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Antibacterial and cytocompatible coatings based on poly(adipic anhydride) for a Ti alloy surface

Bioactive Materials 2020年第3期5卷 709-720页

作者： Katarzyna Leśniak-Ziółkowska MonikaŚmiga-Matuszowicz Agata Blacha-Grzechnik Sebastian Student Monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła Wojciech Simka Alicja Kazek-Kęsik Faculty of chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Faculty of chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Biotechnology centre Silesian University of TechnologyB.Krzywoustego 8 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb *** is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride)((c6H8O3)n)that is loaded with drugs:amoxicillin(c16H19N3O5S),cefazolin(c14H14N8O4S3)or vancomycin(c66H75cl2N9O24·xHcl).The characteristic microstructure of the polymer was evaluated using scanning electron microscopy and confocal *** on the surface treatment,the surface roughness varied(between 1.53μm and 2.06μm),and the wettability was change with the over of time.X-ray photoelectron spectroscopy analysis showed that the oxide layer did not affect the polymer layer or loaded ***,the drugs lose their stability in a phosphate-buffered saline solution after 6.5 h of exposure,and its decrease was greater than 7%(HPLc analysis).The stability,drug release and concentration of the drug loaded into the material were precisely analyzed by high-performance liquid *** results correlated with the degradation of the polymer in which the addition of drugs caused the percent of degraded polymer to be between 35.5%and 49.4%after 1 h of material immersion,depending on the mass of the loaded drug and various biological responses that were ***,all of the coatings were cytocompatible with MG-63 osteoblast-like *** drug concentrations released from the coatings were sufficient to inhibit adhesion of reference and clinical bacterial strains(***).The coatings with amoxicillin showed the best results in the bacterial inhibition zone,whereas coatings with cefazolin inhibited adhesion of the above bacteria on the surface.

关键词： Titanium alloy poly(adipic anhydride) Antibacterial coatings cytocompatible Dental implants

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Application of long-reach directional drilling boreholes for gas drainage of adjacent seams in coal mines with severe geological conditions

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International Journal of coal Science & Technology 2022年第6期9卷 75-88页

作者： Grzegorz Lesniak Daniel JBrunner Tomasz Topòr Malgorzata Slota-Valim Renata cicha-Szot Bartlomiej Jura Jacek Skiba Arnold Przystolik Ben Lyddall Grzegorz Plonka Oil and Gas Institute-National Research Institute Lubicz 25A31-503 KrakówPoland REI Drilling INC.250 West Berger Lane84107 Salt Lake CityUTUSA central Mining Institute 40-166 KatowicePoland Polish Mining Group(PGG) Powstańców 3040-039 KatowicePoland

This study aimed to demonstrate the application of Long Reach Directionally Drilled Boreholes(LRDD)for gas drainage of adjacent seams before and during the longwall face operations of low permeability-high gas content coals Staszic-Wujek Hard coal Mine in the Upper Silesia coal Basin(Poland).Five LRDD Boreholes(TM1a-TM5)with a length of 300 and 400 m were located over coal seam 501 in the fractured zone and monitored over six months of longwall face *** Boreholes were combined with cross-Measured *** characterization and geological modeling supported the results obtained from gas *** drainage efficiency of LRDD Boreholes was the approxi-mately 70%level,while conventional cross-Measured Boreholes were only 30%.The highest goaf gas quality(94%methane concentration)was reported for TM4,placed at an average elevation of 41 m above coal seam *** highest goaf gas production(average 6.2 m^(3)/min)was reported for LRDD Borehole *** borehole was placed within the fracture zone(average elevation of 24.4 m)and drilled through the sandstone lithotype with the best reservoir properties,enhancing drainage *** Boreholes TM2 and TM4 achieved similar *** three LRDD Boreholes were drilled close to the maximum principal horizontal stress direction,providing borehole stability during *** lowest goaf gas production was reported for LRDD Boreholes TM1a and *** Boreholes were placed in the rubble zone.

关键词： coal Mine methane Methane control strategy In-seam horizontal boreholes Long reach directionally

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Multimolecular complex of Par-4 and E2F1 binding to smac promoter contributes to glutamate-induced apoptosis in human-bone mesenchymal stem cells

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南京医科大学学报（自然科学版） 2008年第12期28卷 1609-1609页

作者： Lu, c. chen, J. Q. Zhou, G. P. Wu, S.H. Guan, Y. F. Yuan, c. S. Nanjing Med Univ Dept Pediat Affiliated Hosp 1 Nanjing 210029 Jiangsu Peoples R China

Neural cells undergo glutamate-induced apoptosis in ischaemic brain tissue,in which prostate apoptosis response-4 gene (Par-4)is ***-bone mesenehymal stem cells can be utilized as an effective therapy for ischemic brain *** this study,we found that glutamate could induce apoptosis in human-bone mesenehymal stem cells,accompanied by increased expression of Par-4 gene and smac release from *** Par-4 expression attenuated the glutamate-induced *** Par-4 protein and E2F1 protein could bind to E2F1-binding BS3 site on smac promoter and participated in the formation of a pro- teins-DNA ***,in the eomplex,E2F1,not Par-4,was found to be directly bound to the smac promoter,suggesting that Par-4 exerted indireetly its transcriptional control on the smac gene though interacting with *** of full-length Par-4 in human-bone mesenchymal cells resulted in increased activity of the smac *** addition,the indirect transcripional regula- tion of Par-4 on smac depended on its cOOH terminus-mediated interaction between Par-4 and *** conclude that the forma- tion of proteins-DNA complex,containing Par-4 protein,E2F1 protein and the smac promoter,contributes to the pro-apoptotic effect on glutamate-treated human-bone mesenchymal stem cells.

关键词：多分子复合体谷氨酸诱导方法人骨髓间质干细胞

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Multimolecular complex of Par-4 and E2F1 binding to smac promoter contributes to glutamate-induced apoptosis in human-bone mesenchymal stem cells

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南京医科大学学报(自然科学版) 2008年第11期 1493-1493页

作者： Lu,c.chen,J.Q.Zhou,G.P.Wu,S.H.Guan,Y.F.Yuan,c.S.Nanjing Med Univ,Dept Pediat,Affiliated Hosp 1,Nanjing 210029,Jiangsu,Peoples R china.

关键词： protein-kinase-c transcription smac/diablo mechanisms stroke target cancer apaf-1 bcl-2 arf

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