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Left Atrial Mechanical Function and Aortic Stiffness in Middle-aged Patients with the First Episode of Atrial Fibrillation

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chinese Medical Journal 2017年第2期130卷 143-148页

作者： Alev Kdicgedik Suleyman c Efe Ahmet S Gurbuz Emrah Acar Mehmet F Yilmaz Asian Erdogan Gokhan Kahveci Ibrahim A Izgi c.vat kirma Department of cardiology Kartal Kosuyolu Heart Education and Research Hospital Kartal Istanbu134846 Turkey

Background： In the early stages of atrial remodeling, aortic stiffness might be an indication of an atrial myopathy, in particular, atrial fibrosis. This study aimed to investigate the association between left atrial （LA） mechanical function, assessed by two-dimensional speckle tracking echocardiography, and aortic stiffness in middle-aged patients with tile first episode of nonvalvular atrial fibrillation （AF）. Methods： This prospective study included 34 consecutive patients with the first episode of AF, who were admitted to Kartal Kos.;uyolu Research and Training Hospital between May 2013 and October 2015, and 31 age- and gender-matched healthy controls. During the 1^st month （mostly in the first 2 weeks） following their first admission, 34 patients underwent the first pulse wave measurements. Then, 21 patients were recalled for their second pulse wave measurement at 11.8 ± 6.0 months following their initial admission. Echocardiographic and pulse wave findings were compared between these 34 patients and 31 healthy controls. We also compared the pulse wave and echocardiographic findings between the first and second measurements in 21 patients. Results： Pulse wave analysis showed no significant differences between tile AF patients and healthy controls with respect to PWV （ 10.2 ± 2.5 m/s vs. 9.7 ± 2.1 m/s： P = 0.370）, augmentation pressure （9.6 ± 7.4 mmHg vs. 9. 1± 5.7 mmHg; P = 0.740）, and aortic pulse pressure （AoPP; 40.4 ± 14.0 mmHg vs. 42. 1 ±7.6 mmHg, P = 0.550）. The first LA positive peak of strain was inversely related to the augmentation pressure （r 0.30; P = 0.02） and aortic systolic pressure （r - 0.26, P - 0.04）. comparison between the two consecutive pulse wave measurements in 21 patients showed similar results, except for AoPP. In 21 patients, the AoPP at the second measurement （45.1± 14.1 mmHg） showed a significant increase compared with AoPP at the first measurement （39.0 ±10.6 mmHg, P = 0.028）, which was also higher than that of healthy controls （42.1

关键词： Aortic Stiffness Atrial Fibrillation: Atrial Strain

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combined Transcriptomics and Metabolomics of Arabidopsis thaliana Seedlings Exposed to Exogenous GABA Suggest Its Role in Plants Is Predominantly Metabolic

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Molecular Plant 2014年第6期7卷 1065-1068页

作者： Albert Batushansky Menny kirma Nicole Grillich David Toubiana Phuong Anh Pham Ilse Balbo Hillel Fromm Gad Galili Alisdair R. Fernie Aaron Fait The Jacob Blaustein Institutes for Desert Research Ben-Gurion University of the Negev84990 Sede Boqer Campus Israel Department of Plant Science Weizmann Institute of Science 76100 Rehovot Israel Max-Planck Institute of Molecular Plant Physiology Am Mühlenberg 114476 Potsdam-Golm Germany Department of Molecular Biology and Ecology of Plants Faculty of Life Sciences Tel Aviv University 69978 Tel Aviv Israel

Dear Editor, y-Aminobutyric acid （GABA） is a non-protein amino acid （AA） metabolized via the GABA shunt; a three-enzyme pathway that includes glutamate decarboxylase （GAD）, GABA transaminases （GABA-T）, and succinic semialdehyde dehydrogenase （SSADH）（Bown and Shelp, 1997; Bouch~ and Fromm, 2004）. The majority of work on GABA, to date, has focused on its role as an inhibitory neurotransmitter in mammals. In plants, however, due to its intermediate posi- tion between carbon （c） and nitrogen （N）, the metabolism of GABA has been suggested as a modulator of c-N balance （Fair et al., 2008）. In addition, the numerous observations of a rapid accumulation of GABA in response to （a）biotic stresses has prompted different hypotheses to be postu- lated on its role including a regulator of cytosolic pH and a herbivore deterrent （Bouche and Fromm, 2004; Roberts, 2007）. Additionally, a signaling role has been hypothesized in plants, though evidence remains elusive and the debate on the dual function of GABA as a signaling molecule and as a metabolite in plants remains ongoing. In the present work, we report changes in the metabolite and transcript profiles in Arabidopsis seedlings exposed to exogenous GABA. Liquid-grown seedlings were cultured under c and N limitation to reveal a possible role of GABA as either c or N substrate and to ascertain its influence on transcriptional programs.

关键词： GABA 代谢物拟南芥外源性转录组植物幼苗 γ-氨基丁酸

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替罗非班输注失败后长期华法林治疗成功溶解冠状动脉血栓

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 40-40页

作者： Boztosun B. Gunes Y. kirma c. Barutcu I. 田雨灵(译) 任付先(校) 不详 19 m. mah. s. sok. M. Apt. No. 25/17 Kozyataxi Istanbul Turkey

Here is a case where the right coronary artery is filled with thrombus and has been successfully treated with warfarin.

关键词：冠状动脉血栓华法林替罗非班治疗失败后溶解输注右冠状动脉

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