检索结果-南通市图书馆

NLRP3 inflammasome activation determines the fibrogenic potential of PM_(2.5) air pollution particles in the lung

Journal of Environmental Sciences 2022年第1期34卷 429-441页

作者： Wei Cao Xiang Wang Jiulong Li Ming Yan Chong Hyun Chang Joshua Kim Jinhong Jiang Yu-Pei Liao Shannon Tseng Sydney Kusumoputro candice lau Marissa Huang Pengli Han Pengju Lu Tian Xia Translational Medical Center Zhengzhou Central Hospital Affiliated Zhengzhou UniversityZhengzhou 450007China Division of NanoMedicine Department of MedicineUniversity of CaliforniaLos Angeles 90095CAUnited States Basic Medical College Zhengzhou UniversityZhengzhou 450001China Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles 90095CAUnited States Department of Integrative Biology and Physiology University of CaliforniaLos Angeles 90095CAUnited States Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos Angeles 90095CAUnited States

Airborne fine particulate matter(PM_(2.5))is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung ***3 inflammasome activation has been implicated in these diseases;however,due to the complexity in PM_(2.5)compositions,it is difficult to differentiate the roles of the components in triggering this *** collected eight real-life PM_(2.5)samples for a comparative analysis of their effects on NLRP3 inflammasome activation and lung *** vitro assays showed that although the PM_(2.5)particles did not induce significant cytotoxicity at the dose range of 12.5to 100μg/m L,they induced potent TNF-αand IL-1βproduction in PMA differentiated THP-1 human macrophages and TGF-β1 production in BEAS-2B human bronchial epithelial *** the dose of 100μg/m L,PM_(2.5)induced NLRP3 inflammasome activation by inducing lysosomal damage and cathepsin B release,leading to IL-1β*** was confirmed by using NLRP3-and ASC-deficient cells as well as a cathepsin B inhibitor,ca-074 *** of PM_(2.5)via oropharyngeal aspiration at 2 mg/kg induced significant TGF-β1 production in the bronchoalveolar lavage fluid and collagen deposition in the lung at 21days post-exposure,suggesting PM_(2.5)has the potential to induce pulmonary *** ranking of in vitro IL-1βproduction correlates well with the in vivo total cell count,TGF-β1 production,and collagen *** summary,we demonstrate that the PM_(2.5)is capable of inducing NLRP3 inflammasome activation,which triggers a series of cellular responses in the lung to induce fibrosis.

关键词： Particulate matter Predictive toxicology NLRP3 inflammasome IL-1β Lung fibrosis Lung inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：