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LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice

Animal Models and Experimental Medicine 2024年第5期 696-706页

作者： Xingxian Guo jiangxia Pu Ziqi Tang can jia Fan Yang Tianyi Liu Yinyuan Ding Centre for Lipid Research & Chongqing Key Laboratory of Metabolism on Lipid and Glucose Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Department of Infectious Diseases Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University

Background: LDL receptor-related protein-1(LRP1) is a cell-surface receptor that functions in diverse physiological pathways. We previously demonstrated that hepatocyte-specific LRP1 deficiency(hLRP1KO) promotes diet-induced insulin resistance and increases hepatic gluconeogenesis in mice. However, it remains unclear whether LRP1 regulates hepatic ***: Insulin signaling, glycogenic gene expression, and glycogen content were assessed in mice and HepG2 cells. The pcDNA 3.1 plasmid and adeno-associated virus serotype 8 vector(AAV8) were used to overexpress the truncated β-chain(βΔ) of LRP1 both in vitro and in ***: On a normal chow diet, hLRP1KO mice exhibited impaired insulin signaling and decreased glycogen content. Moreover, LRP1 expression in HepG2 cells was significantly repressed by palmitate in a dose-and time-dependent manner. Both LRP1 knockdown and palmitate treatment led to reduced phosphorylation of Akt and GSK3β, increased levels of phosphorylated glycogen synthase(GYS), and diminished glycogen synthesis in insulin-stimulated HepG2 cells, which was restored by exogenous expression of the βΔ-chain. By contrast, AAV8-mediated hepatic βΔ-chain overexpression significantly improved the insulin signaling pathway, thus activating glycogenesis and enhancing glycogen storage in the livers of high-fat diet(HFD)-fed ***: Our data revealed that LRP1, especially its β-chain, facilitates hepatic glycogenesis by improving the insulin signaling pathway, suggesting a new therapeutic strategy for hepatic insulin resistance-related diseases.

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骨质疏松性椎体压缩骨折诊疗难点及思考

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中国骨伤 2024年第6期37卷 535-537页

作者：王光超苏佳灿上海交通大学医学院附属新华医院骨科上海200092

骨质疏松性椎体压折缩骨(osteoporotic vertebral compression fractures,OVCFs)是骨质疏松的严重并发症之一,也是最常见的脆性骨折,多发生于胸腰椎椎体,严重者表现为剧烈腰背痛、脊柱后凸畸形以及神经功能损害等[1]。流行病学调查显示,... 详细信息

骨质疏松性椎体压折缩骨(osteoporotic vertebral compression fractures,OVCFs)是骨质疏松的严重并发症之一,也是最常见的脆性骨折,多发生于胸腰椎椎体,严重者表现为剧烈腰背痛、脊柱后凸畸形以及神经功能损害等[1]。流行病学调查显示,OVCFs发生率随着年龄的增长而升高,50岁以上女性OVCFs患病率为15%,是严重影响中老年人群生活质量的疾病[2]。

关键词：骨质疏松性椎体压缩骨折疼痛手术治疗

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泛娱乐主义思潮下青年价值观培育的理性审思

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山西大同大学学报（社会科学版） 2024年第1期38卷 46-50页

作者：贾璨璨常开霞中北大学马克思主义学院山西太原030051

资本逻辑推动与新媒体技术发展的内在耦合使泛娱乐化现象逐渐演变为一种社会思潮,并逾越其边界延伸到社会各领域。泛娱乐主义思潮以消费主义为价值内核,受西方多重资本主义价值观念影响,隐含着对当代青年价值观的消极改变,导致一些青年... 详细信息

资本逻辑推动与新媒体技术发展的内在耦合使泛娱乐化现象逐渐演变为一种社会思潮,并逾越其边界延伸到社会各领域。泛娱乐主义思潮以消费主义为价值内核,受西方多重资本主义价值观念影响,隐含着对当代青年价值观的消极改变,导致一些青年人呈现理想信念淡漠化、文化审美庸俗化、价值追求功利化等问题。因此,理性审思泛娱乐思潮下青年价值观培育问题,着重从国家、媒体、青年自身层面寻找有效应对泛娱乐主义思潮侵袭的突围之策,对引导青年树立正确的价值观具有重要意义。

关键词：泛娱乐青年价值观培育

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Optimal Liquidation Strategy of Multi-assets Based on Minimum Loss Probability

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Journal of Systems Science and Systems Engineering 2020年第5期29卷 555-571页

作者： Qixuan Luo can jia Shaobo Zhao Handong Li School of Systems Science Beijing Normal UniversityBeijing 100875China School of Government Beijing Normal UniversityBeijing 100875China

Based on the minimum loss probability criterion,this paper discusses the optimal strategy in multi-asset ***,we give the framework of the multi-asset liquidation problem and obtain the boundary conditions of the optimal liquidation strategy under the assumption of linear price impact functions and transform the multi-asset liquidation problem into the portfolio liquidation *** this basis,the asymptotic solution and numerical solution of the optimal liquidation strategy are ***,we simulate the trajectories of the optimal liquidation strategy and analyze the effects of parameters changes.

关键词： Minimum loss probability multi-asset liquidation permanent impact temporary impact optimal liquidation strategy

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Scatter Search Based Particle Swarm Optimization Algorithm for Earliness/Tardiness Flowshop Scheduling with Uncertainty

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International Journal of Automation and computing 2016年第3期13卷 285-295页

作者： jia-can Geng Zhe Cui Xing-Sheng Gu Key Laboratory of Advanced Control and Optimization for Chemical Process Ministry of EducationEast China University of Science and Technology

Considering the imprecise nature of the data in real-world problems, the earliness/tardiness （E/T） fiowshop scheduling problem with uncertain processing time and distinct due windows is concerned in this paper. A fuzzy scheduling model is established and then transformed into a deterministic one by employing the method of maximizing the membership function of middle value. Moreover, an effective scatter search based particle swarm optimization （SSPSO） algorithm is proposed to minimize the sum of total earliness and tardiness penalties. The proposed SSPSO algorithm incorporates the scatter search （SS） algorithm into the frame of particle swarm optimization （PSO） algorithm and gives full play to their characteristics of fast convergence and high diversity. Besides, a differential evolution （DE） scheme is used to generate solutions in the SS. In addition, the dynamic update strategy and critical conditions are adopted to improve the performance of SSPSO. The simulation results indicate the superiority of SSPSO in terms of effectiveness and efficiency.

关键词： Earliness/tardiness (E/T) scheduling fuzzy modeling scatter search (SS) particle swarm optimization (PSO).

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新医科背景下“基础化学”实验翻转教学模式初探

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教育教学论坛 2024年第15期 137-140页

作者：魏钰卜姚家灿喻芳昆明医科大学药学院暨天然药物药理重点实验室云南昆明650502

为适应新医科建设下培养具有较高综合素质的新型复合型医学人才的教育教学目标,改变传统“基础化学”实验课学生有效参与程度低,成绩评定单一、主观的困境,将翻转课堂应用于“基础化学”实验课教学,先后摸索建立了“部分翻转实验教学模... 详细信息

为适应新医科建设下培养具有较高综合素质的新型复合型医学人才的教育教学目标,改变传统“基础化学”实验课学生有效参与程度低,成绩评定单一、主观的困境,将翻转课堂应用于“基础化学”实验课教学,先后摸索建立了“部分翻转实验教学模式”“全翻转实验教学模式”。翻转课堂教学模式实现了教学主体的切换,激发了学生的学习积极性及课程参与度,学生的综合能力得到了切实的锻炼,为医学生后续医学实践能力的培养奠定了坚实的基础。同时,翻转教学模式的实施也提高了教学质量,优化完善了课程评价体系,成绩评定更加客观、真实,更具有区分度。

关键词：基础化学实验翻转教学模式新医科探索与实践

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超高效液相色谱-四极杆-飞行时间质谱分析匙羹藤化学成分

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中国新药杂志 2024年第15期33卷 1595-1607页

作者：曾志浩肖观林贾灿潮江洁怡汤瑞茵贾德政李养学李绍林毕晓黎广州中医药大学第五临床医学院广州510405 广东省中医药工程技术研究院广州510095 广东省中医药研究开发重点实验室广州510095 广东食品药品职业学院广州510520

目的:基于超高效液相色谱-四极杆-飞行时间质谱(ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry,UPLC-Q-TOF-MS/MS)技术分析匙羹藤的化学成分。方法:采用Waters CORTECS UPLC T_(3)色谱柱(150 mm×2.1 mm,1.6μm)以0.1%甲酸-乙腈的流动相梯度洗脱,电喷雾负离子模式下对色谱流出物进行检测,检测范围m/z 50~2000。结果:通过高分辨质谱数据(一级质谱及二级质谱碎片)分析,结合数据库、文献以及对照品比对,共鉴别出101种成分,包括53种三萜类、37种黄酮类、5种有机酸类、3种单萜类、1种二萜类、1种菲类、1种甾体类化合物。结论:本研究通过UPLC-Q-TOF-MS/MS技术快速鉴别了匙羹藤的化学成分,该方法快速、准确、简便,能够用于匙羹藤化学成分的定性鉴定,为该草药的质量标准以及物质基础研究奠定基础。

关键词：匙羹藤超高效液相色谱-四极杆-飞行时间质谱化学成分三萜类化合物黄酮类化合物

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Recent activity of Chihe segment of Tanlu fault zone

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Acta Seismologica Sinica(English Edition) 2004年第6期17卷 678-685页

作者： YAO Da-quan(姚大全) LIU jia-can(刘加灿) Earthquake Administration of Anhui Province Hefei 230031 China Earthquake Administration of Anhui Province Hefei 230031 China

By means of differentiation of remote sensing image, field seismo-geological survey, analysis on drilling explora- tion materials, sampling and dating of rock samples, combined with seismicity and microscopic tectonic analysis, this paper studies the recent activity of Chihe segment of the Tanlu fault zone. The result indicates that the Chihe fault segment undergoes the deformation alternately in the mode of stick slip and creep during Late Quaternary, and its recent activity is mainly creep.

关键词： Tanlu fault zone Chihe segment structure resolution recent activity

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Online detection of bursty events and their evolution in news streams

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 340-355页

作者： Wei CHEN Chun CHEN Li-jun ZHANC can WANG jia-jun BU Zhejiang Laboratory of Service Robot Zhejiang Universit) Hangzhou 310027 China

Online monitoring of temporally-sequenced news streams for interesting patterns and trends has gained popularity in the last *** this paper,we study a particular news stream monitoring task:timely detection of bursty events which have happened recently and discovery of their evolutionary patterns along the ***,a news stream is represented as feature streams of tens of thousands of features(i.e.,*** news story consists of a set of keywords.).A bursty event therefore is composed of a group of bursty features,which show bursty rises in frequency as the related event *** this paper,we give a formal definition to the above problem and present a solution with the following steps:(1) applying an online multi-resolution burst detection method to identify bursty features with different bursty durations within a recent time period;(2) clustering bursty features to form bursty events and associating each event with a power value which reflects its bursty level;(3) applying an information retrieval method based on cosine similarity to discover the event's evolution(i.e.,highly related bursty events in history) along the *** extensively evaluate the proposed methods on the Reuters Corpus Volume *** results show that our methods can detect bursty events in a timely way and effectively discover their *** power values used in our model not only measure event's bursty level or relative importance well at a certain time point but also show relative strengths of events along the same evolution.

关键词： Online event detection Event’s evolution News stream Affinity propagation

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A facile synthesis of the oxazolidinone antibacterial agent linezolid

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Chinese Chemical Letters 2013年第3期24卷 230-232页

作者： Yan-Wu Li Yan Liu Yun-can jia jian-Yong Yuan Institute of Life Science & Pharmacy College Chongqing Medical University

A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coup... 详细信息

关键词： LinezolidSynthesisGoldberg coupling reaction

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