、右侧额叶和左侧杏仁核NAA/Cr值均显著降低(P<0.05),左侧额叶、右侧额叶、右侧杏仁核脑区Cho/Cr值显著降低(P<0.05),右侧额叶脑区Glu/Cr值显著降低,而左侧杏仁核区Glu/Cr显著增高(P<0.05)。酒精依赖患者即刻记忆及注意功能分值与左侧额叶NAA/Cr值及右侧杏仁核Cho/Cr值呈正相关(P<0.05);言语功能分值与左侧额叶Cho/Cr值呈正相关(P<0.05);而左侧杏仁核Glu/Cr与即刻记忆分值呈负相关(P<0.05)。结论酒精依赖者双侧额叶及杏仁核代谢产物异常,可能是酒精依赖者认知功能损害的神经生物学基础。

关键词：酒精依赖认知损害磁共振波谱代谢物变化神经生物学机制

Prediction of chemical short-range order in high-/medium-entropy alloys

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Journal of Materials Science & Technology 2024年第2期169卷 115-123页

作者： Pei-Yu cao Jing Wang Ping Jiang yun-Jiang Wang Fu-Ping Yuan xiao-Lei Wu State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of ScienceBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Chemical short-range orders(CSROs),as the built-in sub-nanoscale entities in a high-/medium-entropy alloy(H/MEA),have aroused an ever-increasing *** multi-principal elements in an H/MEA to form a complex concentrated solution,a variety of sub-systems of species exist to induce the metastable ordered compounds as candidates for ultimate *** issues remain pending on the origin of CSROs as to how to judge if CSRO will form in an H/MEA and particularly,what kind of CSROs would be stably produced if there were multiple ***,the first-principles method,along with the proposed local formation energy calculation in allusion to the atomic-scale chemical heterogeneities,is used to predict the CSRO formation based on the mechanical stability,thermodynamic formation energy,and electronic *** simulations are detailed in an equiatomic ternary VCoNi MEA with three kinds of potential compounds,i.e.,L1_(1),L1_(2),and B2,in the face-centered cubic *** turns out that L1_(1)is stable but hard to grow up so as to become the final CSRO.L1_(1)is further predicted as CSROs in CrCoNi,but unable to form in FeCoNi and CrMnFeCoNi *** predictions are consistent with the experimental *** findings shed light on understanding the formation of *** method is applicable to other H/MEAs to design and tailor CSROs by tuning chemical species/contents and thermal processing for high performance.

关键词： Short-range order High-entropy alloy Microstructure First-principles calculation Gibbs free energy Local electronic density of states

The Mass Assembly History for Galaxies with MaNGA

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Research in Astronomy and Astrophysics 2024年第3期24卷 58-69页

作者： Xue Ge Hong-Tao Wang Cheng-Long Lei yun-Jun Guo Yi-Long Jiang xiao-xiao cao School of Physics and Information Engineering Jiangsu Second Normal University Jiangsu Province Engineering Research Center of Basic Education Big Data Application Jiangsu Second Normal University Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education School of Science Langfang Normal University

How galaxies assemble masses through their own star formation or interaction with the external environment is still an important topic in the field of galaxy formation and *** use Value Added Catalogs with galaxy features that are spatially and temporally resolved from Sloan Digital Sky Survey Data Release 17 to investigate the mass growth histories of early-type galaxies(ETGs)and late-type galaxies(LTGs).We find that the mass growth of ETGs is earlier than that of LTGs for massive galaxies(M_(*)>10^(10)M_⊙),while low-mass(M_(*)≤10^(10)M_⊙)ETGs have statistically similar mass assembly histories as low-mass *** stellar metallicity of all massive galaxies shows a negative gradient and basically does not change with ***,in low-mass galaxies,the stellar metallicity gradient of elliptical galaxies is negative,and the stellar metallicity gradient of lenticular and spiral galaxies evolves from positive to *** are not all in a high-density environment,but exhibit mass *** the tidal strength increases,the star formation rate of low-mass ETGs rapidly *** results support a picture where massive galaxies exhibit inside-out quenching mode,while low-mass galaxies show outside-in quenching *** effects play an important role in regulating the mass assembly histories of low-mass ETGs.

关键词： Galaxy evolution-galaxies star formation-Galaxy formation

Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis cells

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Frontiers in Energy 2024年第3期18卷 390-398页

作者： Junwen cao yun ZHENG Wenqiang ZHANG Bo YU Institute of Nuclear and New Energy Technology(INET) Collaborative Innovation Center of Advanced Nuclear Energy TechnologyTsinghua UniversityBeijing 100084China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China

Interconnector is a critical component to construct solid oxide cells (SOCs) stack. Oxidation of metallic interconnectors and Cr poisoning caused by oxidation are important factors that lead to long-term performance degradation of SOCs. Coating on the interconnector surface is an important approach to inhibit the oxidation and Cr migration of the interconnector. Herein, (La0.75Sr0.25)0.95MnO3–δ (LSM) and Mn1.5Co1.5O4 (MCO) are used to fabricate the coatings of interconnector. Two advanced thermal spray technology, atmospheric plasma spraying (APS) and low-pressure plasma spray (LPPS), are adopted for the coating preparation. The electrochemical performance, rising and cooling cycle stability, and Cr diffusion inhibition performance of the coatings are tested and evaluated. The result indicates that MCO can generate more uniform and denser coatings than LSM. In addition, MCO coatings prepared by LPPS shows the best electrochemical performance, rising and cooling cycle stability, and Cr diffusion inhibition. The initial area specific resistance (ASR) is 0.0027 Ω·cm2 at 800 °C. After 4 cooling cycle tests, the ASR increases to 0.0032 Ω·cm2 but lower than other samples. Meanwhile, the relative intense of Cr at the interface of SUS430 with MCO coatings fabricated by LPPS is lower than that of MCO fabricated by APS after 4 rising and cooling cycle operations, showing more favorable Cr diffusion inhibition performance.

关键词： interconnector coating plasma spray electrochemical performance Cr diffusion inhibition solid oxide cells(SOCs)

A Novel CCA-NMF Whitening Method for Practical Machine Learning Based Underwater Direction of Arrival Estimation

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Journal of Beijing Institute of Technology 2024年第2期33卷 163-174页

作者： yun Wu Xinting Li Zhimin cao School of Physics and Electronic Engineering Northeast Petroleum UniversityDaqing 163318China

Underwater direction of arrival(DOA)estimation has always been a very challenging theoretical and practical *** to the serious non-stationary,non-linear,and non-Gaussian characteristics,machine learning based DOA estimation methods trained on simulated Gaussian noised array data cannot be directly applied to actual underwater DOA estimation *** order to deal with this problem,environmental data with no target echoes can be employed to analyze the non-Gaussian ***,the obtained information about non-Gaussian components can be used to whiten the array *** on these considerations,a novel practical sonar array whitening method was ***,based on a weak assumption that the non-Gaussian components in adjacent patches with and without target echoes are almost the same,canonical cor-relation analysis(CCA)and non-negative matrix factorization(NMF)techniques are employed for whitening the array *** the whitened array data,machine learning based DOA estimation models trained on simulated Gaussian noised datasets can be used to perform underwater DOA estimation *** results illustrated that,using actual underwater datasets for testing with known machine learning based DOA estimation models,accurate and robust DOA estimation performance can be achieved by using the proposed whitening method in different underwater con-ditions.

关键词： direction of arrival(DOA) sonar array data underwater disturbance machine learn-ing canonical correlation analysis(CCA) non-negative matrix factorization(NMF)

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Targeting synaptic pathology in Alzheimer’s disease

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Zoological Research 2024年第4期45卷 875-876页

作者： Jing cao yun-Wu Zhang Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China

Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by memory and cognitive *** two primary pathological hallmarks of AD include the accumulation ofβ-amyloid(Aβ)plaques and formation of neurofibrillary tangles(NFTs)composed predominantly of hyperphosphorylated tau protein(Zhang et al.,2023).Moreover,synaptic dysfunction is considered another crucial factor in AD pathogenesis and is closely associated with cognitive ***,synaptic damage,loss,and dysfunction manifest earlier than the pathological features of Aβplaques and NFTs(Knopman et al.,2021).Therefore,understanding the mechanisms underlying synaptic dysfunction in AD is vital for providing insights into disease mechanisms and developing novel therapeutic strategies.

关键词： Alzheimer Aβ tau

A Post-Quantum Cross-Domain Authentication Scheme Based on Multi-Chain Architecture

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Computers, Materials & Continua 2024年第2期78卷 2813-2827页

作者： Yi-Bo cao Xiu-Bo Chen yun-Feng He Lu-Xi Liu Yin-Mei Che xiao Wang Ke xiao Gang Xu Si-Yi Chen Information Security Center State Key Laboratory ofNetworking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Information Center of China North Industries Group Corporation Beijing100089China School of Information Science and Technology North China University of TechnologyBeijing100144China

Due to the rapid advancements in network technology,blockchain is being employed for distributed data *** the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in different trust domains,which has resulted in the extensive development of cross-domain authentication ***,the emergence of many attackers equipped with quantum computers has the potential to launch quantum computing attacks against cross-domain authentication schemes based on traditional cryptography,posing a significant security *** response to the aforementioned challenges,our paper demonstrates a post-quantum cross-domain identity authentication scheme to negotiate the session key used in the cross-chain asset exchange ***,our paper designs the hiding and recovery process of user identity index based on lattice cryptography and introduces the identity-based signature from lattice to construct a post-quantum cross-domain authentication ***,our paper utilizes the hashed time-locked contract to achieves the cross-chain asset exchange of blockchain nodes in different trust ***,the security analysis reduces the security of the identity index and signature to Learning With Errors(LWE)and Short Integer Solution(SIS)assumption,respectively,indicating that our scheme has post-quantum *** but not least,through comparison analysis,we display that our scheme is efficient compared with the cross-domain authentication scheme based on traditional cryptography.

关键词： Cross-domain identity authentication lattice-based cryptography blockchain hashed time-locked contract