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Chinese Chemical Letters 2008年第3期19卷 329-332页

作者： cai sheng wu Bao Lin Guo Yu Xin sheng Jin Lan Zhang Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094 China

In this paper, a sensitive and specific liquid chromatography-electrospray ionisation-mass spectrometry （LC-ESI-MS） method has been developed and validated for the identification and determination of seven flavonoids, namely epimedin A, epimedin B, epimedin C, icariin, sagittatoside B, 2＂-O-rhamnosyl icariside II, and baohuoside I in Epimedium from different sources.

关键词： Flavonoids Epimedium Liquid chromatography-electrospray ionization-mass spectrometry Quantitative determination

Rapid discovery and identification of 68 compounds in the active fraction from Xiao-Xu-Ming decoction(XXMD) by HPLC-HRMS and MTSF technique

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Chinese Chemical Letters 2014年第12期25卷 1648-1652页

作者： cai-Hong Wang cai-sheng wu Hai-Lin Qin Jin-Lan Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines.Institute of Materia Medica Chinese Academy of Medical Sciences  Peking Union Medical College State Key Laboratory of Bioactive Substance and Function of Natural Medicines.Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College

Xiao-Xu-Ming decoction（XXMD） was a traditional Chinese prescription and first recorded in ＂Bei Ji Qian Jin Yao Fang＂.It has been widely used to treat theoplegia and the sequel of theoplegia in *** the present work,high-performance liquid chromatography coupled with high resolution mass spectrometry（HPLC-HRMS） combined with the mass spectral tree similarity filter technique（MTSF）was used to rapidly discover and identify the compounds of the active fraction of XXMD.A total of 3362 compounds were automatically detected by HPLC-HRMS,and final 68 compounds were identified in the active fraction of *** 14 templated compounds（reference compounds）,50 related compounds fished by MTSF technique,and 4 unrelated compounds identified by manual *** study successfully applied MTSF technology for the first time to discover and identify the components of Chinese *** results demonstrated that MTSF technique should be useful to the discovery and identification of compounds in Chinese *** study also proved that MTSF can be applied to the targeted phytochemical separation.

关键词： Xiao-Xu-Ming decoction High-performance liquid chromatography with high resolution mass spectrometry Mass spectral trees similarity filter technique

Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry

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Chinese Chemical Letters 2012年第10期23卷 1185-1188页

作者： cai sheng wu Zhi Xin Jia Bao Ming Ning Jin Lan Zhang Song wu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China National Institutes for Food and Drug Control Beijing 100050 China

In this paper, a high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry （HPLC-UV/FrICRMS） method was described for the investigation of impurity profile in moxifloxacin （MOX） drug substance and chemical reference substance. Ten impurities were detected by HPLC-UV, while eight impurities were identified by using the high accurate molecular mass combined with multiple-stage mass spectrometric data and fragmentation rules. In addition, to our knowledge, five impurities were founded for the first time in MOX drug substance.

关键词： Moxifloxacin (MOX) Impurity profile High-performance liquid chromatography coupled with ultraviolet detection and Fouriertransform-ion cyclotron resonance mass spectrometry (HPLC-UV/bTICRMS)

Simultaneous determination of seven prohibited substances in cosmetic products by liquid chromatography-tandem mass spectrometry

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Chinese Chemical Letters 2013年第6期24卷 509-511页

作者： cai-sheng wu Ying Jin Jin-Lan Zhang Yan Ren Zhi-Xin Jia Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

In this paper,we developed and validated a simple,sensitive,and selective high-performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） method to identify and measure the following prohibited substances that may be found in cosmetic products：minoxidil,hydrocortisone, spironolactone,estrone,canrenone,triamcinolone acetonide and *** separation was performed on a Waters Symmetry C18（100 mm×2.1 mm,3.5μm particle size） with a gradient elution system composed of 0.2%（v/v） formic acid aqueous solution and methanol containing 0.2%（v/v） formic acid at a flow rate of 0.3 mL/*** substances were detected using a triple quadrupole mass spectrometer in the multiple reaction monitoring mode with an electrospray ionization *** of the calibration curves showed good linearity（r 〉 0.999） within the tested concentration *** limit of detection was 〈25 *** relative standard deviations for intraday precision for each of the prohibited substances were 〈3.5%at two concentration levels（2μg/g,10μg/g）. The relative recovery rate for each of the prohibited substances ranged from 91.8%to 111%at three concentration levels（0.1μg/g,2μg/g,10μg/g）,including the limit of *** conclusion,we have developed and validated a method that can identify seven prohibited substances in cosmetic products.

关键词： High-performance liquid chromatographytandem mass spectrometry(HPLC-MS/MS) Cosmetic products Prohibited substances Minoxidil Steroids

Separation, determination of six impurities in methotrexate drug substance using ultra-performance liquid chromatography

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Chinese Chemical Letters 2014年第3期25卷 447-450页

作者： cai-sheng wu cai-Hong Wang Jin-Lan Zhang Dong-Mei Wang Yuan-Feng Tong Song wu Hai-Wei Huang Bao-Ming Ning State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College National Institutes for Food and Drug Control

Methotrexate （MTX） is an antineoplastic therapeutic medicine as antimetabolite of folic acid. In this paper, a sensitive and rapid ultra-performance liquid chromatographic （UPLC） method was developed and validated for the separation and determination of impurities in MTX drug substances. The UPLC method was accomplished on an Agilent Zorbax Extend C-18 （50 mm × 4.6 mm, 1.8 μm） with a gradient elution system composed of sodium dihydrogen phosphate in water （20 mmol/L, pH 3.0） and acetonitrile. The flow rate was 2.2 mL/min. The method was validated. The calibration curves displayed good linearity （r 〉 0.999） within the tested concentration ranges. The limit of detection （LOD） and limit of quantification （LOQ） of the six analytes were all less than 0.774 μg/mL and 1.03μg/mL. The relative standard deviation （RSD） for intra- and inter-day precision of the six analytes was less than 9.8%, including at the LOQ. The average recovery ranged from 95.2% to 103 except at the LOQ where recovery ranged from 82.7% to 117%. The validated method was successfully used to determine the relative abundance of six impurities in the MTX drug substances.

关键词： MethotrexateUltra-performanceLiquid chromatographyImpurity

Simultaneous determination of 14β-lactam antibiotics in cosmetic products by liquid chromatography tandem mass spectrometry method

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Chinese Chemical Letters 2011年第3期22卷 334-337页

作者： cai sheng wu Jin Lan Zhang Yan Ling Qiao Yi Lin Wang Zhi Rong Chen Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

In this study,a simple and rapid high-performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） method was established and validated to determine the 14β-lactam antibiotics in cosmetic products,including 1（ceftazidime）,2（cefaclor）, 3（cefdinir）,4（ampicillin）,5（cefalexin）,6（ceftezole）,7（cefotaxim）,8（cefradine）,9（cefuroxime）,10（cephazoline）,11 （cefathiamidine）,12（cefoperazone）,13（cafalotin）,14（piperacillin）.

关键词： High-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) Cosmetic β-Lactam antibiotics

Synergic catalysis of W and Ni originating from substitution of trivacant phosphotungstate for the selective oxidation of aniline to azoxybenzene

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Chinese Chemical Letters 2024年第2期35卷 558-563页

作者： sheng cai Xiao-Yuan wu Weiming wu Sa-Sa Wang Can-Zhong Lu CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Chinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Partial substitution of polyoxometalate(POM)is an efficient route to modulate the catalytic property of maternal *** this work,a new Keggin type POM involving{Ni 6}cluster,{[Ni(H_(2) O)_(2)(Dach)_(2)][Ni(Dach)_(2)]_(2)}{[Ni_(6)Cl(μ-OH)_(3)(H_(2) O)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))][Ni_(6)(μ-OH)_(3)(H_(2) O)_(2)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))]}Cl·27H_(2) O,(1,Dach=1,2-diaminocyclohexane)was *** 1 shows excellent catalytic performance in the selective oxidation of aniline to azoxybenzene(AOB)in *** apparently different results from that with the matrix{PW 9 O_(3)_(4)}({PW9})suggest the successful regulation of the catalytic property of{PW9}by the introduction of the{Ni6}cluster into the *** experimental results indicate that the highlighted performance of 1 is contributed by the synergy of W and Ni sites,which are respectively responsible for the oxidation and condensation steps in the production of *** good selectivity to AOB is essentially attributed to the effective modulation of the reaction rates of oxidation and condensation steps by W and Ni sites,respectively.

关键词： Polyoxometalate {Ni6}cluster Modulated catalytic property Aniline oxidation Azoxybenzene

Polarized imaging dynamic light scattering for simultaneous measurement of nanoparticle size and morphology

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Particuology 2024年第2期85卷 213-223页

作者： Bingyao Wang Tianyi cai Xiaoshu cai wu Zhou Zeqi Liu Schoolof Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai200093China Shanghai Key Laboratory of Multiphase Flow and Heat Transfer in Power Engineering Shanghai200093China Jiaxing MeaParTech Instrument Technology Co. LtdZhejiang314000China

The performance of nanoparticles is often affected by particle size and ***,electron microscopy or atomic force microscopy is typically utilized to determine the size and morphology of ***,there are issues such as difficult sample preparation,long processing times,and challenges in quantitative ***,it is of great significance to develop a fast,accu-rate,and statistical method to measure the size and morphology of *** this study,a new method,called polarized imaging dynamic light scattering(PIDLS),is *** nanoparticles are irradiated with a vertical linearly polarized laser beam,and a polarization camera collected the dynamic light scattering images of particles at four different polarization directions(0°,45°,90°,and 135°)at a scattering angle of 90°.The average particle size and distribution are obtained using the imaging dy-namic light scattering method at 0°polarization direction,and the morphology of the particles is ob-tained based on the depolarization patterns of the scattered *** optical sphericityΦis defined based on the degree of linear polarization(DoLP).It is also implemented for the quantitative evaluation of the sphericity of the nanoparticles,including spherical,octahedral,nanoplate,nanorod,and linear *** with the Poincarésphere parameterψ,the morphology of the nanoparticles can be roughly *** addition,PIDLS enables the measurement of particle size and morphology distributions simultaneously for evaluating the uniformity of *** effectiveness of PIDLS is verified by the measurement of five kinds of industrial titanium dioxide as well.

关键词： Imaging dynamic light scattering Polarized light scattering Non-spherical nanoparticles Morphology Online measurement

Hydrodynamics and OCM reaction performance in a bubbling fluidized bed reactor and a riser reactor

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Particuology 2024年第3期86卷 188-204页

作者： Min cai Shuangzhu Kong sheng Chen Mengxi Liu Chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China China Special Equipment Inspection and Research Institute Beijing102249China

The reasonable reactor design is of great importance for increasing the C_(2) yield(C2H4 and C2H6)of the oxidative coupling of methane(OCM),and the OCM reactor should remove the heat released in reactions quickly and efficiently and minimize the consecutive reaction of ethylene to carbon *** fluidized bed reactor is characterized by excellent heat transfer,superior mass transport,and large handling capacity,while fewer studies focused on large-scale fluidized bed reactors for the OCM ***,large cold-model experiments and computational fluid dynamics simulations were conducted to investigate hydrodynamics and the OCM reaction performance in a large-scale bubbling fluidized bed(BFB)and a large-scale *** the BFB reactor,consecutive reactions of ethylene are acute because of the strong gas back-mixing,high solids holdup,and non-uniform solids *** the consecutive reactions of ethylene are negligible due to the plug flow structure and low solids holdup in the riser ***,both reactors can achieve isothermal operation for the OCM *** C_(2) selectivity of 45.4% and C_(2) yield of 21.1% are obtained in the riser reactor,increasing by 20.3% and 5.8% individually than that in the BFB *** study provides useful information and reference to the OCM reactor designandcommercialization.

关键词： Oxidative coupling of methane Bubbling fluidized bed reactor Riser reactor Hydrodynamics Isothermal operation

Superhydrophobic magnetic Fe_(3)O_(4) polyurethane sponges for oil-water separation and oil-spill recovery

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Journal of Environmental Sciences 2024年第5期139卷 160-169页

作者： Shiyu wu Yunjie Xiang Yaqi cai Jingfu Liu Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The effective and affordable separation of oil and water,a crucial process in the safe han dling of environmental disasters such as crude oil spills and recovery of valuable resources is a highly sought-after yet challenging ***,superhydrophobic PU sponge was fab ricated for the fast and cost-effective adsorptive separation of oil and different organic sol vents from ***(OTS)-functionalized Fe_(3)O_(4)@SiO_(2)core-shell mi crospheres were dip-coated on the surface of porous materials via a dip-coating process thereby endowing them with *** to the hydrophobic interaction between OTS molecules and oil and increased capillary force in the micropores,the result ing superhydrophobic sponge served as a selective oil-sorbent scaffold for absorbing oil from oil-water mixtures,including oil-water suspensions and ***,after the recovery of the adsorbed oil via mechanical extrusion,these superhydrophobic materials could be reused multiple times and maintain their oil-water separation efficacy even afte 10 oil-water separation cycles.

关键词： Fe_(3)O_(4)@SiO_(2)-OTS polyurethane sponge Oil-water separation Adsorption capacity Oil-spill recovery