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Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing

cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： zeguang Wu Qiezhong Lamao Meichao gu Xuanxuan Jin Ying Liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich catherine c.L Wong Wensheng Wei Biomedical Pioneering Innovation center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key Laboratory for complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate *** our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 T cells,we performed a comprehensive genome-scale cRISPR screening of cancer *** found that four molecules belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 T *** coordinated function of these BTN molecules was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPcTL was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T cell killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activity.

关键词： Butyrophilin Vγ9Vδ2 T-cell cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

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Interfacial Oxygen Octahedral coupling-Driven Robust Ferroelectricity in Epitaxial Na_(0.5)Bi_(0.5)TiO_(3)Thin Films

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Research 2024年第2期2023卷 149-157页

作者： Haojie Han Qinghua zhang Wei Li Yiqun Liu Jiasheng guo Yue Wang Qian Li Lin gu ce-Wen Nan Jing Ma State Key Laboratory of New ceramics and Fine Processing Schoolof Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing National Laboratory for condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The oxygen octahedral rotation(OOR)forms fundamental atomic distortions and symmetries in perovskite oxides and definitely determines their properties and ***,epitaxial strain and interfacial structural coupling engineering have been developed to modulate the OOR patterns and explore novel properties,but it is difficult to distinguish the 2 ***,different symmetries are induced in Na_(0.5)Bi_(0.5)TiO_(3)(NBT)epitaxial films by interfacial oxygen octahedral coupling rather than epitaxial *** NBT film grown on the Nb:SrTiO_(3)substrate exhibits a paraelectric tetragonal phase,while with La_(0.5)Sr_(0.5)MnO_(3)as a buffer layer,a monoclinic phase and robust ferroelectricity are obtained,with a remanent polarization of 42μc cm^(-2)and a breakdown strength of 7.89 MV cm^(-1),which are the highest record among NBT-based ***,the interfacial oxygen octahedral coupling effect is demonstrated to propagate to the entire thickness of the film,suggesting an intriguing long-range *** work provides a deep insight into understanding the structure modulation in perovskite heterostructures and an important avenue for achieving unique functionalities.

关键词： effect. interfacial coupling

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zincophilic Ti_(3)c_(2)cl_(2)MXene and anti-corrosive cu NPs for synergistically regulated deposition of dendrite-free zn metal anode

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Journal of Materials Science & Technology 2024年第2期169卷 137-147页

作者： Yunfei Shen Yi Liu Kaisheng Sun Tiantian gu Gang Wang Yue Yang Jianxiang Pang Yang zheng Xiaodong Yang Long chen Key Laboratory for Green Process of chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China Institute for chemistry Chemnitz University of TechnologyChemnitz 09107Germany cAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and DevicesCenter of Materials Science and Optoelectronics EngineeringXinjiang Technical Institute of Physics and Chemistry of CASUrumqi 830011China Key Laboratory of Ecophysics and Department of Physics College of ScienceShihezi UniversityShihezi 832003China

Dendrites growth,chemical corrosion,and hydrogen evolution reaction(HER)on zinc anodes are the main barriers for the development of aqueous zinc-ion batteries(AzIBs).constructing interfacial protec-tive layer is an effective way to alleviate the side reactions on the ***,cu/Ti_(3)c_(2)cl_(2)MXene(cMX)with high zincophilic and hydrophobic property is prepared by the lewis molten salts etching method,and the cMX interface protection layer is constructed by a simple spin *** cMX coat-ing layer can provide abundant nucleation sites and uniformize the charge distribution through the zin-cophilic Ti_(3)c_(2)cl_(2)MXene matrix,leading to homogenous zn *** addition,the hydrophobic coat-ing contained anti-corrosive cu nanoparticles can prevent the zn anode from the electrolyte,beneficial for suppressing the chemical corrosion and ***,the stable and reversible zn plating/stripping is achieved for the zn anode coated by the cMX,which exhibits the lifespan of over 1400 h at 0.5 mA cm^(−2),and even can steadily run for 700 h with 65 mV at 10 mA cm^(−2).Furthermore,cMX@zn shows a high coulombic efficiency of over 100%for 3800 cycles,which indicates that the cMX@zn electrode has excellent stability and reversibility of zn stripping/*** full batteries assembled with zncoMnO/c(zcM)cathodes also exhibits higher capacity(450.6 mAh g^(−1)at 0.1 A g^(−1))and cycle stability(capacity retention of 70%after 1500 cycles).This work enhanced the lifespan of AzIBs and broaden the research of multifunctional coating layer to other secondary batteries based on metal anodes.

关键词： zinc anode Spin coating zincophilic MXene Anti-corrosive cu NPs Multifunctional coating

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coupling changes of soil functional gene abundances and extracellular enzyme activities across the diagnostic horizons of agricultural Isohumosols

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Pedosphere 2024年第3期34卷 540-552页

作者： zhuxiu LIU Haidong gu Xiaojing HU zhenhua YU Yansheng LI Junjie LIU Jian JIN Xiaobing LIU guanghua WANG State Key Laboratory of Black Soils conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081(China) University of chinese Academy of Sciences Beijing 100049(China)

Soil functional microbial taxa and extracellular enzymes are involved in a variety of biogeochemical cycling *** many studies have revealed the vertical change patterns of microbial communities along soil profile,the general understanding of the coupling changes in the functional gene abundances(FGAs)and extracellular enzyme activities(EEAs)in soil profiles is still limited,which hinders us from revealing soil ecosystem ***,we comparatively investigated the FGAs and EEAs in the diagnostic A,B,and c horizons of soil profiles obtained from two suborders of Isohumosols(Mollisols),Ustic and Udic Isohumosols,in Northeast china based on quantitative real-time polymerase chain reaction and standard fluorometric techniques,*** distribution patterns of both FGAs and EEAs significantly distinguished by the two soil suborders and were also separated from A to c ***,the variations of EEAs and FGAs were greater in Udic Isohumosols compared to Ustic Isohumosols along soil profiles,and greater changes were observed in c horizon than in A *** FGAs and EEAs correspondently decreased along the soil ***,when normalized by soil organic carbon,the specific EEAs significantly increased in deep soil horizons,suggesting that microorganisms will input more resources to the production of enzymes to ensure microbial nutrient requirements under resource *** importantly,we revealed that soil microbial nutrient demands were limited by carbon(c)and phosphorus(P),and the c and P limitations significantly increased along soil profiles with a greater c limitation observed in Ustic Isohumosols than in Udic ***,our findings provided solid evidence showing the links between FGAs,EEAs,and microbial nutrient limitations,which would be helpful for a better understanding of the ecosystem processes in soil profiles.

关键词： ecoenzymatic stoichiometry microbial nutrient limitation microbial nutrient requirement Mollisols soil ecosystem process soil profile

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The action mechanism by which c1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice

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Neural Regeneration Research 2024年第9期19卷 2019-2026页

作者： Bo zhao Mei Li Bingyu Li Yanan Li Qianni Shen Jiabao Hou Yang Wu Lijuan gu Wenwei Gao Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina central Laboratory Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of critical care Medicine Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Studies have shown that c1q/tumor necrosis factor-related protein-6 (cTRP6) can alleviate renal ischemia/reperfusion injury in mice. However, its role in the brain remains poorly understood. To investigate the role of cTRP6 in cerebral ischemia/reperfusion injury associated with diabetes mellitus, a diabetes mellitus mouse model of cerebral ischemia/reperfusion injury was established by occlusion of the middle cerebral artery. To overexpress cTRP6 in the brain, an adeno-associated virus carrying cTRP6 was injected into the lateral ventricle. The result was that oxygen injury and inflammation in brain tissue were clearly attenuated, and the number of neurons was greatly reduced. In vitro experiments showed that cTRP6 knockout exacerbated oxidative damage, inflammatory reaction, and apoptosis in cerebral cortical neurons in high glucose hypoxia-simulated diabetic cerebral ischemia/reperfusion injury. cTRP6 overexpression enhanced the sirtuin-1 signaling pathway in diabetic brains after ischemia/reperfusion injury. To investigate the mechanism underlying these effects, we examined mice with depletion of brain tissue-specific sirtuin-1. cTRP6-like protection was achieved by activating the sirtuin-1 signaling pathway. Taken together, these results indicate that cTRP6 likely attenuates cerebral ischemia/reperfusion injury through activation of the sirtuin-1 signaling pathway.

关键词： brain c1q/tumor necrosis factor-related protein-6 cerebral apoptosis diabetes inflammation ischemia/reperfusion injury neuron neuroprotection oxidative damage Sirt1

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Reducing the global cancer burden with gastrointestinal screening: china's 30 years practice

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cancer Biology & Medicine 2024年第3期21卷 204-212页

作者： Lei Yang Li Feng Yong zhu Ning Wang Xinpu Lu Fanghui gu Xiaotian zhang Jiafu Ji Peking University cancer Hospital(Inner Mongolia campus)/Affiliated cancer Hospital of Inner Mongolia Medical University Inner Mongolia Cancer CenterHohhot 010020China Key Laboratory of carcinogenesis and Translational Research(Ministry of Education/Bejing) Bejing Office for Cancer Prevention and ControlPeking University Cancer Hospital&InstituteBejing 100142China Key Laboratory of carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of carcinogenesis and Translational Research(Ministry of Education/Bejing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal cancers Bejing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Gastrointestinal(GI) cancers include esophageal [Ec(International classification of Disease 10^(th) revision: c15)], gastric [Gc(c16)], and colorectal [cRc(c18-c21)] cancers. china is a high-incidence country of GI ca... 详细信息

关键词： esophageal colorectal gastrointestinal

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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

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cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-gu Lee Bong-Ki Hong Saseong Lee Naeun Lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NcOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NcOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NcOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASc,forming cytoplasmic ***,NcOA6 associated with the ATP hydrolysis motifs in the NAcHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASc and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NcOA6 was highly expressed in macrophages derived from gout patients,and NcOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NcOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NAcHT domain Gouty arthritis

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Self-healable gels in electrochemical energy storage devices

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Nano Research 2024年第4期17卷 3302-3323页

作者： Yang Li PeiPei Ding Yuzhe gu Sheng Qian Yuncong Pang Lele Wang Jiayang Feng Baoguang Liu Qi Wan Ping Li zhiwei Liu college of Electronic and Optical Engineering&college of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China college of Materials Science&Engineering Beijing University of TechnologyBeijing 100124China Beijing Advanced Innovation center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Pillar of Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

In the green energy and carbon-neutral technology,electrochemical energy storage devices have received continuously increasing attention ***,due to the unavoidable volume expansion/shrinkage of key materials or irreversible mechanical damages during application,the stability of energy storage and delivery as well as the lifetime of these devices are severely shortened,leading to serious performance degradation or even safety ***,the utilization of self-healable gels into electrochemical energy storage devices,such as electrodes,binders,and electrolytes,is proven as an effective method to realize long-term stable operation of these devices via the self-repairing of mechanical and electrochemical ***,this review first summarizes the feature and fabrication of different gels,paying special attention to hydrogels,organohydrogels,and ***,basic concepts and figure of merit of self-healable gels are analyzed with a detailed discussion at the healing mechanisms,from reversible dynamic bonds to physical molecular diffusion,and to external healing *** we introduce all the important parts of electrochemical energy storage devices,which could be replaced by healable gels to enhance the durability,including electrodes,binders,and ***,the critical challenges and future perspectives regarding the future development of healable gels based high-performance electrochemical energy storage devices or electronics are provided.

关键词： self-healable gels healing mechanisms electrodes binders gel electrolytes

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MOF-mediated synthesis of novel PtFecoNiMn high-entropy nanoalloy as bifunctional oxygen electrocatalysts for zinc-air battery

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Nano Research 2024年第6期17卷 5288-5297页

作者： Mingkuan Xie Xin Xiao Duojie Wu cheng zhen chunsheng Wu Wenjuan Wang Hao Nian Fayan Li Meng Danny gu Qiang Xu Shenzhen Key Laboratory of Micro/Nano-Porous Functional Materials(SKLPM) Shenzhen 518055China Department of chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China SUSTech-Kyoto University Advanced Energy Materials Joint Innovation Laboratory(SKAEM-JIL) Shenzhen 518055China Key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of guangdong Southern University of Science and TechnologyShenzhen 518055China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315200China

High-entropy alloy(HEA)-based materials are expected to be promising oxygen electrocatalysts due to their exceptional *** electronic structure regulation of HEAs plays a pivotal role in enhancing their elctrocatalytic ***,PtFecoNiMn nanoparticles(NPs)with subtle lattice distortions are constructed on metal-organic framework-derived nitrogen-doped carbon by an ultra-rapid Joule heating *** to the modulated electronic structure and the inherent cocktail effect of HEAs,the as-synthesized PtFecoNiMn/Nc exhibits superior bifunctional electrocatalytic performance with a positive half-wave potential of 0.863 V *** hydrogen electrode(RHE)for oxygen reduction reaction and a low overpotential of 357 mV at 10 mA·cm^(-2)for oxygen evolution *** assembled quasi-solid-state zinc-air battery using PtFecoNiMn/Nc as air electrode shows a high peak power density of 192.16 mW·cm^(-2),low charge−discharge voltage gap,and excellent durability over 500 cycles at 5 mA·cm^(-2).This work demonstrates an effective route for rational design of bifunctional nanostructured HEA electrocatalysts with favorable electronic structures,and opens up a fascinating directions for energy storage and conversion,and beyond.

关键词： oxygen reduction reaction oxygen evolution reaction high-entropy nano-alloy zinc-air battery

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Exploration of the mechanism of cavitation vortex rope and vortex development in the draft tube of tubular turbine units

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 163-171,F0002页

作者： chuang cheng zhenggui Li changrong Shen Shenglong gu chuchu zeng chuanzheng Bai Meng Liu Junfeng Hu Qinghai University of Science and Technology Xining 810000China Key Laboratory of Fluid and Power Machinery Ministry of Education(Xihua University)Chengdu 610039China South-to-North Water Diversion East Jiangsu Water Source co. Ltd.Nanjing 210029China School of civil engineering and water resources Qinghai UniversityXining 810016China Dongyuan Branch of Shenzhen Water Planning and Design Institute co. Ltd.Changsha 410000China

Draft tube vortex rope is considered a special cavitation flow phenomenon in tubular turbine *** vortex rope is one of the most detrimental factors affecting the safety of hydraulic *** this study,ANSYS cFX software was utilized to numerically simulate the internal cavitation flow of a hydraulic turbine draft *** evolution of the cavitation vortex core was characterized by vortex line distribution and vorticity transport *** shape and number of blades influenced the revolving direction and distribution characteristics of the vortex close to the runner cone,which formed a counterclockwise-clockwise-counterclockwise distribution ***,there were many secondary flows in the draft *** cancellation and dissipation between the flows was one of the reasons for reduction in *** the cross-sectional shape of the draft tube was changed,the vorticity was distributed from the center of the vortex rope to all parts of the cross-sectional draft tube,with extreme values at the center and at the *** vortex stretching and dilatation terms played a major role in the change in vorticity,with the baroclinic torque having an effect at the center of the vortex rope,this study is helpful to understand the flow of water in the draft tube and guide the design and optimization of the draft tube in engineering application.

关键词： cavitation vortex rope vorticity transport equation vortex line draft tube

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