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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele castellani Vineet Gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman Gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho Urologycentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,Pcontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

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Variable High Order Multiblock Overlapping Grid Methods for Mixed Steady and Unsteady Multiscale Viscous Flows

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communications in computational Physics 2009年第2期5卷 730-744页

作者： Bjorn Sjogreen H.c.yee center for Applied Scientific computing Lawrence Livermore National LaboratoryLivermoreCA 94551USA NASA Ames Research center Moffett FieldCA 94035USA

Flows containing steady or nearly steady strong shocks on parts of the flow field,and unsteady turbulence with shocklets on other parts of the flow field are difficult to capture accurately and efficiently employing the same numerical scheme,even under the multiblock grid or adaptive grid refinement *** sixthorder or higher-order shock-capturing methods are appropriate for unsteady turbulence with shocklets,third-order or lower shock-capturing methods are more effective for strong steady or nearly steady shocks in terms of *** order to minimize the short comings of low order and high order shock-capturing schemes for the subject flows,a multiblock overlapping grid with different types of spatial schemes and orders of accuracy on different blocks is *** recently developed single block high order filter scheme in generalized geometries for Navier Stokes and magnetohydrodynamics systems is extended to multiblock overlapping grid *** first stage in validating the high order overlapping approach with several test cases is included.

关键词： Multiblock grid overset grids high order numerical methods blunt body hypersonic flows mixed steady and unsteady flows

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classification of iatrogenic bile duct injury

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Hepatobiliary & Pancreatic Diseases International 2007年第5期6卷 459-463页

作者： Wan-yee Lau Eric c.H.Lai Department of Surgery the Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

BAcKGROUND: Iatrogenic bile duct injury continues to be an important clinical problem, resulting in serious morbidity, and occasional mortality, to patients. The ease of management, operative risk, and outcome of bile duct injuries vary considerably, and are highly dependent on the type of injury and its location. This article reviews the various classification systems of bile duct injury. DATA SOURcES: A Medline, PubMed database search was performed to identify relevant articles using the keywords 'bile duct injury', 'cholecystectomy', and 'classification'. Additional papers were identified by a manual search of the references from the key articles. RESULTS: Traditionally, biliary injuries have been classified using the Bismuth's classification. This classification, which originated from the era of open surgery, is intended to help the surgeons to choose the appropriate technique for the repair, and it has a good correlation with the final outcome after surgical repair. However, the Bismuth's classification does not encompass the whole spectrum of injuries that are possible. Bile duct injury during laparoscopic cholecystectomy tends to be more severe than those with open cholecystectomy. Strasberg's classification made Bismuth's classification much more comprehensive by including various other types of extrahepatic bile duct injuries. Our group, Bergman et al, Neuhaus et al, csendes et al, and Stewart et al have also proposed other classification systems to complement the Bismuth's classification. cONcLUSIONS: None of the classification system is universally accepted as each has its own limitation. Hopefully, a universally accepted comprehensive classification system will be published in the near future.

关键词： laparoscopic cholecystectomy bile duct injury bile duct stricture bile leak classification

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Hepatocellular carcinoma: current management and recent advances

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Hepatobiliary & Pancreatic Diseases International 2008年第3期7卷 237-257页

作者： Wan-yee Lau Eric c. H. Lai Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong SAR China

BAcKGROUND: Hepatocellular carcinoma (Hcc) is a major health problem worldwide. It is the fifth most common cancer in the world, and the third most common cause of cancer-related death. Without specific treatment, the prognosis is very poor. The goal of management is 'cancer control'-a reduction in its incidence and mortality as well as an improvement in the quality of life of patients with Hcc and their families. This article aims to review the current management of Hcc and its recent advances. DATA SOURcES: A MEDLINE database search was performed to identify relevant article using the keywords 'hepatocellular carcinoma', 'hepatectomy', 'liver transplantation', and 'local ablative therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS: Liver resection and liver transplantation remain the options that give the best chance of a cure. Recent evidence suggests that local ablative therapy may offer comparable survival results in patients with small Hcc, and preserved liver function. Transarterial chemoembolization (TAcE) is the most promising palliative modality for unresectable Hcc, but other techniques, such as transarterial radioembolization (TARE), and local ablative therapy, have also shown comparable results. cONcLUSIONS: Early diagnosis of Hcc remains a key goal in improving the prognosis of patients. During the last two decades, operative mortality and surgical outcome of liver resection and liver transplantation for Hcc have improved. Progress also has been made in multi-modality therapy which can increase the chance of survival and improve the quality of life for patients with advanced Hcc.

关键词： hepatocellular carcinoma hepatectomy liver transplantation local ablative therapy

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Development and controversies of adjuvant therapy for pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 121-125页

作者： Wan-yee Lau Eric c.H.Lai Faculty of Medicine the Chinese University of Hong Kong Prince of Wales Hospital Shatin New TerritoriesHong Kong SAR China

BAcKGROUND: Pancreatic cancer is an aggressive malignancy with a dismal prognosis. Radical surgery provides the only chance for a cure with a 5-year survival rate of 7%-25%. An effective adjuvant therapy is urgently needed to improve the surgical outcome. This review describes the current status of adjuvant therapy for pancreatic cancer, and highlights its controversies. DATA SOURcES: A Medline database search was performed to identify relevant articles using the keywords 'pancreatic neoplasm', and 'adjuvant therapy'. Additional papers were identified by a manual search of the references from the key articles. RESULTS: Eight prospective randomized controlled trials (RcTs) on the use of adjuvant chemotherapy and chemoradiation for pancreatic cancer could be identified. The results for adjuvant regimens based on systemic 5-fluorouracil with or without external radiotherapy were conflicting. The recent two RcTs on gemcitabine based regimen gave promising results. cONcLUSIONS: Based on the available data, no standard adjuvant therapy for pancreatic cancer can be established yet. The best adjuvant regimen remains to be determined in large-scale RcTs. Future trials should use a gemcitabine based regimen.

关键词： pancreatic neoplasm pancreatectomy adjuvant therapy radiotherapy chemotherapy

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Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications

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Journal of Molecular cell Biology 2021年第7期13卷 466-479页

作者： Lai yee cheong Aimin Xu The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina

Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional *** development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic *** is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic *** consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and *** cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning *** addition,inter-organ crosstalk is also important for beige adipocyte ***,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.

关键词： adipose tissue browning circulating factors energy homeostasis adipose biology obesity

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Protection of bridge piers against scouring with tetrahedral frames

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International Journal of Sediment Research 2009年第4期24卷 385-399页

作者： yee-Meng cHIEW School of civil and Environmental Engineering Nanyang Technological University

Armoring countermeasures, such as riprap stones, are the primary method used to protect bridge piers against scouring; however, these methods have not had definitive success. Recently, flow-altering countermeasures, such as sacrificial piles, have been tested as an alternative to armoring countermeasures. This study investigated the mechanics of an innovative flow-altering countermeasure device, frames in the shape of tetrahedrons that act as a pier-scour countermeasure. Results of measured characteristics for turbulence flow showed that the flow around the tetrahedral frames can be divided into three regions: (1) a deceleration region near the sediment bed; (2) an acceleration region in the middle of water depth region; and (3) a restoration region near the water surface. The velocity magnitudes, turbulent intensities and vorticities decreased in the deceleration region, increased in the acceleration region and reverted to that of the unprotected condition in the restoration region. This pier-scour countermeasure is innovative because of its ability to dissipate energy associated with the downflow and the horseshoes vortex generated around the bridge pier. The scour tests revealed that the frames protected the foundation of bridge piers against scour. The experimental results showed that the percentage reduction of scour depth decreased as the velocity ratio, U/U c , decreased, reaching a value of 50% for the range of parameters tested in this study. Moreover, its efficiency was dependent on the placement density of the frames. The data showed that the frames were more effective when η was larger. However, their influence becomes less significant when η≥ 0.16.

关键词： Bridge-pier scour Scour protection Tetrahedral frames protection Flow altering countermeasure

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Loco-regional intervention for hepatocellular carcinoma

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Journal of Interventional Medicine 2019年第2期2卷 43-46页

作者： Wan yee Lau Eric c.H.Lai Faculty of Medicine The Chinese University of Hong KongNew TerritoriesHong KongChina

Anatomic location/size and number of lesions,inadequate volume of future liver remnant,or poor coexisting premorbid conditions preclude surgery in the majority of patients with hepatocellular carcinoma(Hcc).Liver transplantation can cure some patients with poor liver function,but few patients are eligible because of scarcity of *** specific anti-cancer treatment,the prognosis of Hcc is *** locoregional therapies are used to treat patients who are not candidates for surgery,and have emerged as tools for palliation,tumor downstaging,and bridging therapy prior to liver ***,local ablative therapy even competes with partial hepatectomy and liver transplantation as a primary treatment for small *** is well suited to treatment with loco-regional therapy because it has a tendency to stay within the liver,with distant metastasis generally occurring late in the course of *** suggests that an effective local-regional therapy can have a great impact on Hcc patients who are not candidates for surgical ***-regional therapy can further be justified because patients with Hcc usually die of liver failure consequent to intrahepatic growth resulting in liver tissue destruction,rather than extrahepatic metastases.

关键词： Hepatocellular carcinoma Hepatectomy Loco-regional therapy TAcE Local ablation

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Methods of vascular control technique during liver resection:a comprehensive review

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 473-481页

作者： Wan-yee Lau Eric c.H.Lai Stephanie H.Y.Lau Faculty of Medicine the Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

BAcKGROUND: Significant hemorrhage together with blood transfusion increases postoperative morbidity and mortality of hepatic resection. Hepatic vascular occlusion is effective in minimizing bleeding during hepatic parenchymal transection. This article aimed to review the current role and status of various techniques of hepatic vascular occlusion during hepatic resection. DATA SOURcES: The relevant manuscripts were identified by searching MEDLINE, and PubMed for articles published between January 1980 and April 2010 using the keywords 'vascular control', 'vascular clamping', 'vascular exclusion' and 'hepatectomy'. Additional papers were identified by a manual search of the references from the key articles. RESULTS: One randomized controlled trial (RcT) and 5 RcTs showed intermittent Pringle maneuver and ischemic preconditioning followed by continuous Pringle maneuver were superior to continuous Pringle maneuver alone, respectively. Two RcTs compared the outcomes of hepatectomy with and without intermittent Pringle maneuver. One showed Pringle maneuver to be beneficial, while the other failed to show any benefit. One RcT showed that ischemic preconditioning had significantly less blood loss than using intermittent Pringle maneuver. Four RcTs evaluated the use of hemihepatic vascular occlusion. One RcT showed it had significantly less blood loss than Pringle maneuver, while the other 3 showed no significant difference. Only 1 RcT showed it had significantly less liver ischemic injury. No RcT had been carried out to assess segmental vascular occlusion. Two RcTs compared the outcomes of total hepatic vascular exclusion (THVE) and Pringle maneuver. One RcT showed THVE resulted in similar blood loss, but a higher postoperative complication. The other RcT showed less blood loss using THVE but the postoperative complication rate was similar. Both studies showed similar degree of liver ischemic injury. Only one RcT showed that selective hepatic vascular exclusion (SHVE) had

关键词： vascular control vascular exclusion hepatectomy liver neoplasm Pringle maneuver

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The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for hepatocellular carcinoma:a systematic review

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 124-133页

作者： Wan-yee Lau Eric c.H.Lai Stephanie H.Y.Lau State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated HospitalZhejiang University School of Medicine

BAcKGROUND: Following curative treatment for hepatocellular carcinoma (Hcc), 50%-90% of postoperative death is due to recurrent disease. Intra-hepatic recurrence is frequently the only site of recurrence. Thus, any neoadjuvant or adjuvant therapy, which can decrease or delay the incidence of intra-hepatic recurrence, or any cancer chemoprevention which can prevent a new Hcc from developing in the liver remnant, will improve the results of liver resection. This article systematically reviewed the current evidence of neoadjuvant, adjuvant, and chemoprevention in partial hepatectomy of Hcc. DATA SOURcES: Studies were identified by searching MEDLINE and PubMed databases for articles from January 1990 to November 2008 using the keywords 'hepatocellular carcinoma', 'hepatectomy', 'adjuvant therapy', 'neoadjuvant therapy', and 'regional therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS: Neoadjuvant transarterial chemoembolization or adjuvant regional transarterial chemotherapy embolization+systemic chemotherapy did not add benefit. Both adjuvant transarterial radioembolization with (131)I-lipiodol and adjuvant systemic interferon showed promising results. However, there were only a limited number of such studies. cONcLUSIONS: Further randomized controlled studies need to be carried out. currently, there is no consensus on a standard neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for Hcc.

关键词： hepatocellular carcinoma hepatectomy adjuvant therapy neoadjuvant therapy therapeutic embolization

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