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Association between Mental Disorders and Subsequent Medical conditions

四川生理科学杂志 2024年第4期46卷 217-217页

作者： Natalie c Momen From the National center for Register-based Research (N.c.M. O.P.-R. E.A. M.K.C. S.D. J.-C.P.G.D. T.M.L. P.B.M. K.L.M. C.B.P. L.V.P. B.V. N.W. J.J.M.) Center for Integrated Register-based Research (E.A. P.B.M. C.B.P.) the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C. M.F.-G. K.M.I. M.V. A.P.) the Center for Integrative Sequencing (A.D.B.) and the Big Data Center for Environment and Health (C.B.P.) Aarhus University the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A. A.D.B. S.D. O.M. P.B.M. K.L.M. M.N. C.B.P. L.V.P. A.J.S. B.V. T.W.) the Center for Genomics and Personalized Medicine (A.D.B.) the Department of Neurology (J.-C.P.G.D.) and the Research Unit Department of Psychosis (O.M.) Aarhus University Hospital and the Research Unit for General Practice (M.F.-G. A.R.R. M.V. A.P.) Aarhus the Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Copenhagen University Hospital (M.E.B. M.N. H.J.S.) Psychiatric Center Copenhagen (L.V.K.) Faculty of Health and Medical Sciences (L.V.K.) the Department of Clinical Medicine (T.W.) and the Lundbeck Foundation GeoGenetics Center GLOBE Institute (T.W.) University of Copenhagen Copenhagen and the Institute of Biological Psychiatry Mental Health Center Sankt Hans Mental Health Services Capital Region Roskilde (A.J.S. T.W.) - all in Denmark the National Drug and Alcohol Research Centre University of New South Wales Sydney (L.D.) the Department of General Practice Melbourne Medical School University of Melbourne Melbourne VIC (J.M.G.) and the Queensland Brain Institute (C.C.W.L. S.S. J.J.M.) Queensland Centre for Mental Health Research the Park Centre for Mental Health (C.C.W.L. S.S. T.J.S. H.A.W. J.J.M.) and the School of Public Health Faculty of Medicine (H.A.W.) University of Queensland Brisbane - all in Australia the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.) Heymans Institute and the I

Background:Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical ***:We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016,for a total of 83.9 million person-years.

关键词： conditions milli population

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Non-Negative Minimum Volume Factorization (NMVF) for Hyperspectral Images (HSI) unmixing: A Hybrid Approach

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computers, Materials & continua 2022年第11期73卷 3705-3720页

作者： Kriti Mahajan Urvashi Garg Nitin Mittal Yunyoung Nam Byeong-gwon Kang Mohamed Abouhawwash Department of computer Science and Engineering Chandigarh UniversityPunjab140413India Skill Faculty of Science and Technology Shri Vishwakarma Skill UniversityPalwal121102India Department of computer Science and Engineering Soonchunhyang UniversityAsan31538Korea Department of IcT convergence Soonchunhyang UniversityAsan31538Korea Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of computational Mathematics Scienceand Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI48824USA

Spectral unmixing is essential for exploitation of remotely senseddata of Hyperspectral Images (HSI). It amounts to the identification of a position of spectral signatures that are pure and therefore called end members andtheir matching fractional, draft rules abundances for every pixel in HSI. Thispaper aims to unmix hyperspectral data using the minimal volume methodof elementary scrutiny. Moreover, the problem of optimization is solved bythe implementation of the sequence of small problems that are constrainedquadratically. The hard constraint in the final step for the abundance fractionis then replaced with a loss function of hinge type that acc.unts for outlinersand noise. Existing algorithms focus on estimating the endmembers (Ems)enumeration in a sight, discerning of spectral signs of EMs, besides assessmentof fractional profusion for every EM in every pixel of a sight. Nevertheless, allthe stages are performed by only a few algorithms in the process of hyperspectral unmixing. Therefore, the Non-negative Minimum Volume Factorization(NMVF) algorithm is further extended by fusing it with the nonnegativematrix of robust collaborative factorization that aims to perform all the threeunmixing chain steps for hyperspectral images. The major contributions ofthis article are in this manner: (A) it performs Simplex analysis of minimum volume for hyperspectral images with unsupervised linear unmixing isemployed. (B) The simplex analysis method is configured with an exaggeratedform of the elementary which is delivered by vertical component analysis(VcA). (c) The inflating factor is chosen carefully inactivating the constraintsin a large majority for relating to the source fractions abundance that speedsup the algorithm. (D) The final step is making simplex analysis method robustto outliners as well as noise that replaces the profusion element positivity hardrestraint by a hinge kind soft restraint, preserving the local minima havinggood quality. (E) The matrix factorizati

关键词： Hyperspectral Imaging minimum volume simplex source separation end member extraction non-negative minimum volume factorization(NMVF) endmembers(EMs)

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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cancer communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young park chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim chang-Duck Jun Jeanho Yun Sun choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR community-Based Intelligent Novel Drug Discovery Education unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of chemistry Seoul National UniversitySeoulRepublic of Korea college of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLcSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLcSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLcSs,leading to mitochondrial fis-sion and ***4SF5 bound NPc intracellular cholesterol transporter 1(NPc1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TcA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLcSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Post-fire recovery of Puya raimondii, vegetation and birds in the puna of Huascarán National park, Perú

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Journal of Mountain Science 2024年第1期21卷 20-32页

作者： Mery L.SunI Giovana P.VADILLO césar ARANA Enoc JARA-PENA Letty SALINAS M.Estela PONcE Paul M.RAMSAY Plant Physiology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Natural History Museum Universidad Nacional Mayor de San MarcosLima 15072Peru Applied Phytology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Department of Statistics Faculty of Mathematical SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Department of chemical and Biological Sciences Universidad de las Américas PueblaSan Andrés Cholula CP Cholula CP 72810Mexico

A large fire of 233 ha in Huascarán National park in Peru provided an opportunity to compare plant and bird responses in burned and nearby unburned zones of the puna. Heights and live diameters of flagship Puya raimondii rosettes(assigned to four broad developmental phases), plant communities(66 species in 24 families and nine growth forms) and bird communities(77 species in six trophic guilds) were monitored after the fire. Although no mortality was observed, Puya raimondii plants were affected by the fire, losing approximately 60% of their photosynthetic area across all developmental phases, but recovered quickly during the first two years after fire. The comparison of Puya rosette recovery after fire was complicated by the changes in live rosette diameter for unburned plants, which showed plasticity of photosynthetic area linked to seasonal and annual fluctuations in precipitation in this relatively dry environment(decreased by 26% for mature adult plants over the study period). Fire caused an immediate change in the density, biomass and composition of vegetation. Although the species present remained similar, their abundances changed significantly immediately after the fire, with notable reductions in dominant tussock grasses. This provided opportunities for other plants, resulting in higher postfire diversity of plant species, genera, families and growth forms. In turn, the changes in vegetation after fire affected the composition of birds according to their trophic guild. Granivores largely disappeared,generalists were mostly unaffected, and other guilds showed a more complex response. As the vegetation recovered, most displaced birds returned within approximately one year.

关键词： Burning Plant biomass Trophic guilds Andes Giant rosette plants

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H2A.Z contributes to trithorax activity at the AGAMOUS locus

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Molecular Plant 2022年第2期15卷 207-210页

作者： un-Sa Lee Tomasz Bieluszewski Jun Xiao Ayako Yamaguchi Doris Wagner university of Pennsylvania Department of Biology19108 PhiladelphiaPAUSAUniversity of PennsylvaniaDepartment of Biology19108 PhiladelphiaPAUSA Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing100190China centre of Excellence for Plant and Microbial Science(cEPAMS) The John Innes CentreNorwich Research ParkNorwichNR47UHUK

Dear Editor,In multicellular eukaryotes,Polycomb repression heritably si-lences gene expression programs not needed or detrimental for a given developmental stage or tissue(Schuettengruber et al.,2017).During cell fate reprogramming,Polycomb silencing can be overcome by the combined activity of multiple Trithorax group(TrxG)proteins(Wu et al.,2012;Liang et al.,2015;Schuettengruber et al.,2017).TrxG proteins are genetically defined as suppressors of homeotic defects caused by loss of Polycomb function and have diverse enzymatic activities(Schuettengruber et al.,2017).We used a genetic enhancer screen to identify candidate TrxG proteins and uncovered TrxG activity for components of the SWR1 chromatin remodeling complex,which deposits the histone variant H2A.Z(Deal et al.,2007;March-Diaz et al.,2008).

关键词： H2A.Z suppressor

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complete Solution of Diophantine Pairs Induced by Some Fibonacci Formula

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Algebra colloquium 2023年第1期30卷 121-132页

作者： Jinseo park Department of Mathematics Education Catholic Kwandong University Gangneung 25601Korea

A set[ai,a2,...,am)of positive integers is called a Diophantine m-tuple if aiaj+1 is a perfect square for all 1≤imax(a,b].In this paper,we find the condition for the reduction of third element c,and using this result... 详细信息

A set[ai,a2,...,am)of positive integers is called a Diophantine m-tuple if aiaj+1 is a perfect square for all 1≤ic)be the Diophantine triple with c>max(a,b].In this paper,we find the condition for the reduction of third element c,and using this result,we prove the extendibility of Diophantine pair[F_(k)-1F_(k+1),F_(k-2)F_(k+2)],where Fn is the n-th Fibonacci number.

关键词： Diophantine m-tuple Fibonacci numbers Pell equation

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Approaches for enhancing the photocatalytic activities of barium titanate:A review

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Journal of Energy chemistry 2022年第10期31卷 160-188,I0004页

作者： Gopal Panthi Mira park carbon composite Energy Nanomaterials Research center Woosuk UniversityWanjuChonbuk 55338Republic of Korea Woosuk Institute of Smart Convergence Life Care(WSCLC)Woosuk UniversityWanjuChonbuk 55338Republic of Korea

Barium titanate(Ba TiO_(3)),a dielectric/ferroelectric semiconductor with perovskite structures is the most widely used photocatalyst in the field of environmental applications due to its low-cost,chemical stability,and *** types and forms of Ba TiO_(3)have shown their great potential toward the significant photocatalytic reactions owing to the several beneficial properties,including appropriate band positions,high oxygen vacancies,multiple crystal structures,the feasibility of size and morphology tailoring,spontaneous polarization,rapid migration of photogenerated charge carriers,and band ***,the large band gap and recombination of photogenerated charge carriers limit the overall photocatalytic efficiency of Ba TiO_(3).These difficulties can be further overcome by modifying the electronic band structure of Ba TiO_(3)to broaden its absorption to the visible region of the ***,this review encompasses various strategies,including modification of sizes and morphologies of particles by varying the reaction time and synthesis temperature,doping with non-metals/metals,loading with noble metals,and forming heterojunctions for enhancing the photocatalytic activities of Ba TiO_(3)-based photocatalysts possessing the effective capability of charge carrier separation,trapping and their transfer to the surface of ***,this review highlights the photocatalytic applications of Ba TiO_(3)-based photocatalysts along with the proposed mechanism in dyes/drugs degradation,H_(2)production,and bacteria killing.

关键词： Electrospinning BaTiO_(3)-photocatalyst Ferroelectricity Heterojunction Environmental remediation

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The Soft X-ray Imager(SXI)on the SMILE Mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli c.Bicknell c.Bouldin G.Branduardi-Raymont T.crawford J.P.Breuer T.Buggey G.Butcher R.canchal J.A.carter A.cheney Y.collado-Vega H.connor T.crawford N.Eaton c.Feldman c.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov c.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz c.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer c.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad c.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton c.Wang S.Yang School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK Space park Leicester University of LeicesterLeicesterLE17RHUK Mullard Space Science Laboratory University College LondonDorkingRH56NTUK centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway university of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEc European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weather National Space Science CentreBeijing 100190China university of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space GmbH CH-8157 DielsdorfSwitzerland Space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich university of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STM Engineering N-5165 LaksevagNorway John Hopkins university Applied Physics Laboratory MD 20723USA NASA/Goddard Space Flight centre MD 20771USA center for Space Physics Boston UniversityBostonMA 02215USA Department of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China centro de Astrobiologia(cAB) CSIC-INTAMadridSpain

The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)*** is a joint science mission between the European Space Agency(ESA)and the chinese Academy of Sciences(cAS)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE *** is sensitive to the soft X-rays produced by the Solar Wind charge eXchange(SWcX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many *** is led by the university of Leicester in the united Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,china and the united States.

关键词： Soft X-ray Imaging micropore optics large area ccD

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Multidimensional Hybrid Architecture Encapsulating cobalt Oxide Nanoparticles into carbon Nanotube Branched Nitrogen-Doped Reduced Graphene Oxide Networks for Lithium–Sulfur Batteries

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Energy & Environmental Materials 2022年第2期5卷 555-564页

作者： Jeong Seok Yeon Young Hun Ko Tae Ho park Hyunyoung park Jongsoon Kim Ho Seok park School of chemical Engineering College of EngineeringSungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Korea Advanced Batteries Research center Korea Electronics Technology Institute25Saenari-roBundang-guSeongnam-si Gyeonggi-do 13509Korea Department of Energy Science Sungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

Lithium–sulfur batteries(LSBs)are regarded as promising candidates for the next-generation energy storage devices owing to their high-theoretical capacity(1675 mAh g^(−1))and affordable ***,several limitations of LSBs such as the lithium polysulfide shuttle,large volume expansion,and low electrical conductivity of sulfur need to be resolved for practical *** address these limitations,herein,a multidimensional architectured hybrid(co@cNT/nG),where co_(3)O_(4) nanoparticles are encapsulated into threedimensional(3D)porous N-doped reduced graphene oxide interconnected with carbon nanotube(cNT)branches,is synthesized through a simple pyrolysis *** synergistic effect achieved through the homogeneously distributed and encapsulated co_(3)O_(4) nanoparticles,the interconnected cNT branches,and the 3D hierarchical porous structure and N-doping of co@cNT/nG significantly suppresses the shuttle effect of lithium polysulfides and enhances the conversion redox kinetics for the improved sulfur *** validate this effect through various measurements including symmetric cells,Li_(2)S nucleation,shuttle currents,Tafel slopes,diffusion coefficients,and post-mortem ***,co@cNT/nG-70S-based LSB cells achieve a high-specific capacity of 1193.1 mAh g^(−1) at 0.1 c and a low capacity decay rate of 0.030%per cycle for 700 cycles at 5 c,delivering a high areal capacity of 5.62 mAh cm^(−2) even with a loading of 6.5 mg cm^(−2).

关键词： graphene/cNT hybrid lithium-sulfur batteries multidimensional architecture nanoparticle encapsulation redox promoter

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Flexible and disposable paper-based gas sensor using reduced graphene oxide/chitosan composite

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Journal of Materials Science & Technology 2022年第6期101卷 165-172页

作者： Hyunjun park Woong Kim Sang Won Lee Joohyung park Gyudo Lee Dae Sung Yoon Wonseok Lee Jinsung park Department of control and Instrumentation Engineering Korea UniversitySejong 30019Republic of Korea School of Biomedical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Biotechnology and Bioinformatics Korea UniversitySejong 30019Republic of Korea Department of Electrical Engineering Korea National University of TransportationChungju 27469Republic of Korea

Nitrogen dioxide(NO_(2))is a representative toxicant in air pollution that mostly arises from the exhaust gas released by *** is related to various respiratory diseases such as pneumonia and sudden infant death ***,because the toxicity of nitrogen dioxide is high in overpopulated areas(i.e.,a capital or metropolis),the development of simple,practical,and facile sensors is highly *** work presents a flexible and disposable paper-based NO_(2)sensor based on a reduced graphene oxide/chitosan(r GO/cS)*** synthesized r GO/cS composite can be easily flexed and deformed into various shapes,which are attributed to chitosan molecules that function as a dispersion and reduction agent and support *** addition,this composite can be attached to paper owing to its adhesive property;hence it can be utilized in versatile applications in a disposable *** analyzing the conductive change of the r GO/cS composite when it reacts with NO_(2),we can detect nitrogen dioxide in a concentration range of 0–100 ppm with a detection limit of 1 ***,we performed NO_(2)detection in the exhaust gas released by automobiles using the r GO/cS composite for practical *** results indicated that the r GO/cS composite has the potential to be used in feasible gas sensing as a facile and disposable sensor under various conditions.

关键词： Reduced graphene oxide chitosan composite material Nitrogen dioxide Paper-based gas sensor Flexible and disposable sensor

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