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新质生产力与中国经济学自主知识体系的拓新

中共中央党校（国家行政学院）学报 2024年第2期28卷 5-13页

作者：顾海良教育部社会科学委员会北京大学博雅北京大学习近平经济思想研究中心

习近平总书记关于“社会生产力水平总体跃升”和“最大限度解放和激发科技作为第一生产力所蕴藏的巨大潜能”的论断,阐明了经济新常态下生产力新的质态变化的经济根由和科学技术变革的内在规定;以新发展理念、新发展阶段和新发展格局集... 详细信息

习近平总书记关于“社会生产力水平总体跃升”和“最大限度解放和激发科技作为第一生产力所蕴藏的巨大潜能”的论断,阐明了经济新常态下生产力新的质态变化的经济根由和科学技术变革的内在规定;以新发展理念、新发展阶段和新发展格局集成的中国经济学自主知识体系,凝练了新质生产力的精粹,形成中国特色“系统化的经济学说”的逻辑起点。新质生产力适应现代化经济体系建设和高质量发展的新要求,也对现代化经济体系建设和高质量发展提供最根本的势能;新质生产力是中国式现代化发展的根本动力,也是中国式现代化全面推进的标识。作为习近平经济思想在实践创新和理论创新中实现的“术语的革命”,新质生产力彰显了中国特色社会主义政治经济学“术语的革命”的中国智慧和中国力量。

关键词：习近平经济思想新质生产力中国经济学自主知识体系高质量发展中国式现代化

美托洛尔联合稳心颗粒治疗心房颤动患者导管消融术后房性心动过速的价值

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中华老年心脑血管病杂志 2024年第3期26卷 245-249页

作者：谷慧阳顾翔朱业郑州大学第五附属医院心血管内二科 450052 江苏省苏北人民医院心血管内科

目的探讨美托洛尔联合稳心颗粒对心房颤动(AF)患者导管消融术后房性心动过速(AT)的治疗价值。方法选取2018年5月至2022年1月在苏北人民医院心血管内科诊断为AF并成功行导管消融术的患者253例,采用掷币法随机分为稳心颗粒组(56例)、美... 详细信息

目的探讨美托洛尔联合稳心颗粒对心房颤动(AF)患者导管消融术后房性心动过速(AT)的治疗价值。方法选取2018年5月至2022年1月在苏北人民医院心血管内科诊断为AF并成功行导管消融术的患者253例,采用掷币法随机分为稳心颗粒组(56例)、美托洛尔组(79例)、联合组(79例)、对照组(39例)。比较4组患者治疗AT次数、最长AT心搏次数、平均心率及不良反应等情况。结果对照组术后1年平均心率、AT阵数、AT最长心搏次数及Ⅰ、Ⅱ、Ⅲ类房性过早搏动次数均高于基线,差异有统计学意义(P<0.01)。稳心颗粒组、美托洛尔组、联合组术后1年平均心率、AT阵数、AT最长心搏次数及Ⅰ、Ⅱ、Ⅲ类房性过早搏动次数均低于基线,差异有统计学意义(P<0.01);联合组术后1年平均心率、AT阵数、AT最长心搏次数及Ⅰ、Ⅱ、Ⅲ类房性过早搏动次数均低于稳心颗粒组和美托洛尔组,差异有统计学意义(P<0.05);稳心颗粒组、美托洛尔组、联合组不良反应总发生率比较无显著差异(7.1%vs 13.9%vs 8.9%,P=0.301)。结论美托洛尔联合稳心颗粒可用于治疗AF患者导管消融术后AT,可有效降低平均心率,减少AT发生次数、房性过早搏动次数、减少AT最长心搏次数,可能减少术后AF复发,安全性较高。

关键词：心房颤动心动过速异位房性导管消融术美托洛尔稳心颗粒前瞻性研究

Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of castration-Resistant Prostate cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.zetrini HoYin Lip Azhar z.Abbasi Ibrahim Alradwan Taksim Ahmed chunsheng He Jeffrey T.Henderson Andrew M.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (cRPc), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLMDs) to remodel the tumor immune microenvironment (TIME) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLMD treatment sensitized hypoxic human and murine cRPc cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLMDs also polarized hypoxic murine RAW264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine cRPc TRAMP-c2 cells. In a syngeneic TRAMP-c2 tumor model, intravenous injection of PLMDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and myeloid-derived suppressor cells. Pretreatment with PLMDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor cD8+ T cells and M1 macrophages to tumor sites. Taken together, TIME modulation by PLMDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLMDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora Valeria García-zárate Ana Varela-constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna c Rodríguez-zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R colunga-Pedraza Olga G cantú-Rodríguez césar H gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BAcKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHScT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

Effect of guanxin-V Mixture combined with Sacubitril Valsartan on cardiac Function after PcI in STEMI Patients

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Medicinal Plant 2024年第1期15卷 75-78页

作者： zhiliang cHEN Wei zHANG Jun GONG Feng KE Ning gu Department of cardiology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022China Nanjing Hospital of chinese Medicine Nanjing University of Chinese MedicineNanjing 210029China

[Objectives]To observe the effect of guanxin-V Mixture combined with Sacubitril Valsartan on cardiac function in patients after PcI for acute ST-segment elevation myocardial infarction(STE-MI).[Methods]41 cases of STEMI patients(qi and yin deficiency and blood stasis and obstruction)hospitalized in Nanjing Hospital of chinese Medicine affiliated to Nanjing University of chinese Medicine from January 2020 to June 2021 were randomly divided into 21 cases in the treatment group and 20 cases in the control group,and the two groups were given standardized Western medicine treatment as soon as possible after *** control group was treated with Sacubitril Valsartan,and the treatment group was treated with guanxin-V Mixture on the basis of treatment in the control *** patients in the two groups were treated for 3 months,and the TcM syndrome score,left ventricular ejection fraction(LVEF),and N-Terminal Pro-Brain Natriuretic Peptide(NT-proBNP),interleukin-6(IL-6),and high-sensitivity c-reactive protein(hs-cRP)levels,and the incidence of heart failure and adverse reactions in the two groups after treatment were recorded.[Results]After the treatment,the TcM syndrome score and serum NT-proBNP,IL-6 and hs-cRP levels of the two groups significantly decreased(Pcantly lower than those of the control group(Pcantly increased(Pcantly higher than that of the control group(Pcomparison of the incidence of heart failure and adverse reactions in the two groups showed no statistically significant differences(P>0.05).[conclusions]guanxin-V Mixture combined with Sacubitril Valsartan could significantly improve cardiac function in STEMI patients undergoing PcI,and its effect may be related to the suppression of inflammatory response.

关键词： guanxin-V Mixture Sacubitril Valsartan Acute ST-segment elevation myocardial infarction PcI Heart failure

gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLc12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： Dongping Li Rongjuan Wei Xianglong zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling chen Ruofan Liu Yantong Wan Yinghao Hong zhenhua zeng Peng gu zhang Wang Kutty Selva Nandakumar Yong Jiang Hongwei zhou Peng chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China Department of critical care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China Institute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China Department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(cLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLc12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related c3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLc12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： gut microbiota Sepsis Rhamnose SLc12A4 GTP-Rac1 GTP-cdc42 Macrophage Phagocytosis

胸腰椎融合术患者术后胃肠功能障碍的危险因素分析

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中华医学杂志 2024年第3期104卷 186-191页

作者：郑旭顾小萍王琛南京医科大学附属苏州医院麻醉科，苏州215008 南京鼓楼医院麻醉科，南京210008 南京鼓楼医院麻醉科，南京210008 南京医科大学附属苏州科技城医院麻醉科，苏州215153

目的分析胸腰椎融合术患者发生术后胃肠功能障碍(POGD)的危险因素。方法回顾性分析南京鼓楼医院2021年1至12月434例接受胸腰椎融合术患者的临床资料。根据POGD发生情况分为POGD组(n=70)和非POGD组(n=364)。比较两组患者的临床资料,采用... 详细信息

目的分析胸腰椎融合术患者发生术后胃肠功能障碍(POGD)的危险因素。方法回顾性分析南京鼓楼医院2021年1至12月434例接受胸腰椎融合术患者的临床资料。根据POGD发生情况分为POGD组(n=70)和非POGD组(n=364)。比较两组患者的临床资料,采用二元logistic回归分析患者发生POGD的危险因素。结果POGD组男23例,女47例,年龄(60±6)岁;非POGD组男133例,女231例,年龄(62±7)岁。两组患者手术时长、出血量、术中椎管减压、术中低血压、术后24 h白细胞计数、术后24 h c反应蛋白、术后住院时间差异均有统计学意义(均Pc回归分析显示,术中进行椎管减压(OR=2.368,95%cI:1.365~4.106,P=0.002)、出血量≥10.9 ml/kg(OR=2.115,95%cI:1.166~3.835,P=0.014)、术后24 h白细胞计数≥15.2×10^(9)/L(OR=3.580,95%cI:1.773~7.226,PcI:1.080~3.773,P=0.028)是胸腰椎融合术后患者发生POGD的危险因素;使用地塞米松是保护因素(OR=0.408,95%cI:0.218~0.762,P=0.005)。结论胸腰椎融合术中进行椎管减压、出血量≥10.9 ml/kg、术后24 h白细胞计数≥15.2×10^(9)/L、术中低血压是患者发生POGD的危险因素,使用地塞米松是保护因素。

关键词：脊柱融合术术后胃肠功能障碍危险因素

Nanocavity enriched cuPd alloy with high selectivity for cO_(2) electroreduction toward c_(2)H_(4)

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Rare Metals 2024年第4期43卷 1513-1523页

作者： ze-Yu zhang Hai-Bin Wang Fei-Fei zhang Jing-Wei Li Xin-zhuo Hu Si-Wei Yan Yi-Ming Bai Xun zhang gu-Rong Shen Peng-Fei Yin Jing Yang cun-Ku Dong Jing Mao Hui Liu Xi-Wen Du Institute of New-Energy Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China

Electrocatalysis of cO_(2)reduction reaction is an effective way to convert cO_(2)into high value-added products,but the selectivity of cu-based catalysts for c2+products needs to be improved due to the high energy barrier of c-c ***,a viable catalyst design strategy to decrease energy barrier of c-c coupling should be put ***,a nanocavity-enriched cuPd single atom alloy(cuPd SAA)catalyst is designed to promote cc coupling *** faradaic efficiency of cuPd SAA for ethylene and c_(2+)reaches 75.6%and 85.7%at-0.7 V versus reversible hydrogen electrode(RHE),*** on the results given by in situ characterization,the porous hollow structure dramatically increases the ratio of the linear-bond*cO,thus enhancing the faradaic efficiency for *** functional theory(DFT)calculation reveals that the Pd doping can regulate the electronic structure of neighboring cu atoms to decrease the energy barrier of c-c coupling,further improving the faradaic *** work provides a new idea for designing catalyst with high selectivity for ethylene.

关键词： Adsorption configuration c-c coupling cO_(2) electrocatalysis Ethylene Single atom alloy

Eco-friendly iron-catalyzed oxidation of unstrained tertiary aromatic alcohols to ketones

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chinese chemical Letters 2024年第1期35卷 250-253页

作者： Shanmei zhu Penghui Hu Mengying guo Linlin zhao Linlin Yang Wei-Jin gu Wei Han Jiangsu collaborative Innovation center of Biomedical Functional Materials Jiangsu Key Laboratory of Biofunctional MaterialsKey Laboratory of Applied PhotochemistrySchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

A general,facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through c-c bond cleavage even with H_(2)O_(2) as the ***,this transformation can tolerate oxidation-labile functional *** robustness of this method is further demonstrated on the late-stage oxidation of complex bioactive molecules.

关键词： Iron catalysis c-c bond cleavage Oxidation H_(2)O_(2) Late-stage functionalization