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Journal of Energy Chemistry 2024年第2期89卷 10-17,I0002页

作者： Quanzhen Sun Yifan li caixia Zhang Shunli Du Weihao Xie Jionghua Wu Qiao Zheng Hui Deng Shuying Cheng Institute of Micro-Nano Devices and Solar Cells College of Physics and Information EngineeringFuzhou UniversityFuzhou 350108FujianChina Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108FujianChina Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Changzhou 213164JiangsuChina

Focusing on the low open circuit voltage(V_(OC))and fill factor(FF)in flexible Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)solar cells,indium(In)ions are introduced into the CZTSSe absorbers near Mo foils to modify the back interface and passivate deep level defects in CZTSSe bulk concurrently for improving the performance of flexible *** results show that In doping effectively inhibits the formation of secondary phase(Cu(S,Se)_(2))and *** studies demonstrate that the barrier height at the back interface is decreased and the deep level defects(Cu_(Sn)defects)in CZTSSe bulk are ***,the carrier concentration is increased and the V_(OC) deficit(V_(OC,def))is decreased significantly due to In ***,the flexible CZTSSe solar cell with 10.01%power conversion efficiency(PCE)has been *** synergistic strategy of interface modification and bulk defects passivation through In incorporation provides a new thought for the fabrication of efficient flexible kesterite-based solar cells.

关键词： Flexible solar cells Cu_(2)ZnSn(S,Se)_(4) Back interface Deep level defects Barrier height

职业性噪声与重金属单独与联合接触致认知功能障碍研究进展

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中国职业医学 2024年第2期51卷 172-176页

作者：李采霞吴康勇任毅贤林彬张晋蔚王致梁嘉斌广州市第十二人民医院职业环境与健康重点实验室广东广州510620 广州市职业病防治院广东广州510620 广州医科大学公共卫生学院广东广州510182

职业性噪声和重金属是工作场所常见的职业病危害因素。职业性噪声接触对工人健康的危害,除可导致噪声性听力损失外,也可能导致认知功能障碍。在工作过程中接触铅、锰、镉等常见重金属与工人的认知功能障碍密切相关。噪声与重金属联合接... 详细信息

职业性噪声和重金属是工作场所常见的职业病危害因素。职业性噪声接触对工人健康的危害,除可导致噪声性听力损失外,也可能导致认知功能障碍。在工作过程中接触铅、锰、镉等常见重金属与工人的认知功能障碍密切相关。噪声与重金属联合接触普遍存在于工作场所中;目前对职业性噪声接触联合铅或锰对工人认知功能影响的研究,存在不全面、不系统,认知功能障碍的测量工具不一致导致缺乏可比性,以及尚不能确定有关职业接触与工人认知功能障碍的因果关系等问题。因此,研究噪声与常见重金属联合接触致认知功能障碍的发生,对工人的职业健康有重要意义。未来需统一认知功能障碍测量工具,开展系统、全面的关于职业性噪声与铅、锰、镉等重金属单独或联合接触对工人认知功能障碍影响、机制和联合作用方式与效应等方面的研究,以保障劳动者职业健康权益。

关键词：噪声重金属铅锰镉联合作用认知功能障碍研究进展

BI-D1870 Causes the Rats’ Learning and Memory Acquisition Ability Impairment

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Journal of Biosciences and Medicines 2023年第1期11卷 82-97页

作者： Chaojie Zhang Ke He caixia li Yazhen Shang Institute of Traditional Chinese Medicine Chengde Medical College/Hebei Province Key Research Office of Traditional Chinese Medicine against Dementia/Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development/Hebei Key Laboratory of Nerve Injury and Repair Chengde China The Fourth Hospital of Shijiazhuang Shijiazhuang China

Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in the control group were intraperitoneally injected with saline, while those in the solvent control group were intraperitoneally injected with DMSO + sulfobutyl-β-cyclodextrin solvent, and those in the BI-D1870 group were intraperitoneally injected with BI-D1870. All the rats’ appearance and behavior were daily observed, and body weight was recorded on the day 15, 30, 45, 60, 75 and 82 of BI-D1870 injected. Morris water maze was used to screen the rats’ learning and memory acquisition ability on the day 22 - 25, 52 - 55, and 82 - 85 of training by BI-D1870 treated. The successful rates of the rats’ memory impairment were respectively calculated for three times screening. Results: During the whole experiment, there was no obvious difference in appearance and fur color in all rats. The rats’ agitation began to appear on the day 10th of BI-D1870 given. The agitation rats’ number and rats’ body weight gradually increased along with BI-D1870 treated (P P Conclusion: Intraperitoneal injection of BI-D1870 can induce the rats’ learning and memory acquisition ability disorder.

关键词： BI-D1870 Learning and Memory Acquisition Impairment Morris Water Maze RSK Inhibitor

Efficacy and safety of a cream containing octyl salicylic acid,salicylic acid,linoleic acid,nicotinamide,and piroctone olamine combined with 5%benzoyl peroxide in the treatment of acne vulgaris:a randomized controlled study

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Chinese Medical Journal 2022年第11期135卷 1381-1382页

作者： Wei li Qian Yu Zhong Shen Lanxin Zhang Wei Zhang caixia li Department of Medical Cosmetology Shanghai Dermatology HospitalTongji University School of MedicineShanghai 200443China Department of Medical Mycology Shanghai Dermatology HospitalTongji University School of MedicineShanghai 200443China Loreal China Co. LtdShanghai 200040China.

To The Editor:Acne vulgaris is a chronic inflammatory skin disease involving the sebaceous *** has an incidence of approximately 9.4%,often occurring in adolescents.[1]The disease itself and the scars left after treatment can cause psychological stress in adolescents and seriously affect patients’quality of life.[2]At present,skin care products,either alone or in combination with medical drugs,have become important means for treating *** single-center,single-blind(clinician-blind),masculine-paralleled,randomized study(Registration number:ChiCTR2100051398)evaluated the efficacy and safety of a cream containing octyl salicylic acid,salicylic acid,linoleic acid,nicotinamide,and piroctone olamine(Duo+,La Roche-Posay,Paris,France)alone and in combination with benzoyl peroxide(BPO,Galderma,Paris,France)for the treatment of mild-to-moderate *** research was approved by the Ethics Committee of Shanghai Skin Disease Hospital,China(No.2020-13 ke).All participants provided written informed consent.

关键词： benzoyl peroxide treatment

高温越夏日本大葱种质表型性状差异及亲缘关系研究

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蔬菜 2024年第10期 35-41页

作者：王树勇李彩霞杨文霞董小暖肖万里苗锦山昌乐县乔官镇农业综合服务中心山东昌乐262408 潍坊科技学院园艺科学与技术研究所山东寿光262700 东北农业大学农学院黑龙江哈尔滨150030

为了鉴定、筛选出越夏高产大葱种质并用于耐高温品种改良和选育,以42份日本大葱种质为试材,采用形态鉴定方法,在塑料大棚环境下研究了经高温越夏后种质的表型性状差异和亲缘关系远近,并用隶属函数法对初筛种质进行综合评价。结果表明:4... 详细信息

为了鉴定、筛选出越夏高产大葱种质并用于耐高温品种改良和选育,以42份日本大葱种质为试材,采用形态鉴定方法,在塑料大棚环境下研究了经高温越夏后种质的表型性状差异和亲缘关系远近,并用隶属函数法对初筛种质进行综合评价。结果表明:42份种质单株质量、株高、假茎质量、假茎长、假茎直径、叶长、叶扁宽、宿存叶片数、假茎指数和叶形指数10个数量性状的变异范围为10.50%~38.60%,平均值为19.62%。其中,假茎质量和单株质量变异系数较高,分别为38.60%和37.23%。经聚类分析将42份种质聚为1个高细类型、1个矮细类型、2个矮粗类型亚组共计4个组群,组群间性状差异显著。采用隶属函数法对高细类型、矮粗类型第1亚组14份种质进行种质综合评价,排名为喜太郎晚抽、玖源晚抽、什全一本、夏力源、成田一本、智荣、玖美、咏秀、荣辉、金春一本、卡曼、盛源泰32号、川田一本和揽胜。该研究从形态学角度解析了越夏日本大葱种质遗传差异,明确了不同资源亲缘关系远近,为越夏大葱种质筛选和优势杂交育种亲本选择提供了依据。

关键词：塑料大棚高温越夏日本大葱种质形态性状隶属函数法亲缘关系杂交育种

精灵颗粒调控PPARγ/PPARα脂代谢途径改善动脉粥样硬化合并代谢相关脂肪性肝病模型小鼠肝脂肪变机制研究

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江苏中医药 2024年第10期56卷 74-79页

作者：于秋雨刘梦君陈易珠李彩霞蔡超耿志荣王沛刘福明南京中医药大学附属医院江苏省中医院江苏南京210029 南京中医药大学代谢病中医研究重点实验室江苏南京210023 南京中医药大学药学院江苏南京210023

目的:从脂代谢中的关键蛋白过氧化物酶体增殖物激活受体(PPARs)中的常见分型PPARγ/PPARα途径探讨精灵颗粒治疗动脉粥样硬化(AS)合并代谢相关脂肪性肝病(MAFLD)可能的作用机制。方法:将6周龄SPF级雄性ApoE~(-/-)小鼠随机分为模型组、... 详细信息

目的:从脂代谢中的关键蛋白过氧化物酶体增殖物激活受体(PPARs)中的常见分型PPARγ/PPARα途径探讨精灵颗粒治疗动脉粥样硬化(AS)合并代谢相关脂肪性肝病(MAFLD)可能的作用机制。方法:将6周龄SPF级雄性ApoE~(-/-)小鼠随机分为模型组、阳性药物组和精灵颗粒低、高剂量组,每组8只,另取8只相同遗传背景同周龄雄性C57BL/6J小鼠作为空白对照组。ApoE~(-/-)小鼠采用高脂饮食喂养17周建立AS合并MAFLD模型。高脂饲料喂养第6周起阳性药物组和精灵颗粒低、高剂量组每日分别灌胃给予相应剂量的阿托伐他汀钙混悬液或精灵颗粒混悬液,空白对照组与模型组每日灌胃等体积生理盐水,各组均连续灌胃12周。末次给药后12 h,称取各组小鼠体质量;眼眶取血,分离血清,检测各组小鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)含量;处死小鼠,取肝脏,称取肝脏质量,计算肝指数;制作小鼠肝脏冰冻切片,苏木精-伊红(HE)染色观察各组小鼠肝脏病理形态;Western blot法和RT-qPCR法检测各组小鼠肝组织PPARγ、PPARα、胆固醇调节元件结合蛋白-1(SREBP-1)的蛋白及基因表达;RT-qPCR法检测各组小鼠肝组织炎症因子白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α基因表达。结果:模型组小鼠血清TC、TG、LDL-C水平以及肝指数均明显高于空白对照组(P0.05),对TG水平的降低作用明显优于低剂量(P0.05);各治疗组小鼠肝脂肪变减轻,炎性浸润改善。模型组小鼠肝组织PPARγ、SREBP-1蛋白及mRNA表达,IL-1β、TNF-αmRNA表达均明显高于空白对照组(P<0.05,P<0.01),PPARα蛋白及mRNA表达均明显低于空白对照组(P<0.05,P<0.01)。精灵颗粒低、高剂量组小鼠肝组织PPARγ蛋白表达,各给药组小鼠肝组织SREBP-1蛋白、PPARγmRNA表达,精灵颗粒高剂量组、阳性药物组小鼠肝组织SREBP-1 mRNA表达均明显低于模型组(P<0.05,P<0.01);精灵颗粒高剂量组、阳性药物组小鼠肝组织PPARα蛋白及mRNA表达均明显高于模型组(P<0.05,P<0.01)。各给药组小鼠肝组织IL-1β、TNF-αmRNA表达均明显低于模型组(P<0.01)。精灵颗粒高剂量对上述指标的改善作用普遍与阳性药物相当,且相对于低剂量有一定优势。结论:精灵颗粒可能通过调控PPARγ/PPARα脂代谢途径,下调SREBP-1表达,抑制肝脏脂质蓄积及炎症反应发挥对AS合并MAFLD肝脂肪变的治疗作用。

关键词：代谢相关脂肪性肝病动脉粥样硬化精灵颗粒脂质代谢 PPARγ/PPARα SREBP-1

Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation

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Genes & Diseases 2024年第3期11卷 83-86页

作者： Ping Wei Weizhe Shi Tianying Nong caixia Xian Xia li Zhaohui li Xin li Jianping Wu liyuan Shang Fulong Xu Yibo Xu Hongwen Xu Mingwei Zhu Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China Department of Pediatric Orthopedics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China

Metatropicdysplasia(MD,MIM156530)is a rare congenital bone dysplasia primarily characterized by severe platyspondyly with long and wide vertebral bodies and dumbbell deformity of the tubular *** can be caused by heterozygous mutations in the gene encoding transient receptor potential vanilloid family member 4(TRPV4).We identifieda novel de novo mutation,c.2353T>C,in the TRPV4 gene,in a Chinese family with mild MD.

关键词： TRPV4 dysplasia congenital

Optical optimization for Ⅲ-Ⅴ-//Si Multijunction solar cells

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Optical optimization for Ⅲ-Ⅴ-//Si Multijunction solar cell...

QTL mapping for grain number per spikelet in wheat using a high-density genetic map

第七届新型太阳能电池材料科学与技术学术研讨会

作者： caixia li Ziheng liu Xiaojing Hao Martin Green School of Photovoltaic and Renewable Energy Engineering University of New South Wales(UNSW)

Increasing research interest is currently dedicated to silicon-based III-V multijunction solar cells(MJSCs) to explore the potential of high-efficiency and low-cost photovoltaic devices [1-2].To achieve the optimal performance of the MJSCs,the intermediated layer between subcells requires careful photon *** photonic intermediate layer consisted of nanostructure is investigated as the intermediate *** arranged nanostructures are studied through the finite element method,and use the theoretical model proposed above to explore the performance of the overall *** study the effect of structure geometrical parameters on their optical properties,we calculated the reflection and averaged transmission for the periodic silver cylinders under GaAs(Cell 1),with varying geometrical *** 1(a) show the reflection of cylinders with varying diameters as a function of *** shows how varying the geometries of metal particles enables the possibility to spectrally tune the location of *** Figure 1(b),we investigate the dependency between the height of nanostructure and transmission properties of the interfaceThe calculation results indicate that the metal nanostructure can as the function of a flexible intermediate layer in silicon-based tandem solar cells with different bandgap top cells.

关键词： optical optimization multi-junction solar cells

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The Crop Journal 2021年第5期9卷 1108-1114页

作者： Yu lin Xiaojun Jiang Haiyan Hu Kunyu Zhou Qing Wang Shifan Yu Xilan Yang Zhiqiang Wang Fangkun Wu Shihang liu caixia li Mei Deng Jian Ma Guangdeng Chen Yuming Wei Youliang Zheng Yaxi liu State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China WenjiangChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityWenjiangChengdu 611130SichuanChina School of life Science and Technology Henan Institute of Science and TechnologyXinxiang 453003HenanChina College of Resources Sichuan Agricultural UniversityWenjiangChengdu 611130SichuanChina

Grain number per spikelet (GNS) is a key determinant of grain yield in wheat.A recombinant inbred line population comprising 300 lines was developed from a cross between a high GNS variety H461 and Chinese Spring from which the reference genome assembly of bread wheat was *** parents and the recombinant inbred lines were genotyped using the wheat 55K single nucleotide polymorphism(SNP) array.A high-density genetic map containing 21,197 SNPs was *** markers covered each of the 21 chromosomes with a total linkage distance of 3792.71 c *** of these markers in this linkage map were highly consistent with their physical locations in the genome assembly of Chinese *** two parents and the whole RIL population were assessed for GNS in two consecutive years at two different *** on multi-environment phenotype data and best liner unbiased prediction values,three quantitative trait loci (QTL) for GNS were *** of them located on chromosomes 2B and the other two on *** variation explained by these loci varied from 3.07%to26.57%.One of these QTL,***-2D-2,was identified in each of all trials *** on the best linear unbiased prediction values,this locus explained 19.59%–26.57%of phenotypic variation.A KASP(Kompetitive Allele-Specific PCR) marker closely linked with this locus was generated and used to validate the effects of this locus in three different genetic *** identified QTL and the KASP marker developed for it will be highly valuable in fine-mapping the locus and in exploiting it for markerassisted selection in wheat breeding programs.

关键词： Chinese Spring Grain number per spikelet High-density map KASP Quantitative trait locus