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Nonopioid perioperative analgesia in head and neck cancer surgery:A systematic review

World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 107-117页

作者： Beatrice C.go cammille C.go Kevin Chorath Alvaro Moreira Karthik Rajasekaran Department of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics Division of NeonatologyUniversity of Texas Health-San AntonioSan AntonioTexasUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Management of postoperative pain after head and neck cancer surgery is a complex issue,requiring a careful balance of analgesic properties and side *** objective of this review is to discuss the efficacy and safety of multimodal analgesia(MMA)for these ***:Pubmed,Cochrane,Embase,Scopus,and *** were systematically searched for all comparative studies of patients receiving MMA(nonsteroidal anti-inflammatory drugs(NSAIDs),acetaminophen,anticonvulsants,local anesthetics,and corticosteroids)for head and neck cancer *** primary outcome was additional postoperative opioid usage,and secondary outcomes included subjective pain scores,complications,adverse effects,and 30-day ***:A total of five studies representing 592 patients(MMA,n=275;non-MMA,n=317)met inclusion *** most commonly used agents were gabapentin,NSAIDs,and acetaminophen(n=221),NSAIDs(n=221),followed by corticosteroids(n=35),dextromethorphan(n=40),and local nerve block(n=19).Four studies described a significant decrease in overall postoperative narcotic usage with two studies reporting a significant decrease in hospital *** pain scores widely varied with two studies reporting reduced pain at postoperative day *** were no differences in surgical outcomes,medical complications,adverse effects,or 30-day mortality and readmission ***:MMA is an increasingly popular strategy that may reduce dependence on opioids for the treatment of postoperative pain.A variety of regimens and protocols are available for providers to utilize in the appropriate head and neck cancer patient.

关键词： analgesia head and neck neoplasm NSAID opioids pain management

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Gender analysis of the top classic papers in otolaryngology head and neck surgery

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 160-167页

作者： Beatrice go Neeraj Suresh cammille go Kevin Chorath Natasha Mirza Erica Thaler Alvaro Moreira Karthik Rajasekaran Department of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics Division of NeonatologyThe University of Texas Health Science Center at San AntonioSan AntonioTexasUSA

Objective:The aim of this study was to identify and analyze the gender breakdown of first authorship contributing to the most-cited papers in the field of otolaryngology,with a goal of identifying trends in gender representation in ***:The top 150 most-cited papers were identified using the Science Citation Index of the Institute for Scientific *** the first authors,gender,h-index,percentage of first,last,and corresponding authorship positions,total publications,and citations were ***:The majority of papers were in the English language,from the United States,of clinical nature,and on otologic ***-one percent of papers(n=122)had men who were first authors,although there was no difference inh-index score,authorship position,number of publications,citations,and average citations/year between men and women first *** subgroup analysis by decade(1950s-2010s),there was no difference in the number of articles by women first authors(P=0.11);however,there was a statistically significant increase in the percentage of women authors(P=0.001)in papers published later compared to those published ***:While a promising number of women otolaryngologists are publishing high-powered articles,future initiatives to promote academic inclusivity of women should be considered.

关键词： authorship bibliometrics citations gender otolaryngology publications

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Opposite latitudinal gradients for species richness and phylogenetic diversity of endemic snakes in the Atlantic Forest

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Current Zoology 2024年第4期70卷 522-530页

作者： JoséThales da Motta Portillo JosuéAnderson Rēgo Azevedo Fausto Erritto Barbo Ricardo J.Sawaya Programa de Pos-Graduacao em Biologia Animal Instituto de BiocienciasLetras e Ciencias ExatasUniversidade Estadual Paulista"Julio de Mesquita Filho"Rua Cristovao Colombo2265Sao Josédo Rio PretoSao Paulo 15054-000Brazil Programa de Colecoes Cientificas Biologicas Coordenagao de BiodiversidadeInstituto Nacional de Pesquisas da AmazoniaAvenida AndréAraujo2936ManausAmazonas 69067-375Brazil gothenburg Global Biodiversity Centre University of GothenburgBox 461GothenburgVastra Gotaland SE-40530Sweden Instituto Federal de Educacao Ciencia e Tecnologia de Minas GeraisRodovia Machado-Paraguacukm 3MachadoMinas Gerais 37750-000Rraizil Centro de Ciencias Naturais e Humanas UniversidadeFederaldo ABCRua Arcturus03Sao Bernardo do CampoSao Paulo09606-070Brazil

The decrease in species richness toward higher latitudes is an expected biogeographical *** pattern could be related to particular envi-ronmental constraints and the evolutionary history of ***,species richness does not fully represent the evolutionary history of the clades behind their *** diversity better clarifies the role of historical factors in biogeographical *** analyzed envi-ronmental and historical drivers related to latitudinal variation in species richness and phylogenetic diversity of Atlantic Forest endemic *** implemented species distribution models,from voucherbased locality points,to map the snake ranges and *** used generalized additive mixed models to evaluate the relationships among the diversity metrics and area,topographical roughness,and past climate change velocity since the Last Maximum Glacial in the Atlantic Forest latitudinal *** to the expected general pattern,species richness was higher toward higher latitudes,being positively related to past climatic *** richness also increased with total area and higher topographical *** diversity,on the other hand,showed opposite relationships related to the same *** diversity increased with lower climatic stability in lower ***,dimensions of diversity were affected in different ways by historical and environmental constraints in this unique and threatened biodiversity hotspot.

关键词： biodiversity latitudinal gradient neotropical region phylogenetic diversity serpents species richness.

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Pulmonary artery diameter ratio as a prognostic indicator of congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第1期7卷 20-25页

作者： Yuichiro Miyake Hiroyuki Koga Shuko Nojiri Shunsuke Yamada Takanori Ochi go Miyano Geoffrey J Lane Atsuyuki Yamataka Tadaharu Okazaki Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Department of Medical Technology Innovation Center Juntendo UniversityBunkyo-ku TokyoJapan Department of Pediatric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Background Following on from an earlier study published in 2008 about left pulmonary artery(LPA)flow measured on serial echocardiography being strongly prognostic in left-sided congenital diaphragmatic hernia(CDH)and the ratio of LPA to right pulmonary artery(RPA)diameters being a simple and reliable indicator for commencing nitric oxide(NO)therapy,the ratio of LPA:RPA diameters(PA ratio orPAR)was hypothesized to possibly reflect cardiopulmonary stresses accompanying CDH *** Subjects with isolated left-sided CDH treated between 2007 and 2020 at a single pediatric surgical center were recruited and classified according to *** obtained retrospectively for subject demographics,clinical course,LPA/RPA diameters,and PAR were compared between survivors and *** value of PAR for optimizing the prognostic value of PA diameter data in CDH were analyzed with receiver operating characteristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)and 11 non-survivors(17.7%);7 of 11 non-survivors died before surgical repair could be *** PAR for survivors(0.851±0.152)was significantly higher than for non-survivors(0.672±0.108)(p=0.0003).Mean PAR for non-survivors was not affected by surgical *** of survivors were:LPA≥2 mm(n=52 of 54;mean PAR=0.866±0.146)and RPA≥3mm(n=46 of 54;mean PAR=0.857±0.152).Non-survivors with similar LPA and RPA diameters to survivors had significantly lower mean *** curve cut-off for PAR was *** with high PAR(≥0.762)required high-frequency oscillatory ventilation/NO less than subjects with low PAR(<0.762)(p=0.0244 and p=0.0485,respectively)and subjects with high PAR stabilized significantly earlier than subjects with low PAR(1.71±0.68 days vs 3.20±0.87 days)(p<0.0001).Conclusions PAR would appear to be strongly correlated with clinical outcome in CDH and be useful for planning management of cardiopulmonary instability in CDH.

关键词： hernia congenital diameters

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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

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Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu Congnuan Liu Song Hao Lee Lewis Sze Chun Choi Michael T.Wilson Dirk U.Pfeiffer Yun Young go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina Center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina College of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Mid-infrared computational temporal ghost imaging

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Light(Science & Applications) 2024年第6期13卷 1088-1097页

作者： Han Wu Bo Hu Lu Chen Fei Peng Zinan Wang goery Genty Houkun Liang College of Electronics and Information Engineering Sichuan UniversityChengduSichuan610064China College of Electrical Engineering Sichuan UniversityChengduSichuan610064China Key Lab of Optical Fiber Sensing&Communications University of Electronic Science&Technology of ChinaChengduSichuan611731China Laboratory of Photonics Tampere UniversityFI-33014TampereFinland

Ghost imaging in the time domain allows for reconstructing fast temporal objects using a slow *** technique involves correlating random or pre-programmed probing temporal intensity patterns with the integrated signal measured after modulation by the temporal ***,the implementation of temporal ghost imaging necessitates ultrafast detectors or modulators for measuring or pre-programming the probing intensity patterns,which are not available in all spectral regions especially in the mid-infrared ***,we demonstrate a frequency downconversion temporal ghost imaging scheme that enables to extend the operation regime to arbitrary wavelengths regions where fast modulators and detectors are not *** approach modulates a signal with temporal intensity patterns in the near-infrared and transfers the patterns to an idler via difference-frequency generation in a nonlinear crystal at a wavelength where the temporal object can be *** a proof-of-concept,we demonstrate computational temporal ghost imaging in the mid-infrared with operating wavelength that can be tuned from 3.2 to 4.3μ*** scheme is flexible and can be extended to other *** results introduce new possibilities for scan-free pump-probe imaging and the study of ultrafast dynamics in spectral regions where ultrafast modulation or detection is challenging such as the mid-infrared and THz regions.

关键词： ghost Ghost scheme

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乡村教师使用数字化教学资源的责任伦理及风险应对

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中国电化教育 2024年第8期 102-109页

作者：龚洪陈恩伦唐旭西南大学教师教育学院重庆北碚400715 武昌理工学院文法学院湖北武汉430223 西南大学继续教育学院重庆北碚400715

教育数字化转型进程里,确保乡村教师坚守数字与信息责任伦理,已成为合理运用数字资源提升高质量教学的职业操守。当乡村教师在使用数字化教学资源中失去责任伦理的规约与限制,易造成数字化信息茧房行为蔓延,致使数字化教学资源偏离乡土... 详细信息

教育数字化转型进程里,确保乡村教师坚守数字与信息责任伦理,已成为合理运用数字资源提升高质量教学的职业操守。当乡村教师在使用数字化教学资源中失去责任伦理的规约与限制,易造成数字化信息茧房行为蔓延,致使数字化教学资源偏离乡土教情,损害数字化教学资源应用可信生态链。为提升乡村教师合理开发使用数字化教学资源,需要明确数字责任伦理的特定取旨,从强化主体责任伦理意识、紧扣乡村教学实际、恪守求真务实底线向度,纾解“信息茧房”行为泛化隐忧,提升“数实融合”尽责能力水平,夯实“可信尚善”责任行为规范。

关键词：乡村教师数字化教学资源高质量教学数字责任

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Taxonomic Study of Five Parasitic Polypores of the Hymenochaetaceae Family of TIN Vegetation in Western Burkina Faso

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American Journal of Plant Sciences 2024年第6期15卷 441-454页

作者： Kusiélé Somda Andjièrèyir Nankoné Samson Nana R. Sylvie Bakiono Benovana Sédégo K. Jean Edouard Dabiré Kounbo Sanon Elise Department of Plant Biology and Physiology Joseph Ki-Zerbo University Ouagadougou Burkina Faso Life and Earth Sciences Laboratory Science and Technology Training and Research Unit Norbert Zongo University Koudougou Burkina Faso Tenkodogo University Center Ouagadougou Burkina Faso

The aim of this work is to inventory and study the lignicolous parasitic macrofungi of the Tin plant formation. The mycological outings from July to September 2018 and 2019, collected forty-four (44) basidiomes through a random sampling device over an area of 40,000 m2 including 1000 m long by 40 m2 wide. The standard methods and techniques used in mycology for taxonomic studies were used to describe and classify the carpophores collected in three families: Hymenochaetaceae, Ganodermataceae and Polyporaceae, into eight genera: Onnia (4.55%), Amauroderma (4.55%), Ganoderma (20.45%), Phellinus (52.27%), Inonotus (4.55%), Phellinopsis (6.82%), Grammothele (2.27%) and Trametes (4.55%). The genera Phellinus and Ganoderma were the most abundant. Finally, eight species were identified: Inonotus cf. ochroporus, Inonotus cf. pachyphloeus, Phellinus cf. cryptarum, Phellinus cf. hartigii, Phellinus cf. hippophaecola;Phellinus cf. robustus, Phellinus cf. igniarius, et Amauroderma cf. fasciculatum. Seven fungal species belong to the family Hymenochaetaceae and only the species Amauroderma cf. fasciculatum is a Ganodermataceae. However, all these fungal species are shown to be parasites of trunks and/or branches of the following woody: Parkia biglobosa (50%), Anogeissus leiocarpus (25%), Annona senegalensis (12.5%) and Mangifera indica (12.5%). Authors attest that the presence of phytoparasitic polypores in a plant formation is an indicator of aging hence the urgency to put in place the appropriate measures to safeguard and restore Tin’s plant formation.

关键词： Identification Macrofungi Lignicolous Parasites Vegetation Tin Burkina Faso

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多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值

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临床医学工程 2024年第7期31卷 771-772页

作者：齐玉晓郭广春河南省新野县中医院影像科河南南阳473500 南阳市中心医院影像科河南南阳473000

目的探讨多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值。方法选择2019年10月至2023年10月我院收治的疑似腰椎压缩性骨折患者124例,均予以多序列MRI、CT多平面重组,以患者临床综合诊断结果为依据进行一致性分析,比较多序列MRI、C... 详细信息

目的探讨多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值。方法选择2019年10月至2023年10月我院收治的疑似腰椎压缩性骨折患者124例,均予以多序列MRI、CT多平面重组,以患者临床综合诊断结果为依据进行一致性分析,比较多序列MRI、CT多平面重组及联合检测诊断腰椎压缩性骨折的灵敏度、特异度、准确率。结果124例患者经临床综合诊断确定为腰椎压缩性骨折阳性99例,阴性25例;多序列MRI及CT多平面重组诊断结果与临床综合诊断结果一致性均较高(κ=0.847、0.826,P<0.001),多序列MRI联合CT多平面重组诊断结果与临床综合诊断结果几乎完全一致(κ=0.977,P<0.001);多序列MRI联合CT多平面重组灵敏度、特异度、准确率均显著高于单一多序列MRI、CT多平面重组(P<0.05)。结论多序列MRI联合CT多平面重组诊断腰椎压缩性骨折较单一诊断效果更好,应用价值高。

关键词：多序列核磁共振成像 CT多平面重组腰椎压缩性骨折

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