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Tubular conduits,cell-based therapy and exercise to improve peripheral nerve regeneration

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Neural Regeneration Research 2015年第4期10卷 565-567页

作者： camila Oliveira goulart Ana Maria Blanco Martinez Laboratório de Neurodegeneracao e Reparo Departamento de PatologiaFaculdade de MedicinaHUCFF-UFRJ-Rio de Janeiro-RJBrazil

Peripheral nerve injuries （PNI） are a major clinical prob- lem. In general, PNI results from motor vehicle accidents, lacerations with sharp objects, penetrating trauma （gunshot wounds） and stretching or crushing trauma and fractures. It is estimated that PNI occur in 2.8% of trauma patients and this number reaches 5% if plexus and root lesions are in- cluded. However, due to lack of recent epidemiological stud- ies, these data probably underestimate the actual number of nerve injuries

关键词： cell Tubular conduits,cell-based therapy and exercise to improve peripheral nerve regeneration PNI

Past,present and future of preserving and restoring function in the visual system:removing galectin-3 as a promising treatment

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Neural Regeneration Research 2017年第1期12卷 58-59页

作者： Silmara de Lima Henrique Rocha Mendonca camila Oliveira goulart Ana M.Blanco Martinez Laboratories for Neuroscience Research in Neurosurgery and F.M.Kirby Neurobiology Center Children's Hospital BostonDepartmentsof Surgery and Ophthalmology and Program in NeuroscienceHarvard Medical SchoolBostonMAUSA Laboratorio de Neurodegeneracao e Reparo-Departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Polo Universitairio Macae UFRJMacaeRJBrazil

Great advances in retinal ganglion cells survival（RGCs）,optic nerve preservation and regeneration have been made in the past ***,we know that RGCs are capable of regenerating the full length of the optic nerve,cross... 详细信息

关键词： RGCs preserving regeneration preservation galectin removing optic capable ganglion microglia

Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)

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Neural Regeneration Research 2018年第10期13卷 1811-1819页

作者： Fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira Oliveira Daniela F.P.A.Durco camila Oliveira goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos Santos Natália Tavares de Campos Beatriz Theodoro da Silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez Pós Graduacao em Ciências Morfológicas Instituto de Ciências Biomédicas-UFRJRio de Janeiro RJ Brazil Anatomia Patológica-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Laboratório de Neurodegeneracao e Reparo-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Programa de Eng. Química COPPE-UFRJRio de Janeiro Brazil Polo Universitário de Macaé Laboratório Integrado de Produtos Bioativos e BiociênciasMacaê UFRJ Brazil

Poly（lactic acid）（PLA）-containing nerve guidance conduits（NGCs） are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly（lactic acid） and combined or not with polycaprolactone（PLA/PCL） or polyvinylpyrrolidone（PLA/PVP）. To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index（SFI）, and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair.

关键词： sciatic nerve tubulization biodegradable conduit poly(lactic acid) regeneration

WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Neurotrauma and mesenchymal stem cells treatment:From experimental studies to clinical trials

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World Journal of Stem Cells 2014年第2期6卷 179-194页

作者： Ana Maria Blanco Martinez camila de Oliveira goulart Bruna dos Santos Ramalho Júlia Teixeira Oliveira Fernanda Martins Almeida Laboratory of Neurodegeneration and Repair Institute of Biomedical SciencesHealth Science Center Pathology Department Faculty of MedicineFederal University of Rio de Janeiro Federal University of Rio de Janeiro Campus Macaé

Mesenchymal stem cell(MSC)therapy has attracted the attention of scientists and clinicians around the *** and pre-clinical experimental studies have highlighted the positive effects of MSC treatment after spinal cord and peripheral nerve *** effects are believed to be due to their ability to differentiate into other cell lineages,modulate inflammatory and immunomodulatory responses,reduce cell apoptosis,secrete several neurotrophic factors and respond to tissue injury,among *** are many pre-clinical studies on MSC treatment for spinal cord injury(SCI)and peripheral nerve ***,the same is not true for clinical trials,particularly those concerned with nerve trauma,indicating the necessity of more well-constructed studies showing the benefits that cell therapy can provide for individuals suffering the consequences of nerve *** for clinical trials for SCI treatment the results obtained so far are not as beneficial as those described in experimental *** these reasons basic and pre-clinical studies dealing with MSC therapy should emphasize the standardization of protocols that could be translated to the clinical set with consistent and positive *** review is based on pre-clinical studies and clinical trials available in the literature from 2010 until *** the time of writing this article there were 43 and 36 pre-clinical and 19 and 1 clinical trials on injured spinal cord and peripheral nerves,respectively.

关键词： Neurotrauma Stem cell therapy Mesenchymal stem cells Pre-clinical studies Clinical trials

Experimental salt cavern in offshore ultra-deep water and well designevaluation for CO_(2) abatement

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International Journal of Mining Science and Technology 2019年第5期29卷 641-656页

作者： Alvaro Maia da Costa Pedro V.M.Costa Antonio C.O.Miranda Mariana B.R.goulart Okhiria D.Udebhulu Nelson F.F.Ebecken Ricardo C.Azevedo Sérgio M.de Eston Giorgio de Tomi Andre B.Mendes Julio R.Meneghini Kazuo Nishimoto Claudio Mueller Sampaio camila Brandao Alexandre Breda University of Sao Paulo(USP) Sao Paulo 01000-000Brazil Modecom-Technology in Geomechanics and Computing Modeling Rio de Janeiro 27570-000Brazil Department of Civil and Environment Engineering University of Brasília(UnB)Brasília 70000-000Brazil COPPE Federal University of Rio de JaneiroRio de Janeiro 27570-000Brazil Technology Division of Shell Shell BrazilRio de Janeiro 27570-000Brazil

This paper presents a proposal for an experimental salt cavern in offshore ultra-deep water for CO2 abatement,including the instrumentation plan and well conceptual design evaluated for carbon capture and storage(CCS)*** studies are based on applied computational mechanics associated with field experimentation that has contributed to the technical feasibility of the underground potash mine at the State of Sergipe in *** knowhow allowed the stability analysis of several salt caverns for brine production at the State of Alagoas in Brazil and to the drilling through stratified thick layers of salt of the pre-salt reservoirs in Santos ***,this knowledge has been applied in the design of onshore and offshore salt caverns opened by dissolution for storage of natural gas and *** geomechanical study,through the application of computational mechanics,of offshore giant salt caverns of 450 m high by 150 m in diameter,shows that one cavern can store about 4 billion Sm3 or 7.2 million tons of *** the construction of the giant cavern,which will be the first gas storage offshore in the world,it has been decided to develop an experimental one,with smaller size,to obtained field *** experimental cavern will allow the calibration of parameters to be used in the structural integrity analysis of the cavern and well for storage of natural gas which is rich in CO2 under high pressure.

关键词： Salt cavern Pre-salt reservoir Geomechanical study Carbon capture and storage