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Defence Technology（防务技术） 2023年第5期23卷 189-200页

作者： Shi-bin Lu Ying Meng Hai-bo wang Xian-wei Jiang Jin Yang Ning Wei lin Jin Li-juan wan Hao Tang Qian-qian Hou Anhui Province Key Laboratory of Simulation and Design for Electronic Information System Hefei Normal UniversityHefei230601PR China Universities Joint Key Laboratory of Photoelectric Detection Science and Technology in Anhui Province Hefei Normal UniversityHefei230601PR China

A porous 3D cross-linked conductive network pierced by multi-wall carbon nanotubes(MWcNTs) was successfully designed from zeolitic imidazolate framework-8(ZIF-8). Zn@NPc@MWcNTs composites were tailored by the facile regulating the mass ratios and thermal annealing treatment. Due to the combination of less eddy current loss and dielectric loss together with multiple reflection attenuation caused by a unique structure. With a 10 wt% filler loading, the Zn@NPc@MWcNTs composites carbonized at 800℃ show two high reflection loss(RL) values with different thicknesses. An RL value is-53.18 dB with 4.09 mm thickness in the c-Band(4-8 GHz), and a minimum RL can reach-74.83 d B(10.8 GHz)with a matching thickness of 2.749 mm. The effective absorption bandwidth is 4 GHz(from 8 to 12 GHz,RL ≤-10 d B), which just covers the full X-band. Low cost and easy preparation can also provide advantages to develop MOF-based materials as effective EMW absorbents.

关键词： ZIF-8 Electromagnetic wave absorption X-band c-Band

VARS2 gene mutation leading to overall developmental delay in a child with epilepsy: A case report

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World Journal of clinical cases 2022年第24期10卷 8749-8754页

作者： Xiao-Hui Wu Shuang-Zhu lin Yan-Qiu Zhou wan-Qi wang Jia-Yi Li Qian-Dui chen Department of Neurology Quanzhou Children's HospitalQuanzhou 362000Fujian ProvinceChina Diagnosis and Treatment center for children The Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130103Jilin ProvinceChina Pediatrics of Traditional chinese Medicine College of Traditional Chinese MedicineChangchun University of Chinese MedicineChangchun 130117Jilin provinceChina college of Integrated chinese and Western Medicine Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

BAcKGROUND The mitochondrial respiratory chain defects have become the most common cause of neurometabolic disorders in children and adults,which can occur at any time in life,often associated with neurological dysfunction,and lead to chronic disability and premature *** one-third of patients with mitochondrial disease have biochemical defects involving multiple respiratory chain complexes,suggesting defects in protein synthesis within the *** here report a child with VARS2 gene mutations causing mitochondrial *** SUMMARY A girl,aged 3 years and 4 mo,had been unable to sit and crawl alone since birth,with obvious seizures and *** magnetic resonance imaging showed symmetrical,flaky,long T1-weighted and low T2-weighted signals in the posterior part of the bilateral putamen with a high signal shadow.T2 fluidattenuated inversion recovery imaging showed a slightly high signal and diffusion-weighted imaging showed an obvious high ***-exome gene sequencing revealed a compound heterozygous mutation in the VARS2 gene,c.1163(exon11)c>T and c.1940(exon20)c>T,which was derived from the *** child was diagnosed with combined oxidative phosphorylation deficiency type *** In this patient,mitochondrial disorders including Leigh syndrome and MELAS syndrome(mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes)were ruled out,and combined oxidative phosphorylation deficiency type 20 was diagnosed,expanding the phenotypic spectrum of the disease.

关键词： Mitochondrial aminoacyl-tRNA synthetase Mitochondrial diseases VARS2 case report

Novel compound heterozygous variants in the TAF6 gene in a patient with Alazami-Yuan syndrome:A case report

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World Journal of clinical cases 2022年第6期10卷 1889-1895页

作者： Shuang-Zhu lin Jin-Hua Feng Li-Ping Sun Hong-Wei Ma wan-Qi wang Jia-Yi Li Diagnosis and Treatment center for children The First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Developmental Pediatrics Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina changchun University of chinese Medicine Changchun 130021Jilin ProvinceChina

BAcKGROUND This case report describes a novel genotypic and phenotypic presentation of Alazami-Yuan syndrome,and contributes to the current knowledge on the *** SUMMARY We report an 11-year-old boy with Alazami-Yuan *** main clinical manifestations were rapid development of puberty,typical facial features of cornelia de Lange syndrome,and normal *** blood DNA samples obtained from the patient and his parents were sequenced using highthroughput whole-exosome sequencing,which was verified by Sanger *** results showed that there was a compound heterozygous mutation of c.1052delT and c.76A>T in the TATA-Box Binding Protein Associated Factor 6(TAF6)*** mutation of c.1052delT was from his mother and the mutation of c.76A>T was from his *** This study extends the mutation spectrum of the TAF6 gene,and provides a molecular basis for the etiological diagnosis of Alazami-Yuan syndrome and genetic consultation for the family.

关键词： Alazami-Yuan syndrome TAF6 children cornelia de Lange syndrome case report

Optimal timing for the oral administration of Dacheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis

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World Journal of Gastroenterology 2017年第39期23卷 7098-7109页

作者： Yu-Mei Zhang lin Zhu Xian-lin Zhao Huan chen Hong-Xin Kang Jian-Lei Zhao Mei-Hua wan Juan Li Lv Zhu Wen-Fu Tang Department of Integrative Medicine West China Hospital Sichuan University Digestive System Department Sichuan Integrative Medicine Hospital Department of Integrative Medicine Chengdu Integrated TCM and Western Medicine Hospital Department of Pharmacology School of Preclinical and Forensic Medicine West China Medical Center Sichuan University

AIM To identify the optimal oral dosing time of Da-cheng-Qi decoction(DcQD) in rats with acute pancreatitis(AP) based on the pharmacokinetic and pharmacodynamic *** First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4 h G(a), 12 h G(a) and 24 h G(a)]. The NG(a) and model groups were administered DcQD(10 g/***) intragastrically at 4 h, 4 h, 12 h and 24 h, respectively, after AP models induced by 3% sodium taurocholate. Plasma samples were collected from the tails at 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after a single dosing with DcQD. Plasma and pancreatic tissue concentrations of the major components of DcQD were determined by high-performance liquid chromatography tandem mass spectroscopy. The pharmacokinetic parameters and serum amylase were detected and compared. Second, rats were divided into a sham-operated group [NG(b)] and three treatment groups [4 h G(b), 12 h G(b) and 24 h G(b)] with three corresponding control groups [MG(b)s]. Blood and pancreatic tissues were collected 24 h after a single dosing with DcQD. Serum amylase, inflammatory cytokines and pathological scores of pancreatic tissues were detected and *** The concentrations of emodin, naringin, honokiol, naringenin, aloe-emodin, chrysophanol and rheochrysidin in the 12 h G(a) group were higher than those in the 4 h G(a) group in the pancreatic tissues(P concentration-time curve from time 0 to the time of the last measurable concentration values(AUc0→t) for rhein, chrysophanol, magnolol and naringin in the 12 h G(a) group were larger than those in the 4 h G(a) or 24 h G(a) groups. The 12 h G(a) group had a higher cmax than the other two model groups. The IL-10 levels in the 12 h G(b) and 24 h G(b) groups were higher than in the MG(b)s(96.55 ± 7.84 vs 77.46 ± 7.42, 251.22 ± 16.15 vs 99.72 ± 4.7 respectively, P < 0.05), while in the 24 h G(b) group, the IL-10 leve

关键词： Da-cheng-Qi decoction Acute pancreatitis Pharmacokinetics Oral dosing time Pharmacodynamics

Formation of Inclusion in Ti–Al Killed Low c–Mn Steel

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Journal of Iron and Steel Research International 2014年第S1期21卷 87-90页

作者： cheng-wei YANG Xin-hua wanG Tie OU Jiang-hua QI wan-jun ZHU Jun-fu cHEN Li-ping lin Research and Development center Wuhan Iron and Steel (Group) Corp. School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Research and Development center Wuhan Iron and Steel (Group) Corp. Wuhan 430080 Hubei China

The formation of inclusion in Ti–Al complex deoxidized c–Mn steel was investigated. When Al content in steel is very low([Al]=0.0005%), for 0.003%0.006%, inclusions would be pure Al2O3. The experimental results agre... 详细信息

The formation of inclusion in Ti–Al complex deoxidized c–Mn steel was investigated. When Al content in steel is very low([Al]=0.0005%), for 0.003%clusion is the Al2O3–SiO2–MnO–TiOx composite inclusion; for [Ti]≥0.009%, the inclusion is TiOx in the steel. When [Ti]=0.005%, [Al]clusion is the Al2O3–SiO2–MnO–TiOx composite inclusion; while [Al]>0.006%, inclusions would be pure Al2O3. The experimental results agree with the thermodynamics conclusions.

关键词： Ti-killed steel oxide metallurgy inclusion

基于UPLc-MS/MS法比较不同产地布渣叶中19个成分含量

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药学学报 2024年第5期59卷 1374-1381页

作者：何民友王利伟刘林张珀瑜蓝金权万欣亚李振雨陈向东孙冬梅广东一方制药有限公司广东省中药配方颗粒企业重点实验室广东佛山528244

基于UPLc-MS/MS法同时测定不同产地布渣叶中19个化合物的含量。以50%甲醇为提取溶剂,采用Agilent ZORBAX SB c18 (150 mm×2.1 mm,1.8μm)色谱柱;以乙腈-0.1%乙酸为流动相进行梯度洗脱,流速为0.3 m L·min^(-1),柱温30℃,进样量为2μL;... 详细信息

基于UPLc-MS/MS法同时测定不同产地布渣叶中19个化合物的含量。以50%甲醇为提取溶剂,采用Agilent ZORBAX SB c18 (150 mm×2.1 mm,1.8μm)色谱柱;以乙腈-0.1%乙酸为流动相进行梯度洗脱,流速为0.3 m L·min^(-1),柱温30℃,进样量为2μL;采用电喷雾离子源,在负离子模式下进行检测。结果表明,建立的UPLc-MS/MS方法可较好地分离19个成分,19个成分的方法学考察结果良好。通过正交偏最小二乘法-判别分析(OPLS-DA)可将28批不同产地布渣叶样品分为3类,广东、广西、海南各自归为一类,并筛选出影响不同产地质量差异的10个标志性化合物。本实验所建立的方法准确、可靠、灵敏度高、重复性好,可为布渣叶质量标准的建立及后续深入完善其质量控制体系、临床安全用药等相关研究提供依据。

关键词：布渣叶 UPLc-MS/MS 含量测定统计学分析黄酮类酚酸类

Study of human B7 homolog 1 expression in patients with hepatitis B virus infection

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World Journal of Gastroenterology 2012年第28期18卷 3681-3695页

作者： Wen-Jin Zhang Hai-Yang Xie Xin Duan Yun-Le wan chuan-Hui Peng Shao-Hua Shi Rong Su Zhang-Hui Zheng Le-lin Pan lin Zhou Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China Key Laboratory of combined Multi-organ Transplantation Ministryof Public Health Hangzhou 310003 Zhejiang Province China Department of Hepatobiliary Surgery Sun Yat-SenMemorial Hospital Sun Yat-Sen University Guangzhou 510120Guangdong Province China

AIM: To further investigate the role of human B7 homolog 1 (B7-H1) in the mechanism of persistent hepatitis B virus (HBV) infection. METHODS: Peripheral and intra-hepatic B7-H1 expression were compared by flow cytometry and immunochemical staining between two 2 distinct groups, one being chronic HBV tolerance patients (cHB-T) and the other being acute hepatitis B patients (AHB). B7-H1 mRNA expression level was also compared by real time polymerase chain reaction between cHB-T and AHB patients. The location of intra-hepatic B7-H1 and cD40 expression were analyzed by immunofluorescence. The levels of B7-H1 and cD40 expression on cultured myeloid dendritic cells (mDcs) with or without hepatitis B surface antigen (HBsAg) treatment were analyzed dynamically by flow cytometry. Intracellular interferon-γ (IFN-γ) staining and the stimulatory capacity of mDc of cultured mDc with or without HBsAg treatment were also compared by flow cytometry. RESULTS: Peripheral B7-H1 expression on mDcs was increased significantly in AHB compared to cHB-T patients (P cHB-T patients, B7-H1 positive cells were almost absent despite a persistently elevated serum HBsAg load. In contrast, there were indeed increased B7-H1-positive cells in situ in the liver tissue from AHB. In vitro analysis showed the parallel upregulation of B7-H1 and cD40 on cD11c+ mDcs after the onset of stimulation. Addition of recombinant hepatitis B surface antigen (rHBsAg) significantly decreased cD40 expression (P cD40 was greater than that of B7-H1. This preferential inhibition of cD40 expression on mDcs by rHBsAg resulted in the dysfunction of mDcs and T cells in the mixed leucocyte reaction (MLR) system. With rHBsAg pretreatment, in a carboxyfluorescein diacetate succinimidyl ester (cFSE) labeled MLR system at a ratio of 1:5 responder cell-stimulator cell (R/S), the c

关键词： Hepatitis B virus Hepatitis B Human B7 homolog 1 Immune tolerance co-stimulatory molecule

醒脾养儿颗粒联合布拉氏酵母菌散对轮状病毒肠炎患儿肠道微生态及炎症免疫反应的影响

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现代生物医学进展 2024年第9期24卷 1787-1791页

作者：陶琳梁军冯绪强王克强万晓莉济南市第二妇幼保健院药剂科山东济南271100 济南市第二妇幼保健院儿科山东济南271100

目的:探讨醒脾养儿颗粒联合布拉氏酵母菌散对轮状病毒肠炎患儿肠道微生态及炎症免疫反应的影响。方法:选取济南市第二妇幼保健院于2021年6月~2023年6月收治的轮状病毒肠炎患儿共118例,通过随机数字表法将患儿分为观察组(n=59)和对照组(n... 详细信息

目的:探讨醒脾养儿颗粒联合布拉氏酵母菌散对轮状病毒肠炎患儿肠道微生态及炎症免疫反应的影响。方法:选取济南市第二妇幼保健院于2021年6月~2023年6月收治的轮状病毒肠炎患儿共118例,通过随机数字表法将患儿分为观察组(n=59)和对照组(n=59)。对照组接受布拉氏酵母菌散治疗,在对照组基础上观察组接受醒脾养儿颗粒治疗。评估两组临床疗效、症状改善时间、肠道微生态指标、炎症因子、免疫功能、不良反应。结果:观察组总有效率为91.53%,高于对照组的76.27%(Pc反应蛋白(cRP)、白介素-1β(IL-1β)、肿瘤坏死因子α(TNFα)、白介素-6(IL-6)均低于对照组(PcD3^(+)、cD4^(+)/cD8^(+)、cD4^(+)比对照组高,cD8^(+)比对照组低(P0.05)。结论:醒脾养儿颗粒联合布拉氏酵母菌散治疗轮状病毒肠炎患儿具有良好的疗效,可改善患儿临床症状,降低炎症因子水平,调节肠道微生态,提高免疫功能,且安全性良好。

关键词：醒脾养儿颗粒布拉氏酵母菌散轮状病毒肠炎肠道微生态炎症反应免疫功能

Geomagnetic field absenee reduces adult body weight of a migratory insect by disrupt!ng feeding behavior and appetite regulation

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Insect Science 2021年第1期28卷 251-260页

作者： Gui-Jun wan Shou-lin Jiang Ming Zhang Jing-Yu Zhao Ying-chao Zhang Wei-Dong Pan Gregory A.Sword Fa-Jun chen Department of Entomology Nanjing Agricultural UniversityNanjingChina Beijing Key Laboratory of Bioelectromagetics Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina Department of Entomology Texas A&M UniversityCollege StationTXU.S.A.

The geomagnetic field(GMF)is well documented for its essential role as a cue used in animal orientation or *** evidence indicates that the absence of GMF(mimicked by the near-zero magnetic field,NZMF)can trigger stress-like responses such as reduced body weight,as we have previously shown in the brown planthopper,Nilaparvata *** this study,we found that consistent with the significantly decreased body weight of newly emerged female(—14.67%)and male(—13.17%)adult ***,the duration of the phloem ingestion feeding waveform was significantly reduced by 32.02%in 5th instar nymphs reared under the NZMF versus ***,5th instar nymphs that exhibited reduced feeding had significantly higher glucose levels(+16.98%and+20.05%;24 h and 48 h after molting),which are associated with food aversion,and expression patterns of their appetite-related neuropeptide genes(neuropeptide F,dow regulated overall;short neuropeptide F,dowregulated overall;adipokinetic hormone up-regulated overall;and adipokinetic hormone receptor,down-regulated overall)were also altered under the absence of GMF in a manner consistent with diminishing ***,the expressions of the potential magnetosensor croptochromes(crys)were found significantly altered under the absence of GMF,indicating the likely upstream signaling of the cry-mediated magnetoreception *** findings support the hypothesis that strong changes in GMF intensity can reduce adult body weight through affecting insect feeding behavior and underlying regulatory processes including appetite *** results highlight that GMF could be necessary for the maintenanee of energy homeostasis in insects.

关键词： appetite body weight feeding behavior geomagnetic field magnetoreception Nilaparvata lugens

Raindrop Size Distribution Parameters Retrieved from Xinfeng c-Band Polarimetric Radar Observations

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Journal of Tropical Meteorology 2020年第3期26卷 275-285页

作者： DING Yan wan Qi-lin YANG ling LIU Xian-tong XIA Feng FENG Lu college of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225 China china Meteorological Administration Key Laboratory of Atmospheric Sounding Guangzhou 510641 China Guangzhou Institute of Tropical and Marine Meteorology China Meteorological AdministrationChengdu 610225 China

The objective of this research was to acquire a raindrop size distribution(DSDs)retrieved from c-band polarimetric radar observations scheme for the first time in south *** observation period of the precipitation process was selected,and the shape-slope(μ-Λ)relationship of this region was statistically analyzed using the raindrop sample observations from the two-dimensional video disdrometer(2DVD)at Xinfeng Station,Guangdong *** data of the c-band polarimetric radar reflectivity ZHHand differential reflectivity ZDRwere obtained through scattering *** simulation data were combined with DSD fitting to determine the ZDR-Λand log10(ZHH/N0)-Λ*** Xinfeng c-band polarimetric radar observations ZDRand ZHH,the raindrop Gamma size distribution parametersμ,Λ,and N0were retrieved.A scheme for using c-band polarimetric radar to retrieve the DSDs was *** research revealed that during precipitation process,the DSDs obtained using the c-band polarimetric radar retrieval scheme are similar to the 2DVD observations,the precipitation characteristics of rainfall intensity(R),mass-weighted mean diameter(Dm)and intercept parameter(Nw)with time obtained by radar retrieval are basically consistent with the observational results of the *** scheme establishes the relationship between the observations of the c-band polarimetric radar and the physical quantities of the numerical *** method not only can test the prediction of the model data assimilation system on the convective scale and determine error sources,but also can improve the microphysical precipitation processes analysis and radar quantitative precipitation *** present research will facilitate radar data assimilation in the future.

关键词： c-band polarimetric radar 2DVD raindrop size distribution DSDs retrieval precipitation characteristics