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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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xiangshao Granules Ameliorate Post-stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex

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Chinese Journal of Integrative Medicine 2025年第1期31卷 28-38页

作者： LI Cheng-gang XU Lu-shan SUN Liang XU Yu-hao cao xiang ZHAO Chen-chen XIA Sheng-nan ZHANG Qing-xiu XU Yun Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Objective To investigate the therapeutic effect of xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),and PSD+XSG(n=14)groups according to a random number *** PSD models were constructed using chronic unpredictable mild stress(CUMS)after middle cerebral artery occlusion(Mcao).The sham group only experienced the same surgical operation,but without MACO and CUMS *** XSG group received XSG(60 mg/kg per day)by gavage for 4 *** mice in the sham and vehicle groups were given the same volume of 0.9%saline at the same *** body weight and behavior tests including open field test,sucrose preference test,tail suspension test,and elevated plus-maze test,were used to validate the PSD mouse ***-time fluorescence quantitative polymerase chain reaction(RT-qPCR),enzyme-linked immunosorbent assay(ELISA),and immunofluorescence staining were used to evaluate the anti-inflammatory effects of *** potential molecular mechanisms were explored and verified through network pharmacology analysis,Nissl staining,Western blot,ELISA,and RT-qPCR,*** The body weight and behavior tests showed that Mcao combined with CUMS successfully established the PSD *** alleviated neuronal damage,reduced the expressions of pro-apoptotic proteins Caspase-3 and B-cell lymphoma-2(BCL-2)-associated X(BAX),and increased the expression of anti-apoptotic protein BCL-2 in PSD mice(P<0.05 or P<0.01).XSG inhibited microglial activation and the expressions of pro-inflammatory cytokines including tumor necrosis factor-α,interleukin(IL)-1β,and IL-6 via the toll-like receptor 4/nuclear factor kappa-B signaling pathway in PSD mice(P<0.05 or P<0.01).Furthermore,XSG decreased the expression of indoleamine 2,3-dioxygenase1(IDO1)and increased the concentration of 5-hydroxytryptamine in PSD mice(P<0.05 or P<0.01).Conclusion XSG could reverse

关键词： post-stroke depression xiangshao Granules indoleamine 2,3-dioxygenase 1 Chinese medicine

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一种全工况自适应的二氧化碳供暖热泵

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工程热物理学报 2025年第1期46卷 68-71页

作者：何宇佳邵亮亮曹祥张春路同济大学机械与能源工程学院上海201804

CO_(2)热泵具有良好的低温供热能力和环保性。然而,在供暖场景下,单一模式的CO_(2)热泵难以应对多变的工况。为解决这一问题,本文从热力循环融合和换热匹配优化两个层面提出了一种能够在全工况下自适应最优运行的CO_(2)热泵供暖系统。... 详细信息

CO_(2)热泵具有良好的低温供热能力和环保性。然而,在供暖场景下,单一模式的CO_(2)热泵难以应对多变的工况。为解决这一问题,本文从热力循环融合和换热匹配优化两个层面提出了一种能够在全工况下自适应最优运行的CO_(2)热泵供暖系统。在热力循环融合层面,该系统具备切换运行机械过冷跨临界CO_(2)循环和过热回收复叠循环的能力。而在换热匹配优化层面,系统通过拆分换热器实现多级加热,从而提升温度场的均匀性。通过仿真分析,本文构建了适应变工况的自适应切换策略,为全工况CO_(2)热泵的实际运行提供指导。最后,通过对比分析,新系统的全供暖季能效相较于现有系统可提升1.9%∼17.7%。

关键词：二氧化碳热泵空间供暖热力循环融合自适应运行能效提升

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Design and numerical analysis of serpentine microchannel integrated with inner-wall ridges for enhanced droplet mixing

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Science China(Technological Sciences) 2023年第2期66卷 560-573页

作者： cao xiang CHEN YongPing Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Environmental Science and EngineeringSuzhou University of Science and TechnologySuzhou 215009China

A numerical model is developed for three-dimensional droplet mixing in serpentine microchannels with inner-wall ridges(referred to as SMR microchannels).The underlying mechanisms of mixing in SMR microchannels are revealed,and the effects of the ridge width and ridge number on mixing inside droplets of different sizes are *** results indicate that SMR microchannels are capable of enhancing the mixing efficiency by 3.6%–12.5%compared with that in smooth serpentine microchannels,particularly when the droplet length is larger than the microchannel width and the width ratio of the ridge to the microchannel is 0.25–*** above mixing enhancement is determined by two main factors:the combined effects of the vortex pair and reverse flow,and non-horizontal ***,when the width ratio is 1,there is a maximum 16.0%increase in mixing efficiency for small droplets with a length equal to the microchannel ***,for small droplets,mixing in an SMR microchannel is worse than in a smooth serpentine microchannel when the width ratio is less than *** increasing the ridge number,when the width ratio is 0.25,the mixing efficiency is reduced for small droplets but increased for larger droplets.

关键词： droplet mixing serpentine microchannel ridge microfluidics

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Admissibility for Linear Estimator of Parameter on Growth Curve Model with Respect to Linear Constraint

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Acta Mathematicae Applicatae Sinica 2009年第1期25卷 171-176页

作者： Ming-xiang cao Fan-chao Kong Department of Mathematics Hefei Teachers College Heifei 230061 China Department of Mathematics Anhui University Hefei 230038 China

By using the vector-method of matrix, we study Growth Curve Model with respect to linear constraint. Under matrix loss function and vector loss function, we obtain necessary and sufficient conditions for admissibility... 详细信息

关键词： Growth curve model linear estimators admissibility

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General Admissibility for Linear Estimators in a General Multivariate Linear Model under Balanced Loss Function

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Acta Mathematica Sinica,English Series 2013年第9期29卷 1823-1832页

作者： Ming xiang cao Fan Chao KONG Department of Mathematics Hefei Normal University School of Mathematics Anhui University

A generalization of Zellner’s balanced loss function is proposed. General admissibility in a general multivariate linear model is investigated under the generalized balanced loss function. And the sufficient and necessary conditions for linear estimators to be generally admissible in classes of homogeneous and nonhomogeneous linear estimators are given, respectively.

关键词： Balanced loss function linear estimators general optimality general admissibility

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Impact of climate change on building heating energy consumption in Tianjin

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Frontiers in Energy 2013年第4期7卷 518-524页

作者： cao xiang Zhe TIAN School of Environmental Science and Engineering Tianjin University Tianjin 300072 China

This paper investigated the variation of build- ing heating energy consumption caused by global warming in Tianjin, China. Based on the hourly historical and monthly projected future （B1/A1B emissions scenarios） meteorological data, the variation of those relevant meteorological parameters was first analyzed. A TRNSYS simulation model for a reference building was introduced to investigate historical variation of office building energy consumption. The results showed that the 10-year-average heating energy consumption of 2001-2010 had reduced by 16.1% compared to that of 1961-1970. By conducting principal component analysis and regression analysis, future variation of building heating load was studied. For B1/A1B emissions scenarios, the multi-year-average heating load was found to decrease by 9.7% （18.1%）/ 10.2% （22.7%） compared to that of 1971-2010 by 2011- 2050 （2051-2100）.

关键词： global warming office building heating energy consumption

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Wavelet Analysis of Fluctuation of Plasma Density in Hypersonic Flow

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Chinese Physics Letters 1999年第3期16卷 190-192页

作者： YANG Hong-bo cao Jin-xiang Department of Modern Physics University of Science and Technology of ChinaHefei 230027

By use of wavelet transform, a high frequency fluctuation is identified in the presence of low frequency disturbance through the zoned wavelet energy spectrum. The high frequency fluctuation of the plasma density may be stimulated by an ion-acoustic instability. These results can help to study the mechanism of the perturbation of plasma density in hypersonic wake.

关键词： spectrum. instability. Plasma

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The Characterizations and Constructions of Sprays of Isotropic Curvature

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Acta Mathematica Sinica,English Series 2022年第9期38卷 1612-1620页

作者： Xin Yue CHENG Ke xiang cao Chun Yan QING School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331P.R.China

This paper discusses the sprays of isotropic *** first determine the relationship betweenχ-curvatures of two projectively related *** on this,we find an approach to construct sprays of isotropic curvature and find infinitely many sprays of isotropic curvature via some known sprays of isotropic *** particular,by using famous Funk metricΘ,we can construct infinitely many sprays of isotropic curvature,some of which can be induced by Finsler metrics,but others cannot be induced by any Finsler metric.

关键词： Spray spray of isotropic curvature χ-curvature S-curvature Funk metric

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A neurodynamics control strategy for real-time tracking control of autonomous underwater vehicle

A neurodynamics control strategy for real-time tracking cont...

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第25届中国控制与决策会议

作者： Xun Hua Daqi Zhu xiang cao Laboratory Of Underwater Vehicles and Intelligent Systems Shanghai Maritime University

ISBN: (纸本)9781467355322

How to control an AUV accurately to complete an underwater path-following task is still an open challenging problem. A biological inspired neurodynamics based tracking controller of underactuated autonomous underwater vehicle （AUV） is proposed in this paper. The proposed control strategy includes a velocity controller with the biological neurons and an adaptive sliding mode controller. The biological neurons are embedded into the backstepping velocity controller to eliminate the sharp speed jumps commonly existing in vehicle due to tracking errors changing suddenly. The outputs of the velocity controller are used as the command inputs of the sliding mode controller, and the thrusters control constraints problem which are commonly seen in the backstepping control of AUV are overcomed by the proposed controller. Simulation results show that the control strategy achieved success in the position and velocity smoothly tracking of AUV.

关键词： Autonomous underwater vehicle Tracking control Biological inspired neurodynamics Backstepping control Sliding mode control.

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