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Dehydrozaluzanin c,a novel type of anti-bacterial agent which targets transporting proteins,Opp and Opuc

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Genes & Diseases 2022年第4期9卷 830-832页

作者： Xiangyang Qin Jinmei Xu Dandan Yin Fan Feng Xianfei Zeng Bing Niu Xingbin hu Department of chemistry School of PharmacyFourth Military Medical UniversityXi'anShaanxi 710032PR China Department of Transfusion Medicine Xijing HospitalFourth Military Medical UniversityXi'anShaanxi 710032PR China Department of Hematology Tangdu HospitalFourth Military Medical UniversityXi'anShaanxi 710038PR China Division of Digestive Surgery Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXianShaanxi 710032PR China School of Medicine Northwest UniversityXi'anShaanxi 710069PR China Xi'an Area Medical Laboratory center Xi'anShaanxi 710000PR China School of Life Sciences Shanghai UniversityShanghai 200444PR China

To the Editor:The evolution and widespread distribution of antibiotic-resistant elements in bacterial pathogens is eroding our ability to control infections with existing *** aureus(***)and Methicillin-resistant ***(MRSA)have acquired alarming broad-spectrum antibiotic resistance resulting in hospital-and community-associated infections,which has been responsible for significant morbidities and deaths worldwide.1 It is estimated that the number of deaths caused by antibiotic resistance may exceed 10 million per year by 2050.

关键词： agent resistance deaths

水稻胚乳突变体cse-2的表型分析及基因定位

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作物杂志 2024年第5期 1-7页

作者：孙家猛高原陈虎花芹林泉祥陈庆全李金才张海涛安徽农业大学农学院安徽合肥230036

淀粉是水稻籽粒中含量最多的大分子物质,其组分及含量对于稻米的各项品质指标均有直接影响。本研究鉴定了1个新的粉质胚乳突变体(chalkiness and shrunken endosperm-2,cse-2),分析了突变体的农艺和品质相关性状,并对其开展了基因定位... 详细信息

淀粉是水稻籽粒中含量最多的大分子物质,其组分及含量对于稻米的各项品质指标均有直接影响。本研究鉴定了1个新的粉质胚乳突变体(chalkiness and shrunken endosperm-2,cse-2),分析了突变体的农艺和品质相关性状,并对其开展了基因定位。结果表明,与野生型相比,突变体的株高、穗粒数和结实率等农艺性状以及淀粉含量、淀粉组分比例、淀粉粒形态结构、蛋白质含量、脂肪酸含量等品质性状均发生了显著变化。遗传分析表明,突变性状是由位于4号染色体上的1对隐性核基因控制。序列分析表明,精细定位区间内LOc_Os04g55230/FLO2基因第6064位碱基胞嘧啶(c)突变为胸腺嘧啶(T),形成TAA无义突变。以上结果证明,cse-2是已报道突变体flo2的一个新等位突变体。

关键词：水稻粉质胚乳淀粉性质基因定位 FLO2

Examining the impact of early enteral nutritional support on postoperative recovery in patients undergoing surgical treatment for gastrointestinal neoplasms

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2222-2233页

作者： Zhi chen Bo Hong Jiang-Juan He Qian-Qian Ye Qiao-Yi hu Department of Rehabilitation Xiangshan First People’s Hospital Medical and Health GroupNingbo 315700Zhejiang ProvinceChina Department of Gastroenterology Xiangshan First People’s Hospital Medical and Health GroupNingbo 315700Zhejiang ProvinceChina center of Nursing Management The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Nutrition Xiangshan First People’s Hospital Medical and Health GroupNingbo 315700Zhejiang ProvinceChina

BAcKGROUND Patients with gastrointestinal tumors often suffer from poor nutritional status during *** is the main treatment for these patients,but the long postoperative recovery period is often accompanied by digestive and absorption dysfunction,leading to further deterioration of the nutritional *** enteral nutrition support is hypothesized to be helpful in improving this situation,but the exact effects have yet to be studied in *** To observe the effect of early enteral nutritional support on postoperative recovery in patients with surgically treated gastrointestinal tract tumors,with the expectation that by improving the nutritional status of patients,the recovery process would be accelerated and the incidence of complications would be reduced,thus improving the quality of *** A retrospective analysis of 121 patients with gastrointestinal tract tumors treated in our hospital from January 2020 to January 2023 was ***-three of these patients received complete parenteral nutrition support as the control group for this *** other 68 patients received early enteral nutritional support as the observation group of this *** clinical indicators comparing the two groups included time to fever,time to recovery of postoperative bowel function,time to postoperative exhaustion,and length of hospital *** changes in immune function and nutritional indexes in the two groups were ***,we utilized the SF-36 scale to compare the changes in the quality of life between the two groups of ***,the occurrence of postoperative complications between the two patient groups was also *** The postoperative fever time,postoperative bowel function recovery time,postoperative exhaustion time,and hospitalization time were all higher in the control group than in the observation group(PcD3+,cD4+,immunoglobulin(Ig)A,IgM,and IgG in the observation group were significantly hi

关键词： Early enteral nutrition support Surgical treatment Gastrointestinal tumor Postoperative recovery Immune function

Range and Annealing Behaviour of Pb^+ Ions Implanted into LiNbO3 crystals at Moderate Energies

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chinese Physics Letters 2002年第1期19卷 101-104页

作者： chen Feng hu hui Zhang Jian-hua Liu Xiang-Dong Xia hui-Hao Shi Bo-Rong Wang Ke-Ming Department of Physics Shandong University Ji'nan 250100 Department of Physics Hong Kong University of Science and Technology Hong Kong

Pb+ ions have been implanted into LiNbO3 crystals in the energy range of 100-350keV at doses of 5×1015, 1×1016 and 2×1016 ions/cm2. The profile of the implanted ions was measured by Rutherford backscattering. The mean projected range and the range straggling obtained from the experiment were compared with the TRIM'98 and SRIM 2000 code. In the present case, the TRIM'98 code predicts experimental values better than those of the SRIM 2000 code. The depth distribution is also found to be independent of dose for 350keV Pb+ implanted into LiNbO3 crystals. After 800°c annealing for 60min in ambient air, obvious diffusion occurs to the implanted Pb+ ions at 150keV with a dose of 5×1015ions/cm2. After a low-temperature treatment at 77K in liquid nitrogen, no obvious diffusion phenomenon occurs for the implanted Pb+ ions in LiNbO3.

关键词： Range Annealing Behaviour of Pb+ Ions Implanted LiNbO3 crystals Moderate Energies

Improved conductivity and capacitance of interdigital carbon microelectrodes through integration with carbon nanotubes for micro-supercapacitors

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Nano Research 2016年第8期9卷 2510-2519页

作者： Yanjuan Yang Liang He chunjuan Tang Ping hu Xufeng Hong Mengyu Yan Yixiao Dong Xiaocong Tian Qiulong Wei Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 Chino Department of Mathematics and Physics Luoyang Institute of Science and Technology Luoyang 471023 China

In the last decade, pyrolyzed-carbon-based composites have attracted much attention for their applications in micro-supercapacitors. Although various methods have been investigated to improve the performance of pyrolyzed carbons, such as conductivity, energy storage density and cycling performance, effective methods for the integration and mass-production of pyrolyzed-carbon- based composites on a large scale are lacking. Here, we report the development of an optimized photolithographic technique for the fine micropatterning of photoresist/chitosan-coated carbon nanotube （cHIT-cNT） composite. After subsequent pyrolysis, the fabricated carbon/cHIT-cNT microelectrode-based micro-supercapacitor has a high capacitance （6.09 ***-2） and energy density （4.5 ***-3） at a scan rate of 10 mV.s-L Additionally, the micro-supercapacitor has a remarkable long-term cyclability, with 99.9% capacitance retention after 10,000 cyclic voltammetry cycles. This design and microfabrication process allow the application of carbon microelectromechanical system （c-MEMS）-based micro-supercapacitors due to their high potential for enhancing the mechanical and electrochemical performance of micro-supercapacitors.

关键词： photolithography supercapacitors pyrolysis microelectromechanicalsystem (MEMS) carbon nanotubes

螺旋采集改善SPEcT定量准确性及图像质量:体模研究

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中国医学影像技术 2024年第3期40卷 446-450页

作者：宋国庆马成皓杨双臣杨鑫张新超田丛娜胡玉敬秦亚楠魏强边艳珠河北省人民医院核医学科河北石家庄050051 河北省脑网络与认知障碍疾病重点实验室河北石家庄050051 石家庄市人民医院影像科河北石家庄050011

目的观察螺旋采集用于改善SPEcT定量准确性及图像质量的价值。方法针对1个包含6个球体(直径分别为37、28、22、17、13和10 mm)的体模模型,分别向球体及体模腔内灌注640 kBq/ml及20 kBq/ml^(99)Tc^(m)O_(4)^(-)溶液,并以5、10及15秒/帧... 详细信息

目的观察螺旋采集用于改善SPEcT定量准确性及图像质量的价值。方法针对1个包含6个球体(直径分别为37、28、22、17、13和10 mm)的体模模型,分别向球体及体模腔内灌注640 kBq/ml及20 kBq/ml^(99)Tc^(m)O_(4)^(-)溶液,并以5、10及15秒/帧行螺旋采集与常规步进采集;比较2种采集方式所获图像质量主观评分及客观参数,包括本底变异系数(cV)、对比度噪声比(cNR)、平均放射性计数(c_(sphere))和测量定量误差百分比(Error%)的差异。结果各采集时间下,螺旋采集图像质量评分均高于常规步进采集,以5秒/帧时二者差值最大;螺旋采集的cV、cNR、c_(sphere)均优于常规步进采集(P均0.05)。结论相同采集时间、尤其较短采集时间下,以螺旋采集所获SPEcT的定量准确性及图像质量优于常规步进采集。

关键词：体层摄影术,发射型计算机,单光子体模,显像术定量图像质量

Semileptonic decays B_c■(η_c, J/ψ)l■_l in the “PQcD+Lattice” approach

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chinese Physics c 2020年第2期44卷 51-61页

作者： Xue-Qing hu Su-Ping Jin Zhen-Jun Xiao Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Jiangsu Key Laboratory for Numerical Simulation of Large Scale complex Systems Nanjing Normal UniversityNanjing 210023China

We study the semileptonic decaysBc-→(ηc,J/ψ)l-■lusing the PQcD factorization approach with the newly defined distribution amplitudes of the B c meson and a new kind of parametrization for extrapolating the form factors which takes into account the recent lattice QcD *** find the following main results:(a)the PQcD predictions of the branching ratios of theBc→(ηc,J/ψ)l■decays are smaller by about 5%-16%when the lattice results are taken into account in the extrapolation of the relevant form factors;(b)the PQcD predictions of the ratio Rηc,RJ/ψand of the longitudinal polarization PτareRηc=0.34±0.01,RJ/ψ=0.28±0.01,Pτ(ηc)=0.37±0.01and Pτ(J/ψ)=-0.55±0.01;and(c)after including the lattice results,the theoretical predictions slightly change:Rηc=0.31±0.01,RJ/ψ=0.27±0.01,Pτ(ηc)=0.36±0.01andPτ(J/ψ)=-0.53±*** theoretical predictions of RJ/ψagree with the measurements within the *** other predictions could be tested by the LHcb experiment in the near future.

关键词： semileptonic Bc decays PQcD approach lattice QcD results ratio of branching ratios longitudinal polarization

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脂肪酸修饰胰岛素与白蛋白结合活性的研究

药物生物技术 2024年第2期31卷 137-140页

作者：胡宏飞徐同杰魏莹张甜甜秦宇正大天晴药业集团股份有限公司江苏南京210000

文章对胰岛素-白蛋白体外结合活性测定方法进行研究,以判定自制长效胰岛素TQ05849与原研药物的相似性,同时探索脂肪酸链在该结合过程中的作用。通过活性琼脂糖基质固定化白蛋白体外结合长效胰岛素、SPR亲和力及结合/解离动力学测定两种... 详细信息

文章对胰岛素-白蛋白体外结合活性测定方法进行研究,以判定自制长效胰岛素TQ05849与原研药物的相似性,同时探索脂肪酸链在该结合过程中的作用。通过活性琼脂糖基质固定化白蛋白体外结合长效胰岛素、SPR亲和力及结合/解离动力学测定两种方法对结合率进行测定,并设置长效胰岛素前体为阴性对照组,考察脂肪酸链在长效胰岛素与白蛋白结合过程中发挥的作用。通过固定化白蛋白体外结合长效胰岛素的方法测得TQ05849及原研制剂的体外白蛋白结合率分别为86.52%及86.71%,通过SPR亲和力及结合/解离动力学测定法测得TQ05849及原研制剂体外白蛋白亲和力R_(max)值分别为332及346 RU,KD值分别为124.8及122.4μmol/L,均基本一致,且结合/解离动力学图谱无显著差异。两种方法中阴性对照组长效胰岛素前体与白蛋白基本无结合,自制长效胰岛素TQ05849与原研制剂体外白蛋白结合活性相似,脂肪酸链在长效胰岛素与白蛋白体外结合过程中起主要作用。

关键词：长效胰岛素固定化白蛋白表面等离子共振脂肪酸体外结合率

荧光素酶免疫吸附法高灵敏检测蓝舌病病毒抗体方法的建立

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中国兽医科学 2024年第7期54卷 881-887页

作者：张鸿歌田占成独军政王琼洁康棣户鑫兵张忠辉关贵全殷宏中国农业科学院兰州兽医研究所动物疫病防控全国重点实验室甘肃兰州730046 江苏省动物重要疫病与人兽共患病防控协同创新中心江苏扬州225009

为了建立一种高效检测动物血清中蓝舌病病毒(BTV)抗体的检测方法,以BTV血清群特异性VP7抗原与荧光素酶蛋白相融合表达的标记蛋白(VP7-NLuc)为检测抗原建立了荧光素酶免疫吸附(VP7-NLuc-LISA)方法,用于检测BTV抗体。结果表明:BTV阳性血... 详细信息

为了建立一种高效检测动物血清中蓝舌病病毒(BTV)抗体的检测方法,以BTV血清群特异性VP7抗原与荧光素酶蛋白相融合表达的标记蛋白(VP7-NLuc)为检测抗原建立了荧光素酶免疫吸附(VP7-NLuc-LISA)方法,用于检测BTV抗体。结果表明:BTV阳性血清能特异性识别VP7-NLuc融合蛋白;监测BTV-1灭活疫苗免疫绵羊血清中BTV抗体动态结果表明,VP7-NLucLISA方法与商品化竞争性ELISA(c-ELISA)试剂盒的检测结果呈高度相关性(R=0.76,Pc LISA方法与商品化c-ELISA试剂盒的符合率为98.86%,其相对特异性为99.52%,相对敏感性为96.49%。结论:所建立的VP7-NLuc-LISA方法可作为大规模动物BTV流行病学调查和监测的新方法。

关键词：蓝舌病病毒 VP7蛋白荧光素酶免疫吸附试验 c-ELISA 血清学检测