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航空发动机 1991年第2期12卷 44-59页

作者： calmon,j 孙广华

New avenues for the treatment of immunotherapy-resistant pancreatic cancer

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World journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： Luis Guilherme de Oliveira Silva Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Mariana dos Santos calmon Gabriel Lima Correa Santos Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases ***,due to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and *** in genes such as KRAS,TP53,and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,*** this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive *** to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as *** this way,finding new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC ***,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined immunotherapy

Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva Mariana Santos calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Immune pathway through endometriosis to ovarian cancer

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World journal of Clinical Oncology 2024年第4期15卷 496-522页

作者： Mariana Santos calmon Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Luis Guilherme de Oliveira Silva Gabriel Lima Correa Santos Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Endometriosis is an estrogen-dependent inflammatory disease,defined by the presence of functional endometrial tissue outside of the uterine *** disease is one of the main gynecological diseases,affecting around 10%-15%women and girls of reproductive age,being a common gynecologic *** endometriosis is a benign disease,it shares several characteristics with invasive *** support that it has been linked with an increased chance of developing endometrial ovarian cancer,representing an earlier stage of neoplastic *** is particularly true for women with clear cell carcinoma,low-grade serous carcinoma and ***,the carcinogenic pathways between both pathologies remain poorly *** studies suggest a connection between endometriosis and endometriosis-associated ovarian cancers(EAOCs)via pathways associated with oxidative stress,inflammation,and *** article aims to review current data on the molecular events linked to the development of EAOCs from endometriosis,specifically focusing on the complex relationship between the immune response to endometriosis and cancer,including the molecular mechanisms and their *** recent developments in immunotherapy and their potential to boost the effectiveness of future treatments.

关键词： Ovarian neoplasms Endometriosis Endometriosis-associated ovarian cancers Immune response Immunotherapy

Forensic data management and database systems in forensic investigations for cases of missing and unidentified persons in Brazil

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Forensic Sciences Research 2022年第4期7卷 599-608页

作者： Melina calmon Grupo de Pesquisa em Antropologia Forense e Identificação de Pessoas Academia Nacional de Polícia-Polícia Federal do BrasilBrasiliaBrazil

Forensic investigations,especially those related to missing persons and unidentified remains,produce different types of data that must be managed and *** data collected and produced are extensive and originate from various sources:the police,non-governmental organizations(NGOs),medical examiner offices,specialised forensic teams,family members,and *** examples of information include,but are not limited to,the investigative background information,excavation data of burial sites,antemortem data on missing persons,and postmortem data on the remains of unidentified *** complex data must be stored in a secured place,analysed,compared,shared,and then reported to the investigative actors and the public,especially the families of missing persons,who should be kept informed of the ***,a data management system with the capability of performing the tasks relevant to the goals of the investigation and the identification of an individual,while respecting the deceased and their families,is critical for standardising *** management is crucial to assure the quality of investigative processes,and it must be recognised as a holistic integrated *** aim of this article is to discuss some of the most important components of an effective forensic data management *** discussion is enriched by examples,challenges,and lessons learned from the erratic development and launching of databases for missing and unidentified persons in *** main objective of this article is to bring attention to the urgent need for an effective and integrated system in Brazil.

关键词： Forensic sciences forensic data management database missing persons unidentified persons Brazil

Bayesian inference of biomass growth characteristics for sugi(***)and hinoki(***)forests in self-thinned and managed stands

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Forest Ecosystems 2021年第4期8卷 1006-1023页

作者： Valerie Nicoulaud-Gouin Marc-Andre Gonze Pierre Hurtevent Phillippe calmon Institut de Radioprotection et de Surete Nucleaire St Paul-Lez-DuranceFrance

Background:Forests are an important sink for atmospheric carbon and could release that carbon upon deforestation and *** stand biomass dynamic of evergreen forests has become necessary to improve current biomass production *** different growth processes of managed forests compared to self-managed forests imply an adaptation of biomass prediction ***:In this paper we model through three models the biomass growth of two tree species(japanese cedar,japanese cypress)at stand level whether they are managed or not(self-thinning).One of them is named self-thinned model which uses a specific self-thinning parameterαand adapted to self-managed forests and an other model is named thinned model adapted to managed *** latter is compared to a Mitscherlich *** self-thinned model takes into account the light competition between trees relying on easily observable parameters(*** density).A Bayesian inference was carried out to determine parameters values according to a large database ***:In managed forest,Bayesian inference results showed obviously a lack of identifiability of Mitscherlich model parameters and a strong evidence for the thinned model in comparison to Mitscherlich *** self-thinning forest,the results of Bayesian inference are in accordance with the self-thinning 3/2 rule(α=1.4).Structural dependence between stand density and stand yield in self-thinned model allows to qualifying the expression of biological time as a function of physical time and better qualify growth and mortality *** mortality rate is 2.5 times more important than relative growth rate after about 40 years *** density and stand yield can be expressed as function of biological time,showing that yield is independent of initial ***:This paper addressed stand biomass dynamic models of evergreen forests in order to improve biomass growth dynamic assessment at regional scale relying on easily observable

关键词： Dynamic Biomass Self-thinning Sugi Hinoki Competition-Density rule

Soil organic carbon storage in forest restoration models and environmental conditions

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journal of Forestry Research 2022年第4期33卷 1123-1134页

作者： Ranieri Ribeiro Paula Miguel calmon Maria Leonor Lopes-Assad Eduardo de SáMendonça Departamento de Agronomia Programa de Pós-Graduação em Produção VegetalUniversidade Federal do Espírito SantoAlto UniversitárioGuararemaAlegreEspírito Santo CEP 29500-000Brazil World Resources Institute SalvadorBahia CEP 40290-040Brazil Departamento de Recursos Naturais e Proteção Ambiental Universidade Federal de São CarlosArarasSão Paulo CEP 13600-970Brazil

The scale of forest and landscape restoration is expected to increase during the UN Decade on Ecosystem Restoration and its contribution to the provision of critical ecosystem services to *** models of forest restoration may improve ecosystem services,including soil organic carbon(SOC)storage.A review was carried out to access:(1)the variability of SOC storage between worldwide forest restoration models and,(2)the effects of climate,soil class,soil texture,and vegetation type on SOC *** reviewed 119 primary studies with information on SOC and soil texture for different forest restoration *** restoration models were grouped into four categories:natural regeneration,monocultures,agroforestry,and mixed *** data was extracted from these four restoration models,other land uses(cropland,bare land,grassland,and natural forest),climate regimes,and soil *** SOC storage in the forest restoration models and other land uses at a global scale ranged between 0.1 to 514 Mg ha^(-1).The overall mean value for SOC storage was higher for natural regeneration(112 Mg ha^(-1)),followed by agroforestry(74 Mg ha^(-1)),mixed forest(73 Mg ha^(-1)),and monocultures(68 Mg ha^(-1)).However,the average SOC storage was similar among the four restoration models in the moist warm climate *** SOC storage mean value in the moist cool zone was 23%higher than the dry cool zone(81 and 62 Mg ha^(-1),respectively),and 50%higher for the moist warm zone when compared to the dry warm climatic zone(74 and 38 Mg ha^(-1),respectively).The SOC storage of the restoration models was positively related to soil depth(0.59;p<0.01),clay content(0.29;p<0.01),and stand age(0.17;p<0.01).Globally,the mean values of SOC storage were 26,66,and 139 Mg ha^(-1) at zero-10,zero-30,and zero-100 cm depths,*** addition,sandy soils showed smaller mean values of SOC storage than medium to clay soils,especially in deeper soil ***,SOC storage was positively re

关键词： Forest restoration Land uses Soil type Soil texture Climate

The reality of the dead in Brazil:perspectives on identification in forensic anthropology

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Forensic Sciences Research 2022年第4期7卷 577-579页

作者： Eugénia Cunha Bridget Algee-Hewitt Melina calmon National Institute of Legal Medicine and Forensic Sciences CoimbraPortugal Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal CCSRE Center for Comparative Studies in Race and Ethnicity(CCSRE)Stanford UniversityStanfordCAUSA Grupo de Pesquisa em Antropologia Forense e Identificação de Pessoas-ANP/CNPq Lago SulBrazil

What is the current state of Forensic Anthropology in Brazil and where do we stand when identification is concerned?Coming to terms with the reality of identifying the dead in Brazil is the challenge we proposed to several Brazilian forensic anthropology experts and it is the focus of this special *** asked the contributor to drill-down to the fundamental questions in order to define the baseline upon which we can build our understanding and establish the future pathways for the *** are the most typical cases?Is there a more frequent case type?Does the way the issues are being solved reflect advancements in the discipline in the country?Are standards procedures being followed?What are the main obstacles faced by the experts in this field?

关键词： dead Brazil concerned

Recommendations for procedures related to the evidence chain of custody in forensic anthropology in Brazil

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Forensic Sciences Research 2022年第4期7卷 609-622页

作者： Nicole Prata Damascena Melina calmon Silva Alexandre Raphael Deitos Rosane Pérez Baldasso Renata Cristina Grangeiro Ferreira Cristian Kotinda júnior Carlos Eduardo Palhares Machado Departamento de Polícia Técnica da Bahia BahiaBrazil Grupo de Pesquisa em Antropologia Forense e Identificação de Pessoas BrasiliaBrazil Instituto Nacional de Criminalística da Polícia Federal BrasiliaBrazil Departamento Médico-Legal do Instituto-Geral de Perícias do Rio Grande do Sul(IGP/RS) Porto AlegreBrazil Instituto de Criminalística da Polícia Civil do Distrito Federal BrasiliaBrazil.

Forensic anthropologists perform specialised analysis,mainly involving skeletonised human remains,cadavers in advanced stages of decomposition,disassociated elements from the human body,and human remains in extreme *** main objectives of the forensic anthropology expertise are human identification and assisting in determining the cause and manner of *** the time since death is also a priority for some cases,especially ones involving missing *** science works on individual cases,violent deaths,missing persons,mass disasters,suspected violations of human rights,and crimes against *** anthropological evidence is,in general,very ***,it is important to detail aspects relevant to the maintenance of the chain of custody at all phases of the investigation,as well as standardise the actions of the individuals *** aims to preserve the evidence integrity and sameness(Sameness:free translation of the Portuguese word“mesmidade”,derived from a Spanish word that does not possess a translation to *** of evidence is understood as the guarantee that the evidence under valuation(or under analysis of its probative value)is exactly and integrally the same one which was collected,corresponding,therefore,to“the same”(and not“part of”,“derived from”),safeguarding its *** Law No.13.964 of 14 December 2019 establishes and lists 10 phases related to the evidence chain of custody that must be *** newly introduced requirements resulted in the need for adaptation of the forensic,investigative,and legal actors involved in an investigation,and in the detailed description of the procedures for the different areas related to criminalistics,including forensic *** information provided in this article should be interpreted as recommendations,even though their non-compliance may weaken the investigative and forensic analysis processes in whole or in part.

关键词： Forensic sciences forensic anthropology chain of custody evidence law Brazil

Using Condensed Water of Air Conditioners for Toilet Flushing： A Case Study in Brazil

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journal of Civil Engineering and Architecture 2013年第1期7卷 98-104页

作者： Celso Silva Bastos joao Luiz calmon Postgraduate Program in Civil Engineering Technology Center Federal University of Espirito Santo Vit6ria 29000-000 Brazil

Within the concept of sustainable construction, with sensible and conscious use of finite natural resources, every effort to save and reuse raw-materials is considered an important step to be adopted in buildings, from project, implantation and construction to operation and maintenance throughout their lifecycle. This study aims at showing the application of a system that reuses condensed water drained from air-conditioner evaporators （which are usually disposed of）, and a plan to use this water for toilet flushing, reducing consumption of treated water bought from water companies. The authors verified that each air-conditioner specified in the project of a commercial building--used as reference here--produces 4.8 L of water per hour of operation. This result in a daily accumulated volume of 4,290 L, which represents a significant part of the amount needed to supply all the toilets in the building. A water capture system located at a strategic intermediate floor would be able to store this water and pump it into a special reservoir on the roof of the building, to be distributed into toilet flush pipes. By applying this technology, the authors seek to considerably reduce the expected treated water consumption and consequently decrease water bill costs.

关键词： Water reuse air-conditioner toilet flush.