检索结果-南通市图书馆

MicroRNAs in colorectal cancer as markers and targets:Recent advances

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第15期20卷 4288-4299页

作者： Jing-Jia Ye jiang cao Clinical Research Center The Second Affiliated HospitalZhejiang University School of Medicine

MicroRNAs are evolutionarily conserved small noncoding RNA molecules encoded by eukaryotic genomic DNA,and function in post-transcriptional regulation of gene expression via base-pairing with complementary sequences in target mRNAs,resulting in translational repression or degradation of target *** represent one of the major types of epigenetic modification and play important roles in all aspects of cellular *** expression of microRNAs has been found in various human diseases including *** efforts have been made to discover the characteristic microRNA expression profiles,to understand the roles of aberrantly expressed microRNAs and underlying mechanisms in different *** the application of DNA microarray,real-time quantitative polymerase chain reaction and other molecular biology techniques,increasing evidence has been accumulated which reveal that aberrant microRNAs can be detected not only intracellularly within the cancer cells,but also extracellularly in plasma of patients,postulating the potential of aberrant microRNAs as promising diagnostic/prognostic markers and attracting therapeutic *** review is intended to provide the most recent advances in microRNA studies in one of the most common cancers,colorectal cancer,especially the identification of those specifically altered microRNAs in colorectal cancer,validation for their relevance to clinical pathological parameters of patients,functional analyses and potential applications of these microRNAs.

关键词： MicroRNA Epigenetic modification Colorectal cancer Marker Therapy

Estrogen receptors in gastric cancer:Advances and perspectives

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第8期22卷 2475-2482页

作者： Muhammad Saif Ur Rahman jiang cao Clinical Research Center The Second Affiliated Hospital Zhejiang University School of Medicine

Worldwide, gastric cancer is one of the most common malignancies with high mortality. Various aspects of thedevelopment and progression of gastric cancer continue to be extensively investigated in order to further our understanding and provide more effective means for the prevention, diagnosis, and treatment of the disease. Estrogen receptors(ERs) are steroid hormone receptors that regulate cellular activities in many physiological and pathological processes in different tissues. There are two distinct forms of ERs, namely ERα and ERβ, with several alternative-splicing isoforms for each. They show distinct tissue distribution patterns and exert different biological functions. Dysregulation of ERs has been found to be associated closely with many diseases, including cancer. A number of studies have been conducted to investigate the role of ERs in gastric cancer, the possible mechanisms underlying these roles, and the clinical relevance of deregulated ERs in gastric cancer patients. To date, inconsistent associations of different ERs with gastric cancer have been reported. These inconsistencies may be caused by variations in in vitro cell models and clinical samples, including assay conditions and protocols with regard to different forms of ERs. Given the potential of the deregulated ERs as diagnostic/prognostic markers or therapeutic targets for gastric cancer, it will be important to identify/confirm the association of each ER isoform with gastric cancer, to determine the specific roles and interactions that these individual ER isoforms play under specific conditions in the development and/or progression of gastric cancer, and to elucidate precisely these mechanisms. In this review, we summarize the achievements from early ER studies in gastric cancer to the most up-to-date discoveries, with an effort to provide a comprehensive understanding of the role of ERs roles in gastric cancer and its possible mechanisms. Furthermore, we propose directions for future investig

关键词： Gastric cancer Estrogen receptor Isoform Carcinogenesis Mechanism Genomic pathway Nongenomic pathway

COMPLEX SYMMETRIC TOEPLITZ OPERATORS ON THE UNIT POLYDISK AND THE UNIT BALL

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2020年第1期40卷 35-44页

作者： cao jiang Xingtang DONG Zehua ZHOU School of Mathematics and Information Sciences Nanchang Hangkong UniversityNanchang 330063China School of Mathematics Tianjin UniversityTianjin 300350China

In this article,we study complex symmetric Toeplitz operators on the Bergman space and the pluriharmonic Bergman space in several ***,the necessary and sufficient conditions for Toeplitz operators to be complex symmetric on these two spaces with certain conjugations are just the ***,some interesting symmetry properties of complex symmetric Toeplitz operators are obtained.

关键词： complex symmetric operator Toeplitz operator Bergman space pluriharmonic Bergman space

Comparison of the modified Wiltse’s approach with spinal minimally invasive system and traditional approach for the therapy of thoracolumbar fracture

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2020年第5期34卷 379-386页

作者： Jie Chang jiang cao Ziyan Huang Boyao Wang Tao Sui Xiaojian cao Department of Orthopedics the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Thoracolumbar fractures are usually treated by open posterior pedicle screw ***,this procedure involves massive paraspinal muscle stripping,inflicting surgical trauma,and prolonged X-ray *** this study,we observed 127 patients with single-segment injury thoracolumbar ***-six patients were treated by the modified Wiltse’s paraspinal approach with minimally invasive channel system,while 91 patients were treated via traditional posterior *** time,intraoperative blood loss,intraoperative fluoroscopy frequency,screw placement accuracy,visual analogue scale score,and Cobb’s angle of two groups were *** X-ray exposure times were notably reduced(4.2±1.6) in the new approach group(P<0.05).The pedicle screw placement accuracy and Cobb’s angle after surgery were similar in the two *** conclude that modified Wiltse’s paraspinal approach w ith spinal minimally invasive channel system surgery can significantly reduce the X-ray exposure times and is an alternative therapy for the thoracolumbar fracture.

关键词： thoracolumbar fracture Wiltse’s paraspinal approach spinal minimally invasive channel system

A New Approach for Estimating Kinetic Luminosity of Jet in AGNs

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Astronomy and Astrophysics 2008年第1期8卷 39-49页

作者： Mao-Li Ma Xin-Wu cao Dong-Rong jiang Min-Feng Gu Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030

The Konigl inhomogeneous jet model can successfully reproduce most observational features of jets in active galactic nuclei （AGN）, when suitable physical parameters are adopted. We improve Konigl＇s calculations on the core emission from the jet with a small viewing angle θ0 - φ （φ is half opening angle of the conical jet）. The proper motion of the jet component provides a constraint on the jet kinematics. Based on the inhomogeneous jet model, we use the proper motion data of the jet component to calculate the minimal kinetic luminosity of the jet required to reproduce the core emission measured by the very-long- baseline interferometry （VLBI） for a sample of BL Lac objects. Our results show that the minimal kinetic luminosity is slightly higher than the bolometric luminosity for most sources in the sample, which implies that radiatively inefficient accretion flows （RIAFs） may be in those BL Lac objects, or/and the properties of their broad-line regions （BLRs） are significantly different from flat-spectrum radio-loud quasars.

关键词： galaxies jet -kinematics and dynamics theory - radiation mechanisms nonthermal-BL Lac objects general

The role of AGFA high-energy CR in the calibration and quality con-trol of multileaf collimators(MLC)

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2007年第3期18卷 145-149页

作者： LI Zhaobin XIONG Fei HUANG Guofeng cao Zheng jiang Ruiyao FU Shen Department of Radiation Oncology the No.6 Hospital of Shanghai Jiaotong University Shanghai 200233 China

Linear accelerators equipped with multileaf collimators (MLC) are becoming more common and are widely used in the intensity-modulated radiotherapy (IMRT). There is an imperative need to ensure the commissioning specification of the linear accelerators for the sake of quality assurance (QA) and quality control (QC). This paper is aimed to investigate the role of AGFA high-energy CR (Computed Radiography) in calibrating dynamic multileaf col- limators and evaluating the accuracy of the leaf position. The result shows that AGFA high-energy CR can easily and conveniently be used to calibrate MLC and verify its position. Hence, the application of AGFA high-energy CR is proved to be an accurate and time-saving method for routine MLC QC, especially when MLC calibration adjustments are required.

关键词：高能量CR MLC校准质量控制放射疗法

Radiofrequency ablation,heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers:a minireview

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 361-365页

作者： Teng, Li-Song Jin, Ke-Tao Han, Na cao, jiang Zhejiang Univ Sch Med Ctr Canc Affiliated Hosp 1 Hangzhou 310003 Zhejiang Peoples R China Zhejiang Univ Sir Run Run Shaw Inst Clin Med Key Lab Biotherapy Zhejiang Prov Hangzhou 310016 Zhejiang Peoples R China

BACKGROUND: Radiofrequency ablation (RFA) is a minimally invasive surgical procedure which has widespread popularity in the treatment of hepatic and pancreatic cancers. Increased evidence indicates that RFA stimulates anti-tumor immunity, possibly through the induction heat shock protein 70 (HSP70) expression. HSP70 has the capacity to affect the immunogenicity of tumor cells, to chaperone antigenic peptides and deliver these into antigen presentation pathways within antigen-presenting cells, and to activate and regulate innate and adaptive immunity, which makes it useful in immunotherapeutic strategies for the treatment of cancers. DATA SOURCES: An English-language literature search was conducted using MEDLINE (1991-2010) on anti-tumor immunity, heat shock protein 70, radiofrequency ablation, hepatic cancer, pancreatic cancer, and other related subjects. RESULTS: RFA has an increasing application in the surgical treatment of hepatic and pancreatic cancers. Increased evidence indicates that RFA can induce the expression of HSP70 which possesses properties that enable it to influence a variety of immunological processes. Tumor-derived HSP70 is regarded as a potent adjuvant facilitating presentation of tumor antigens and induction of anti-tumor immunity. CONCLUSIONS: This review addresses the potential association of RFA, HSP70, and anti-tumor immunity in treatment of hepatic and pancreatic cancers. To establish direct evidence of a potential association of RFA, HSP70, and anti-tumor immunity in hepatic and pancreatic cancers, further investigations should be conducted.

关键词： anti-tumor immunity heat shock protein 70 hepatic cancer pancreatic cancer radiofrequency ablation

Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 1845-1855页

作者： jiang cao Leilei Yu Jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China Department of Gastroenterology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different ***,6 *** strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of *** strains are *** results of this study showed that the ingestion of *** GBI-30,6086,and *** CCFM1041 significantly alleviated IBS symptoms in *** contrast,other *** strains showed no or limited alleviating effects on IBS *** to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary *** strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional *** *** results also suggest that administration of *** could significantly regulate microbiota dysbiosis in animal ***,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

关键词： Baciillus coagulans Irritable bowel syndrome Resistance to bile salts Comparative genomic analysis Gut microbiota

Extradural contralateral S1 nerve root transfer for spastic lower limb paralysis

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2023年第5期37卷 394-400页

作者： jiang cao Jie Chang Chaoqin Wu Sheng Zhang Binyu Wang Kaixiang Yang Xiaojian cao Tao Sui Department of Orthopedics the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Orthopedics the Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China.

The current study aims to ascertain the anatomical feasibility of transferring the contralateral S1 ventral root(VR)to the ipsilateral L5 VR for treating unilateral spastic lower limb *** formalin-fixed(three males and three females)cadavers were *** VR of the contralateral S1 was transferred to the VR of the ipsilateral *** sural nerve was selected as a bridge between the donor and recipient *** number of axons,the cross-sectional areas and the pertinent distances between the donor and recipient nerves were *** extradural S1 VR and L5 VR could be separated based on anatomical markers of the dorsal root *** gross distance between the S1 nerve root and L5 nerve root was 31.31(±3.23)mm in the six cadavers,while that on the diffusion tensor imaging was 47.51(±3.23)mm in 60 patients without spinal diseases,and both distances were seperately greater than that between the outlet of S1 from the spinal cord and the *** numbers of axons in the S1 VRs and L5 VRs were 13414.20(±2890.30)and 10613.20(±2135.58),*** cross-sectional areas of the S1 VR and L5 VR were 1.68(±0.26)mm2 and 1.08(±0.26)mm2,*** conclusion,transfer of the contralateral S1 VR to the ipsilateral L5 VR may be an anatomically feasible treatment option for unilateral spastic lower limb paralysis.

关键词： paralysis spinal nerve roots nerve transfer ankle joint