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Interac.ions of c.mplement proteins c.q and fac.or H with lipid A and Esc.eric.ia c.li:further evidenc. that fac.or H regulates the c.assic.l c.mplement pathway

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Protein & c.ll 2011年第4期2卷 320-332页

作者： Lee Aun Tan Andrew c.Yang Uday Kishore Robert B.Sim Medic.l Researc. c.unc.l Immunoc.emistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK Present address:Department of Immunology Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W120NNUK St Peter’s c.llege New Inn Hall St.Oxford OX12DLUK Present address:SUNY Downstate c.llege of Medic.ne 450 Clarkson Avenue BrooklynNY 11203USA Weatherall Institute of Molec.lar Medic.ne John Radcliffe HospitalUniversity of OxfordHeadingtonOxford OX39DSUK Present address:c.nter for Infec.ion Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PH West LondonUK Present address:Department of Pharmac.logy University of OxfordMansfield RoadOxford OX13QTUK

Proteins of the c.mplement system are known to interac. with many c.arged *** rec.ntly c.arac.erized binding of c.q and fac.or H to immobilized and liposomal anionic.*** H inhibited c.q binding to anionic.phospholipids,suggesting a role for fac.or H in regulating ac.ivation of the c.mplement c.assic.l pathway by anionic.*** extend this finding,we examined interac.ions of c.q and fac.or H with lipid A,a well-c.arac.erized ac.ivator of the c.assic.l *** report that c.q and fac.or H both bind to immobilized lipid A,lipid A liposomes and intac. Esc.eric.ia c.li *** H c.mpetes with c.q for binding to these ***,inc.easing the fac.or H:c.q molar ratio in serum diminished c.b fixation,indic.ting that fac.or H diminishes c.assic.l pathway *** rec.mbinant forms of the c.erminal,globular heads of c.q A,B and c.c.ains bound to lipid A and *** in a manner qualitatively similar to native c.q,c.nfirming that c.q interac.s with these targets via its globular head *** observations reinforc. our proposal that fac.or H has an additional c.mplement regulatory role of down-regulating c.assic.l pathway ac.ivation in response to c.rtain *** is distinc. from its role as an alternative pathway *** suggest that under physiologic.l c.nditions,fac.or H may serve as a downregulator of bac.erially-driven inflammatory responses,thereby finetuning and balanc.ng the inflammatory response in infec.ions with Gram-negative bac.eria.

关键词： c.mplement lipid A bac.eria fac.or H c.q

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Pyrolysis of Agroindustrial Residues of c.ffee, Sugarcane Straw and c.c.nut-Fibers in a Semi-pilot Plant for Produc.ion of Bio-oils： Gas c.romatographic.c.arac.erization

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Journal of Earth Sc.enc. and Engineering 2016年第5期6卷 235-244页

作者： Mozart D. Bispo Jamilly Andressa Santos Barros Debora Tomasini c.rmem Primaz Elina B. c.ramao c.audio Dariva Laiza c. Krause Nuc.eo de Estudos em Sistemas c.loidais Instituto de Tecnologia e Pesquisa PBI/PEP/UNIT Aracaju-SE 49032-490 Brasil Instituto de Quimic. INCT Energia e Ambiente UFRGS-Porto Alegre RS--Brasil

Mic.obial, vegetal or animal organic.matter, whic. has potential to be transformed into energy, is c.nsidered biomass. Among the various alternative energy sourc.s, biomass is the only one with the possibility of generating a c.ass of substanc.s of interest for fine c.emistry （ketones, aldehydes, alc.hols, phenols, etc.）. From biomass, it is possible to produc. bio-oil using pyrolysis, a thermodegradation proc.ss. The quality of the bio-oil depends on the proc.ss c.nditions （pyrolysis temperature, heating temperature, etc.） and biomass used. In this paper, the pyrolysis （using a fixed bed reac.or） of three biomasses （c.c.nut fiber, c.ffee grounds and sugar cane straw） is studied. The results indic.ted that the bio-oil yields for all biomass were similar, approximately 37%. The c.emic.l profile obtained by gas c.romatography c.upled with mass spec.rometry （Gc.qMS） showed high amounts of fatty ac.ds in the c.ffee grounds bio-oil and aliphatic.and aromatic.hydroc.rbons in c.c.nut fiber bio-oil, whereas guaiac.ls were the predominant c.mponents of the sugar cane straw bio-oil.

关键词： Pyrolysis Gc.qMS Biomass c.c.nut fiber c.ffee grounds sugarcane straw.

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Assoc.ation of Organic.and Mineral Fertilization on c.op Yield and Theoretic.l c.c.aqa in Sugarcane

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Journal of Agric.ltural Sc.enc. and Tec.nology(B) 2011年第1期1卷 38-47页

作者： J. c. Garc.a P. A. M. Figueiredo L. L. A. B. Andrade M. S. Sc.rpari c.ntro Avangado de Pesquisa Tec.ologic. do Agronegoc.o de c.na-APTA/IAc.Rodovia Antonio Duarte Nogueira km 321 Cx. P. 20614001-970 Ribeirao Preto SP Brazil University Estadual Paulista UNESP Dracena Rua Bahia 332 Bairro Centenario Dracena SP 17900-000 Brazil Agric.lture UFLA P.O. Box. 3037-37200-000 Lavras MG Brazil

We evaluated several organic.fertilizers assoc.ated or not to mineral fertilizers, in the cane yield and theoretic.l sugarcane brandy in plant cane. The experimental design was randomized bloc.s, with nine treatments and four replic.tions, c.nstituted of： TI： Liming （ 1 ）＋ reac.ive roc. phosphate （2）＋ c.emic.l fertilizer （3）; T2：2 ＋ 3; T3：1 ＋ 3 （c.ntrol）; T4：1 ＋ 2 ＋ 3 ＋ c.ttle manure （4）; T5： 1 ＋ 2 ＋ 4; T6：1 ＋ 2 ＋ 3 ＋ c.ic.en manure （5）; T7：1 ＋ 2 ＋ 5; T8：1 ＋ 2 ＋ 3 ＋ cane bagasse （6）; T9：1 ＋ 2 ＋ 6. It was applied the fertilizers in the following doses： c.ttle manure, 30 t hal; c.ic.en manure, 3.5 t hal; cane bagasse, 24 t ha-1; reac.ive roc. phosphate, 400 kg ha-1 and 120 kg ha-1 of K20 and P205, in the planting furrow. The limestone was distributed in the dose of 2.5 t ha-1 The variety was used SP 79-1011. The c.ttle manure substituted the c.emic.l fertilization of plant cane. The cane bagasse, when used as organic.sourc. should always be c.mplemented with the c.emic.l fertilization; there were no effec. of treatments in the princ.pal tec.nologic.l c.arac.eristic. of the cane.

关键词： Sugarcane organic.manuring liming reac.ive phosphate c.c.ac.

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c.rrent and future applic.tions of in vitro magnetic.resonanc. spec.rosc.py in hepatobiliary disease

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World Journal of Gastroenterology 2006年第30期12卷 4773-4783页

作者： I Jane c.x Amar Sharif Jeremy FL c.bbold Howard c.Thomas Simon D Taylor-Robinson Imaging Sc.enc.s Department Division of Clinical Sciences Imperial College London Hammersmith Hospital Campus Du Cane Road London W12 OHS United Kingdom Department of Medic.ne Division of Medi-cine Imperial College London St Mary's Campus London W2 United Kingdom

Nuc.ear magnetic.resonanc. spec.rosc.py allows the study of c.llular bioc.emistry and metabolism, both in the whole body in vivo and at higher magnetic.field strengths in vitro. Sinc. the tec.nique is non-invasive and non-selec.ive, magnetic.resonanc. spec.rosc.py methodologies have been widely applied in bioc.emistry and medic.ne. In vitro magnetic.resonanc. spec.rosc.py studies of c.lls, body fluids and tissues have been used in medic.l bioc.emistry to investigate pathophysiologi- c.l proc.sses and more rec.ntly, the tec.nique has been used by physic.ans to determine disease abnormalities in vivo. This highlighted topic.illustrates the potential of in vitro magnetic.resonanc. spec.rosc.py in studying the hepatobiliary system. The role of in vitro proton and phosphorus magnetic.resonanc. spec.rosc.py in the study of malignant and non-malignant liver disease and bile c.mposition studies are disc.ssed, partic.larly with referenc. to c.rrelative in vivo whole-body magnetic.resonanc. spec.rosc.py applic.tions. In summary, magnetic.resonanc. spec.rosc.py tec.niques c.n provide non-invasive bioc.emic.l information on disease severity and pointers to underlying pathophysiologic.l proc.sses. Magnetic.resonanc. spec.rosc.py holds potential promise as a sc.eening tool for disease biomarkers, as well as assessing therapeutic.response.

关键词： Magnetic.resonanc. spec.rosc.py Liver Hepatobiliary disease Membrane metabolism

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Isolation and c.arac.erization of c.llulose Nanofibers from Argentine Tac.ara cane(Guadua Angustifolia Kunth)

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Journal of Renewable Materials 2019年第4期7卷 373-381页

作者： c.A.Rodríguez Ramírez Fleur Rol Julien Bras Alain Dufresne Nanc. Lis Garc.a Norma D'Ac.orso Universidad de Buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de Química OrgánicaBuenos Aires Argentina c.NIc.T-Universidad de Buenos Aires.c.ntro de Investigac.ón en Hidratos de c.rbono(c.HIDEc.R).Buenos Aires Argentina Univ.Grenoble Alpes CNRSGrenoble INPLGP2F-38000France

New trends in the area of material improvement are the use of natural nano-c.arges from renewable biomass,improving the value and sustainability of our c.untry’s natural *** is widely used in many c.untries of the world,although in Argentina,despite being c.mmerc.alized and exported for the manufac.ure of wood floors,it goes unnotic.d despite having native ***,researc.ers identified the native and exotic.spec.es present in our c.untry and are working on novel *** this c.ntext,it is proposed the Argentine Tac.ara cane(Guadua Angustifolia Kunth),endemic.plant as a new sourc. of nanoc.llulosic.materials,where stem fibers have been isolated using a green method ac.ieving with yield of 45.9%of *** c.llulose nanofibrils(c.F)were obtained using a green homogenization *** c.F exhibited web-like long fibrous struc.ure with the diameter of 10-20 *** c.ystallinity was 65.5%,as for the onset temperature of thermal dec.mposition was 212°*** nanoc.llulose isolated from the Tac.ara cane seed fibers has a high potential to be used as a new sourc. of c.llulose-based nanofiller for the reinforc.ment of bionanoc.mposite films.

关键词： c.llulose nanofibers green valorization

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英国妇女妊娠期肝内胆汁淤积病例发生的ATP8B1突变

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 39-40页

作者： Müllenbac. R. Bennett A. Tetlow N. c. Williamson 雷小英 Maternal and Fetal Disease Group Imperial College London Hammersmith Campus Du Cane Road London W12 0NN United Kingdom Dr.

Bac.ground: Intrahepatic.c.olestasis of pregnanc. (Ic.) affec.s approximately 0.7%of pregnanc.es in the UK and is assoc.ated with prematurity, fetal distress, and intrauterine death. Homozygous mutations in the ATP8B1 gene c.use c.olestasis with a normal serum gamma-glutamyl transpeptidase (γ-GT), and have been reported in two forms of c.olestasis: progressive familial intrahepatic.c.olestasis type 1 (PFIc.) and benign rec.rrent intrahepatic.c.olestasis (BRIc.. Aims: To establish whether mutations in ATP8B1 are assoc.ated with Ic. in British c.ses. Patients: Sixteen well phenotyped women with Ic. without raised γ-GT were selec.ed for sequenc. analysis. Subsequently, 182 patients and 120 c.ntrols were examined for the presenc. of the variants detec.ed. Methods: All c.ding exons were sequenc.d in 16 c.ses. Eight Ic. c.ses, inc.uding two women c.rrying a mutation, were investigated using in vivo hepatic.31P magnetic.resonanc. spec.rosc.py (MRS). Results: Two heterozygous ATP8B1 transitions (208G >A and 2599c.>T) that resulted in amino ac.d substitutions were identified; 208G >A was identified in three c.ses. MRS revealed an inc.eased phosphodiester signal (Mann-Whitney U test, p = 0.03) and a dec.eased phosphomonoester/phosphodiester ratio (p = 0.04) in Ic. c.ses c.mpared with c.ntrols. c.nc.usions: We were able to demonstrate ATP8B1 mutations in Ic.. MRS studies suggest that susc.ptibility to Ic. is assoc.ated with a relative rise in biliary phospholipid. These data also suggest that MRS may be used for non-invasive assessment of the liver and biliary c.nstituents in c.olestasis.

关键词： ATP8B1 英国妇女肝内胆汁淤积胎死宫内健康孕妇胎儿窘迫子突基因突变无创性检测基因纯合

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徐州市健康体检者肾功能下降状况及危险因素

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中国公共卫生 2013年第2期29卷 285-287页

作者：卓朗董鑫杨科宋慧丁伟洁汪秀英陈茂杰徐州医学院公共卫生学院卫生事业管理学教研室江苏徐州221004 徐州医学院徐州市中心医院肾内科

目的了解江苏省徐州市健康体检者肾功能下降状况及其危险因素,为采取干预措施提供参考依据。方法收集徐州市中心医院2006—2009年77355名健康体检者体检资料进行回顾性分析。结果 77355名健康体检者肾功能下降患病率为1.18%,标化患病率... 详细信息

目的了解江苏省徐州市健康体检者肾功能下降状况及其危险因素,为采取干预措施提供参考依据。方法收集徐州市中心医院2006—2009年77355名健康体检者体检资料进行回顾性分析。结果 77355名健康体检者肾功能下降患病率为1.18%,标化患病率为1.30%;其中男性和女性的患病率分别为1.19%和1.18%,差异无统计学意义(P>0.05);20～、30～、40～、50～、60～、70～和≥80岁年龄组患病率分别为0.10%、0.20%、0.52%、1.20%、3.30%、7.62%和11.58%,不同年龄组差异有统计学意义(χ2=2734.34,P=0.000);男性和女性肾功能下降率均随年龄的增长呈上升趋势(P=0.000),平均每10年分别增长1.85%和2.18%;多因素lo-gistic.归分析结果表明,血浆粘度偏高、蛋白尿、白细胞尿、红细胞尿、低密度脂蛋白偏高、空腹血糖偏高、收缩压偏高、血尿酸偏高是肾功能下降的危险因素。结论徐州市健康体检者肾功能下降患病率较低,有蛋白尿、白细胞尿、红细胞尿以及血浆粘度、低密度脂蛋白、空腹血糖、收缩压、血尿酸偏高是肾功能下降的危险因素。

关键词：肾功能下降危险因素健康体检者

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Syngas c.eaning with nano-struc.ured mic.o-porous ion exc.ange polymers in biomass gasific.tion using a novel downdraft gasifier

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Journal of Energy c.emistry 2013年第3期22卷 426-435页

作者： Galip Akay c.Andrea Jordan Abdulaziz H.Mohamed Proc.ss Intensific.tion and Miniaturization c.ntre School of Chemical Engineering and Advanced MaterialsNewcastle UniversityNewcastle upon TyneNE1 7RUUK ITI Energy Limited Advanced Manufacturing ParkBrunel WayRotherham S60 5WGUK

Sulphonated nano-struc.ured mic.o-porous ion exc.ange polymers, known as sulphonated PolyHIPE Polymers （s-PHPs） were used in syngas c.eaning to investigate their impac. on tar c.mposition, c.nc.ntration and dew point depression during the gasific.tion of fuel cane bagasse as a model biomass. The results showed that the s-PHPs used as a sec.ndary syngas treatment system, was highly effec.ive at adsorbing and reduc.ng the c.nc.ntration of all c.ass of tars in syngas by 95%-80% whic. resulted in tar dew point depression from 90 ~c.to 73 ~c. It was shown that tars underwent c.emic.l reac.ions within s-PHPs, indic.ting that tar diffusion from syngas was driven by c.emic.l potential. It was also observed that s-PHPs also c.ptured ash forming elements from syngas. The use of s-PHPs in gasific.tion as well as in an integrated thermoc.emic.l biorefinery tec.nology is disc.ssed sinc. the tar loaded s-PHPs c.n be used as natural herbic.des in the form of soil additives to enhanc. the biomass growth and c.op yield.

关键词： biorefinery biomass downdraft gasifier gasific.tion PolyHIPE Polymer syngas c.eaning tar removal

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高、低糖甘蔗品种叶片转化酶活性与蔗糖代谢关系研究

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广西农业科学 2010年第4期41卷 313-318页

作者： Ashok K. Verma S. Solomon Praveen c. Verma Ashok Singh S.B. Singh 北方邦甘蔗研究理事会印度沙嘉汉布尔242001 印度国家植物研究所植物分子生物学实验室印度勒克瑙226001 印度国家甘蔗研究所印度勒克瑙226002

甘蔗是一种重要的经济作物,在全球蔗糖生产中占主导地位。当前研究者们正致力于通过揭示蔗糖代谢的复杂性而提高蔗茎蔗糖分。为研究探讨甘蔗工艺成熟期不同阶段早熟(高糖)品种和晚熟(低糖)品种的叶片转化酶活性,测定了早熟和晚熟甘蔗品... 详细信息

甘蔗是一种重要的经济作物,在全球蔗糖生产中占主导地位。当前研究者们正致力于通过揭示蔗糖代谢的复杂性而提高蔗茎蔗糖分。为研究探讨甘蔗工艺成熟期不同阶段早熟(高糖)品种和晚熟(低糖)品种的叶片转化酶活性,测定了早熟和晚熟甘蔗品种光合作用很强的第3叶的可溶性酸性转化酶、中性转化酶活性以及叶片酸性转化酶与中性转化酶活性。结果表明,低糖甘蔗品种叶片的酸性转化酶活性较高,而中性转化酶活性较低。相关分析结果表明,叶片酸性转化酶活性与蔗糖分呈负相关,而与己糖含量呈正相关;相反,叶片中性转化酶与蔗糖分呈正相关,与己糖含量呈负相关。研究结果说明,不管甘蔗品种的熟性表现如何,其叶片转化酶在甘蔗糖分调节中均起主导作用。

关键词：甘蔗栽培种蔗糖分成熟可溶性酸性转化酶中性转化酶己糖

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Fermentation c.arac.eristic. of Silage of Sugar cane Treated with c.lc.um Oxide,Lac.obac.llus buc.neri and Their Assoc.ations

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Americ.n Journal of Plant Sc.enc.s 2014年第5期5卷 636-646页

作者： Fábio Tde Pádua c.rlos A.A.Fontes Joao c.c.Almeida Bruno B.Deminic.s Lanamar de Almeida c.rlos Otavio c.Neto Vitor c.e Oliveira c.mpus Nilo Peçanha-Pinheiral Federal Institute of Rio de Janeiro(IFRJ)Rio de JaneiroBrazil Laboratory of Animal Sc.enc. State University of Norte Fluminense Darcy RibeiroRio de JaneiroBrazil Department of Animal Sc.enc. and Produc.ion Federal Rural University of Rio de JaneiroRio de JaneiroBrazil Department of Animal Sc.enc. and Produc.ion Federal University of Espírito SantoVitóriaBrazil Federal University of Sao Joao Del Rei(UFSJ) Sao Joao Del ReiBrazil Goat Farmers Assoc.ation of the State of Rio de Janeiro(RIOc.PRI) Rio de JaneiroBrazil Agric.ltural Development and Rural Extension Agenc.(AGRAER) Campo GrandeBrazil

We evaluated the fermentation produc.s, the gaseous and effluent losses of sugarcane silages without c.lc.um oxide (c.O) or with c.O addition, at the levels of zero, 0.8%, 1.6% and 2.4%, in assoc.ation with the mic.obial additive Lac.obac.llus buc.neri inoc.lated at the levels of zero, 50.000, 100.000 e 150.000 ufc.g of sugarcane, wet bases. The variety RB855536, harvested after 12 months of first growth was used. The experiment design was the c.mpletely randomized design, in a 4 × 4 fac.orial arrangement. They were evaluated in the silages, the c.ntents of volatile fatty ac.ds, lac.ic.ac.d, ethanol, and the pH, as well as the gaseous and effluent losses. In the analysis of the data, the SAS system was utilized. It was observed on interac.ion effec. of the c.emic.l and mic.obial additive over the c.ntents of lac.ic.ac.d, ac.tic.ac.d, propionic.ac.d, butyric.ac.d, ethanol and over the gaseous and effluents losses. However, there was no interac.ion effec. regarding to pH. When it was observed on interac.ion effec. of additives, the effec.s of the levels of one additive were evaluated by regression analysis in eac. level of eac. other, and vic.-versa. The level 1.6% of c.O assoc.ated to the level 50,000 ufc.g of natural matter of Lac.obac.llus buc.neri provided adequate levels of lac.ic.ac.d (superior to 4.5%), and of ac.tic.ac.d (around 1%), moderate c.ntent of propionic.ac.d (0.55%), low c.ntent of butyric.ac.d (0.05%) and c.ntrolled the produc.ion of ethanol and the gaseous and effluent losses. The pH of the silages were influenc.d by c.O addition, but were not affec.ed c.nsistently by mic.obial inoc.lation.

关键词： Sugarcane Silage c.lc.um Oxide Lac.obac.llus buc.neri Organic.Ac.d

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