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Unraveling one billion years of geological evolution of the southeastern Amazonia Craton from detrital zircon analyses

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Geoscience Frontiers 2022年第5期13卷 129-152页

作者： camille rossignol Paul Yves Jean Antonio Francesco Narduzzi Eric Siciliano Rego Lívia Teixeira Romário Almeida de Souza Janaína N.Ávila Marco A.L.Silva Cristiano Lana Ricardo I.F.Trindade Pascal Philippot Departamento de Geofísica Instituto de AstronomiaGeofísica e Ciências Atmosféricas da Universidade de São PauloRua do Matão1226-Cidade UniversitáriaSão Paulo 05508-090Brazil Institut de Physique du Globe de Paris Universitéde ParisCNRSParisFrance Géosciences Montpellier Universitéde MontpellierCNRSUniversitédes AntillesMontpellierFrance Instituto de Geociências Universidade de São PauloRua do Lago562-Cidade UniversitáriaSão Paulo 05508-080Brazil Instituto de Geociências e Engenharias Universidade Federal do Sul e Sudeste do Pará–UNIFESSPAFolha 17Quadra 04Lote especialNova MarabáMarabáPará68505-080Brazil Research School of Earth Sciences The Australian National University142 Mills RoadCanberraACT 2601Australia Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoRua Diogo de Vasconcelos12235400-000 Ouro PretoMGBrazil

Despite representing one of the largest cratons on Earth,the early geological evolution of the Amazonia Craton remains poorly known due to relatively poor exposure and because younger metamorphic and tectonic events have obscured initial *** this study,we investigated the sedimentary archives of the Carajás Basin to unravel the early geological evolution of the southeastern Amazonia *** Carajás Basin contains sedimentary rocks that were deposited throughout a long period spanning more than one billion years from the Mesoarchean to the *** oldest archives preserved in this basin consist of a few ca.3.6 Ga detrital zircon grains showing that the geological roots of the Amazonia Craton were already formed by the *** the Paleoarchean or the early Mesoarchean(<3.1 Ga),the Carajás Basin was large and rigid enough to sustain the formation and preservation of the Rio Novo Group greenstone ***,during the Neoarchean,at ca.2.7 Ga,the southeastern Amazonia Craton witnessed the emplacement of the Parauapebas Large Igneous Province(LIP)that probably covered a large part of the craton and was associated with the deposition of some of the world largest iron *** emplacement of this LIP immediately preceded a period of continental extension that formed a rift infilled first by iron formations followed by terrigenous *** major change of sedimentary regime might have been controlled by the regional tectonic evolution of the Amazonia Craton and its emergence above *** the Paleoproterozoic,at ca.2.1 Ga,the Rio Fresco Group,consisting of terrigenous sediments from the interior of the Amazonia Craton,was deposited in the Carajás *** that time,the Amazonian lithosphere could have either underwent thermal subsidence forming a large intracratonic basin or could have been deformed by long wavelength flexures that induced the formation of basins and swells throughout the craton under the influence of

关键词： Carajás Basin Chemical Abrasion–LA-ICP-MS analyses Age distribution comparison Parauapebas Large Igneous Province Transamazonian orogeny

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Clinical significance of the loss of CD20 antigen on tumor cells in patients with relapsed or refractory follicular lymphoma

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Cancer Drug Resistance 2021年第3期4卷 710-718页

作者： Jean-Marie Michot Alice Buet-Elfassy Maxime Annereau Julien Lazarovici Alina Danu Clémentine Sarkozy Claude Chahine camille Bigenwald Jacques Bosq Julien rossignol Patricia Romano-Martin Capucine Baldini David Ghez Peggy Dartigues Christophe Massard Vincent Ribrag Gustave Roussy UniversitéParis-SaclayDépartement des Innovations Thérapeutiques et Essais PrécocesVillejuif 94800France Gustave Roussy UniversitéParis-SaclayPharmacy DepartementVillejuif 94800France Gustave Roussy UniversitéParis-SaclayDepartement of HematologyVillejuif 94800France Gustave Roussy UniversitéParis-SaclayDepartement of PathologyVillejuif 94800France

Aim:Anti-CD20 monoclonal antibody is a cornerstone therapy for follicular *** anti-CD20 therapy,a potential decrease in CD20 antigen,and therefore a loss of the tumor target might be ***,the incidence and clinical significance of CD20 loss on tumor cells in patients with relapsed or refractory follicular lymphoma are *** study aims to investigate the incidence and outcome of patients with relapsed or refractory follicular lymphoma patients harboring the loss of the tumor target,***:All consecutive adult patients with relapsed or refractory follicular lymphoma referred to the Early Drug Department at Gustave Roussy were *** main objectives were to assess the incidence and prognosis of the loss in expression of CD20 antigen on the surface of tumor cells on patient ***:Over the study period 2013-2018,131 patients were screened for clinical trials with B-cell malignancies in the early drug department of Gustave Roussy in ***-four patients presented with relapsed or refractory follicular lymphoma and 32 had tumor biopsies at the time of relapse that were retained for *** median(range)age was 67.5 years(55.3-75.3)and the median number of prior anti-cancer systemic therapies was 3(2-4).At the time of relapse,CD20 expression was positive in 84%of tumors(n=27)and negative in 16%of tumors(n=5).At a median follow-up of 18.3(0.6-83.3)months,CD20 negativity was associated with a poorer prognosis with a median overall survival of 8.9 months(95%CI:2.4-19.1)in comparison to CD20 positive patients(28.3 months,95%CI:25.1-75.3 months,P=0.019).Conclusion:The loss of the tumor target antigen,CD20,occurred in 16%of patients with relapse or refractory follicular *** to confounding factors in patients who received anti-CD20 immunotherapy,it was not possible to formally establish the prognostic significance of CD20 ***,we suggest that a check for CD20 antigen positivity nevertheless

关键词： Follicular lymphoma CD20 tumor antigen anti-CD20 monoclonal antibody cancer drug resistance

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