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chinese chemical Letters 2011年第9期22卷 1099-1102页

作者： Wan Min Liu Guo Rong hu Zhong Dong Peng Ke Du Yan Bing cao Qiang Liu School of Metallurgical Science and Engineering Central South University Changsha 410083 China School of chemistry and Chemical Engineering Hunan Institute of Engineering Xiangtan 411104 China

Spherical LiNi0.8co0.15Al0.05O2 OOH precursor prepared by a co-oxidation-controlled crystallization method, was used to synthesize LiNi0.5co0.15Al0.05O2. The obtained LiNi0.8co0.15Al0.05O2 materials showed excellent electrochemical performance, with an initial discharge capacity of 193.5 mAh/g and capacity retention of 95.1% after 50 cycles when cycled at 0.2 c rate between 2.8 and 4.3 V.

关键词： Li-ion battery cathode material LiNi0.8co0.15Al0.05O2 co-oxidation-controlled crystallization

Evaluation of Dosages Regimen of Fluconazole in Patients of candidemia with Gender by PK/PD and Mote carlo Simulation

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Open Journal of Blood Diseases 2022年第4期12卷 79-86页

作者： Jiuli hu Xiaolei Yu Junhui hu Xiaoqin Zhu Department of clinic Pharmacy The Affiliated Hospital of Chengde Medical University Chengde China Department of Oncology Department The Affiliated Hospital of Chengde Medical University Chengde China

candidemia is one of the four most common nosocomial blood infections and is the most common hospital-acquired fungemia in a recent multi-institutional study from the US. The mortality of candidemia can be up to 50%. Fluconazole is a triazole derivative widely used for the treatment of invasive candidiasis. It was recommended as first-line drugs for the treatment and prevention of mycoses. In our study, we aimed to optimise the dosage of fluconazole with gender against candida spp. based on pharmacokinetic/pharmacodynamics (PK/PD) analysis. We collected the published data about pharmacokinetic parameters of fluconazole and the MIc distribution of candida spp. on fluconazole. We decided to evaluate the gender between males and females with the pharmacokinetics of fluconazole. Using probability of target attainment (PTA) and cumulative fraction of response (cFR) as indexes, crystal ball software 11.***.2.4 was used for Monte carlo simulation of different dosage regimens of different males and females. For c. albicans, c. tropicalis and c. lusitaniae, when doses of regimen are 100 mg IV, 200 mg IV and MIc was lower than 1 g/ml, PTA was higher than 90%. For c. tropicalis, each dosing regimen and MIc was less than 2 g/ml. PTA was higher than 90%. As c. glabrata, c. parapsilosis, c. krusei, c. guilliermondii for PTA with more than 90%, MIc of fluconazole 200 mg were less than 32 g/ml, 64 g/ml and 64 g/ml, respectively. For the different dosage regimens 100 mg IV and 200 mg IV of fluconazole for candida spp., it is desirable that fluconazole dosage regimens take into account both the gender of the patient.

关键词： Monte carlo Simulation (MSc) Fluconazole candidemia Gender

Synthesis, crystal Structure and Magnetic Property of Disodium Biscarbonato cobaltate(Ⅱ) Tetrahydrate, Na_2co(cO_3)_2·4H_2O

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chemical Research in chinese Universities 1999年第4期15卷 311-316页

作者： ZHENG Yue-Qing YE Yu-Han hu Fu-Tao PETERS Karl and von ScHNERING Hans Georg chemistry Department Ningbo UniversityNingbo 315211P.R.China Max Planck Institut für Festkrperforschung D 70569 StuttgartGermany

The title compound, Na 2co(cO 3) 2·4H 2O, was synthesized by dropwise addition of 1.0 mL of 1 mol/L co(cH 3cOO) 2 to 50 mL of aqueous solution containing 7.0 g(66.0 mmol) of Na 2cO 3 and 2.5 g(29.8 mmol) of NaHcO 3 under stirring. A rose colored rhombohedral crystal grew by the slow evaporation of the solution of the title compoud at room temperature. The crystal structure was established on the basis of the single crystal X ray diffraction data. Na 2co(cO 3) 2·4H 2O crystallizes in the monoclinic space group c2/c with a =0.856 6(1) nm, b =0.714 6(1) nm, c = 1 438 7(2) nm, β =97.59(1)° , V =0.873 0(2) nm 3 , D x=2.260 g/cm 3, F (000)=596, M r=296 99, μ (Mo K α)=21.06 cm -1 , Z =4 and the final R(F) =0.032 and wR(F 2) =0.068 on the basis of 947 reflections ( F 2 ≥ 2σ(F 0 2)). The crystal consists of H 2O molecules, Na + ions and 2D 2 ∞[co(cO 3) 2] 2- layers extending parallel to (001). H 2O molecules and Na + cations are located between the 2D layers. Each co atom is tetrahedrally coordinated by four O atoms from four cO 2- 3 groups with d (co\_O)=0.206 5(2) nm, 0.207 6(2) nm and the angle of O\_co\_O is in the range of 97.7(1)°—128.5(1)°. The cO 2- 3 group bridging two co atoms via two O atoms deviates from D 3h symmetry with d (c\_O)=0.127 2(3)\_0.129 9(3) nm and the angle of O\_c\_O is in the range of 119.5(2)°\_123.4(2)°. Each Na atom, with two close Na neighbours at 0.338 4(2) nm and 0 346 7(2) nm, respectively, is octahedrally coordinated by six O atoms from four H 2O molecules and two carbonate groups belonging to two layers with d (Na\_O)=0.232 7(2)\_0.241 1(2) nm. Of two crystallographically different H 2O molecules, one forms hydrogen bonds to two cO 3 2- groups of one 2D layer, and the other to those from two different 2D layers. Na 2co(cO 3) 2·4H 2O is antiferromagnetic below 16 K, and between 30\_300

关键词： Synthesis Disodium biscarbonatocobaltate(Ⅱ) tetrahydrate crystal structure complex carbonate Magnetic property

High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition

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World Journal of Gastroenterology 2019年第36期25卷 5434-5450页

作者： Ting-Jie Ye Yan-Lin Lu Xiao-Feng Yan Xu-Dong hu Xiao-Ling Wang Department of Biology School of Basic Medical Sciences Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Oncology and Institute of Traditional chinese Medicine in Oncology Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

BAcKGROUND High mobility group box-1 (HMGB1), recognized as a representative of damageassociated molecular patterns, is released during cell injury/death, triggering the inflammatory response and ultimately resulting in tissue damage. Dozens of studies have shown that HMGB1 is involved in certain diseases, but the details on how injured hepatocytes release HMGB1 need to be elicited. AIM To reveal HMGB1 release mechanism in hepatocytes undergoing oxidative stress. METHODS c57BL6/J male mice were fed a high-fat diet for 12 wk plus a single binge of ethanol to induce severe steatohepatitis. Hepatocytes treated with H2O2 were used to establish an in vitro model. Serum alanine aminotransferase, liver H2O2 content and catalase activity, lactate dehydrogenase and 8-hydroxy-2- deoxyguanosine content, nicotinamide adenine dinucleotide (NAD+) levels, and Sirtuin 1 (Sirt1) activity were detected by spectrophotometry. HMGB1 release was measured by enzyme linked immunosorbent assay. HMGB1 translocation was observed by immunohistochemistry/immunofluorescence or Western blot. Relative mRNA levels were assayed by qPcR and protein expression was detected by Western blot. Acetylated HMGB1 and poly(ADP-ribose)polymerase 1 (Parp1) were analyzed by Immunoprecipitation. RESULTS When hepatocytes were damaged, HMGB1 translocated from the nucleus to the cytoplasm because of its hyperacetylation and was passively released outside both in vivo and in vitro. After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ). Parp1 and Sirt1 are two NAD+-dependent enzymes which play major roles in the decision of a cell to live or die in the context of stress . We showed that NAD+ depletion attributed to Parp1 activation after DNA damage was caused by oxidative stress in hepatocytes and resulted in Sirt1 activity inhibition. On the contrary, Sirt1 suppressed Parp1 by neg

关键词： Sirtuin1 Poly ADP-ribose polymerase 1 High mobility group box-1 Hepatocytes Hydrogen peroxide

Z-bpy,a New c2-Symmetric Bipyridine Ligand and Its Application in Enantioselective copper(Ⅰ)-catalyzed cyclopropanation of Olefins

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chinese Journal of chemistry 2019年第8期37卷 807-810页

作者： Yizhao Ouyang Miao Zhan Jing Zhou Jiao Jiao Hao hu Yoichi M.A.Yamada Pengfei Li Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'anShaanxi 710054China Department of Applied chemistry School of ScienceXi'an Jiaotong UniversityXi'anShaanxi 710049China Xi'an Key Laboratory of Sustainable Energy Materials chemistry Xi'an Jiaotong UniversityXi'anShaanxi 710049China RIKEN center for Sustainable Resource Science WakoSaitama 3510198Japan

Summary of main observation and conclusion A rigid c2-symmetric chiral bipyridine ligand Z-bpy with a triptycene-like backbone was designed and synthesized from simple chemicals in a scalable *** this new ligand,copper(Ⅰ) catalyzed cyclopropanation of styrenes with commercial ethyl diazoacetate produced various corresponding cyclopropanes in high yields,diastereoselectivity and enantioselectivity up to 97% ee.

关键词： Its was

carbonaceous aerosol transport from the Indo-Gangetic Plain to the Himalayas:carbon isotope evidence and light absorption characteristics

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Geoscience Frontiers 2023年第2期14卷 105-115页

作者： Pengfei chen Shichang Kang chaoliu Li Zhaofu hu Lekhendra Tripathee Mukesh Rai Tao Pu Xiufeng Yin Örjan Gustafsson State Key Laboratory of cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)Lanzhou 730000China University of chinese Academy of Sciences Beijing 100049China Department of Environmental Science The Bolin Centre for Climate ResearchStockholm UniversityStockholm 10691Sweden The Bolin centre for climate Research Stockholm UniversityStockholm 10691Sweden

The Indo-Gangetic Plain(IGP)is a major regional and global emitter of atmospheric pollutants,which adversely affect surrounding areas such as the *** present a comprehensive dataset on carbonaceous aerosol(cA)composition,radiocarbon(D14c)-based source apportionment,and light absorption of total suspended particle(TSP)samples collected over a 3-year period from high-altitude Jomsom in the central *** 3-year mean TSP,organic carbon(Oc),and elemental carbon(Ec)concentrations were 92.0±28.6,9.74±6.31,and 2.02±1.35 lg m^(3),respectively,with the highest concentrations observed during the pre-monsoon season,followed by the post-monsoon,winter,and monsoon *** △^(14)c analysis revealed that the contribution of fossil fuel combustion(ffossil)to Ec was 47.9%±11.5%,which is consistent with observations in urban and remote regions in South Asia and attests that Ec likely arrives in Jomsom from upwind IGP sources via long-range *** addition,the lowest f_(fossil)(38.7%±13.3%)was observed in winter,indicating large contributions in this season from local biomass *** mass absorption cross-section of Ec(MAcEc:8.27±1.76 m^(2)/g)and watersoluble organic carbon(MAcWSOc:0.98±0.45 m^(2)/g)were slightly higher and lower than those reported in urban regions,respectively,indicating that cA undergo an aging *** aerosol coating during transport and variation of biomass burning probably led to the seasonal variation in MAc of two ***,WSOc contributed considerably to the light absorption(11.1%±4.23%)of *** findings suggest that to protect glaciers of the Himalayas from pollution-related melting,it is essential to mitigate emissions from the IGP.

关键词： carbonaceous aerosol Long-range transport carbon isotope Source apportionment Light absorption The Himalayas

Neuroprotective effects of BDNF and GDNF in intravitreally transplanted mesenchymal stem cells after optic nerve crush in mice

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 35-42页

作者： Zong-Li hu Ni Li Xin Wei Li Tang Ting-hua Wang Xiao-Ming chen Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Institute of Neurological Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM： To assess the neuro-protective effect of bone marrow mesenchymal stem cells （BMScs） on retinal ganglion cells （RGcs） following optic nerve crush in mice. METHODS： c56BL/6J mice were treated with intravitreal injection of PBS, BMScs, BDNF-interference BMScs （BIM）, and GDNF-interference BMScs （GIM） following optic nerve crush, respectively. The number of surviving RGcs was determined by whole-mount retinas and frozen sections, while certain mRNA or protein was detected by q-PcR or ELISA, ***： The density （cell number/mm^2） of RGcs was 410.77±56.70 in the retina 21d after optic nerve crush without any treatment, compared to 1351.39±195.97 in the normal control （P〈0.05）. RGcs in BMScs treated eyes was 625.07±89.64/mm^2, significantly higher than that of no or PBS treatment （P〈0.05）. While RGcs was even less in the retina with intravitreal injection of BIM （354.07±39.77） and GIM （326.67±33.37） than that without treatment （P〈0.05）. BMScs injection improved the internal BDNF expression in ***： Optic nerve crush caused rust loss of RGcs and intravitreally transplanted BMScs at some extent protected RGcs from death. The effect of BMScs and level of BDNF in retinas are both related to BDNF and GDNF expression in BMScs.

关键词： optic nerve crash retinal ganglion cells stemcells brain-derived neurotrophie factor glial cell line-derived neurotrophic factor

Utility of somatosensory and motor-evoked potentials in reflecting gross and fine motor functions after unilateral cervical spinal cord contusion injury

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Neural Regeneration Research 2021年第7期16卷 1323-1330页

作者： Rong Li Zu-cheng huang Hong-Yan cui Zhi-Ping huang Jun-Hao Liu Qing-An Zhu Yong hu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina Department of Spine Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology The University of Hong KongHong Kong Special Administrative RegionChina Department of Orthopedics and Traumatology The Hong Kong University Shenzhen HospitalShenzhenGuangdong ProvinceChina

Fine motor skills are thought to rely on the integrity of ascending sensory pathways in the spinal dorsal column as well as descending motor pathways that have a neocortical ***, the neurophysiological processes underlying communication between the somatosensory and motor pathways that regulate fine motor skills during spontaneous recovery after spinal cord contusion injury remain ***, we established a rat model of cervical hemicontusive injury using c5 laminectomy followed by contusional displacement of 1.2 mm(mild injury) or 2.0 mm(severe injury) to the c5 spinal *** recordings were performed on the brachial muscles up to 12 weeks after injury to investigate the mechanisms by which spinal cord pathways participate in motor *** spinal cord contusion injury, the amplitudes of somatosensory and motor-evoked potentials were reduced, and the latencies were *** forelimb open field locomotion test, grooming test, rearing test and Montoya staircase test revealed improvement in *** increasing time after injury, the amplitudes of somatosensory and motor-evoked potentials in rats with mild spinal cord injury increased gradually, and the latencies gradually *** comparison, the recovery times of somatosensory and motor-evoked potential amplitudes and latencies were longer, and the recovery of motor function was delayed in rats with severe spinal cord *** analysis revealed that somatosensoryevoked potential and motor-evoked potential parameters were correlated with gross and fine motor function in rats with mild spinal cord contusion *** contrast, only somatosensory-evoked potential amplitude was correlated with fine motor skills in rats with severe spinal cord *** results show that changes in both somatosensory and motor-evoked potentials can reflect the changes in gross and fine motor functions after mild spinal cord contusion injury, and that the change in somatosen

关键词： central nervous system motor-evoked potential motor function regeneration repair somatosensory-evoked potential spinal cord spinal cord injury

不同性别早发急性冠脉综合征患者危险因素及病变特点分析

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心血管康复医学杂志 2024年第2期33卷 136-139页

作者：尹萍范例胡靖超卓杨曾华甦许左隽上海交通大学医学院附属第九人民医院心内科上海200011

目的:探讨不同性别早发急性冠脉综合征(PAcS)患者的危险因素及病变特点。方法:选择上海交通大学医学院附属第九人民医院心内科2016年1月至2019年1月收治的PAcS患者338例,按性别分为男性组(195例)和女性组(143例),比较两组患者的基线资料... 详细信息

目的:探讨不同性别早发急性冠脉综合征(PAcS)患者的危险因素及病变特点。方法:选择上海交通大学医学院附属第九人民医院心内科2016年1月至2019年1月收治的PAcS患者338例,按性别分为男性组(195例)和女性组(143例),比较两组患者的基线资料、AcS分型、实验室检查指标、冠状动脉病变以及心脏结构变化情况。结果:与男性组比较,女性组年龄、糖尿病、脑梗死、不稳定型心绞痛比例、HDL-c、载脂蛋白A1、载脂蛋白A1/B水平显著升高,BMI、吸烟史、饮酒史、心肌梗死史、STEMI、NSTEMI比例,TG水平显著降低,Pc水平显著升高,左回旋支病变比例显著降低。两者之间存在显著差异。

关键词：急性冠状动脉综合征性别危险因素

Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway

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World Journal of Gastroenterology 2019年第12期25卷 1492-1501页

作者： Jie hu Wei Hong Kan-Nan Yao Xiao-Hong Zhu Zhi-Yun chen Lei Ye Department of Infectious Diseases The First Affiliated Hospital of Zhejiang Chinese Medical University the Second central Laboratory The First Affiliated Hospital of Zhejiang Chinese Medical University

BAcKGROUND Nonalcoholic fatty liver disease(NAFLD), the most common chronic liver disease, can progress into nonalcoholic steatohepatitis(NASH), cirrhosis, and even hepatocellular carcinoma. Bile acids such as ursodeoxycholic acid(UDcA)play an essential role in the pathogenesis of NAFLD by regulating the level of sterol regulatory element-binding protein(SREBP) 1 c, but the underlying regulatory mechanism remains elusive. Increased evidence indicates that the AKT/mTOR/SREBP-1 signaling pathway is a key pathway to regulate hepatic cellular lipid metabolism. UDcA may regulate the AKT/mTOR/SREBP-1 signaling pathway to ameliorate hepatic lipid *** To investigate the functional mechanism of UDcA in an oleic acid(OA)-induced cellular model of *** The cellular model of NAFLD was established using OA and treated with ***, the best concentration of UDcA was selected. For the best time-dependent assay, cells were stimulated with OA only or co-treated with OA and 2 mmol/L UDcA for 24 h, 48 h, and 72 h. Oil red O staining was used to observe the accumulation of intracellular lipids, while the intracellular contents of triglyceride, alanine aminotransferase(ALT), gamma-glutamyl transpeptidase(GGT), and aspartate aminotransferase(AST) were detected by enzymatic methods. Meanwhile, the expression levels of AKT/mTOR/SREBP-1 signaling pathway-related proteins were detected by real-time PcR and Western *** In the NAFLD cell model established with LO2 cells induced using OA, lipid accumulation was obvious. UDcA significantly inhibited lipid accumulation at different concentrations(especially 2 mmol/L) and decreased cell growth ability at different time points. The biochemical parameters like ALT, AST, and GGT were significant improved by UDcA. UDcA treatment vividly repressed the activation of AKT, mTOR, and cRTc2 and the expression of nSREBP-1 in LO2 cells induced with *** Our findings demonstrate the effect of UDcA in improving NAFLD. U

关键词： Ursodeoxycholic acid Hepatic lipid metabolism AKT/mTOR/SREBP-1 Hepatic steatosis