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Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1796-1807页

作者： Ren-Qi Mu Jun-Wei Lv cai-yun ma Xiao-Hui ma Dong Xing Hou-Sheng ma Department of Radiology Yantai Mountain HospitalYantai 264001Shandong ProvinceChina Department of Radiology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina Department of Gynaecology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina The First Clinical Medical College Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Rectal carcinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of *** present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum carbohydrate antigen 19-9(CA19-9)and CA125 Levels have been used in clinical practice to evaluate the T stage and differentiation of ***,the accuracy of these evaluation modalities still needs further *** study explores the application and value of these methods in evaluating the T stage and differentiation degree of *** To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathological processes and prognosis of RC *** A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from may 2018 to January *** were categorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation *** addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation *** levels of DCE-MRI parameters and serum CA19-9 and CA125 in different groups of patients were *** addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(Ve)in assessing the differentiation and T staging of RC patients was ***,the usefulness of DCE-MRI parameters combined with serum CA19-9 and CA125 Levels in the evaluation of RC differentiation and T staging was *** Ktrans,Ve,CA19-9 and CA125 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(P<0.05).The areas under the curve(AUCs)of the Ktran and Ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0

关键词： Rectal carcinoma Volume transfer constant Rate constant Extravascular extracellular volume fraction Serum carbohydrate antigen 19-9 Serum carbohydrate antigen 125

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Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Parkinson’s disease in rats

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Neural Regeneration Research 2023年第5期18卷 1090-1098页

作者： Yu Guo Yuan-Yuan Wang Ting-Ting Sun Jia-Jia Xu Pan Yang cai-yun ma Wei-Jun Guan Chun-Jing Wang Gao-Feng Liu Chang-Qing Liu School of Laboratory Medicine School of Life SciencesBengbu Medical CollegeBengbuAnhui ProvinceChina National Germplasm Resource Center for Domestic Animals Institute of Animal ScienceChinese Academy of Agricultural ScienceBeijingChina Department of Neuroscience University of Connecticut Health CenterFarmingtonCTUSA

Neural progenitor cells(NPCs) capable of self-renewal and differentiation into neural cell lineages offer broad prospects for cell therapy for neurodegenerative diseases. However, cell therapy based on NPC transplantation is limited by the inability to acquire sufficient quantities of NPCs. Previous studies have found that a chemical cocktail of valproic acid, CHIR99021, and Repsox(VCR) promotes mouse fibroblasts to differentiate into NPCs under hypoxic conditions. Therefore, we used VCR(0.5 mM valproic acid, 3 μM CHIR99021, and 1 μM Repsox) to induce the reprogramming of rat embryonic fibroblasts into NPCs under a hypoxic condition(5%). These NPCs exhibited typical neurosphere-like structures that can express NPC markers, such as Nestin, SRY-box transcription factor 2, and paired box 6(Pax6), and could also differentiate into multiple types of functional neurons and astrocytes in vitro. They had similar gene expression profiles to those of rat brain-derived neural stem cells. Subsequently, the chemically-induced NPCs(ciNPCs) were stereotactically transplanted into the substantia nigra of 6-hydroxydopamine-lesioned parkinsonian rats. We found that the ciNPCs exhibited long-term survival, migrated long distances, and differentiated into multiple types of functional neurons and glial cells in vivo. Moreover, the parkinsonian behavioral defects of the parkinsonian model rats grafted with ciNPCs showed remarkable functional recovery. These findings suggest that rat fibroblasts can be directly transformed into NPCs using a chemical cocktail of VCR without introducing exogenous factors, which may be an attractive donor material for transplantation therapy for Parkinson’s disease.

关键词： cell reprogramming cell transplantation hypoxia neural progenitor cells neurological function Parkinson’s disease small molecule compounds substantia nigra

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Preparation and performance evaluation of the slickwater using novel polymeric drag reducing agent with high temperature and shear resistance ability

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Petroleum Science 2024年第2期21卷 1113-1121页

作者： Ming-Wei Zhao Zhen-Feng ma cai-Li Dai WeiWu Yong-Quan Sun Xu-Guang Song yun-Long Cheng Xiang-Yu Wang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao266580ShandongChina Sinopec Shengli Oilfield Dongying257001ShandongChina Department of Chemical and materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada East China Petroleum Bureau of Sinopec Nanjing210011JiangsuChina

Slickwater fracturing fluids are widely used in the development of unconventional oil and gas resources due to the advantages of low cost,low formation damage and high drag reduction ***,their performance is severely affected at high *** reducing agent is the key to determine the drag reducing performance of *** this work,in order to further improve the temperature resistance of slickwater,a temperature-resistant polymeric drag reducing agent(PDRA)was synthesized and used as the basis for preparing the temperature-resistant *** slickwater system was prepared with the compositions of 0.2 wt%PDRA,0.05 wt%drainage aid nonylphenol polyoxyethylene ether phosphate(NPEP)and 0.5 wt%anti-expansion agent polyepichlorohydrindimethylamine(PDM).The drag reduction ability,rheology properties,temperature and shear resistance ability,and core damage property of slickwater were systematically studied and *** contrast to on-site drag reducing agent(DRA)and HPAM,the temperature-resistant slickwater demonstrates enhanced drag reduction efficacy at 90℃,exhibiting superior temperature and shear resistance ***,the drag reduction retention rate for the slickwater achieved an impressive 90.52%after a 30-min shearing ***,the core damage is only 5.53%.We expect that this study can broaden the application of slickwater in high-temperature reservoirs and provide a theoretical basis for field applications.

关键词： Unconventional resources Polymeric drag reducing agent Slickwater High drag reduction rate Temperature resistance

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Particle residence time distribution and axial dispersion coefficient in a pressurized circulating fluidized bed by using multiphase particle-in-cell simulation

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Chinese Journal of Chemical Engineering 2024年第5期69卷 167-176页

作者： Jinnan Guo Daoyin Liu Jiliang ma cai Liang Xiaoping Chen Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education Southeast UniversityNanjing 210096China

The particle residence time distribution(RTD)and axial dispersion coefficient are key parameters for the design and operation of a pressurized circulating fluidized bed(PCFB).In this study,the effects of pressure(0.1-0.6 MPa),fluidizing gas velocity(2-7 m·s^(-1)),and solid circulation rate(10-90 kg·m^(-2)·s^(-1))on particle RTD and axial dispersion coefficient in a PCFB are numerically investigated based on the multiphase particle-in-cell(MP-PIC)*** details of the gas-solid flow behaviors of PCFB are *** on the gas-solid flow pattern,the particles tend to move more orderly under elevated *** an increase in either fluidizing gas velocity or solid circulation rate,the mean residence time of particles decreases while the axial dispersion coefficient *** an increase in pressure,the core-annulus flow is strengthened,which leads to a wider shape of the particle RTD curve and a larger mean particle residence *** back-mixing of particles increases with increasing pressure,resulting in an increase in the axial dispersion coefficient.

关键词： Pressurized circulating fluidized bed MP-PIC method Residence time distribution Axial dispersion coefficient

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SDCC: software-defined collective communication for distributed training

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Science China(Information Sciences) 2024年第9期67卷 105-125页

作者： Xin JIN Zhen ZHANG yunshan JIA yun ma Xuanzhe LIU School of Computer Science Peking University Department of Computer Science and Technology Johns Hopkins University

Communication is crucial to the performance of distributed training. Today's solutions tightly couple the control and data planes and lack flexibility, generality, and performance. In this study, we present SDCC, a software-defined collective communication framework for distributed training. SDCC is based on the principle of modern systems design to effectively decouple the control plane from the data *** abstracts the operations for collective communication in distributed training with dataflow operations and unifies computing and communication with a single dataflow graph. The abstraction, together with the unification, is powerful: it enables users to easily express new and existing collective communication algorithms and optimizations, simplifies the integration with different computing engines(e.g., Py Torch and Tensor Flow) and network transports(e.g., Linux TCP and kernel bypass), and allows the system to improve performance by exploiting parallelism exposed by the dataflow graph. We further demonstrate the benefits of SDCC in four use cases.

关键词： machine learning systems distributed training deep learning collective communication software-defined networking

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Age of Information for Short-Packet Covert Communication with Time Modulated Retrodirective Array

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China Communications 2024年第4期21卷 23-37页

作者： ma Yue ma Ruiqian Lin Zhi Yang Weiwei cai Yueming Miao Chen Wu Wen Key Laboratory of Near-Range RF Sensing ICs&Microsystems(NJUST) Ministry of EducationSchool of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China College of Electronic Engineering National University of Defense TechnologyHefei 230037China College of Communications Engineering Army Engineering University of PLANanjing 210007China

In this paper,the covert age of information(CAoI),which characterizes the timeliness and covertness performance of communication,is first investigated in the short-packet covert communication with time modulated retrodirective array(TMRDA).Specifically,the TMRDA is designed to maximize the antenna gain in the target direction while the side lobe is sufficiently *** this basis,the covertness constraint and CAoI are derived in closed *** facilitate the covert transmission design,the transmit power and block-length are jointly optimized to minimize the CAoI,which demonstrates the trade-off between covertness and *** results illustrate that there exists an optimal block-length that yields the minimum CAoI,and the presented optimization results can achieve enhanced performance compared with the fixed block-length ***,we observe that smaller beam pointing error at Bob leads to improvements in CAoI.

关键词： age of information covert communication retrodirective array time modulation

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Microstructures,Deformation Mechanisms and Seismic Properties of Synkinematic Migmatite from Southeastern Tibet:Insights from the Migmatitic Core of the Ailao Shan-Red River Shear Zone,Western yunnan,China

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Journal of Earth Science 2024年第4期35卷 1149-1169页

作者： Weiwei ma Bo Zhang Fulong cai Baoyou Huang Lei Zhang Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing100871China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing100085China

Seismic anisotropy originating within the continental crust is commonly used to determine the deformation and kinematic flow within active orogens and is attributed to regionally oriented mica or hornblende ***,naturally deformed rocks usually contain compositional layers(e.g.,parallel compositional banding).It is necessary to understand how both varying mineral contents and differing intensities of compositional layering influence the seismic properties of the deep *** this study,we analyzed the seismic response of migmatitic amphibolite with compositional banding *** present the microstructures,fabrics,calculated seismic velocities,and seismic anisotropies of mylonitic amphibolite from a horizontal shear layer preserved within the Ailao Shan-Red River shear zone,southwestern yunnan,*** investigated sample is characterized by pronounced centimeter-scale compositional *** microstructures and fabrics suggest that migmatitic amphibolite rocks within deep crust may delineate regions of deformation-assisted,channelized,reactive,porous melt *** origin of compositional banding in the studied migmatitic amphibolite is attributed primarily to partial melting together with some horizontal shearing *** microfabrics and structures investigated in this study are considered to be typical for the base of active horizontal shear layers in the deep crust of southeastern *** responses are modeled by using crystal preferred orientations for minerals of the migmatitic amphibolite by applying the Voigt-Reuss-Hill homogenization *** P-wave and S-wave velocities are largely consistent in the various layers of the ***,seismic anisotropies of P-wave(AV_(p))and S-wave(AVs)are higher in the melanosomes(AV_(p)=5.6%,AV_(s)=6.83%)than those in the leucosomes and the whole rock(AV_(p)=4.2%–4.6%,AV_(s)=3.1%–3.2%).In addition,there is pronounced,S-wave splitting oblique to the foliation plane in the migm

关键词： deformation-assisted melt flow seismic anisotropy microstructure compositional banding migmatite deep crust southeastern Tibet

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Roughness characterization and shearing dislocation failure for rock-backfill interface

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International Journal of Minerals,Metallurgy and materials 2024年第6期31卷 1167-1176页

作者： Meifeng cai Zhilou Feng Qifeng Guo Xiong Yin Minghui ma Xun Xi Key Laboratory of High-Efficient Mine and Safety of Metal Mines of Ministry of Education Beijing 100083China Key Laboratory of Urban and Underground Space Engineering University of Science and Technology BeijingBeijing 100083China Shandong Gold Group Co LtdJinan 250102China

Shearing dislocation is a common failure type for rock–backfill interfaces because of backfill sedimentation and rock strata movement in backfill mining *** paper designed a test method for rock–backfill shearing *** digital image techno-logy and three-dimensional(3D)laser morphology scanning techniques,a set of 3D models with rough joint surfaces was ***,the mechanical behavior of rock–backfill shearing dislocation was investigated using a direct shear *** effects of interface roughness on the shear–displacement curve and failure characteristics of rock–backfill specimens were *** 3D fractal dimen-sion,profile line joint roughness coefficient(JRC),profile line two-dimensional fractal dimension,and the surface curvature of the frac-tures were *** correlation characterization of surface roughness was then analyzed,and the shear strength could be measured and calculated using *** results showed the following:there were three failure threshold value points in rock–backfill shearing dis-location:30%–50%displacement before the peak,70%–90%displacement before the peak,and 100%displacement before the peak to post-peak,which could be a sign for rock–backfill shearing dislocation *** surface JRC could be used to judge the rock–backfill shearing dislocation failure,including post-peak sliding,uniform variations,and gradient change,corresponding to rock–backfill disloca-tion failure on the field *** research reveals the damage mechanism for rock–backfill complexes based on the free joint surface,fills the gap of existing shearing theoretical systems for isomerism complexes,and provides a theoretical basis for the prevention and control of possible disasters in backfill mining.

关键词： rock–backfill roughness correlation characterization shearing dislocation interface failure

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Study on trifluoromethanesulfonic acid-promoted synthesis of daidzein: Process optimization and reaction mechanism

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Chinese Journal of Chemical Engineering 2024年第7期71卷 132-139页

作者： Hai Cao Haibin Yang Yanxiong Fang Yuandi Zeng Xiaolan cai Jingjing ma School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Daidzein has been widely used in pharmaceuticals,nutraceuticals,cosmetics,feed additives,*** preparation process and related reaction mechanism need to be further investigated.A cost-effective process for synthesizing daidzein was developed in this *** this article,a two-step synthesis of daidzein(Friedel–Crafts acylation and[5+1]cyclization)was developed via the employment of trifluoromethanesulfonic acid(TfOH)as an effective promoting *** effect of reaction conditions such as solvent,the amount of TfOH,reaction temperature,and reactant ratio on the conversion rate and the yield of the reaction,respectively,was systematically investigated,and daidzein was obtained in 74.0%isolated yield under optimal *** to the facilitating effect of TfOH,the Friedel–Crafts acylation was completed within 10 min at 90℃ and the[5+1]cyclization was completed within 180 min at 25℃.In addition,a possible reaction mechanism for this process was *** results of the study may provide useful guidance for industrial production of daidzein on a large scale.

关键词： Synthesis Optimal design Chemical processes Reaction mechanism

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Promoted Non-enzymatic Glucose Sensor Based on Synergistic Effect of Hydrothermal Synthesized Ni(OH)2-Graphene Nanocomposite

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 914-921页

作者： cai, Yuqing Cui, Qingyan Zhang, Huanrong ma, Xinlei Xue, Mianqi Renmin Univ China Sch Chem & Life Resources Beijing 100872 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Beijing 100190 Peoples R China

Although glucose electrochemical sensors based on enzymes play a dominant role in market, their stability remains a problem due to the inherent nature of enzymes. Therefore, glucose sensors that are independent on enzymes have attracted more attention for the development of stable detection devices. Here we present an enzyme-free glucose sensor based on Ni(OH)(2) and reduced graphene oxide (rGO). The as-fabricated sensor still exhibits excellent electrocatalytic activity for detecting glucose under enzyme independent conditions. The enhanced catalytic performance may due to synergistic effect as follows: (i) the interaction between the Ni2+ and pi electron of graphene induces the formation of the beta-phase Ni(OH)(2) with higher catalytic activity; (ii) the frozen dry process works as a secondary filtration, getting rid of poorly formed Ni(OH)(2) particles with low catalytic activity; (iii) the rGO network with good conductivity provides a good electronic pathway for promoting electron transfer to reduce the response time. Based on the synergistic effect, the sensor exhibits a wide linear detection range from 0.2 mu mol/L to 1.0 mu mol/L and a low detection limit (0.1 mu mol/L, S/N=3). The excellent detection performance, as well as the easy and low-cost preparation method, suggests the promising applicability of the sensor in the glucose detection market.

关键词： Glucose sensing Non-enzyme sensor Graphene 2D material Ni(OH)(2) nanosheet GRAPHENE OXIDE DIABETES maNAGEMENT ARCHITECTURE

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