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Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

Traditional Medicine Research 2024年第6期9卷 42-54页

作者： Jing-Yan yang xiao-Xing Li Juan Chen Yan-Jun Liu Yue-Hong Wu Ning-Yu Luo cai-xia yang yang Li Si-Jing Liu Jin-Lin Guo College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chengdu 611137China Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still ***,our study aimed to investigate the impact of Jianqu on functional dyspepsia in ***:The phytochemical profile of Jianqu was analyzed by ***,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit *** pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin *** occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical ***,the serum gastrointestinal hormones were detected by *** addition,the gut microbiota composition was determined using 16S rRNA gene *** cecal short chain fatty acids were assessed by gas ***:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(p<0.01),increased the body weight and food intake(p<0.0001)in HCHP mice as *** HCHP did not cause significant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(p<0.05)was ***,Jianqu attenuated this abnormal expression of CD45(p<0.05).The levels of serum gastrointestinal hormones were significantly normalized by Jianqu intervention(p<0.05).Moreover,Jianqu increased the relative abundance of Roseburia as well as short chain fatty acids levels in cecum(p<0.05).Conclusion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal *** effects may be partly related to the increasing cecal short ch

关键词： herbal formula dyspepsia gastrointestinal hormones gastric emptying intestinal transit

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Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes:a bioinformatics analysis

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1411-1417页

作者： cai-Han Yu cai-xia Wu Dai Li Lan-Lan Gong Xu-Dong Lyu Jie yang Department of Ophthalmology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Optometry Hubei University of Science and TechnologyXianning 430071Hubei ProvinceChina

AIM:To prevent neovascularization in diabetic retinopathy(DR)patients and partially control disease ***:Hypoxia-related differentially expressed genes(DEGs)were identified from the GSE60436 and GSE102485 datasets,followed by gene ontology(GO)functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** candidate drugs were screened using the CMap ***,a protein-protein interaction(PPI)network was constructed to identify hypoxia-related hub genes.A nomogram was generated using the rms R package,and the correlation of hub genes was analyzed using the Hmisc R *** clinical significance of hub genes was validated by comparing their expression levels between disease and normal groups and constructing receiver operating characteristic curve(ROC)***,a hypoxia-related miRNA-transcription factor(TF)-Hub gene network was constructed using the NetworkAnalyst online ***:Totally 48 hypoxia-related DEGs and screened 10 potential candidate drugs with interaction relationships to upregulated hypoxia-related genes were identified,such as ruxolitinib,meprylcaine,and *** addition,8 hub genes were also identified:glycogen phosphorylase muscle associated(PYGM),glyceraldehyde-3-phosphate dehydrogenase spermatogenic(GAPDHS),enolase 3(ENO3),aldolase fructose-bisphosphate C(ALDOC),phosphoglucomutase 2(PGM2),enolase 2(ENO2),phosphoglycerate mutase 2(PGAM2),and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3).Based on hub gene predictions,the miRNA-TF-Hub gene network revealed complex interactions between 163 miRNAs,77 TFs,and hub *** results of ROC showed that the except for GAPDHS,the area under curve(AUC)values of the other 7 hub genes were greater than 0.758,indicating their favorable diagnostic ***:PYGM,GAPDHS,ENO3,ALDOC,PGM2,ENO2,PGAM2,and PFKFB3 are hub genes in DR,and hypoxia-related hub genes exhibited favorable diagnostic perform

关键词： diabetic retinopathy hypoxia-related genes hub genes miRNA-TF-Hub gene drug prediction

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High-resolution neutronics model for ^(238)Pu production in high-flux reactors

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Nuclear Science and Techniques 2024年第5期35卷 226-236页

作者： Qing-Quan Pan Qing-Fei Zhao Lian-Jie Wang Bang-yang xia Yun cai Jin-Biao Xiong xiao-Jing Liu School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610200China

We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux *** filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1 eV,thereby constructing the importance curve and yield curve of the full energy *** burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme *** three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were *** neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 18.81%.The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.

关键词： ^(238)Pu Neutronics model High-flux reactor Spectrum resolution Spectrum optimization

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The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao Dali Wei Qinglai yang cai yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian xia Gang Huang Jianjun Liu Zeyu xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

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Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles

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Food Science and Human Wellness 2024年第3期13卷 1303-1310页

作者： Qile xia Yan Liang Ailing Cao Yan Cao Luyun cai Key Laboratory of Post-Harvest Handling of Fruits Food Science InstituteZhejiang Academy of Agricultural SciencesHangzhou 310021China Ningbo Research Institute College of Biosystems Engineering and Food ScienceZhejiang UniversityNingbo 315100China School of Biological and Chemical Engineering Zhejiang Engineering Research Center for Intelligent Marine Ranch EquipmentNingboTech UniversityNingbo 315100China College of Food Science and Engineering Bohai UniversityJinzhou 121013China Hangzhou Customs District Hangzhou 310007China

In this paper,tannic acid(TA)and Fe~(3+)were added to form a layer of metal-polyphenol network structure on the surface of the nanoparticles which were fabricated by zein and carbon quantum dots(CQDs)encapsulating phlorotannins(PTN).pH-Responsive nanoparticles were prepared successfully(zein-PTN-CQDs-Fe-~Ⅲ).Further,the formation of composite nanoparticles was confirmed by a series of characterization *** zeta-potential and Fourier transform infrared spectroscopy data proved that electrostatic interaction and hydrogen bonding are dominant forces to form *** encapsulation efficiency(EE)revealed that metal-polyphenol network structure could improve the EE of *** analysis and differential scanning calorimetry experiment indicated the thermal stability of zein-PTN-CQDs-Fe~Ⅲnanoparticles increased because of metal-polyphenol network *** pH-responsive nanoparticles greatly increased the release rate of active substances and achieved targeted release.

关键词： Metal Phlorotannins Nanoparticles pH-Responsive Characterization

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Genetic parameter evaluation for growth and cold resistance traits of the giant freshwater prawn Macrobrachium rosenbergii

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Journal of Oceanology and Limnology 2024年第2期42卷 609-619页

作者： Haihui TU Qianqian XING Zhenxiao ZHONG Qiongying TANG Shaokui YI Zhenglong xia Miaoying cai Jingfen LI Quanxin GAO Guoliang yang Zhejiang Provincial Key Laboratory of Aquatic Resources Conservation and Development College of Life SciencesHuzhou UniversityHuzhou 313000China Fengjiashan Reservoir Administration Bureau Baoji 721300China Jiangsu Shufeng Prawn Breeding Co.Ltd. Gaoyou 225654China

The giant freshwater prawn Macrobrachium rosenbergii distributed from tropical to subtropical regions,is a warm-water species,and its survival temperature is 14-35°C,which greatly limits its culture cycle and culture area in ***,it is urgent to cultivate a new high quality,high yield variety with improved cold-resistance,but the genetic parameters for cold-resistance traits are unknown in *** this study,the cold-resistance of adult *** populations was tested using the indoor artificial cooling *** were selected from 139 families of Shufeng G3 generation and cultured for 200 days.A linear mixed model was constructed by ASReml-R to evaluate the genetic parameters of the cold-resistance trait(cooling degree hours,CDH)and growth traits(body weight,BW,and body length,BL)based on the restricted maximum likelihood(REML)*** results show that the heritability of CDH was low(0.12±0.05),while the growth traits(BW and BL)had low to moderate heritability,with 0.20±0.06 for BW and 0.06±0.04 for *** phenotypic and genetic correlation between BW and BL was significantly positive,but significantly negative phenotypic and genetic correlations were detected between CDH and BW and between CDH and ***,the analysis of the differences between cold-resistance and phenotypic traits showed that the female reproductive status,exoskeleton hardness and claw number of adult prawns had a great influence on the cold-resistance of ***(P<0.05),indicating that adults with claws and hard exoskeletons are preferred as parents in subsequent breeding *** present results can be attributed to the selection and breeding of a new cold-resistant variety of ***.

关键词： cold-resistance growth traits heritability correlation Macrobrachium rosenbergii

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Different lymph node staging systems for predicting the prognosis of colorectal neuroendocrine neoplasms

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1745-1755页

作者： Yuan-Yi Zhang Yue-Wei cai xia Zhang Department of Pathology Zhaoqing Medical CollegeZhaoqing 526020Guangdong ProvinceChina Department of Emergency Zhaoqing Second People’s HospitalZhaoqing 526020Guangdong ProvinceChina Department of Pathology and Physiology Zhaoqing Medical CollegeZhaoqing 526020Guangdong ProvinceChina

BACKGROUND Colorectal neuroendocrine neoplasms(NENs)are a rare malignancy that primarily arises from the diffuse distribution of neuroendocrine cells in the colon and *** studies have pointed out that the status of lymph node may be used to predict the *** To investigate the predictive values of lymph node ratio(LNR),positive lymph node(PLN),and log odds of PLNs(LODDS)staging systems on the prognosis of colorectal NENs treated surgically,and compare their predictive *** This cohort study included 895 patients with colorectal NENs treated surgically from the Surveillance,Epidemiology,and End Results *** endpoint was mortality of patients with colorectal NENs treated surgically.X-tile software was utilized to identify most suitable thresholds for categorizing the LNR,PLN,and *** were selected in a random manner to form training and testing *** prognosis of surgically treating colorectal NENs was examined using multivariate cox analysis to assess the associations of LNR,PLN,and LODDS with the prognosis of colorectal NENs.C-index was used for assessing the predictive *** conducted a subgroup analysis to explore the different lymph node staging systems’predictive *** After adjusting all confounding factors,PLN,LNR and LODDS staging systems were linked with mortality in patients with colorectal NENs treated surgically(P<0.05).We found that LODDS staging had a higher prognostic value for patients with colorectal NENs treated surgically than PLN and LNR staging *** results were obtained in the different G staging subgroup ***,the area under the receiver operating characteristic curve values for LODDS staging system remained consistently higher than those of PLN or LNR,even at the 1-,2-,3-,4-,5-and 6-year follow-up *** LNR,PLN,and LODDS were found to significantly predict the prognosis of patients with colorectal NENs treated surgically.

关键词： Positive lymph node Lymph node ratio Log odds of positive lymph nodes Prognosis Colorectal neuroendocrine neoplasms

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Subnanometric bimetallic Pt-Pd clusters in zeolites for efficient hydrogen production and selective tandem hydrogenation of nitroarenes

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Science China Chemistry 2024年第9期67卷 2911-2917页

作者： Jiafu Li Tao cai Yanran Feng xia Liu Ning Wang Qiming Sun Institute of Sustainable Energy and Resources College of Chemistry and Chemical EngineeringKey Laboratory of Shandong Provincial Universities for Functional Molecules and MaterialsQingdao UniversityQingdao 266071China Innovation Center for Chemical Sciences College of ChemistryChemical Engineering and Materials ScienceJiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China

The solvolysis of ammonia borane(AB)and the hydrogenation of nitroarenes represent significant reactions for hydrogen generation and value-added chemical *** strategic engineering of the catalysts is imperative for surmounting obstacles associated with their stability and catalytic *** this work,subnanometric bimetallic Pt–Pd clusters were encapsulated within silicalite-1(S-1)zeolites through a ligand-protected in-situ hydrothermal synthesis *** synergetic effect of bimetallic composition and zeolite confinement markedly enhances the catalytic performance of representative Pt_(0.5)Pd_(0.5)@S-1-H catalyst,affording exceptional turnover frequency(TOF)values of 1,043 and 573 mol_(H_(2))mol_(metal)^(-1)min^(-1)for AB hydrolysis and methanolysis at ambient conditions,respectively,surpassing most of the state-of-the-art Pt-based *** and isotopic experiments reveal that the bimetallic catalytic system remarkably boosts the O-H cleavage of water,thereby facilitating the H_(2) production from AB ***,a conspicuous synergistic effect is demonstrated in the shape-selective tandem hydrogenation of nitroarenes,with the bimetallic catalyst facilitating both AB hydrolysis and nitroarene hydrogenation,giving a high TOF value of 1,260 h^(-1)under atmospheric *** study not only demonstrates the effectiveness of bimetallic nanocatalysts encapsulated in zeolites for hydrogen production from chemical hydrogen storage materials,but also paves the way for the design of catalysts with multifunctional active sites capable of synergistically promoting tandem catalytic processes.

关键词： subnanometer bimetallic cluster zeolite synergistic effect ammonia borane solvolysis selective tandem hydrogenation

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Examining the association between delay discounting,delay aversion and physical activity in Chinese adults with type-2 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 675-685页

作者： Yong-Dong An Guo-xia Ma Xing-Kui cai Ying yang Fang Wang Zhan-Lin Zhang Department of Endocrinology People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina Department of Gynecology People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina The First Clinical Medical College Lanzhou UniversityLanzhou 730013Gansu ProvinceChina Department of Internal Medicine People's Hospital of HezhengLinxia Hui Autonomous Prefecture 731200Gansu ProvinceChina Department of Geratology People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina Department of Medical People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina

BACKGROUND The role of physical activity in diabetes is critical,influencing this disease's development,man-agement,and overall *** China,22.3%of adults do not meet the minimum level of physical activity recommended by the World Health ***,it is imperative to identify the factors that contributing to lack of physical activity must be *** To investigate the relationship among delay discounting,delay aversion,glycated hemoglobin(HbA1c),and various levels of physical activity in Chinese adults diagnosed with type 2 diabetes mellitus(T2DM).METHODS In 2023,400 adults with T2DM were recruited from the People's Hospital of Linxia Hui Autonomous Prefecture of Gansu Province.A face-to-face questionnaire was used to gather demographic data and details on physical activity,delay discounting,and delay *** addition,HbA1c levels were measured in all 400 *** primary independent variables considered were delay discounting and delay *** outcome variables included HbA1c levels and different intensity levels of physical activity,including walking,moderate physical activity,and vigorous physical *** linear regression models were utilized to assess the relationship between delay discounting,delay aversion,and HbA1c levels,along with the intensity of different physical activity measured in met-hours per *** After controlling for the sample characteristics,delay discounting was negatively associated with moderate physical activity(β=-2.386,95%CI:-4.370 to-0.401).Meanwhile,delay aversion was negatively associated with the level of moderate physical activity(β=-3.527,95%CI:-5.578 to-1.476)in the multiple linear regression model,with statistically significant *** Elevated delay discounting and increased delay aversion correlated with reduced levels of moderate physical *** suggests that delay discounting and aversion may influence engagement in moderate physical activity.

关键词： Type 2 diabetes mellitus Delay discounting Delay aversion Physical activity

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Research on Evaluating the Efficiency of the Project Financing of the Energy Service Company

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Frontiers of Engineering Management 2016年第3期3卷 252-257页

作者： Bao-zhen Zhang Han-ding Guo cai-xia yang Lei Wang School of Economics & Management Tianjin Chengjian University Tianjin Institute China Academy of Building Research

The financing efficiency evaluation of the ESCO(Energy Service Company) is an important approach to improve the operation efficiency of existing building energy-saving projects. To scientifically and reasonably evaluate the financing efficiency of the ESCO,this paper puts forward a combination evaluation model based on the method set. Firstly, the method set is composed of different methods that meet the demand of statistical coherence, and KENALL-W coefficient test of concordance is used to check up the coherence of the ranking results of the different methods. Secondly, mean,Borda and Copeland are used separately for calculating the combination evaluation results and the circular combination method is used to ensure the coherence of evaluation results. Finally, the combination evaluation model is used to evaluate the 10 ESCO business project financing benefits, and the effectiveness of the models is verified accordingly.

关键词： ESCO project financing financing efficiency method set combination evaluation

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