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A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan Zhang jia-Jie Zhu Zong-Ming Liu Yu-Xuan Zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:Hepatocellular carcinoma(HCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC ***-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The cancer Genome Atlas(TCGA)cohort and International cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： Hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

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New method for multibody dynamics based on unknown constraint force

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Science China(Technological Sciences) 2024年第3期67卷 791-808页

作者： TIAN Ying jia YingHong ZHANG Jun School of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of Space Intelligent Control Beijing 100190China

This paper presents a new method for the dynamics of multibody systems based on unknown constraint force. The method can uniformly solve multibody systems with typical configurations, including the system with rigid-flexible coupling, the system in tree topology, and the system with loop constraints. Unlike common methods, the proposed method can model the loop system without “cutting off” loop constraints, leading to the exact same modelling process as the tree-like system performs. Based on graph theory, a topological record matrix M_(rec) is proposed to capture the arbitrary system configuration. Moreover, constraint forces are selected as the key variables in semi-recursive framework. With the recursive kinematics relationship between adjacent bodies, the constraint force equation is further assembled to achieve the full-state system solution. The numerical simulations demonstrate the accuracy of the proposed method.

关键词： multibody system dynamic modelling rigid-flexible coupling unknown constraint force graph theory semi-recursive algorithm

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Large isolated fibrous tumors in the upper esophagus: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 543-549页

作者： jia-jia Yu Huan-Shuang Pei Yu Meng Department of Anesthesiology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Solitary fibrous tumors(SFT)are rare spindle cell tumors that are usually benign.A total of 10 cases of SFTs in the upper esophagus have ever been ***,we report the anesthetic management of a patient with a large isolated fibrous tumor of the upper esophagus compressing the tracheal *** also provide a literature review of the current *** SUMMARY We report the case of a 49 year old male with“cough aggravation and wheezing after exercise”,who underwent esophagectomy for a large isolated fibrous tumor compressing the tracheal membrane in the upper *** advise the use of a single-lumen tube with a blocker in patients with difficult airways to reduce the incidence of airway injury and fibrinoscopy at all stages of the perioperative period to guide airway *** case study is the first report of the anesthetic management of a large,isolated fibrous tumor compressing the tracheal membrane in the upper *** This rare case emphasizes the importance of perioperative management of anesthesia in patients with large isolated fibrous tumors of the upper esophagus that compress the tracheal *** use of blocker reduce the incidence of airway injury and fibrinoscopy at the perioperative period to guide airway mana-gement.

关键词： Upper esophagus Isolated fibrous tumor Tracheal membrane Peak airway pressure Case report

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膝关节功能评分:现状与展望

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中国组织工程研究与临床康复 2010年第39期14卷 7367-7370页

作者：辛雷苏佳灿解放军第二军医大学长海医院骨科上海市200433

背景:膝关节功能障碍严重影响人们的生活质量,损伤关节治疗修复后,科学、合理、准确的膝关节功能评估方法一直是关节外科研究的热点。尽管现在国际上各种评分系统纷繁复杂,但是迄今没有一个能在国际上被广泛接受的金标准。目的:分析膝... 详细信息

背景:膝关节功能障碍严重影响人们的生活质量,损伤关节治疗修复后,科学、合理、准确的膝关节功能评估方法一直是关节外科研究的热点。尽管现在国际上各种评分系统纷繁复杂,但是迄今没有一个能在国际上被广泛接受的金标准。目的:分析膝关节功能评分的现状,综合应用,取长补短,以期对现有评分系统进行改进与升级。方法:由第一作者检索1990/2008PubMed数据库、万方数据库、清华同方数据库、重庆维普数据库、elsevier数据库及JBJS。英文检索词为"kneescore,function score,score status",中文检索词为"膝关节评分,功能评分,评分现状"。主要纳入近5年来的最新论文研究进展,比较不同评分系统的应用领域与优劣,并通过追查所用文献的引用文献材料,了解评分的基本信息和概况。结果与结论:通过对58篇文献的筛检,整理出31篇文献支持该综述的完成。总结归纳获悉,虽然不同评分系统都能对膝关节功能状况进行一定的评价,但其各有侧重,Lysholm膝关节评分适用于评价膝关节韧带损伤和软骨损伤,牛津膝关节评分、美国膝关节协会评分、高活性关节成形术评分适用于于全膝关节置换和全膝关节成形术,膝关节损伤和骨关节炎结果评分、膝骨关节炎突发评分在评价膝骨关节炎方面更显优势。

关键词：膝关节关节功能评分现况展望

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Even-odd layer-dependent multiferroic in freestanding rare-earth orthorhombic perovskite

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 151-157页

作者： Shaowen Xu Fanhao jia Ning Dai School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Physics College of ScienceHangzhou Dianzi UniversityHangzhou 310018China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

Freestanding oxide perovskites possess strong interlayer coupling between adjacent atomic layers,thus exerting a determinative effect on the magnetism and ferroelectricity of these atomic-scale ***,we propose an effective strategy to manipulate magnetism and ferroelectricity in freestanding rare-earth orthorhombic perovskite via modulation of layer *** performing first-principles calculations,an even-odd oscillation is demonstrated in few-layer GdAlO_(3)perovskite(GAP).Specifically,odd-layer systems with charged atomic layers are ferromagnetic polar metals,while even-layer systems are antiferromagnetic ferroelectric *** thickness-dependent magnetic phase transition originates from carrier doping,as rationalized by the Stoner ***,we demonstrate the promotion of in-plane ferroelectricity via the concurrent application of two distinct antiferrodistortive displacements,each driven by formation and breaking of *** multiferroic phases may emerge in other transition metal oxide perovskites supporting multiple valence states,e.g.,few-layer Gd MO_(3)(M=V,Cr,Mn,and Ni).This work puts forward a strategy for layer thickness engineering of magnetism and ferroelectricity in 2D oxide perovskite multiferroic materials.

关键词： few-layer rare-earth perovskite multiferroicity size effect first principles calculations

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Contribution of high-latitude permafrost regions in the Northern Hemisphere to global wildfire carbon emissions

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Science China Earth Sciences 2024年第10期67卷 3239-3251页

作者： Xingru ZHU Xiyan XU Gensuo jia Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Wildfires are major disturbances in permafrost ecosystems, with increasing frequency and intensity in recent years. In permafrost regions, wildfires not only burn surface and subsurface organic matter but also accelerate permafrost thawing,releasing significant amounts of greenhouse gases such as carbon dioxide and methane into the atmosphere. However, the contribution of high-latitude permafrost regions in the Northern Hemisphere to global wildfire carbon emissions remains poorly understood. This study integrates remote sensing data and ground observations to analyze the contributions of aboveground and belowground fuel combustion in high-latitude permafrost regions to global wildfire carbon emissions from 2002 to 2020, as well as the spatiotemporal variations in these contributions. Our findings indicate that permafrost regions contribute approximately11.96% of global wildfire carbon emissions, with aboveground emissions accounting for approximately 3.94% of global aboveground emissions and belowground emissions contributing approximately 63.57% of global belowground emissions. The contribution of high-latitude permafrost regions to global emissions peaked in July and August, whereas the continuous permafrost zones(areas with more than 90% permafrost coverage) showed the most significant increase in June and July. The contributions of both aboveground and belowground emissions from high-latitude permafrost regions to global wildfire emissions have been increasing, primarily due to the reduction in global wildfire emissions, in contrast with the rising emissions from wildfires in high-latitude permafrost regions. This study highlights the significant role of wildfires, particularly the combustion of belowground biomass in high-latitude permafrost regions, in global carbon emissions. The decomposition and combustion of organic carbon in permafrost regions due to wildfires release more greenhouse gases into the atmosphere, potentially amplifying the positive feedback

关键词： Wildfire Permafrost Carbon emissions Climate change Belowground fuel consumption

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Stacking MoS_(2) flower-like microspheres on pomelo peels-derived porous carbon nanosheets for high-efficient X-band electromagnetic wave absorption

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Nano Research 2024年第3期17卷 1607-1615页

作者： jia Zhao Zhe Gu Qingguo Zhang College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China

The key to solve increasingly severe electromagnetic(EM)pollution is to explore sustainable,easily prepared,and cost-effective EM wave absorption materials with exceptional absorption ***,instead of anchoring on carbon materials in single layer,MoS_(2) flower-like microspheres were stacked on the surface of pomelo peels-derived porous carbon nanosheets(C)to fabricate MoS_(2)@C nanocomposites by a facile solvothermal *** wave absorption performances of MoS_(2)@C nanocomposites in X-band were systematically investigated,indicating the minimum reflection loss(RLmin)of-62.3 dB(thickness of 2.88 mm)and effective absorption bandwidth(EAB)almost covering the whole X-band(thickness of 2.63 mm)with the filler loading of only 20 wt.%.Superior EM wave absorption performances of MoS_(2)@C nanocomposites could be attributed to the excellent impedance matching characteristic and dielectric loss capacity(conduction loss and polarization loss).This study revealed that the as-prepared MoS_(2)@C nanocomposites would be a novel prospective candidate for the sustainable EM absorbents with superior EM wave absorption performances.

关键词： pomelo peels-derived porous carbon nanosheets(C) MoS_(2)@C nanocomposites stacked structure electromagnetic(EM)wave absorption

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Chemoselective epoxidation of electron-deficient olefins with molecular oxygen via conjugated olefins epoxidation and BHT hydroxylation

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Science China Chemistry 2024年第9期67卷 3012-3018页

作者： jia Nie Huanfeng jiang Chuanle Zhu School of Chemistry and Chemical Engineering Key Lab of Functional Molecular Engineering of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510640China

The chemoselective epoxidation of electron-deficient olefins in the presence of electron-rich alkene moieties is *** chemoselective epoxidation strategy undergoes a conjugated olefin epoxidation and BHT hydroxylation process to give various useful oxiranes in high yields,especially for the 2-substituted ***,this protocol features mild conditions,is transition-metal free,operationally simple,and gram-scalable,and tolerates diverse functional *** candidate HSD-16 is synthesized smoothly by this *** studies indicate molecular oxygen is the terminal oxidant and the O-source of the oxiranes.

关键词： chemoselective epoxidation alkene fluorine molecular oxygen

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Embracing connected intelligence with the YuanOS architecture:one OS kit for all

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Frontiers of Computer Science 2024年第1期18卷 1-3页

作者： Haibo CHEN Ning jia Jie YIN Institute of Parallel and Distributed Systems School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China OS Kernel Lab Huawei Technologies Co.Ltd.Beijing 100085China

Operating system abstracts hardware and creates application execution environment,and thus is the key pillar for IT *** its first invention in 1956,operating system has been evolved over three main stages:Mainframe,PC&Internet,Mobile Internet[1].Now,the entire society is firmly stepping towards the connected intelligence era[2],how should operating system be evolved to embrace this new era?

关键词： hardware execution connected

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我国青少年健康幸福感促进政策研究

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中国青年政治学院学报 2011年第3期30卷 20-23页

作者：张树辉李家灿中国青年政治学院院长办公室北京100089 中国政法大学政治与公共管理学院北京100080

为提高青少年健康幸福感水平,各国政府、教育、科技、卫生、社会福利部门以及地方儿童服务部门联合起来制定促进青少年健康发展的规划和政策,建立国家青少年健康管理组织机构,设立青少年健康研究和干预项目;设置青少年健康教育核心课程... 详细信息

为提高青少年健康幸福感水平,各国政府、教育、科技、卫生、社会福利部门以及地方儿童服务部门联合起来制定促进青少年健康发展的规划和政策,建立国家青少年健康管理组织机构,设立青少年健康研究和干预项目;设置青少年健康教育核心课程,培训教育管理者、教师、家长,培养学生交往能力和生存技能等。学习和借鉴这些措施对促进我国青少年幸福感具有重要的理论价值和现实意义。

关键词：青少年健康幸福感促进

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