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Effective common chinese Herbal Medicines Used in Treating chronic cholecystitis with Liver-Gallbladder Dampness-Heat Syndrome: A Review of clinical Studies in the Past 10 Years

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World Journal of Traditional chinese Medicine 2023年第1期9卷 8-20页

作者： Desmond wei Kang tee Hon Foong Wong centrefor complementary and Alternative Medicine International Medical UniversityKuala LumpurMalaysia

The objective of the study is to identify the effective common chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome(ccLGDHS) through reviewing relevant clinical studies published in the past 10 years. Data were collected from Science Direct and chinese National Knowledge Infrastructure. Data screening was carried out for the abstracts and full texts of the data. The top 15 chinese herbal medicines with the highest occurring frequency were selected, statistically analyzed, and classified by their medicinal properties, actions, and indications according to the chinese Pharmacopoeia 2015 edition. The top 15 effective common chinese herbal medicines comprise chai Hu, Huang Qin, Jin Qian cao, Bai Shao, Yin chen, Yu Jin, chuan Lian Zi, Yan Hu Suo, Zhi Shi, Ban Xia, Bai Zhu, Pu Gong Ying, Gan cao, Zhi Zi, and Qing Pi. The predominant natures were cold, cool, and warm. This combination can clear stagnant heat, warm Yang, and regulate Qi dynamics. In addition, bitter, pungent, and sweet were the predominant flavors. They can clear dampness-heat, regulate Qi dynamics to relieve cramps and pain, as well as tonify the deficiency. Along with entering the liver and gallbladder meridians, these herbal medicines also entered the spleen, stomach, and lung meridians to prevent potential disease transmission. The combinatorial medicinal actions of the effective common chinese herbal medicine highlight the importance of the holistic concept of traditional chinese medicine when treating ccLGDHS. In addition, the inclusion of activating blood to promote blood circulation, relieving cramps and alleviating pain, and tonifying the spleen and stomach represents a new finding in the treatment principle for ccLGDHS.

关键词： chronic cholecystitis common chinese herbal medicines liver-gallbladder dampness-heat syndrome traditional chinese medicine treatment

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Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis

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World Journal of Gastroenterology 2006年第4期12卷 588-594页

作者： Beatrice J Goh Bee tee Tan wei Min Hon Kang Hoe Lee Hoon Eng Khoo Department of Biochemistry Yong Loo Lin School of Medicine National University ofSingapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Research Biolabs Pte Ltd

AIM： Portal hypertension is a common complication of liver cirrhosis. Intrahepatic pressure can be elevated in several ways. Abnormal architecture affecting the vasculature, an increase in vasoconstrictors and increased circulation from the splanchnic viscera into the portal system may all contribute. It follows that endogenous vasodilators may be able to alleviate the hypertension. We therefore aimed to investigate the levels of endogenous vasodilators, nitric oxide （NO） and carbon monoxide （cO） through the expression of nitric oxide synthase （NOS） and heme oxygenase （HO）. METHOD： cirrhotic （n = 20） and non-cirrhotic （n = 20） livers were obtained from patients who had undergone surgery. The mRNA and protein expressions of the various isoforms of NOS and HO were examined using competitive PcR, Western Blot and immunohistochemistry. RESULTS： There was no significant change in either inducible NOS （iNOS） or neuronal NOS （nNOS） expressions while endothelial NOS （eNOS） was up- regulated in cirrhotic livers. concomitantly, caveolin-1, an established down-regulator of eNOS, was upregulated. Inducible HO-1 and constitutive HO-2 were found to show increased expression in cirrhotic livers albeit in different Iocalizations. cONcLUSION： The differences of NOS expression might be due to their differing roles in maintaining liver homeostasis and/or involvement in the pathology of cirrhosis. Sheer stress within the hypertensive liver may induce increased expression of eNOS. In turn, caveolin-1 is also increased. Whether this serves as a defense mechanism against further cirrhosis or is a consequence of cirrhosis, is yet unknown. The elevated expression of HO-1 and HO-2 suggest that cO may compensate in its role as a vasodilator albeit weakly. It is possible that cO and NO have parallel or coordinated functions within the liver and may work antagonistically in the pathophysiology of portal hypertension.

关键词： Liver cirrhosis Nitric oxide synthase Heine oxygenase Gene expression competitive PcR

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基于动态完整性度量的机密计算运行时监控方案

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计算机研究与发展 2024年第10期61卷 2482-2500页

作者：李为冯伟秦宇冯登国中国科学院大学北京100049 计算机科学国家重点实验室(中国科学院软件研究所) 北京100190 中国科学院软件研究所北京100190

机密计算(confidential computing,cc)技术基于硬件可信执行环境(tee),通过隔离、完整性度量和远程证明等技术保护使用中数据的机密性和完整性,并免受特权敌手的攻击.然而,现有机密计算平台的完整性度量和远程证明机制主要针对启动时,... 详细信息

机密计算(confidential computing,cc)技术基于硬件可信执行环境(tee),通过隔离、完整性度量和远程证明等技术保护使用中数据的机密性和完整性,并免受特权敌手的攻击.然而,现有机密计算平台的完整性度量和远程证明机制主要针对启动时,而缺少运行时完整性保护,例如当用户工作负载潜在的内存漏洞被敌手利用时容易遭受控制流劫持等攻击,目前仅包含启动时完整性保护的机密计算平台无法有效防止或者检测此类运行时攻击.针对该问题,提出了一种基于动态完整性度量的机密计算运行时监控方案,通过向tee中引入控制流和数据流度量,并扩展可信验证方功能以进行运行时远程证明,实现了机密计算平台内用户工作负载的运行时完整性保护.使用cSV/SEV服务器作为机密计算平台,在其机密虚拟机/容器基础上进行了系统原型实现与实验评估,评估结果表明,方案在增强运行时安全性的同时,引入了约16%的性能损耗.

关键词：机密计算可信执行环境运行时证明控制流完整性数据流完整性

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Predictors for success of non-operative management of adhesive small bowel obstruction

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1116-1124页

作者： Zi Qin Ng Vivien Hsu William wei Han tee Jih Huei Tan Ruwan Wijesuriya Department of General Surgery St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of Radiology St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of General Surgery Hospital Sultanah AminahJohor Bahru 80000JohorMalaysia

BAcKGROunD Majority of adhesive small bowel obstruction(SBO)cases can be managed ***,a proportion of patients failed non-operative *** To evaluate the predictors of successful non-operative management in adhesive *** A retrospective study was performed for all consecutive cases of adhesive SBO from November 2015 to May *** collated included basic demographics,clinical presentation,biochemistry and imaging results and management *** imaging studies were independently analyzed by a radiologist who was blinded to the clinical *** patients were divided into group A operative(including those that failed initial non-operative management)and group B non-operative for *** Of 252 patients were included in the final analysis;group A(n=90)(35.7%)and group B(n=162)(64.3%).There were no differences in the clinical features between both *** tests of inflammatory markers and lactate levels were similar in both *** the imaging findings,the presence of a definitive transition point[odds ratio(OR)=2.67,95%confidence interval(cI):0.98-7.32,P=0.048],presence of free fluid(OR=2.11,95%cI:1.15-3.89,P=0.015)and absence of small bowel faecal signs(OR=1.70,95%cI:1.01-2.88,P=0.047)were predictive of the need of surgical *** patients that received water soluble contrast medium,the evidence of contrast in colon was 3.83 times predictive of successful non-operative management(95%cI:1.79-8.21,P=0.001).cONcLUSION The computed tomography findings can assist clinicians in deciding early surgical intervention in adhesive SBO cases that are unlikely to be successful with non-operative management to prevent associated morbidity and mortality.

关键词： Small bowel obstruction Adhesive conservative Non-operative

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Quality indicators in pediatric colonoscopy in a low-volume center:Implications for training

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World Journal of Gastroenterology 2018年第9期24卷 1013-1021页

作者： Way-Seah Lee c.un-wei tee Zhong-Lin Koay Tat-Seng Wong Fatimah Zahraq Hee-wei Foo Sik-Yong Ong Shin-Yee Wong Ruey-Terng Ng Department of Paediatrics University Malaya Medical CentreKuala Lumpur 59100Malaysia Paediatric and child Health Research Group University MalayaKuala Lumpur 50603Malaysia

AIM To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training *** We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years(January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as *** Median(± SD) age of 121 children [males = 74(61.2%)] who had 177 colonoscopies was 7.0(± 4.6) years. On average, 30 colonoscopies were performed each year(range: 19-58). Except for investigations of abdominal pain(21/177, 17%), indications for colonoscopies were appropriate in the remaining 83%. Bowel preparation was good in 87%. One patient(0.6%) with severe crohn's disease had bowel perforation. cecum examination and ileal intubation rate was 95% and 68.1%. Ileal intubation rate was significantly higher in diagnosing or assessing inflammatory bowel disease(IBD) than non-IBD(72.9% vs 50.0%; P = 0.016). Performance of four trainees was consistent throughout the study period. Average cecum and ileal examination rate among trainees were 97% and 77%.cONcLUSION Benchmarking against established guidelines helps units with a low-volume of colonoscopies to identify area for further improvement.

关键词： Pediatric colonoscopies Quality indicators Performance

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Ophthalmology simulation for undergraduate and postgraduate clinical education

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 920-924页

作者： Daniel Shu wei Ting Shaun Sebastian Khung Peng Sim christine Wen Leng Yau Mohamad Rosman Ai tee Aw Ian Yew San Yeo Third Hospital Avenue Singapore National Eye Centre168751Singapore college Road DUKE-NUS Medical School Singapore169857Singapore

This is a review education paper on the current ophthalmology simulators utilized worldwide for undergraduate and postgraduate training. At present, various simulators such as the EYE Exam Simulator （Kyoto Kagaku co. Ltd., Kyoto, Japan）, Eyesi direct ophthalmoscope simulator （VRmagic, GmbH, Mannheim, Germany）, Eyesi indirect ophthalmoscope simulator （VRmagic, GmbH, Mannheim, Germany） and Eyesi cataract simulators （VRmagic, GmbH, Mannheim, Germany）. These simulators are thought to be able to reduce the initial learning curve for the ophthalmology training but further research will need to be conducted to assess the effectiveness of the simulation-assisted ophthalmology training. Future research will be of great value to assess the medical students and residents responses and performance regarding the usefulness of the individual eye simulator.

关键词： ophthalmology simulator cataract simulator ophthalmology residency training direct ophthalmoscopysimulator

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侧深施肥装置三通管气固两相流仿真与试验

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中国农机化学报 2024年第3期45卷 74-80页

作者：陈威王川王丽伟张瑾王伟卢碧芸安徽省农业科学院农业工程研究所合肥市230001

为探究气吹式侧深施肥装置三通管不同结构特征对气流和肥料颗粒运动的影响,通过理论分析,设计气流入口与出口轴线垂直的a型三通管、气流入口与出口轴线呈45°夹角的b型三通管、气流入口与出口同轴的c型三通管。在三通管内径为28 mm、通... 详细信息

为探究气吹式侧深施肥装置三通管不同结构特征对气流和肥料颗粒运动的影响,通过理论分析,设计气流入口与出口轴线垂直的a型三通管、气流入口与出口轴线呈45°夹角的b型三通管、气流入口与出口同轴的c型三通管。在三通管内径为28 mm、通入气流速度为16.4 m/s、肥料颗粒流量为20 g/s的条件下,采用cFD-EDM耦合方式对不同管道内气流、压力、颗粒运动状态进行仿真分析。结果表明:气流经a、b、c三种类型三通管产生不同的流动效果,进而影响肥料颗粒运动特性,颗粒最大运动速度分别为1.99 m/s、2.94 m/s、2.07 m/s,期间颗粒产生最大碰撞力分别为0.05 N、0.13 N、0.34 N。通过验证试验对比表明,采用b型管侧深施肥装置排肥稳定性变异系数为0.81,肥料破损率为0.72%,施肥过程中无肥料堵塞。

关键词：水稻侧深施肥气吹式三通管气固两相流仿真分析

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Prevalence and risk factors of intestinal parasitism among two indigenous subethnic groups in Peninsular Malaysia

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Infectious Diseases of Poverty 2016年第1期5卷 700-714页

作者： Yuee Teng chin Yvonne Ai Lian Lim c.un Wie chong cindy Shuan Ju Teh Ivan Kok Seng Yap Soo ching Lee Mian Zi tee Vinnie wei Yin Siow Kek Heng chua Department of Biomedical Science Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Department of Parasitology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Department of Life Sciences School of PharmacyInternational Medical University57000 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia

Background:Intestinal parasitic infections(IPIs)among indigenous people have been widely documented in Malaysia,however,the prevalence of these infections remains *** the past,most studies have focused on specific species of parasites but polyparasitism has received limited *** addition,epidemiology studies on indigenous people tend to consider them as a homogenous group,whereas in reality different sub-ethnic groups have different cultural and living *** in living habits such as personal hygiene practices may predispose different groups to different parasitic *** better understand prevalence and risk factors of intestinal parasitism among different sub-ethnic groups,the present study was conducted among two sub-ethnic groups of indigenous people(Temuan and Mah Meri)residing in Selangor state,***:A cross-sectional study that focused on two distinct sub-ethnic groups was carried out from February to September *** samples were collected from 186 participants and examined using the formalin-ether sedimentation technique.A molecular approach was adopted to conduct a genetic characterisation of the ***,questionnaires were administered to obtain information on the demographics,socioeconomic backgrounds and behavioural risks relating to the participants,as well as information about their *** analyses(*** and multivariate logistic regression analyses)were performed to measure risk ***:For Temuan communities,trichuriasis(64.2%)was the most common infection found,preceding hookworm infection(34%),ascariasis(7.5%),giardiasis(14.2%)and amoebiasis(7.5%).As for the Mah Meri communities,trichuriasis(77.5%)prevailed over ascariasis(21.3%),hookworm(15%),giardiasis(7.5%)and amoebiasis(3.8%).Significant differences in proportions of trichuriasis,ascariasis and hookworm infections were observed between the Temuan and Mah Meri sub-ethnic *** was more

关键词： Intestinal parasites Intestinal parasitism Indigenous people Risk factors Prevalence Sub-ethnic group Temuan sub-ethnic group Mah Meri sub-ethnic group Peninsular Malaysia

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基于tee和SE的移动平台双离线匿名支付方案

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软件学报 2024年第8期35卷 3553-3576页

作者：杨波冯伟秦宇张彦超佟冬国家金融科技测评中心北京100041 银行卡检测中心研发中心北京100041 中国科学院软件研究所可信计算与信息保障实验室北京100190

近年来,中央银行数字货币(cBDc)受到全球多个国家和地区的高度关注.双离线交易作为cBDc的可选属性,在无网络连接的情况下进行支付,被认为具有较大的实用价值.面向cBDc的双离线匿名支付场景,基于可信执行环境(tee)和安全单元(SE)技术,提... 详细信息

近年来,中央银行数字货币(cBDc)受到全球多个国家和地区的高度关注.双离线交易作为cBDc的可选属性,在无网络连接的情况下进行支付,被认为具有较大的实用价值.面向cBDc的双离线匿名支付场景,基于可信执行环境(tee)和安全单元(SE)技术,提出了一种专为移动平台设计的高效双离线匿名支付方案(dual offline anonymous E-payment for mobile devices,OAPM).OAPM适用于资源受限的移动设备,允许移动付款者在不联网状态下安全地向收款者支付数字货币,且不向收款者及商业银行泄露个人隐私信息,付款者的支付行为也不会被链接,同时允许收款者设备处于离线状态,监管机构(如中央银行)在必要情况下能够识别匿名付款者的真实身份.该方案满足数字货币交易的多项重要属性,包括正确性、不可链接性、可追踪性、不可陷害性、机密性、真实性、防双花性以及可控匿名性等.实现了原型系统,并对可能的参数进行了评估.安全性分析和实验结果表明,该方案从安全性和效率两方面均能满足移动用户cBDc双离线交易的实际需求.

关键词：央行数字货币(cBDc) 双离线支付可信执行环境(tee) 安全单元(SE) 移动设备安全架构

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The Importance of RTL DFT check In ASIc Design

The Importance of RTL DFT Check In ASIC Design

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7th Workshop on RTL and High Level Testing

作者： Ng,wei tee Ong,chin Hu Ang,Boon Hui Marvell Semiconductor Marvell Semiconductor Marvell Semiconductor

＜正＞This paper discusses the RTL DFT check in ASIc design flow for achieving faster turn-around time. We discuss the key RTL DFT design rules and flow followed by its general benefits. The correlation between RTL an... 详细信息

关键词： DFT ATPG Scan Design RTL DFT

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