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Chinese Journal of Natural Medicines 2024年第5期22卷 385-386页

作者： chen qian FAN Xiaohui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

With the awarding of the 2015 Nobel Prize in Physiology or Medicine to Chinese pharmacologist Tu Youyou,and the significant contributions of traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),TCM has garnered increasing attention and interest *** advanced research progress has been made in the efficacy research,mechanism elucidation and target prediction of TCM in recent years[1].

关键词： Protein interactome Traditional Chinese medicine Therapeutic effectiveness

Complex interactions among insect viruses-insect vector-arboviruses

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Insect Science 2024年第3期31卷 683-693页

作者： Hui Wang qian chen Taiyun Wei State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Vector-borne Virus Research CenterFujian Agriculture and ForestryUniversityFuzhouChina

Insects are the host or vector of diverse viruses including those that infect vertebrates,plants,and *** viruses reside inside their insect hosts and are vertically transmitted from parent to *** insect virus-host relationship is intricate,as these viruses can impact various aspects of insect biology,such as development,reproduction,sex ratios,and ***-borne viruses(arboviruses)that cause substantial global health or agricultural problems can also be vertically transmitted to insect vector *** infections with insect viruses and arboviruses are common in *** coinfections involve complex interactions,including synergism,dependence,and *** studies have shed light on the influence of insect viruses on the competence of insect vectors for *** this review,we focus on the biological effects of insect viruses on the transmission of arboviruses by *** also discuss the potential mechanisms by which insect viruses affect the ability of hosts to transmit arboviruses,as well as potential strategies for disease control through manipulation of insect *** of the interactions among insect vectors,insect viruses and arboviruses will provide new opportunities for development of innovative strategies to control arbovirus transmission.

关键词： arbovirus insect biology insect vectors insect virus interaction transmission

Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation

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World Journal of Stem Cells 2024年第4期16卷 459-461页

作者： Yi Li qian-qian chen En-qiang Linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology First Medical Center of Chinese PLA General HospitalBeijing 100853China

Hypoxia can get more ability to inhibit *** how it impact on survival time of mesenchymal stem cells(MSCs)is confusing and how preconditioned MSCs inhibiting inflammation are partially *** issues decided the value of ... 详细信息

关键词： Mesenchymal stem cell Hypoxia-inducible factor 1α Hypoxia Inflammation Macrophage

Novel high-safety aeroengine performance predictive control method based on adaptive tracking weight

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Chinese Journal of Aeronautics 2024年第7期37卷 352-374页

作者： qian chen Hanlin SHENG Jie ZHANG Jiacheng LI College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Increasing attention has been attracted to the dynamic performance and safety of advanced performance predictive control systems of the next-generation *** latest research demonstrates that Subspace-based Improved Model Predictive Control(SIMPC)can overcome the difficulty in solving the predictive model in MPC/NMPC ***,applying constant design parameters cannot maintain consistent control effects in all ***,the designed system relies too much on sensor-measured data,and thus it is difficult to thoroughly validate the safety of the system because of its high *** means that any potential hardware/software faults will endanger the ***,this paper first presents a novel nonlinear mapping relationship to adaptively tune the tracking weight online with the change of Power Lever Angle(PLA)and real-time relative tracking ***,without introducing additional design parameters,an Adaptive Tracking Weight-based SIMPC(ATW-SIMPC)controller is designed to improve the control performance in all operating states ***,a Primary/Backup Hybrid Control(PBHC)strategy with the ATW-SIMPC controller as the primary system and the traditional speed(Nf)controller as the backup system is proposed to ensure *** designed affiliated switching controller and the real-time monitor therein can be used to realize reasonable and smooth switching between primary/backup systems,so as to avoid bump *** PBHC system switches to the Nf controller when the ATW-SIMPC controller is wrong because of potential hardware/software faults;otherwise,the ATW-SIMPC controller keeps acting on the *** main results prove that the ATW-SIMPC controller with the optimal nonlinear mapping relationship,compared with the existing SIMPC controller,uplifts the dynamic control performance by 32%and reduces overshoots to an allowable limit,resulting in a better control effect in full *** comparison results consistently i

关键词： Aeroengine Model predictive control Hybrid system Adaptive weight Safety

Spatio-Temporal Service Analysis in Multi-Layer Non-Terrestrial Networks

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Journal of Communications and Information Networks 2024年第1期9卷 43-55页

作者： qian chen Weixiao Meng Shuai Han cheng Li School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China School of Engineering Science Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Electrical and Computer Engineering Memorial UniversitySt.John’sNL A1B 3X5Canada

In the advent of the 6G era, non-terrestrial networks (NTN) with expansive coverage are being increasingly recognized as a vital supplement to cellular networks for facilitating seamless communication. The intricate interplay between network performance and service quality necessitates a thorough investigation into the modeling and analysis of services for efficient construction of *** studies on service analysis, predominantly focused on terrestrial networks,fall short in addressing the unique challenges posed by NTN,particularly those related to platform distribution and antenna gain modeling. This deficiency in research,coupled with the varying preferences of users for different network types, forms the basis of this study. This paper explores the spatio-temporal characteristics of services within a multi-layered NTN *** this context,the spatial distribution of the platforms is modeled using a binomial point process, and the antennas are characterized by a sectorized beam pattern. We derive the closed-form expressions for the association probability,the number of accessed users, and the arrival rate of services with certain delay requirements towards different types of NTN. Simulation results are provided to evaluate the influence of various parameters on the association probability, the number of accessed users, and the total arrival rate of services. The number of satellites can be determined to achieve the optimal system utility,balancing the accessed services, offloading effects, and launching costs. This initial investigation lays the groundwork for further theoretical progress in the service analysis and platform deployment of NTN.

关键词： association strategy non-terrestrial networks service analysis stochastic geometry system utility

Diagnostic values of questionnaires of Convergence Insufficiency Symptom Survey and College of Optometrists Vision Development Quality of Life in the screening of convergence insufficiency

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 904-908页

作者： Ling Xiong qian chen Ye Wu Department of Ophthalmology West China HospitalSichuan University/Laboratory of Optometry and Vision ScienceWest China School of MedicineChengdu 610041Sichuan ProvinceChina Department of Clinical Research Management Center of BiostatisticsDesignMeasurement and EvaluationWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To compare and analyse the diagnostic efficacy of the College of Optometrists Vision Development Quality of Life Questionnaire(COVD-QOL)and the Convergence Insufficiency Symptom Survey(CISS)in detecting convergence insufficiency and to compare their diagnostic value in clinical ***:Using the diagnostic test method,62 adult patients with convergence insufficiency(age:24.74±3.75y)and 62 normal participants(age:23.61±3.13y)who visited the Optometry Clinic of West China Hospital of Sichuan University from April 2021 to January 2023 were *** subjects completed the CISS and *** analysis of the sensitivity and specificity of the CISS and COVD-QOL and comparison and joint experimental analysis of their diagnostic efficacy were ***:The sensitivity of the CISS and COVD-QOL for convergence insufficiency was 64.5%and 71.0%,respectively,while the specificity was 96.8%and 67.7%,*** to the CISS alone,the combination of the CISS and COVD-QOL demonstrated lower sensitivity and *** areas under the receiver operating characteristic curve of CISS,COVD-QOL and CISS combined with COVD-QOL were 0.806,0.694 and 0.782,***:Considering the low sensitivity of the CISS and the low specificity of the COVD-QOL,it is recommended to supplement these questionnaires with other screening tests for the detection of convergence insufficiency.

关键词： convergence insufficiency symptom survey College of Optometrists Vision Development Quality of Life Questionnaire convergence insufficiency asthenopia

A novel algorithm for evaluating cement azimuthal density based on perturbation theory in horizontal well

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Petroleum Science 2024年第1期21卷 244-251页

作者： Ji-Lin Fan Feng Zhang qian chen Hao-chen Song Lu-Yu Zhong Yue-Xiang Dai National Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of Petroleum(East China)Qingdao 266580ShandongChina China National Logging Corporation Xi'an 710076ShaanxiChina Sinopec Matrix Corporation Qingdao 266001ShandongChina

Cement density monitoring plays a vital role in evaluating the quality of cementing projects,which is of great significance to the development of oil and ***,the presence of inhomogeneous cement distribution and casing eccentricity in horizontal wells often complicates the accurate evaluation of cement azimuthal *** this regard,this paper proposes an algorithm to calculate the cement azimuthal density in horizontal wells using a multi-detector gamma-ray detection *** spatial dynamic response functions are simulated to obtain the influence of cement density on gamma-ray counts by the perturbation theory,and the contribution of cement density in six sectors to the gamma-ray recorded by different detectors is obtained by integrating the spatial dynamic response *** with the relationship between gamma-ray counts and cement density,a multi-parameter calculation equation system is established,and the regularized Newton iteration method is employed to invert casing eccentricity and cement azimuthal *** approach ensures the stability of the inversion process while simultaneously achieving an accuracy of 0.05 g/cm^(3) for the cement azimuthal *** accuracy level is ten times higher compared to density accuracy calculated using calibration ***,this algorithm enhances the accuracy of cement azimuthal density evaluation,provides valuable technical support for the monitoring of cement azimuthal density in the oil and gas industry.

关键词： Cement azimuthal density Perturbation theory Casing eccentricity Spatial dynamic response function Regularized Newton iteration

Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

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Food Science and Human Wellness 2024年第2期13卷 765-777页

作者： qian chen Chunxia Mei Min Guo Botao Wang Haiqin chen Jianxin Zhao Gang Wang Wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China Bloomage Biotechnology Co. Ltd.Jinan 250000China

Lipid metabolism disorders commonly occur during *** deficiency has been shown to lead to excessive energy intake and abnormal lipid metabolism in ovariectomized rats,resulting in *** exhibit anti-obesity properties,and their underlying mechanism has been widely *** this study,we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 in suppressing appetite,controlling body weight,correcting obesity-induced abnormalities,enhancing liver lipid metabolism,and protecting liver function in estrogen-deficient *** mechanisms associated with the anti-obesity and anti-dyslipidemia effects of CCFM1180 on estrogen-deficient rats were *** results showed that CCFM1180 dramatically reduced food intake by activating the expression of estrogen receptor alpha(ERα)and increasing the level of leptin in abdominal adipose *** changes,combined with the increased butyrate concentration and recovered bile acid structure,helped enhance lipid ***,CCFM1180 treatment was found to be safer than exogenous estrogen ***,*** CCFM1180 could be considered a new therapeutic strategy for preventing and alleviating menopausal lipid abnormalities.

关键词： Bile acid Gut microbiota Menopause Ovariectomy Short chain fatty acid

Review on article of effects of tenofovir alafenamide and entecavir in chronic hepatitis B virus patients

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World Journal of Hepatology 2024年第1期16卷 109-111页

作者： Yu-Tong Sun qian-qian chen Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100193China

This letter comments on the article which reported that tenofovir alafenamide may increase blood lipid levels compared with entecavir in patients with chronic hepatitis B published on World J Hepatol 2023 August *** review the related research content,topic selection,methodology,conclusions,strengths and weaknesses of this *** evaluate it in relation to other published relevant articles.

关键词： Tenofovir alafenamide Entecavir Serum lipid levels Hepatitis B virus

Structural and Chemical Characterization of the Ediacaran Embryo-Like Fossils via the Combination of 3D-XRM and FIB-SEM Approaches

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Journal of Earth Science 2024年第4期35卷 1204-1214页

作者： qian chen Weichen Sun Suping Wu Zongjun Yin State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing210008China University of Chinese Academy of Sciences Nanjing211135China

The three-dimensional(3D)morphology,anatomy,and in-situ chemical composition analysis of fossils are crucial for systematic paleontology and determining their phylogenetic *** electron microscopy(SEM)coupled with energy-dispersive X-ray spectroscopy(EDS),offers valuable structural and chemical information for the analysis of ***,its primary limitation is the restriction to two-dimensional surface data,which limits the exploration of fossils’3D ***,3D X-ray microscopy(3D-XRM),also known as a novel form of micro-computed tomography(micro-CT)facilitates the non-destructive 3D reconstruction of fossil ***,it lacks the capability to provide in-situ compositional *** the constraints inherent in these individual techniques,and in response to the evolving requirements of paleontological research,this study introduces an integrated approach that combines 3D-XRM with EDS-coupled focused ion beam scanning electron microscopy(FIB-SEM).This innovative strategy is designed to synergize the advantages of both techniques,thereby addressing challenges that conventional methods *** enables the rapid identification of regions of interest(ROI)within fossil specimens at micrometer ***,this method collects detailed data on both 3D structures and chemical compositions at the nanometer scale for the identified *** integrated approach represents a significant advancement in paleontological and geological research methodologies,promising to meet the increasing demands of these fields.

关键词： Embryo-like microfossils structural and chemical characterization 3D-XRM FIB-SEM 3D reconstruction

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