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Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi chenG Niang-mei LIU Wen-han YANG Ye chen Wei ZHANG Xiang-zhi ZHENG Xiao-yuan chen ming-sheng ZHUANG Qiu-yu ZHAO Bi-xing LIU Cong-sheng LIU Xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P<0.01).Transcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

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数字基础设施的家庭收入效应——基于中国家庭金融调查(CHFS)的实证研究

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湘潭大学学报（哲学社会科学版） 2024年第2期48卷 46-53页

作者：陈明生王乾坤中国政法大学商学院北京100080

数字基础设施建设践行与彰显共同富裕的本质要求。基于2011—2019年五轮中国家庭金融调查(CHFS)数据,借助“宽带中国”战略准自然实验,研究了数字基础设施建设与家庭收入之间的关系。研究发现,数字基础设施建设显著提高了家庭收入,而且... 详细信息

数字基础设施建设践行与彰显共同富裕的本质要求。基于2011—2019年五轮中国家庭金融调查(CHFS)数据,借助“宽带中国”战略准自然实验,研究了数字基础设施建设与家庭收入之间的关系。研究发现,数字基础设施建设显著提高了家庭收入,而且还有效抑制了收入差距。从作用机制来看,数字基础设施建设通过增加创业机会、就业机会,提高家庭收入,具有显著的“创业效应”和“就业效应”。数字基础设施建设的家庭收入效应在城市、城镇化率高的地区,年龄中等、受教育程度高的群体中更为显著,表现出明显的地区差异和人力资本差异。

关键词：数字基础设施家庭收入创业效应就业效应收入差距

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金融强监管与企业数字化转型——来自“资管新规”的证据

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南昌大学学报（人文社会科学版） 2024年第3期55卷 46-61页

作者：陈明生王乾坤中国政法大学商学院北京100088

强化金融监管、引导金融资源赋能企业高质量发展是建设金融强国的重要路径。基于“资管新规”这一准自然实验,可以研究金融强监管与企业数字化转型的关系。研究发现,“资管新规”实施后,金融化程度较高企业的数字化转型程度显著提升,表... 详细信息

强化金融监管、引导金融资源赋能企业高质量发展是建设金融强国的重要路径。基于“资管新规”这一准自然实验,可以研究金融强监管与企业数字化转型的关系。研究发现,“资管新规”实施后,金融化程度较高企业的数字化转型程度显著提升,表明加强金融监管能够抑制企业“脱实向虚”。机制分析表明,对于金融化程度较高的企业,金融强监管能有效发挥替代效应和融资效应,促进企业数字化转型。异质性分析表明,金融强监管对于企业数字化转型的促进作用在非国有、逐利型、资本要素密集型企业中表现更为明显。研究结论不仅为监管有效观提供了新的微观证据,还丰富了企业数字化转型的制度驱动因素,对于推动我国金融高质量发展具有现实意义。

关键词：金融强国金融监管 “资管新规” 数字化转型影子银行

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壮药拟草果中3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品的制备及其质量控制研究

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药物分析杂志 2024年第2期44卷 333-339页

作者：赖克道柴玲陈明生冯军袁健童刘布鸣广西壮族自治区中医药研究院、广西中药质量标准研究重点实验室南宁530022

目的:从壮药拟草果中制备纯化3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品并建立其质量分析方法。方法:采用硅胶柱色谱、重结晶和高效制备液相色谱等,从拟草果中制备纯化得到高纯度的3,5-二羟基-7,4’-二甲氧基黄酮,通过红外、紫外、... 详细信息

目的:从壮药拟草果中制备纯化3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品并建立其质量分析方法。方法:采用硅胶柱色谱、重结晶和高效制备液相色谱等,从拟草果中制备纯化得到高纯度的3,5-二羟基-7,4’-二甲氧基黄酮,通过红外、紫外、核磁共振等综合波谱解析方法及质谱确定其化学结构,采用薄层色谱法、高效液相色谱法检测色谱纯度,炽灼残渣法测定灰分,质量平衡法计算3,5-二羟基-7,4’-二甲氧基黄酮的含量。采用高效液相色谱法对建立的3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品质量分析方法进行方法学考察。结果:3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品用高效液相色谱法面积归一化法测定的含量均值为99.85%,炽灼残渣法测得灰分值为0.02%,以质量平衡法计算的含量为99.83%。建立的含量测定方法专属性强,精密度良好。结论:制备得到的3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品符合化学对照品的质量标准要求,可作为拟草果及其他含有此成分的药材与制剂质量控制的对照品。建立的质量分析方法准确、可靠,可为该对照品质量标准研究与制定提供科学依据。

关键词：壮药拟草果 3,5-二羟基-7,4’-二甲氧基黄酮候选化学对照品制备纯化结构鉴定纯度检查含量测定

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某医院2019-2021年住院新生儿疾病谱特点及帕累托图分析

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医学信息 2024年第9期37卷 54-59页

作者：吴芗陈鸣声如东县人民医院病案管理科南京医科大学公共卫生学院南京医科大学医政学院

目的通过对某县级公立综合医院2019-2021年住院新生儿疾病种类及构成情况的统计归纳，以期为该医院新生儿科的学科建设和临床工作提供理论依据和改进建议。方法查询医院病案统计信息系统中出院时间为2019年1月1日-2021年12月31日的新... 详细信息

目的通过对某县级公立综合医院2019-2021年住院新生儿疾病种类及构成情况的统计归纳，以期为该医院新生儿科的学科建设和临床工作提供理论依据和改进建议。方法查询医院病案统计信息系统中出院时间为2019年1月1日-2021年12月31日的新生儿科全部住院患儿的病案首页数据，统计并分析住院新生儿的基本信息包括年龄、性别、母体胎龄、出生体重，住院新生儿的疾病信息包括出院主诊断、转归情况、住院天数、住院总费用，绘制帕累托图。结果 2019、2020、2021年患儿的平均住院日逐年增加，2019-2021年的住院新生儿前5位疾病顺位存在一致性，差异有统计学意义（P0.05）；早产儿与足月儿的前5位疾病谱有相似之处，患儿是否足月出生及不同出生体重比较，差异有统计学意义（P<0.05）;2019-2021年前5位的住院新生儿疾病分别为新生儿高胆红素血症、新生儿肺炎、新生儿低血糖症、新生儿败血症、新生儿湿肺，其中新生儿高胆红素血症和新生儿肺炎的疾病累计占比76.76%，为A类因素，是该院收治的新生儿主要疾病种类。结论新生儿高胆红素血症、新生儿肺炎、新生儿低血糖症等疾病在住院患儿中的发生率较高，住院患儿3年中疾病谱前5位的疾病变化不大。早产儿、新生儿肺炎、新生儿窒息、新生儿高胆红素血症为医院新生儿最常见住院病因，应有针对性的加强对上述疾病的诊断治疗及围生期保健宣教。

关键词：新生儿疾病谱帕累托图流行病学

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Nitrogen–sulfur co-doped porous carbon derived from asphalt as efficient catalyst for oxygen reduction

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Rare Metals 2024年第1期43卷 380-388页

作者： Jing-sheng Ma ming-Zai Wu Ling chen Li-Xing Zhang Ying Xiong Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of EducationInstitute of EnergyHefei Comprehensive National Science CenterAnhui UniversityHefei 230601China

As an environment-friendly and low-cost petrochemical by-product, asphalt has great potential in the preparation of metal-free oxygen reduction electrocatalysts with excellent performance and outstanding stability. In this paper, we converted asphalt into porous carbon nanosheets by a simple activation method, using potassium citrate as the swelling agent.

关键词： stability porous catalyst

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有机溶剂型道路沥青路面养护剂的研究

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广州化工 2024年第16期52卷 49-51页

作者：朱国霖刘清吴洁亮苏平陈献琦易志强陈明胜茂名沥青储运中心广东茂名525099

研究探讨了在不同情况下,加入润滑油、废机油、还原剂和防水剂对老化沥青的还原作用,通过对沥青性能的还原作用,探讨最优配比。通过不停的实验,得出以下结论:在单组元实验中,润滑油和废机油能通过改变老化沥青的组分变化,芳香分和饱和... 详细信息

研究探讨了在不同情况下,加入润滑油、废机油、还原剂和防水剂对老化沥青的还原作用,通过对沥青性能的还原作用,探讨最优配比。通过不停的实验,得出以下结论:在单组元实验中,润滑油和废机油能通过改变老化沥青的组分变化,芳香分和饱和分增加,胶质和沥青质减少,改善沥青的性能;加入防水剂对沥青的塑性有微小变化。通过正交实验,得出废机油、硅醇钠对各性能的影响较大,并得出沥青养护剂的最佳配比。

关键词：有机溶剂道路沥青养护剂研究

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Using Copula functions to predict climatic change impacts on floods in river source regions

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Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-Xing chen Hai-Shen LYU Robert HORTON Yong-Hua ZHU Ren-sheng chen ming-Yue SUN ming-Wen LIU Yu LIN The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA Qilian Alpine Eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(Q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model Intercomparison Project Phase 6 *** results show that Q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,p<0.05).Flood frequency will increase in the future,and mid-(2050e2074)and long-term(2075e2099)floods will be more severe than those in the near-term(2025e2049).The probability of flood occurrence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** Q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMIP6 River source regions

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One-step calcination synthesis of interface-coherent crystallized and surface-passivated LiNi_(0.5)Mn_(1.5)O_(4) for high-voltage lithium-ion battery

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Nano Research 2024年第5期17卷 4192-4202页

作者： Min Xu Bifu sheng Yong cheng Junjie Lu Minfeng chen Peng Wang Bo Liu Jizhang chen Xiang Han ming-sheng Wang Siqi Shi College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China College of Mathematics and Physics Jinggangshan UniversityJi’an 343009China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Western Digital Corporation 951 Sandisk DrMilpitasCA 95035USA

LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)with a spinel crystal structure presents a compelling avenue towards the development of economic cobalt-free and high voltage(~5 V)lithium-ion ***,the elevated operational voltage of LNMO gives rise to pronounced interfacial interactions between the distorted surface lattices characterized by Jahn-Teller(J-T)distortions and the electrolyte ***,a localized crystallized coherent LaNiO_(3) and surface passivated Li_(3)PO_(4) layer is deposited on LNMO via a one-step calcination *** evidenced by transmission electron microscopy(TEM),time-of-flight secondary ion mass spectrometry(ToF-SIMS)and density functional theory(DFT)calculation,the epitaxial growth of LaNiO_(3) along the LNMO lattice can effectively stabilize the structure and inhibit irreversible phase transitions,and the Li_(3)PO_(4) surface coating can prevent the chemical reaction between HF and transition metals without sacrificing the electrochemical *** addition,the ionic conductive Li_(3)PO_(4) and atomic wetting inter-layer enables fast charge transfer transport ***,the LNMO material enabled by the lattice bonding and surface passivating features,demonstrates high performance at high current densities and good capacity retention during long-term *** rational design of interface coherent engineering and surface coating layers of the LNMO cathode material offers a new perspective for the practical application of high-voltage lithium-ion batteries.

关键词： high-voltage cathode interface-coherent surface passivating electrochemical performance

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Main controlling factor and mechanism of gas-in-place content of the Lower Cambrian shale from different sedimentary facies in the western Hubei area, South China

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Petroleum Science 2024年第3期21卷 1488-1507页

作者： Gang Li Xian-ming Xiao Bo-Wei cheng chen-Gang Lu Yue Feng Dong-sheng Li School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing100083 China

The Lower Cambrian shale gas in the western Hubei area,South China has a great resource prospect,but the gas-in-place(GIP)content in different sedimentary facies varies widely,and the relevant mechanism has been not well *** the present study,two sets of the Lower Cambrian shale samples from the Wells YD4 and YD5 in the western Hubei area,representing the deep-water shelf facies and shallowwater platform facies,respectively,were investigated on the differences of pore types,pore structure and methane adsorption capacity between them,and the main controlling factor and mechanism of their methane adsorption capacities and GIP contents were *** results show that the organic matter(OM)pores in the YD4 shale samples are dominant,while the inorganic mineral(IM)pores in the YD5 shale samples are primary,with underdeveloped OM *** pore specific surface area(SSA)and pore volume(PV)of the YD4 shale samples are mainly from micropores and mesopores,respectively,while those of the YD5 shale samples are mainly from micropores and macropores,*** methane adsorption capacity of the YD4 shale samples is significantly higher than that of the YD5 shale samples,with a maximum absolute adsorption capacity of 3.13 cm^(3)/g and 1.31 cm^(3)/g in average,*** with the shallow-water platform shale,the deep-water shelf shale has a higher TOC content,a better kerogen type and more developed OM pores,which is the main mechanism for its higher adsorption *** GIP content models based on two samples with a similar TOC content selected respectively from the Wells YD4 and YD5 further indicate that the GIP content of the deep-water shelf shale is mainly 34 m^(3)/t within a depth range of 1000—4000 m,with shale gas exploration and development potential,while the shallow-water platform shale has normally a GIP content of<1 m^(3)/t,with little shale gas *** the geological and geochemical conditions of shale gas formation a

关键词： Lower Cambrian shale Deep-water shelf facies Shallow-waterplat form facies Pore structure Methane adsorption Gas-in-place content Controlling factor

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