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A historical review of hybrid rice breeding

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Journal of Integrative Plant Biology 2024年第3期66卷 532-545页

作者： Xiaoming Zheng Fei Wei cheng cheng Qian Qian State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Yazhouwan National Laboratory Sanya City 572024China

The development of germplasm resources and advances in breeding methods have led to steady increases in yield and quality of rice (Oryza sativa L.). Three milestones in the recent history of rice breeding have contributed to these increases: dwarf rice breeding, hybrid rice breeding, and super rice breeding. On the 50th anniversary of the success of three-line hybrid rice,we highlight important scientific discoveries in rice breeding that were made by Chinese scientists and summarize the broader history of the field. We discuss the strategies that could be used in the future to optimize rice breeding further in the hope that China will continue to play a leading role in international rice breeding.

关键词： Chinese experience dwarf breeding hybrid rice breeding super rice breeding

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Factors Influencing Fracture Propagation in Collaborative Fracturing ofMultiple HorizontalWells

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Energy Engineering 2024年第2期121卷 425-437页

作者： Diguang Gong Junbin Chen cheng cheng Yuanyuan Kou Shanxi Key Laboratory of Well Stability and Fluid&RockMechanics inOil andGas Reservoirs Xi’an Shiyou UniversityXi’an710065China The Second Oil Production Plant Petro China Changqing Oilfield CompanyQingyang745100China

Horizontal well-stimulation is the key to unconventional resource exploration and *** development mode of the well plant helps increase the stimulated reservoir ***,fracture interference between wells reduces the fracturing ***,a 2D hydro-mechanical coupling model describing hydraulic fracture(HF)propagation is established with the extended finite element method,and the effects of several factors on HF propagation during multiple wells fracturing are *** results show that with an increase in elastic modulus,horizontal principal stress difference and injection fluid displacement,the total fracture area and the reservoir stimulation efficiency are both improved in all three fracturing *** a comparison of the three technologies,the method of improved zipper fracturing is proposed,which avoids mutual interference between HFs,and the reservoir stimulation effect is improved *** study provides guidance for optimizing the fracturing technology of multiple horizontal wells.

关键词： Multi-well fracturing inter-fracture interference hydraulic fracturing hydro-mechanical coupling extended finite element horizontal well

Machine learning and numerical investigation on drag coefficient of arbitrary polygonal particles

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International Journal of Mechanical System Dynamics 2024年第3期4卷 317-330页

作者： Haonan Xiang cheng cheng Pei Zhang Genghui Jiang School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjingChina School of Engineering Westlake UniversityHangzhouChina

The drag coefficient,as the most important parameter that characterizes particle dynamics in flows,has been the focus of a large number of *** good predictability is achieved for simple shapes,it is still challenging to accurately predict drag coefficient of complex-shaped particles even under moderate Reynolds number(Re).The problem is that the small-scale shape details of particles can still have considerable impact on the drag coefficient,but these geometrical details cannot be described by single shape *** address this challenge,we leverage modern deep-learning method's ability for pattern recognition,take multiple shape factors as input to better characterize particle-shape details,and use the drag coefficient as *** obtain a high-precision data set,the discrete element method coupled with an improved velocity interpolation scheme of the lattice Boltzmann method is used to simulate and analyze the sedimentation dynamics of polygonal *** different machine-learning models for predicting the drag coefficient are developed and *** results show that our model can well predict the drag coefficient with an average error of less than 5%for *** findings suggest that data-driven models can be an attractive option for the drag-coefficient prediction for particles with complex shapes.

关键词： drag coefficient arbitrary polygonal particle shape factor DEM–LBM machine Learning

Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal–chemodynamic therapy with AIE guidance

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National Science Review 2024年第5期11卷 326-342页

作者： Feng Liu Tianfeng Yang Xiaowei Chang Li Chen cheng cheng Xiuhong Peng Haihu Liu Yanmin Zhang Xin Chen School of Energy and Power Engineering Xi'an Jiaotong University Department of Chemical Engineering Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical Engineering School of Chemical Engineering and Technology Xi'an Jiaotong University School of Pharmacy Health Science Center Xi'an Jiaotong University

Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission（AIE） molecules, copper ion chelator（acylthiourea） and tumor-targeting agent（folic acid） were fabricated to perform AIE-guided and tumor-specific synergistic therapy with great spatio-temporal controllability for the targeted elimination and metastasis inhibition of malignant tumors. During therapy, the functional gold nanoclusters（Au NTF） would rapidly accumulate in the tumor tissue due to the enhanced permeability and retention effect as well as folic acid-mediated tumor targeting, which was followed by endocytosis by tumor cells. After that, the overexpressed copper ions in the tumor cells would trigger the aggregation of these intracellular Au NTF via a chelation process that not only generated the photothermal agent in situ to perform the tumor-specific photothermal therapy damaging the primary tumor, but also led to the copper deficiency of tumor cells to inhibit its ***, the copper ions were reduced to cuprous ions along with the chelation, which further catalysed the excess H2O2in the tumor cells to produce cytotoxic reactive oxygen species, resulting in additional chemodynamic therapy for enhanced antitumor efficiency. The aggregation of Au NTF also activated the AIE molecules to present fluorescence, which not only imaged the therapeutic area for real-time monitoring of this tumor-specific synergistic therapy, but also allowed us to perform near-infrared radiation at the correct time point and location to achieve optimal photothermal therapy. Both in vitro and in vivo results revealed the strong tumor elimination, effective metastasis inhibition and high survival rate of tumor-bearing mice after treatment using the Au NTF nanoclusters, indicating that this AIE-guided and tumor-specific synergistic strategy could offer a promising approach for tumor therapy.

关键词： AIE-guided precise tumor treatment copper-dependent photothermal therapy copper-triggered chemodynamic therapy primary tumor elimination copper-plunder-induced metastasis inhibition

Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei SHI Xia MA Xin YU Jun Lei XU Jin Chuan QIAN cheng cheng HU Zhi Dong ZHANG Hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples

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Study of inter-well interference in shale gas reservoirs by a robust production data analysis method based on deconvolution

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Petroleum Science 2024年第4期21卷 2502-2519页

作者： Wen-Chao Liu cheng-cheng Qiao Ping Wang Wen-Song Huang Xiang-Wen Kong Yu-Ping Sun He-Dong Sun Yue-Peng Jia School of Civil and Resource Engineering University of Science and Technology Beijing PetroChina Research Institute of Petroleum Exploration and Development

In order to overcome the defects that the analysis of multi-well typical curves of shale gas reservoirs is rarely applied to engineering, this study proposes a robust production data analysis method based on deconvolution, which is used for multi-well inter-well interference research. In this study, a multi-well conceptual trilinear seepage model for multi-stage fractured horizontal wells was established, and its Laplace solutions under two different outer boundary conditions were obtained. Then, an improved pressure deconvolution algorithm was used to normalize the scattered production data. Furthermore, the typical curve fitting was carried out using the production data and the seepage model solution. Finally,some reservoir parameters and fracturing parameters were interpreted, and the intensity of inter-well interference was compared. The effectiveness of the method was verified by analyzing the production dynamic data of six shale gas wells in Duvernay area. The results showed that the fitting effect of typical curves was greatly improved due to the mutual restriction between deconvolution calculation parameter debugging and seepage model parameter debugging. Besides, by using the morphological characteristics of the log-log typical curves and the time corresponding to the intersection point of the log-log typical curves of two models under different outer boundary conditions, the strength of the interference between wells on the same well platform was well judged. This work can provide a reference for the optimization of well spacing and hydraulic fracturing measures for shale gas wells.

关键词： Shale gas Inter-well interference Deconvolution Production data analysis Typical curves Multi-stage fractured horizontal well

LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis

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Current Medical Science 2024年第4期44卷 726-734页

作者： Liang WANG Ping WANG Bing LIU Hui ZHANG cheng-cheng WEI Ming XIONG Gang LUO Miao WANG Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014.China

Objective This study aimed to investigate the role of the long noncoding RNA(lncRNA)maternally expressed gene 3(MEG3)in the epithelial-mesenchymal transition(EMT)of bladder cancer cells and the potential *** Cell invasion,migration,and wound healing assays were conducted to assess the effects of MEG3 on the invasive and migratory capabilities of bladder cancer *** expression levels of E-cadherin were measured using Western blotting,RT-qPCR,and dual luciferase reporter *** immunoprecipitation and pull-down assays were performed to investigate the interactions between MEG3 and its downstream *** MEG3 suppressed the invasion and migration of bladder cancer cells and modulated the transcription of *** binding of MEG3 to the zinc finger region of the transcription factor Snail prevented its ability to transcriptionally repress ***,MEG3 suppressed the phosphorylation of extracellular regulated protein kinase(ERK),c-Jun N-terminal kinase(JNK),and P38,thereby decreasing the expression of Snail and stimulating the expression of *** MEG3 plays a vital role in suppressing the EMT in bladder cancer cells,indicating its potential as a promising therapeutic target for the treatment of bladder cancer.

关键词： long noncoding RNA bladder cancer maternally expressed gene 3 epithelial-mesenchymal transition Snail

Analysis of acupoint massage combined with touch on relieving anxiety and pain in patients with oral implant surgery

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World Journal of Psychiatry 2024年第4期14卷 533-540页

作者： Jin-Hong Qu cheng-cheng Shou Xin He Qin Wang Yue-Xia Fang Department of Stomatology Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina Department of Software R&D Hangzhou Broadlink Technology CoLtd.Hangzhou 311300Zhejiang ProvinceChina Department of Stomatology Hangzhou Red Cross HospitalHangzhou 310003Zhejiang ProvinceChina Department of Cardiovascular Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina Department of Traditional Chinese Medicine Development Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local *** patients under local anesthesia are conscious during this procedure,compared with general anesthesia-related operations,they are more likely to experience negative emotions,such as anxiety and *** emotional reactions result in shivering and chills in the limbs,leading to poor doctor-patient cooperation and even avoidance of *** traditional Chinese medicine,it is believed that acupoint massage regulates blood and Qi,dredge menstruation,and relieve pain,which is beneficial for patients’emotional adjustment;however,there are few related clinical *** To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch *** One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups,according to a random number table,with 50 patients in each *** control group received routine intervention,and the study group received acupoint massage combined with touch on the basis of the control ***[assessed using the Modified Dental Anxiety Scale(MDAS)],pain severity,blood pressure,heart rate,and satisfaction were compared between the two *** Before intervention,the difference in MDAS score between the two groups was not significant(P>0.05),while after the intervention,the MDAS scores decreased in both groups compared with those before the intervention(P0.05).The systolic and d

关键词： Oral implant Acupoint massage Touch Anxiety Degree of pain

Achieving a superior Na storage performance of Fe-based Prussian blue cathode by coating perylene tetracarboxylic dianhydride amine

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Carbon Energy 2024年第5期6卷 53-64页

作者： Xin-Yuan Fu Lu-Lu Zhang Zhao-Yao Chen Yunkai Xu Junxiu Wu cheng-cheng Wang Xiao-Kai Ding Xue-Lin Yang Jun Lu Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering&New EnergyChina Three Gorges UniversityYichangHubeiChina College of Materials and Chemical Engineering China Three Gorges UniversityYichangHubeiChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina

Fe-based Prussian blue(Fe-PB)cathode material shows great application potential in sodium(Na)-ion batteries due to its high theoretical capacity,long cycle life,low cost,and simple preparation ***,the crystalline water and vacancies of Fe-PB lattice,the low electrical conductivity,and the dissolution of metal ions lead to limited capacity and poor cycling *** this work,a perylene tetracarboxylic dianhydride amine(PTCDA)coating layer is successfully fabricated on the surface of Fe-PB by a liquid-phase *** aminated PTCDA(PTCA)coating not only increases the specific surface area and electronic conductivity but also effectively reduces the crystalline water and vacancies,which avoids the erosion of Fe-PB by ***,the PTCA layer reduces the charge transfer resistance,enhances the Na-ion diffusion coefficient,and improves the structure *** PTCA-coated Fe-PB exhibits superior Na storage performance with a first discharge capacity of 145.2 mAh g^(−1) at 100 mA g^(−1).Long cycling tests exhibit minimal capacity decay of 0.027%per cycle over 1000 cycles at 1 A g^(−1).Therefore,this PTCA coating strategy has shown promising competence in enhancing the electrochemical performance of Fe-PB,which can potentially serve as a universal electrode coating strategy for Na-ion batteries.

关键词： cathode material coating Fe-based Prussian blue Na-ion batteries perylene tetracarboxylic dianhydride amine