检索结果-南通市图书馆

STING-mediated IL-6 Inhibits OATP1B1 expression via the TCF4 Signaling Pathway in Cholestasis

Journal of Clinical and Translational Hepatology 2024年第8期12卷 701-712页

作者： Yan Guo Hongjia Zhang Nan Zhao Ying Peng Dongya Shen Yubin Chen Xiaoxun Zhang can-e tang Jin Chai Department of endocrinology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Gastroenterology Institute of Digestive Diseases of PLACholestatic Liver Diseases Center and Center for Metabolic Associated Fatty Liver DiseaseThe First Affiliated Hospital(Southwest Hospital)to Third Military Medical University(Army Medical University)ChongqingChina Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Cardiac Surgery Xiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Background and Aims Organic anion-transporting polypeptides(OATPs)play a crucial role in the transport of bile acids and *** our previous study,interleukin 6(IL-6)reduced OATP1B3 levels in cholestatic ***,it remains unclear whether IL-6 inhibits OATP1B1 expression in cholestatic *** study aimed to investigate whether IL-6 can inhibit OATP1B1 expression and explore the underlying *** The effect of stimulator of interferon genes(STING)signaling on inflammatory factors was investigated in a cholestatic mouse model using RT-qPCR and enzyme-linked immunosorbent *** assess the impact of inflammatory factors on OATP1B1 expression in hepatocellular carcinoma,we analyzed OATP1B1 expression by RT-qPCR and Western Blot after treating PLC/PRF/5 cells with TNF-α,IL-1β,and *** elucidate the mechanism by which IL-6 inhibits OATP1B1 expression,we examined the expression of the OATP1B1 regulator TCF4 in PLC/PRF/5 and HepG2 cells using RT-qPCR and Western *** interaction mechanism betweenβ-catenin/TCF4 and OATP1B1 was investigated by knocking downβ-catenin/TCF4 through siRNA *** The STING inhibitor decreased inflammatory factor levels in the cholestatic mouse model,with IL-6 exhibiting the most potent inhibitory effect on ***-6 downregulatedβ-catenin/TCF4,leading to decreased OATP1B1 ***-downβ-catenin/TCF4 counteracted theβ-catenin/TCF4-mediated repression of *** STING-mediated IL-6 up-regulation may inhibit OATP1B1,leading to reduced transport of bile acids and bilirubin by *** may contribute to altered pharmacokinetics in patients with diseases associated with increased IL-6 production.

关键词： Inflammation Bile acid Bilirubin Cholestasis STING IL-6 β-catenin TCF4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance of iron-air battery with iron nanoparticle-encapsulated C-N composite electrode

引用

Frontiers in energy 2024年第1期18卷 42-53页

作者： can FANG Xiangmei tang Jiaoyan WANG Qingfeng YI School of Chemistry and Chemical engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Advanced Materials for New energy Storage and Conversion Xiangtan 411201China

Highly efficient and stable iron electrodes are of great significant to the development of iron-air battery(IAB).In this paper,iron nanoparticle-encapsulated C–N composite(NanoFe@CN)was synthesized by pyrolysis using polyaniline as the C–N *** performance of the NanoFe@CN in different electrolytes(alkaline,neutral,and quasi-neutral)was investigated via cyclic voltammetry(CV).The IAB was assembled with NanoFe@CN as the anode and IrO_(2)+Pt/C as the *** effects of different discharging/charging current densities and electrolytes on the battery performance were also *** K_(2)SO_(4)electrolyte can effectively suppress the passivation of iron electrode,and the battery showed a good cycling stability during 180 charging/discharging *** to the pure nano-iron(NanoFe)battery,the NanoFe@CN battery has a more stable cycling stability either in KOH or NH_(4)Cl+KCl electrolyte.

关键词： energy storage and conversion metallic composites nanocomposites iron-air battery iron anode

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting transformer temperature field based on physics-informed neural networks

引用

High Voltage 2024年第4期9卷 839-852页

作者： Pengfei tang Zhonghao Zhang Jie Tong Tianhang Long can Huang Zihao Qi China electric Power Research Institute BeijingChina

The safe operation of oil-immersed transformers is critical to the safety and stability of the power *** the operating time increases,the failure rate of oil-immersed transformers shows an increasing trend,posing serious challenges to safe *** is necessary to investigate the internal state of the oil-immersed transformer to improve the digital degree and achieve digitalisation and intelligent operation and maintenance.A physics-informed neural network(PINN)for oil-immersed transformers was introduced to reconstruct the temperature distribution inside the *** to the approach,the loss function of the network would be optimised by incorporating physical constraint loss terms including heat transfer equations,initial conditions and boundary *** results show that the method proposed can be used to reconstruct and predict the temperature field of transformers in a few seconds with satisfactory *** conclusion,the PINN proposed outperforms deep neural networks in terms of accuracy,reliability and interpretability,especially in data-poor cases.

关键词： immersed conclusion constraint

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Knockdown of circular RNA (CircRNA)_001896 inhibits cervical cancer proliferation and stemness in vivo and in vitro

引用

BIOCeLL 2024年第4期48卷 571-580页

作者： JIA SHAO can ZHANG YAONAN tang AIQIN He WeIPeI ZHU Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of Gynecology Oncology Affiliated Tumor Hospital of Nantong UniversityNantong226361China

Objective:Previous studies indicated that aberrant circular RNA(circRNA)expression affects gene expression regulatory networks,leading to the aberrant activation of tumor pathways and promoting tumor cell ***,the expression,clinical signiﬁcance,and effects on cell propagation,invasion,and dissemination of circRNA_001896 in cervical cancer(CC)tissues remain ***:The Gene expression Omnibus(GeO)datasets(GSe113696 and GSe102686)were used to examine differential circRNA expression in CC and adjacent *** expression of circRNA_001896 was detected in 72 CC patients usingﬂuorescence quantitative *** analysis with clinical pathological features was performed through COX multivariate and univariate *** effect of circRNA_001896 downregulation on CC cell propagation was examined using the cell counting kit-8(CCK-8)test,clonogenic,3D sphere formation,and in vivo tumorigenesis ***:Intersection of the GSe113696 and GSe102686 datasets revealed an increased expression of four circRNAs,including circRNA_001896,in CC *** quantitative PCR conﬁrmed circRNA_001896 as a circular *** expression of circRNA_001896 was considerably associated with lymph node metastasis,International Federation of Gynecologists and Obstetricians(FIGO)stage,tumor diameter,and survival period in CC *** hazards model(COX)univariate and multivariate analyses revealed that circRNA_001896 expressions are a distinct risk factor affecting CC patients’*** functional experiments showed that downregulating circRNA_001896 substantially suppressed CC cell growth,colony formation,and 3D sphere-forming *** vivo,tumorigenesis analysis in nude mice demonstrated that downregulating circRNA_001896 remarkably reduced the in vivo proliferation capacity of CC ***:CircRNA_001896 is highly expressed in CC tissues and is substantially related to lymph node metastasis,FIGO stage,tumor size,and surviva

关键词： Uterine cervical neoplasms RNA Circular Cell proliferation cancer stem cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metamaterial terahertz device with temperature regulation function that can achieve perfect absorption and complete reflection conversion of ultrawideband

引用

Communications in Theoretical Physics 2024年第7期76卷 123-133页

作者： Hao Sun Zao Yi can Ma Shubo Cheng Bin tang Qingdong Zeng Sohail Ahmad School of Mathematics and Science Joint Laboratory for Extreme Conditions Matter PropertiesState Key Laboratory of Environment-Friendly Energy MaterialsTianfu Institute of Research and InnovationSouthwest University of Science and TechnologyMianyang 621010China Department of Oncology Sichuan Science City HospitalMianyangSichuan Province621000China School of Chemistry and Chemical engineering Jishou UniversityJishou 416000China School of Physics and Optoelectronic engineering Yangtze UniversityJingzhouHubei 434023China School of Microelectronics and Control engineering Changzhou UniversityChangzhou 213164China School of Physics and electronic Information engineering Hubei Engineering UniversityXiaogan 432000China Institute of Physics Bahauddin Zakariya UniversityMultan 66000Pakistan

The field of terahertz devices is important in terahertz ***,most of the current devices have limited functionality and poor *** improve device performance and achieve multifunctionality,we designed a terahertz device based on a combination of VO_(2)and *** device can be tuned using the phase-transition characteristics of VO_(2),which is included in the triple-layer structure of the device,along with SiO_(2)and *** terahertz device exhibits various advantageous features,including broadband coverage,high absorption capability,dynamic tunability,simple structural design,polarization insensitivity,and incidentangle *** simulation results showed that by controlling the temperature,the terahertz device achieved a thermal modulation range of spectral absorption from 0 to *** 313 K,the device exhibited complete reflection of terahertz *** the temperature increased,the absorption rate also *** the temperature reached 353 K,the device absorption rate exceeded 97.7%in the range of 5-8.55 *** study used the effective medium theory to elucidate the correlation between conductivity and temperature during the phase transition of VO_(2).Simultaneously,the variation in device performance was further elucidated by analyzing and depicting the intensity distribution of the electric field on the device surface at different ***,the impact of various structural parameters on device performance was examined,offering valuable insights and suggestions for selecting suitable parameter values in real-world *** characteristics render the device highly promising for applications in stealth technology,energy harvesting,modulation,and other related fields,thus showcasing its significant potential.

关键词： terahertz perfect absorption complete reflection temperature regulation ultrawideband smart device

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-functional metasurface:ultra-wideband/multi-band absorption switching by adjusting guided-mode resonance and local surface plasmon resonance effects

引用

Communications in Theoretical Physics 2024年第6期76卷 174-184页

作者： Wenxin Li Shubo Cheng Huafeng Zhang Zao Yi Bin tang can Ma Pinghui Wu Qingdong Zeng Rizwan Raza School of Physics and Optoelectronic engineering Yangtze UniversityJingzhouHubei 434023China Joint Laboratory for extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010China School of Chemistry and Chemical engineering Jishou UniversityJishou 416000China School of Microelectronics and Control engineering Changzhou UniversityChangzhou 213164China Department of Oncology Sichuan Science City HospitalMianyangSichuan Province 621000China Office of Science and Technology Quanzhou Normal UniversityQuanzhou 362000China School of Physics and electronic-information engineering Hubei Engineering UniversityXiaogan 432000China Department of Physics COMSATS Institute of Information Technology 54000 LahorePakistan

This study introduces an innovative dual-tunable absorption film with the capability to switch between ultra-wideband and narrowband *** manipulating the temperature,the film can achieve multi-band absorption within the 30-45 THz range or ultra-wideband absorption spanning 30-130 THz,with an absorption rate exceeding ***,the structural parameters of the absorption film are optimized using the particle swarm optimization(PSO)algorithm to ensure the optimal absorption *** absorption response of the film is primarily attributed to the coupling of guided-mode resonance and local surface plasmon resonance *** film's symmetric structure enables polarization incoherence and allows for tuning through various means such as doping/voltage,temperature and structural *** the case of a multi-band absorption response,the film exhibits good sensitivity to refractive index changes in multiple absorption ***,the absorption spectrum of the film remains effective even at large incidence angles,making it highly promising for applications in fields such as biosensing and infrared stealth.

关键词： PSO optimization ultra-wideband/narrowband absorption switching intelligent absorption film vanadium dioxide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gas sensor array based on carbon-based thin-film transistor for selective detection of indoor harmful gases

引用

Rare Metals 2024年第9期43卷 4401-4411页

作者： can Liu Yu Sun Jia-Yi Guo Xiu-Lei Li Lu Tao Jin-Yong Hu Jue-Xian Cao Ping-Hua tang Yong Zhang School of electrical and Information engineering Hunan Institute of EngineeringXiangtan 411104China Physics and Optoelectronics&Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

The identification of indoor harmful gases is imperative due to their significant threats to human health and *** achieve accurate identification,an effective strategy of constructing a sensor array combined with the pattern recognition algorithm is ***-based thin-film transistors are selected as the sensor array unit,with semiconductor carbon nanotubes(CNTs)within the TFT channels modified with different metals(Au,Cu and Ti)for selective responses to NH_(3),H_(2)S and HCHO,*** accurate gas species identification,an identification mode that combines linear discriminant analysis algorithms and logistic regression classifier is *** test results demonstrate that by preprocessing the sensor array’s sensing data with the LDA algorithm and subsequently employing the LR classifier for identification,a 100%recognition rate can be achieved for three target gases(NH3,H2S and HCHO).This work provides significant guidance for future applications of chip-level gas sensors in the realms of the Internet of Things and Artificial Intelligence.

关键词： Carbon-based thin-film transistors Gas sensor arrays Semiconductor carbon nanotubes Multi-gas detection Linear discriminant analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deformations at earth’s dayside magnetopause during quasi-radial IMF conditions:Global kinetic simulations and Soft X-ray Imaging

引用

earth and Planetary Physics 2024年第1期8卷 59-69页

作者： ZhongWei Yang RiKu Jarvinen XiaoCheng Guo TianRan Sun Dimitra Koutroumpa George K.Parks can Huang BinBin tang QuanMing Lu Chi Wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Finnish Meteorological Institute FI-00101 HelsinkiFinland LATMOS/IPSL CNRSUVSQ UniversitéParis-SaclaySorbonne UniversitéGuyancourt78280France Space Sciences Laboratory University of CaliforniaBerkeleyCalifornia 94720USA CAS engineering Laboratory for Deep Resources equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029 China Deep Space exploration Laboratory/School of earth and Space Sciences University of Science and Technology of ChinaHefei 230026China

The Solar wind Magnetosphere Ionosphere Link explorer(SMILe)is a joint mission of the european Space Agency(eSA)and the Chinese Academy of Sciences(CAS).Primary goals are investigating the dynamic response of the earth's magnetosphere to the solar wind(SW)impact via simultaneous in situ magnetosheath plasma and magnetic field measurements,X-Ray images of the magnetosheath and magnetic cusps,and UV images of global auroral *** deformations associated with magnetosheath high speed jets(HSJs)under a quasi-parallel interplanetary magnetic field condition are studied using a threedimensional(3-D)global hybrid *** X-ray intensity calculated based on both physical quantities of solar wind proton and oxygen ions is *** obtain key findings concerning deformations at the magnetopause:(1)Magnetopause deformations are highly coherent with the magnetosheath HSJs generated at the quasi-parallel region of the bow shock,(2)X-ray intensities estimated using solar wind h+and self-consistentO7+ions are consistent with each other,(3)Visual spacecraft are employed to check the discrimination ability for capturing magnetopause deformations on Lunar and polar orbits,*** SMILe spacecraft on the polar orbit could be expected to provide opportunities for capturing the global geometry of the magnetopause in the equatorial plane.A striking point is that SMILe has the potential to capture small-scale magnetopause deformations and magnetosheath transients,such as HSJs,at medium altitudes on its *** results also demonstrate that a lunar based imager(e.g.,Lunar environment heliospheric X-ray Imager,LeXI)is expected to observe a localized brightening of the magnetosheath during HSJ events in the meridian *** preliminary results might contribute to the pre-studies for the SMILe and LeXI missions by providing qualitative and quantitative soft X-ray estimates of dayside kinetic processes.

关键词： collisionless shock SMILe mission foreshock

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly Hydrolysis-Resistant Polyimide Fibers Prepared by Thermal Crosslinking with Inherent Carboxyl Groups

引用

Chinese Journal of Polymer Science 2024年第2期42卷 247-255,I0010页

作者： can-can Zhang Jun-Long Yang Ya-Jiang Huang Guang-Xian Li College of Polymer Science and engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

easy hydrolysis in alkaline environments limits the use of polyimide fibers in environmental protection. The hydrolysis resistance levels of polyimide fibers can be improved by crosslinking of the macromolecular chains. In this work, crosslinked polyimide fibers(CPI fibers) were produced by intrinsic carboxyl decarboxylation for the first time. The thermal stability of the polyimide fibers containing the intrinsic carboxyl groups(PIC fibers) was studied, and the temperature of the decarboxylation-crosslinking reaction was determined to be 450 ℃. The PIC fibers were hotdrawn to initiate thermal crosslinking of the carboxyl groups and molecular chain orientation at high temperature. The CPI fibers had high tensile strengths(0.72-1.46 GPa) and compressive strengths(401-604 MPa). The oriented macromolecules and chemically crosslinked structure improved the tightness of the molecular chains and endowed the CPI fibers with excellent hydrolytic resistance. The CPI-50 fiber did not dissolve in a 0.5 wt% NaOH solution during heating at 90 ℃ for 10 h, and the tensile strength retention reached 87% when treated in 0.5 wt% NaOH solutions at 90 ℃ for 1 h, providing a guarantee for its application in alkaline corrosive environments.

关键词： Polyimide Carboxyl group Crosslinking Hydrolysis-resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice

引用

Animal Models and experimental Medicine 2024年第5期 696-706页

作者： Xingxian Guo Jiangxia Pu Ziqi tang can Jia Fan Yang Tianyi Liu Yinyuan Ding Centre for Lipid Research & Chongqing Key Laboratory of Metabolism on Lipid and Glucose Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Department of Infectious Diseases Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University

Background: LDL receptor-related protein-1(LRP1) is a cell-surface receptor that functions in diverse physiological pathways. We previously demonstrated that hepatocyte-specific LRP1 deficiency(hLRP1KO) promotes diet-induced insulin resistance and increases hepatic gluconeogenesis in mice. However, it remains unclear whether LRP1 regulates hepatic ***: Insulin signaling, glycogenic gene expression, and glycogen content were assessed in mice and HepG2 cells. The pcDNA 3.1 plasmid and adeno-associated virus serotype 8 vector(AAV8) were used to overexpress the truncated β-chain(βΔ) of LRP1 both in vitro and in ***: On a normal chow diet, hLRP1KO mice exhibited impaired insulin signaling and decreased glycogen content. Moreover, LRP1 expression in HepG2 cells was significantly repressed by palmitate in a dose-and time-dependent manner. Both LRP1 knockdown and palmitate treatment led to reduced phosphorylation of Akt and GSK3β, increased levels of phosphorylated glycogen synthase(GYS), and diminished glycogen synthesis in insulin-stimulated HepG2 cells, which was restored by exogenous expression of the βΔ-chain. By contrast, AAV8-mediated hepatic βΔ-chain overexpression significantly improved the insulin signaling pathway, thus activating glycogenesis and enhancing glycogen storage in the livers of high-fat diet(HFD)-fed ***: Our data revealed that LRP1, especially its β-chain, facilitates hepatic glycogenesis by improving the insulin signaling pathway, suggesting a new therapeutic strategy for hepatic insulin resistance-related diseases.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：