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Gastric heterotopia of colon found cancer workup in liver abscess:A case report

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World Journal of clinical cases 2022年第15期10卷 5012-5017页

作者： Jun Gi park Jeong Ill Suh Yeo un Kim Department of Internal Medicine College of MedicineDongguk UniversityGyeongju 38067South Korea

BAcKGROunD Recently reported cases of pyogenic liver abscess associated with colonic cancer in the absence of underlying disease,have included a small number of cases of gastric heterotopia(GHT).GHT is a congenital anomaly composed of ectopic gastric mucosa and can occur anywhere in the gastrointestinal tract but is more frequently enc.untered in the cervical ***,it is rarely observed in ***,most reported cases of GHT of the colon involved the rectum,and GHT involving the colon proximal to the rectum is *** SUMMARY An 83-year-old male patient presented with fever and a diagnosis of pyogenic liver *** was performed for colon cancer workup and revealed a 1.0 cm sized polyp at the transverse *** polyp was removed by endoscopic mucosal resection by monopolar electrocauterization using a *** examination revealed *** administering intravenous antibiotics,the patient recovered *** GHT in the colon could affect the development of pyogenic liver abscess by enabling hematogenous propagation of Klebsiella pneumoniae through mucosal ***,more study is needed due to the lack of cases.

关键词： Gastric heterotopia colon Liver abscess case report

Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYunG Sun KIM Yun Sun LEE SEunG MYunG DONG HYO JunG KIM DA Eun LEE HYEON WOONG KANG MYEONG JIN KIM JOON SEONG park Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAc)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Energy Aware Metaheuristic Optimization with Location Aided Routing Protocol for MANET

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computers, Materials & continua 2022年第4期71卷 1567-1580页

作者： E.Ahila Devi K.c.Ramya K.Sathesh Kumar Sultan Ahmad Seifedine Kadry Hyung Ju park Byeong-gwon Kang Department of Instrumentation and control Engineering St.Joseph’s College of EngineeringChennai600119India Department of Electrical and Electronics Engineering Sri Krishna College of Engineering and TechnologyCoimbatore641008India School of computing Kalasalingam Academy of Research and EducationKrishnankoil626128India Department of computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of Applied Data Science Noroff University CollegeKristiansand4612Norway Department of IcT convergence Soonchunhyang UniversityAsan31538Korea

A mobile ad hoc network(MANET)involves a group of wireless mobile nodes which create an impermanent network with no central authority and *** nodes in the MANET are highly mobile and it results in adequate network topology,link loss,and increase the re-initialization of the route discovery *** planning in MANET is a multi-hop communication process due to the restricted transmission range of the *** aided routing(LAR)is one of the effective routing protocols in MANET which suffers from the issue of high energy *** few research works have focused on resolving energy consumption problem in LAR,energy efficiency still remains a major design *** this aspect,this study introduces an energy aware metaheuristic optimization with LAR(EAMO-LAR)protocol for *** EAMO-LAR protocol makes use of manta ray foraging optimization algorithm(MRFO)to help the searching process for the individual solution to be passed to the LAR *** fitness value of the created solutions is determined next to pass the solutions to the objective *** MRFO algorithm is incorporated into the LAR protocol in the EAMO-LAR protocol to reduce the desired energy *** ensure the improved routing efficiency of the proposed EAMO-LAR protocol,a series of simulations take *** resultant experimental values pointed out the supreme outcome of the EAMO-LAR protocol over the recently compared *** resultant values demonstrated that the EAMO-LAR protocol has accomplished effectual results over the other existing techniques.

关键词： MANET routing lar protocol energy efficiency mrfo algorithm metaheuristics

Investigation of Refractory Bricks and Oxide Materials Heated in Hydrogen Reduction conditions

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china's Refractories 2024年第2期33卷 22-26页

作者： Sangbae cHOI Raehyeong park Gideok YANG Yeonghyeon KIM chosun Refractories co. Ltd.Seongnam 463-020South Korea

This study aims to provide the basic knowledge for furnace refractory design by investigating refractory property changes occurred in a hydrogen *** refractory bricks are thermodynamically stable in a hydrogen atmosphere at 1100°c,we tried to find out the minute *** this experiment,a refractory brick was prepared by andalusite,mullite chamotte,and clay as raw materials and heated to 1100°c in a 100%hydrogen atmosphere for 72 *** was found that the strength of the brick was decreased and the color was changed to black by the reduction of *** in addition,this study covered research on the slaking risk of MgO raw materials because the minimum temperature is expected to 400°c in fluidized reduction furnaces unlike shaft furnaces.

关键词： hydrogen reduction furnace refractory bricks refractory raw materials

Variations in microstructure and bending formability of extruded Mg–Al–Zn–ca–Y–MM alloy with precompression and subsequent annealing treatment conditions

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Journal of Magnesium and Alloys 2022年第9期10卷 2475-2490页

作者： Jong un Lee Sang-Hoon Kim Dong Hee Lee Hyun Ji Kim Young Min Kim Sung Hyuk park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study, the bending formability of an extruded Mg–9Al–1Zn–0.3Mn–0.9ca–0.6Y–0.5 MM(AZXWMM91100, wt%) alloy at room temperature is significantly improved through application of a combined precompression and subsequent annealing(PcA) treatment. As the amount of precompression applied along the extrusion direction(ED)(i.e., the total strain) increases from 4% to 6%, the area fraction of ED-oriented grains of the PcA-treated alloy increases, which consequently causes an improvement in its bending formability because these grains accommodate larger tensile strain along the ED during bending. As the temperature of the subsequent annealing treatment increases from 350 ℃ to 450 ℃, both the area fraction of the ED-oriented grains and the average grain size increase, and the residual dislocation density decreases owing to the promotion of boundary migration and occurrence of the recovery process at higher ***, the bending formability of both the 4%-precompressed and the 6%-precompressed samples increases with an increase in the annealing temperature. However, when the precompressed samples are annealed at 300 ℃, their bending formability is lower than that of the extruded alloy because the dislocations formed by precompression remain even after the subsequent annealing at this temperature.

关键词： Magnesium Extrusion Bending Formability Texture

Multifunctional MXene/carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal Byungkwon Yoo Jun Young Jo Nilufer cakmakci Shabbir Madad Naqvi Hyerim Kim Sungmin Jung Noushad Hussain Ujala Zafar Soo Yeong cho Seunghwan Jeong Jaewoo Kim Jung Min Oh Sangwoon park Youngjin Jeong chong Min Koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D center INNOMXENE co. Ltd.Daejeon 34365Republic of Korea School of chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)c_(2)T_(x) MXene and mechanically-robust carbon nanotube(cNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resistance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissivity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance when exposed to 250 W IR *** multifunctional MXene/cNT Janus film offers a feasible solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo Kang Sung Hee Lim Min-Ji Kim Jeeyun Lee Young Suk park Ho Yeong Lim Won Ki Kang Seung Tae Kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BAcKGROunD Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-c,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(cRc)according to the expression of *** This analysis included cRc patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(cPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 cPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 cPS less than 1 and those with PD-L1 cPS of 1 or more(PD-L1cPS less than 5 and of 5 or more(PD-L1cPS less than 10 and of 10 or more(PD-L1cONcLUSION chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic cRc irrespective of PD-L1 expression.

关键词： Bevacizumab colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2024年

作者： Daehyeon Kim Seong-Eun park Eun-Ju Kim Seung-Ho Seo Kwang-Moon cho Sun Jae Kwon Hong-Seok Son Department of Biotechnology college of Life Sciences and Biotechnology Korea university Sonlab Inc. 3. AccuGene Inc.

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce. Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years. The complex bacterial community was simplified to two genera， Tetragenococcus and Halanaerobium， after approximately 0.55 years of fermentation. Although genera， such as Saccharomyces， cladosporium， candida， and Aspergillus， were relatively dominant， no clear pattern was identified in fungal community analysis. The longitudinal metabolite profile demonstrated that approximately half (55.8%) of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation. Despite the static microbial community， the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce. This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research center for cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea c.uncheon center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence core Imaging center and Bioimaging Data curation center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with Genechip analysis that Run and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic