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Nanoimprint-induced strain engineering of two-dimensional materials

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Microsystems & Nanoengineering 2024年第2期10卷 323-332页

作者： Chuying Sun Jianwen Zhong Zhuofei Gan Liyang chen Chuwei Liang Hongtao Feng Zhao Sun Zijie Jiang Wen-di Li The University of Hong Kong Hong KongChina

The high stretchability of two-dimensional(2D)materials has facilitated the possibility of using external strain to manipulate their ***,strain engineering has emerged as a promising technique for tailoring the performance of 2D materials by controlling the applied elastic strain *** various types of strain engineering methods have been proposed,deterministic and controllable generation of the strain in 2D materials remains a challenging ***,we report a nanoimprint-induced strain engineering(NISE)strategy for introducing controllable periodic strain profiles on 2D materials.A three-dimensional(3D)tunable strain is generated in a molybdenum disulfide(MoS_(2))sheet by pressing and conforming to the topography of an imprint *** strain profiles generated in MoS_(2)are demonstrated and verified by Raman and photoluminescence(PL)*** strain modulation capability of NISE is investigated by changing the imprint pressure and the patterns of the imprint molds,which enables precise control of the strain magnitudes and distributions in MoS_(2).Furthermore,a finite element model is developed to simulate the NISE process and reveal the straining behavior of MoS_(2).This deterministic and effective strain engineering technique can be easily extended to other materials and is also compatible with common semiconductor fabrication processes;therefore,it provides prospects for advances in broad nanoelectronic and optoelectronic devices.

关键词： strain dimensional molybdenum

经食管实时三维超声心动图在伴房间隔缺损的房间隔膨胀瘤中的应用

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中国医学影像技术 2015年第11期31卷 1685-1688页

作者：郑智超费洪文陈欧迪朱伟陈烁广东省人民医院广东省医学科学院广东省心血管病研究所心内科广东广州510080

目的探讨经食管实时三维超声心动图(RT3D-TEE)在伴房间隔缺损(ASD)的房间隔膨胀瘤(ASA)中的应用。方法回顾性分析于我院接受RT3D-TEE检查、伴ASD的ASA患者31例,观察ASA发生的部位、形态、大小及与ASD的毗邻关系。结果 2例ASA累及整个房... 详细信息

目的探讨经食管实时三维超声心动图(RT3D-TEE)在伴房间隔缺损(ASD)的房间隔膨胀瘤(ASA)中的应用。方法回顾性分析于我院接受RT3D-TEE检查、伴ASD的ASA患者31例,观察ASA发生的部位、形态、大小及与ASD的毗邻关系。结果 2例ASA累及整个房间隔组织;余29例ASA均位于房间隔中部的卵圆窝;5例ASA为3RL型,26例ASA为1R型;经RT3D-TEE检查17例患者合并双孔及以上的筛孔型ASD;1例ASA合并单纯卵圆孔未闭;13例ASA合并单孔型ASD。结论 RT3D-TEE可清晰显示ASA的形态、大小、部位及与伴发ASD的空间位置关系,可为临床治疗方式的选择提供准确的诊断信息。

关键词：房间隔膨胀瘤超声心动描记术,三维超声心动描记术,经食管

Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

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World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： Sha-Sha Sun Xiao-di Guo Wen-Dong Li Jing-Long chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGRouND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

Effect of solidification mode on microstructure evolution and properties of magnesium alloy with long-period stacking ordered phase

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Journal of Iron and Steel Research International 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei chen Xu Zhang Qian-hao Zang Jing Zhang di Feng Yan-xin Qiao Yu-hang Guo School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina School of Metallurgy and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employed to prepare Mg–6Gd–3Y–xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy microstructures and the changes in properties were analyzed for different Zn *** has been observed that in alloys without electromagnetic stirring,as the Zn content increases,the alloy structure gradually *** primary second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloys subjected to electromagnetic stirring,there is a relatively higher content of the second phase,primarily consisting of LPSO *** applying electromagnetic stirring,the quantity and the type of LPSO phase in the alloy *** alloy structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloys with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property

Enhanced activity and durability of FeCoCrMoCBY nanoglass in acidic hydrogen evolution reaction

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Journal of Materials Science & Technology 2024年第3期170卷 212-220页

作者： Mengyang Yan Shuangqin chen Shangshu Wu Xuechun Zhou Shu Fu di Wang Christian Kübel Horst Hahn Si Lan Tao Feng Herbert Gleiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Institute of Nanotechnology Karlsruhe Institute of TechnologyKarlsruhe 76021Germany

In the present work,a multi-element nanoglass(m-NG)of FeCoCrMoCBY is obtained first time by the laser ablation combined with inert gas condensation(laser-IGC)*** with the conventional rapid-quenched metallic glass(MG)with identical composition,the Fe-based m-NG demonstrates a superior performance as a self-supported electrocatalyst for hydrogen evolution reaction(HER)in acidic *** enhanced HER activity of m-NG is proposed to be closely related to its high en-ergy states,which is originated from the unique inhomogeneous nanostructures with a high density of low-coordinated ***,the Fe-based m-NG exhibits an outstanding comprehensive catalytic performance even beyond the commercial Pt/C catalyst in long-term test due to its self-optimization *** work not only opens the way to the preparation of m-NGs by the novel laser-IGC technique,but also makes a great contribution to developing low-cost,high-efficient,and super-durable HER electrocat-alysts in acidic environment.

关键词： Nanoglass Inert gas condensations High energy states Hydrogen evolution reactions

Early and Sensitive Detection of Pathogens for Public Health and Biosafety:An Example of Surveillance and Genotyping of SARS-CoV-2 in Sewage Water by Cas12a-Facilitated Portable Plasmonic Biosensor

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Research 2024年第2期2023卷 259-272页

作者： Tianzhong Li Yuzhi chen Zhi chen Yuan Hao Minyi Liang Yingxia Liu Guanyong ou Huanian Zhang Yuxuan Tang Yabing Hao Swelm Wageh Omar AAl-Hartomy Abul Kalam Bin Zhang Xin Shi Xuejin Li Han Zhang College of Physics and Optoelectronic Engineering Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Sensor Technology Shenzhen 518060China The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalQingyuan 511518China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China School of Medicine Southern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255049China Department of Physics Faculty of ScienceKing Abdulaziz University Jeddah 21589Saudi Arabia Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityP.0.Box 9004Abha 61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.0.Box9004Abha 61413 Saudi Arabia Health Sciences Institute China Medical UniversityShenyang 110000China The Chinese University of Hong Kong Shenzhen 518060China

Infectious diseases severely threaten public health and global *** addition to transmission through the air,pathogenic microorganisms have also been detected in environmental liquid samples,such as sewage *** biochemical detection methodologies are time-consuming and cost-ineffective,and their detection limits hinder early *** the present study,ultrafine plasmonic fiber probes with a diameter of 125μm are fabricated for clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR/Cas)-12a-mediated sensing of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Single-stranded DNA exposed on the fiber surface is trans-cleaved by the Cas12a enzyme to release gold nanoparticles that are immobilized onto the fiber surface,causing a sharp reduction in the surface plasmon resonance(SPR)*** proposed fiber probe is virus-specific with the limit of detection of~2,300 copies/ml,and genomic copy numbers can be reflected as shifts in wavelengths.A total of 21 sewage water samples have been examined,and the data obtained are consistent with those of quantitative polymerase chain reaction(qPCR).In addition,the Omicron variant and its mutation sites have been fast detected using S gene-specific *** study provides an accurate and convenient approach for the real-time surveillance of microbial contamination in sewage water.

关键词： fiber consuming hinder

Reconfigurable and orthogonal stiffness-structure patterning of dynamically crosslinked amphigels

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SmartMat 2024年第2期5卷 145-155页

作者： chen Yang Weizhong Zheng Chujun Ni Ye Li di chen Tao Xie Qian Zhao State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina Ningbo Innovation Center Zhejiang UniversityNingboChina School of Chemical Engineering East China University of Science and TechnologyShanghaiChina

Patterning diversified properties and surface structure of polymer materials are of great importance toward their potential in biology,optics,and ***,achieving both the patternability of stiffness and microstructure in a reconfigurable manner remains ***,we prepare amphigels crosslinked by dynamic disulfide bonds,which can be reversibly swollen by immiscible water or liquid *** the paraffingel form,the materials exhibited a high modulus of 130 MPa due to densified hydrogen *** swollen by water,the modulus fell over two orders of magnitude owing to the destruction of the hydrogen *** regionalized swelling of the solvents,well-controlled and rewritable soft/stiff mechanical patterns can be *** the other hand,the dynamic exchange of the disulfide crosslinking enables mechanophoto patterning to fabricate sophisticated macrogeometries and *** reconfigurable stiffness-structure patterning can be manipulated orthogonally,which will create more application opportunities beyond conventional hydrogels and organogels.

关键词： amphigels dynamic crosslinking hydrogels organogels surface patterning

Sweat-permeable electronic patches by designing threedimensional liquid diodes

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Journal of Semiconductors 2024年第7期45卷 2-5页

作者： Kangdi Guan di chen Qilin Hua Guozhen Shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing 102488China

Wearable electronics face a significant challenge related to the limited permeability of electronic materials/*** issue results in sweat accumulation across the interface of the device and skin following a specific period of use[1−3].Not only does it bring about discomfort for users regarding thermos-physiology,but it also has a detrimental effect on interface adhesion and signal quality,thus hindering exact sig-nal monitoring during prolonged periods[4−6].

关键词： diodes electronic interface

Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis

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Chinese Journal of Natural Medicines 2024年第7期22卷 643-653页

作者： DANG Wen GUO Tingting ZHou di MENG Qingqi FANG Mingxia chen Gang LIN Bin Hou Yue LI Ning School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning ProvinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China College of Life and Health Sciences Northeastern UniversityShenyang 110004China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia *** primary bioactive constituents,sesquiterpene coumarins,have demonstrated notable therapeutic potential against *** this study,a structure-guided fractionation method was used to isolate nine novel sesquiterpene coumarins from the resin of *** compounds were characterized and structurally elucidated using comprehensive physicochemical and spectroscopic techniques,including calculated electronic circular dichroism(ECD).Anti-neuroinflammatory assays revealed that compounds 2,3,and 6 significantly inhibited nitric oxide(NO)production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells,with IC_(50)values ranging from 1.63 to 12.25μmol·L^(−1).

关键词： Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity