检索结果-南通市图书馆

Treatment and survival in a population-based sample of patients diagnosed with gastroesophageal adenocarcinoma

World Journal of Gastroenterology 2008年第20期14卷 3165-3173页

作者： Deirdre P Cronin-Fenton Margaret M mooney Limin X Clegg Linda C Harlan Surveillance Research Program DCCPS National Cancer Institute CTEP DCTD National Cancer Institute Applied Research Program DCCPS National Cancer Institute

AIM： TO examine the extent of use of specific therapies in clinical practice, and their relationship to therapies validated in clinical trials. METHODS： The US National Cancer Institutes＇ Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroesophageal adenocarcinoma （/7 = 1356）. The study re-abstracted data and verified therapy with treating physicians for a population-based stratified random sample. RESULTS： Approximately 62% of patients had stomach adenocarcinoma （SAC）, while 22% had gastric-cardia adenocarcinoma （GCA）, and 16% lower esophageal adenocarcinoma （EAC）. Stage 1V/ unstaged esophageal cancer patients were most likely and stage Ⅰ -Ⅲ stomach cancer patients least likely to receive chemotherapy as all or part of their therapy; gastric-cardia patients received chemotherapy at a rate between these two. In multivariable analysis by anatomic site, patients 70 years and older were significantly less likely than younger patients to receive chemotherapy alone or chemoradiation for all three anatomic sites. Among esophageal and stomach cancer patients, receipt of chemotherapy was associated with lower mortality; but no association was found among gastric-cardia patients. CONCLUSION： This study highlights the relatively low use of clinical trials-validated anti-cancer therapies in community practice. Use of chemotherapy-based treatment was associated with lower mortality, dependent on anatomic site. Findings suggest that physicians treat lower esophageal and SAC as two distinct entities, while gastric-cardia patients receive a mix of the treatment strategies employed for the two other sites.

关键词： Adenocarcinoma Esophageal adeno-carcinoma Gastroesophageal Gastric adenocarcinoma Survival Chemotherapy Radiotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

西北太平洋俯冲带大地幔楔及地幔过渡带各向异性证据和特征

引用

地球物理学报 2021年第2期64卷 455-470页

作者：郭广瑞李娟陈思丹 Walter D.mooney 中国科学院地质与地球物理研究所北京100029 中国科学院大学北京100049 漠河地球物理国家野外科学观测研究站北京100029 美国地质调查局 CA 94025

地震层析成像研究清晰给出了地球深部俯冲板片的大尺度形态,但与俯冲过程相关的地幔流动特征仍不明确.在俯冲地幔楔系统中,前人观测到了与海沟平行和垂直的快波偏振方向.本文研究了西北太平洋俯冲板片在地幔过渡带中停滞形成的"大地幔楔... 详细信息

地震层析成像研究清晰给出了地球深部俯冲板片的大尺度形态,但与俯冲过程相关的地幔流动特征仍不明确.在俯冲地幔楔系统中,前人观测到了与海沟平行和垂直的快波偏振方向.本文研究了西北太平洋俯冲板片在地幔过渡带中停滞形成的"大地幔楔"中的各向异性特征.对具有长期稳定观测数据的MDJ台站SKS震相和区域深源地震的直达S波震相进行了详细的剪切波分裂研究.采用多波形同时反演方法在保证数据后方位角覆盖范围的基础上得到了更加精确的SKS震相各向异性结果.剪切波分裂参数具有明显的频率依赖性和随初始极化方向变化的特征,表明台站下方存在多个可能的各向异性源区.对不同频段各向异性观测结果的双层各向异性模型拟合表明,上层各向异性参数为φ=32°±12°,δt=1.4±0.4 s,表现出受郯庐断裂带影响的岩石圈中"固化"各向异性特征;下层各向异性参数为φ=-71°±6°,δt=2.4±0.4 s,与海沟近乎垂直.下层较大的各向异性延时表明研究区域的地幔楔和地幔过渡带中存在明显各向异性,推测是由地幔中软流圈流动引起的橄榄石晶格优势取向和停滞的西北太平洋板片引起的地幔水平流动产生的瓦兹利石晶格优势取向共同作用所导致.

关键词：各向异性剪切波分裂大地幔楔地幔过渡带频率依赖性双层各向异性模型多波形同时反演

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A study on 3-D velocity structure of crust and upper mantle in Sichuan -Yunnan region, China

引用

Acta Seismologica Sinica(English Edition) 2002年第1期15卷 1-17页

作者：王椿镛 mooney W.D 王溪莉吴建平楼海王飞 Institute of Geophysics China Seismological Bureau Beijing 100081 China U. S. Geological Survey Menlo Park CA94025 USA

Based on the first arrival P and S data of 4 625 regional earthquakes recorded at 174 stations dispersed in the Yunnan and Sichuan Provinces, the 3-D velocity structure of crust and upper mantle in the region is determined, incorporating with previous deep geophysical data. In the upper crust, a positive anomaly velocity zone exists in the Sichuan basin, whereas a negative anomaly velocity zone exists in the western Sichuan plateau. The boundary between the positive and negative anomaly zones is the Longmenshan fault zone. The images of lower crust and upper mantle in the Longmenshan fault, Xianshuihe fault, Honghe fault and others show the characteristic of tectonic boundary, indicating that the faults likely penetrate the Moho discontinuity. The negative velocity anomalies at the depth of 50 km in the Tengchong volcanic area and the Panxi tectonic zone appear to be associated with the temperature and composition variations in the upper mantle. The overall features of the crustal and the upper mantle structures in the SichuanYunnan region are the lower average velocity in both crust and uppermost mantle, the large crustal thickness variations, and the existence of high conductivity layer in the crust or/and upper mantle, and higher geothermal value. All these features are closely related to the collision between the India and the Asia plates. The crustal velocity in the SichuanYunnan rhombic block generally shows normal value or positive anomaly, while the negative anomaly exists in the area along the large strike-slip faults as the block boundary. It is conducive to the crustal block side-pressing out along the faults. In the major seismic zones, the seismicity is relative to the negative anomaly velocity. Most strong earthquakes occurred in the upper-mid crust with positive anomaly or normal velocity, where the negative anomaly zone generally exists below.

关键词： regional earthquake Moho discontinuity 3-D velocity structure network method plate collision seismicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent developments in topoisomerase-targeted cancer chemotherapy

引用

Acta Pharmaceutica Sinica B 2018年第6期8卷 844-861页

作者： Kirk E.Hevener Tatsiana A.Verstak Katie E.Lutat Daniel L.Riggsbee Jeremiah W.mooney Department of Pharmaceutical Sciences University of Tennessee Health Science Center

The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously in all domains of life. The various topoisomerase enzymes perform a wide range of functions related to the maintenance of DNA topology during DNA replication, and transcription are the targets of a wide range of antimicrobial and cancer chemotherapeutic agents. Natural product-derived agents, such as the camptothecin, anthracycline, and podophyllotoxin drugs, have seen broad use in the treatment of many types of cancer. Selective targeting of the topoisomerase enzymes for cancer treatment continues to be a highly active area of basic and clinical research. The focus of this review will be to summarize the current state of the art with respect to clinically used topoisomerase inhibitors for targeted cancer treatment and to discuss the pharmacology and chemistry of promising new topoisomerase inhibitors in clinical and preclinical development.

关键词： Topoisomerase Inhibition Cancer Oncology Clinical Pre-clinical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of a ten step protocol to decrease postoperative spinal wound infections

引用

World Journal of Orthopedics 2018年第11期9卷 271-284页

作者： Hossein Elgafy Craig J Raberding Megan L mooney Kyle A Andrews Joan M Duggan Department of Orthopedics and Infectious Diseases University of Toledo Medical Center

AIM To define a ten-step protocol that reduced the incidence of surgical site infection in the spine surgery practice of the senior author and evaluate the support for each step based on current *** In response to unexplained increased infection rates at our institution following spine surgery,a ten-step protocol was implemented:(1) preoperative glycemic management based on hemoglobin A1 c(HbA1 c);(2) skin site preoperative preparation with 2% chlorhexidine gluconate disposable cloths;(3) limit operating room traffic;(4) cut the number of personnel in the room to the minimum required;(5) absolutely no flash sterilization of equipment;(6) double-gloving with frequent changing of outer gloves;(7) local application of vancomycin powder;(8) re-dosing antibiotic every 4 h for prolonged procedures and extending postoperative coverage to 72 h for high-risk patients;(9) irrigation of subcutaneous tissue with diluted povidone-iodine solution after deep fascial closure; and(10) use of Dura Prep skin preparation at the end of a case before skin closure. Through an extensive literature review,the current data available for each of the ten steps was *** Use of vancomycin powder in surgical wounds,routine irrigation of surgical site,and frequent changing of surgical gloves are strongly supported by the literature. Preoperative skin preparation with chlorhexidine wipes is similarly supported. The majority of current literature supports control of HbA1 c preoperatively to reduce risk of infection. Limiting the use of flash sterilization is supported,but has not been evaluated in spine-specific surgery. Limiting OR traffic and number of personnel in the OR are supported although without level 1 evidence. Prolonged use of antibiotics postoperativelyis not supported by the literature. Intraoperative use of Dura Prep prior to skin closure is not yet *** The ten-step protocol defined herein has significantly helped in decreasing surgical site

关键词： Wound infections Spine Ten step protocol Surgical site infections

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

台湾—阿尔泰地学断面阿尔金—龙门山剖面的地壳纵波速度结构

引用

地球物理学报 2005年第1期48卷 98-106页

作者：王有学 W D mooney 韩果花袁学诚姜枚桂林工学院资源与环境工程系广西桂林541004 美国地质调查局中国地质调查局发展研究中心北京100081 中国地质科学院地质研究所北京100037

通过分析阿尔金—龙门山地学断面的地震资料 ,建立了该剖面的地壳纵波速度结构 .研究结果表明 ,阿尔金北侧的塔里木盆地地区莫霍面为 5 0km ,而在其南侧的祁连地块莫霍面突然加深至 73km ,在柴达木盆地莫霍面又抬升至 5 8km左右 ,然后 ... 详细信息

通过分析阿尔金—龙门山地学断面的地震资料 ,建立了该剖面的地壳纵波速度结构 .研究结果表明 ,阿尔金北侧的塔里木盆地地区莫霍面为 5 0km ,而在其南侧的祁连地块莫霍面突然加深至 73km ,在柴达木盆地莫霍面又抬升至 5 8km左右 ,然后 ,在松潘甘孜地块莫霍面降至 70km ,并呈现为台阶状向龙门山方向抬升到 6 0km左右 ,最后在四川盆地 ,莫霍面的埋深仅为 5 2km .以昆仑断裂为界 ,在其北部地区的中地壳底部存在一速度为 5 80km s的低速层 ,而在其南部地区则没有低速层出现 ,推测低速层为地壳中部的局部熔融物质 .阿尔金—龙门山剖面上的两个莫霍面坳陷区分别与祁连地块和松潘—甘孜地块上的两个莫霍面坳陷区相对应 ,指示出这两个地块具有较深的山根 ,青藏高原北部的巨厚地壳很可能是由于中生代以来发生的印度板块与亚洲板块碰撞时受到来自东西及南北方向的挤压 ,使地壳缩短所致 .

关键词：阿尔金-龙门山地学断面地壳纵波结构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extensive adhesion formation in a total knee replacement in the setting of a gastrointestinal stromal tumor:A case report

引用

World Journal of Orthopedics 2022年第5期13卷 538-543页

作者： Steven Mitchell Anderson Lee Ryan Stenquist David YatsonskyⅡ Megan L mooney Vithal B Shendge Department of Orthopaedic Surgery The University of Toledo Medical CenterToledoOH 43614United States

BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare primary neoplasms of the gastrointestinal tract,accounting for 1%to 2%of all gastrointestinal neoplasms *** are frequently discovered incidentally during workup for other diagnosis or intestinal obstruction,as they can present with few or no ***,GISTs confer a high degree of malignant transformation,with a progression in about 10%to 30%of *** SUMMARY A 63-year-old healthy female presented to our institution with complaints of right knee pain and limited passive and active motion in the setting of a previous right total knee arthroplasty(TKA).One year after TKA,the patient was incidentally diagnosed with a GIST,which was successfully *** removal,the patient continued to have limited range of motion of the right knee and subsequently underwent revision *** significant fibrotic adhesions were found encapsulating the femoral and tibial *** patient’s pain improved postoperatively,however,she continued to have decreased range of motion with difficulty *** We propose that this case may demonstrate a proinflammatory milieu arising from a GIST,which had a direct influence on the outcome of recent total knee *** proposed mechanism between neoplastic cytokinetic activity and adhesion formation could have implications on preoperative and postoperative orthopedic management of total knee arthroplasty.

关键词： Gastrointestinal stromal tumor Adhesion formation Total knee arthroplasty Inflammatory response Decreased range of motion Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Developments of Earthquake Early Warning in California,USA

引用

Earthquake Research in China 2014年第3期28卷 274-284页

作者： Wang Honglei Walter D.mooney Earthquake Administration of Hebei Province Earthquake Science Center USGS345 Middlefield Rd.

In this paper we outline the science,engineering,and societal considerations of the prototype Earthquake Early Warning System( EEWS) in California and detail the development and testing of methodologies in the last 10 years in America. Also,we give a brief introduction of Earthquake Early Warning( EEW) in China,and based on the summary of EEW in California we make an analysis of the perspectives,misconceptions,and challenges that China may have.

关键词： Earthquake Early Warning Prototype ShakeAlert California

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nursing Staff’s Experiences of Providing Toilet Assistance to Elderly Nursing Home Residents with Urinary Incontinence

引用

Open Journal of Nursing 2017年第2期7卷 145-157页

作者： Doris Hagglund Emma Momats Tiffany mooney Department of Nursing School of EducationHealth and Social StudiesDalarna UniversityFalunSweden Mora Emergency Ward MoraSweden Leksand Primary Health Care Clinic LeksandSweden

Introduction: Urinary incontinence is a common condition among elderly. It affects their daily life and quality of life. Toilet assistance may decrease urinary incontinence episodes among elderly. Many nursing home residents do not receive the available evidence-based toilet assistance they need. Aim: The aim of the present study was to describe nursing staff members’ experiences of providing toilet assistance to elderly nursing home residents with urinary incontinence. Design: A descriptive design with a qualitative content analysis method was used. Method: Four nurses and seven auxiliary nurses were interviewed in three homogenous focus groups. Data were collected during spring 2015. Results: The most essential opportunity factor for good toilet assistance was the nursing staff’s attitude and behavior regarding the elderly’s need to visit the lavatory. This resulted in individual toilet assistance in which the elderly’s integrity and needs were cared for. Functioning routines and sufficient staff availability were crucial in determining whether the elderly could visit the lavatory. Other enabling factors for good toilet assistance were information and education of staff. The main obstructing factors for good toilet assistance were the elderly’s decreased cognitive ability, negative attitudes toward receiving toilet assistance and lack of communication and co-operation between professionals with regard to prescribing and fastening individual incontinence aids. Conclusion: Providing toilet assistance is a considerable nursing intervention for elderly to help them regain continence or contain incontinence, whenever possible. Person-centered incontinence care is important for developing and adjusting toilet assistance based on each older person’s individual needs.

关键词： Focus Groups Nursing Staff Nursing Home Residents Toilet Assistance Urinary Incontinence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

芦山Mw6.6级地震烈度调查及北美震例对比分析

引用

地震工程与工程振动 2014年第S1期34卷 108-117页

作者：王红蕾 WalterD.mooney 河北省地震局河北石家庄050021 美国地质调查局地震科研中心美国加利福尼亚门罗帕克94025

2013年4月20日,四川雅安-芦山地区发生了Mw6.6级强震,该地震造成了严重的人员伤亡和经济损失,引起了国内外地震学者的广泛关注。美国地质调查局地球物理学家Walter ***和河北省地震局科研人员王红蕾分别在震后进入震区,在震中35 km的范... 详细信息

2013年4月20日,四川雅安-芦山地区发生了Mw6.6级强震,该地震造成了严重的人员伤亡和经济损失,引起了国内外地震学者的广泛关注。美国地质调查局地球物理学家Walter ***和河北省地震局科研人员王红蕾分别在震后进入震区,在震中35 km的范围内进行了地震灾害调查和烈度评定。根据修正麦加利地震烈度表(MMI),将考察区域内地震烈度划分为IX度到VI度分布。通过国家数字强震动台网获取了震中40 km范围的地面峰值加速度(PGA)从1005~270 cm/s2,地面峰值速度(PGV)从25.6~11.8 cm/s。将此次芦山地震观测到的地震烈度与PGA和PGV建立相关性关系并与发生在美国加利福尼亚州和美国东部的震例的相关性关系做了比较,得出MMIPGA/PGV关系中,地震烈度VI度到VII度中对应的PGA数据比美国震例的数据高出2~3倍。

关键词：芦山地震地震烈度强震动记录震中距美国震例

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：