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Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage

World Journal of critical care Medicine 2023年第2期12卷 63-70页

作者： Leonardo Lorente María M Martín Antonia Pérez-cejas Luis Ramos-Gómez Jordi Solé-Violan Juan J cáceres Alejandro Jiménez Agustín F González-Rivero department of Intensive care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain department of Intensive care Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010TenerifeSpain department of Laboratory Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain department of Intensive care Hospital Universitario de La PalmaBreña Alta 38713Spain department of critical care Hospital Universitario de Gran Canaria Dr NegrinLas Palmas de Gran Canaria 35010Spain department of critical care Universidad Fernando Pessoa CanariasLas Palmas de Gran Canaria 35450Spain department of Intensive care Hospital InsularLas Palmas de Gran Canaria 35016Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain

BAcKGROUND Several studies of spontaneous intracerebral hemorrhage(SIcH)patients have shown apoptotic changes in brain samples after hematoma ***,there have been no data on the association between blood concentrations of soluble fas(sFas)(the main surface death receptor of the extrinsic apoptosis pathway)and the prognosis of spontaneous intracranial hypotension(SIH)*** To determine whether there is an association between blood sFas concentrations and SIcH patient *** We included patients with severe and supratentorial *** was defined as having Glasgow coma Scaledetermined serum sFas concentrations at the time of severe SIcH *** We found that non-surviving patients(n=36)compared to surviving patients(n=39)had higher IcH score(P=0.001),higher midline shift(P=0.004),higher serum sFas concentrations(Pcuation(P=0.04).Multiple logistic regression analysis showed an association between serum sFas concentrations and 30-d mortality(odds ratio=1.070;95%confidence interval=1.014-1.129;P=0.01)controlling for IcH score,midline shift,and early hematoma *** The association of blood sFas concentrations and SIcH patient mortality is a novel finding in our study.

关键词： Spontaneous intracerebral hemorrhage Soluble fas Apoptosis Patients Mortality

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Piptadenia stipulacea(Benth.)Ducke Seed Germination in Response to Temperature,Light and Water Stress

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American Journal of Plant Sciences 2014年第26期5卷 3796-3904页

作者： Francisco c.rlos Barboza Nogueira Maria Luiza Bezerra charles Lobo Pinheiro Selma Freire de Brito Sebastiao Medeiros Filho Brazilian Institute of Environment and Renewable Natural Resources—IBAMA City of FortalezaBrazil Seed Analysis Laboratory(las—Laboratorio de Analise de Sementes) Plant Science DepartmentFederal University of Ceara(UFC)Campus of PiciCity of FortalezaBrazil

The current study aimed to investigate the effects of the temperature, light, and water stress on Piptadenia stipulacea seed germination. It assessed germination percentage, speed and average germination time, root and stem length as well as the dry weight of seedlings subjected to the constant temperatures of 20°c, 25°c and 30°c and alternating temperatures from 20°c to 30°c. A 12-hour photoperiod was established in addition to the following light conditions: white, darkness, red and far red. The experimental design was completely randomized and four replicates of 25 seeds were performed for each treatment. Regarding water stress, seeds were subjected to osmotic potentials of 0, -0.2, -0.4, -0.6, -0.8, -1.0, and -1.2 MPa, at 30°c and 12 h light/12 h darkness photoperiods. After they were mixed, 100 seeds were randomly selected for biometric measurement and they were found to be uneven with respect to size and weight. P. stipulacea seeds germinated under all tested temperature and light conditions. Germination under water stress occurred up to -0.8 MPa. The conclusion is that there was no germination from -1.0 MPa. The seeds are light-indifferent and germinate at the constant temperatures of 20°c, 25°c and 30°c and alternating temperatures from 20°c to 30°c.

关键词： Forest-Tree Seeds Native Species Semi-Arid Region Polyethylene Glycol

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以昆虫生理为基础预测预报的探讨

以昆虫生理为基础预测预报的探讨

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北京昆虫学会成立四十周年学术讨论会

作者：陈建新舍列斯托娃B.c. 北京农业大学植保系苏联乌克兰农业大学

苹果蠹蛾las peyresia pomonella Linna.是苏联果树的一种重大害虫,由于它的危害致使苹果等果树的产量及质量受到很大影响。因此苏联对苹果蠹蛾的防治及预测预报工作十分重视,以昆虫生理学为基础给预测预报工作提供科学依据。

关键词：预测预报幼虫昆虫生理学过氧化氢酶苹果蠹蛾酶活性血淋巴

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Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.caceres Samantha c.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil c.Senanayake Saranyaphat Boonmee Jie chen Zong-Long Luo chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira cristina Mariade Souza-Motta Oliane Maria correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao Milan c.Samarakoon Dhandevi Pem Anuruddha Karunarathna chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika c.Dayarathne Anusha H.Ekanayaka Subashini c.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei cai Touny Sorvongxay Vinodhini Thiyagaraja chada Norphanphoun Napalai chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini chethana deping Wei Martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips chang-Hsin Kuo Erio camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India department of crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(caatingomyces,cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,caatingomyces brasiliensis,calophoma humuli,camarosporidiella mori,canalisporium dehongense,cantharellus brunneopallidus,***,castanediella meliponae,coprinopsis psammophila,cordyceps succavus,cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

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Pre-hospital assessment with ultrasound in emergencies: implementation in the field

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World Journal of Emergency Medicine 2016年第2期7卷 117-123页

作者： Kevin P. Rooney Sari Lahham Shadi Lahham craig L. Anderson Bryan Bledsoe Bryan Sloane Linda Joseph Megan B. Osborn John c. Fox department of Emergency Medicine Henry Ford Hospital Detroit Michigan 48202 USA Emergency Medicine University of California Irvine Orange California 92868 USA Emergency Medicine University of Nevada School of Medicine Las Vegas Nevada 89102 USA

BAcKGROUND: Point-of-care ultrasound(US) is a proven diagnostic imaging tool in the emergency department(ED). Modern US devices are now more compact, affordable and portable, which has led to increased usage in austere environments. However, studies supporting the use of US in the prehospital setting are limited. The primary outcome of this pilot study was to determine if paramedics could perform cardiac ultrasound in the fi eld and obtain images that were adequate for interpretation. A secondary outcome was whether paramedics could correctly identify cardiac activity or the lack thereof in cardiac arrest ***: We performed a prospective educational study using a convenience sample of professional paramedics without ultrasound experience. Eligible paramedics participated in a 3-hour session on point-of-care US. The paramedics then used US during emergency calls and saved the scans for possible cardiac complaints including: chest pain, dyspnea, loss of consciousness, trauma, or cardiac ***: Four paramedics from two distinct fire stations enrolled a total of 19 unique patients, of whom 17 were deemed adequate for clinical decision making(89%, 95%cI 67%–99%). Paramedics accurately recorded 17 cases of cardiac activity(100%, 95%cI 84%–100%) and 2 cases of cardiac standstill(100%, 95%cI 22%–100%).cONcLUSION: Our pilot study suggests that with minimal training, paramedics can use US to obtain cardiac images that are adequate for interpretation and diagnose cardiac standstill. Further large-scale clinical trials are needed to determine if prehospital US can be used to guide care for patients with cardiac complaints.

关键词： Prehospital ultrasound cardiac ultrasound Emergency ultrasound

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基于GIS的南极冰盖物质平衡与冰架底部物质通量研究——以Lambert冰川-Amery冰架系统为例

基于GIS的南极冰盖物质平衡与冰架底部物质通量研究——以Lambert...

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中国地理学会2007年学术年会

作者：温家洪刘吉英王亚凤 Kenneth c.Jezek 上海师范大学地理系 Byrd Polar Research center The Ohio State UniversityColumbusOH 43210 USA

＜正＞GIS 作为地理空间数据集成与综合分析平台, 在极地研究中正在得到广泛应用。GIS 的数据源包括野外现场观测数据,模型模拟数据,特别是大量遥感观测数据。本文以 Lambert 冰川-Amery 冰架系统（las）为例,说明 ArcGIS 地理信息系统在南

关键词：物质平衡冰架底部物质通量 GIS Lambert 冰川-Amery 冰架系统南极冰盖

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由放牧压力所影响的肉牛的饲草进食

由放牧压力所影响的肉牛的饲草进食

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“加强世界饲草——牲畜系统”第十四届国际草地会议

作者： c.D.ALLISON M.M.KOTHMANN L.R.RITTENHOUSE 李鸥 New Mexico State University Las CrncesN.M.U.S.A

在1977年做了一系列的试验,来确定放牧压力水平对有机物质进食量的影响,以及进食量与饲草消失之间的关系。在四、七和九月的14天试验中所研究的放牧压力水平为每天给每个家畜单位提供10、20、40和50公斤饲草（公斤/家畜单位/天）。每次...

在1977年做了一系列的试验,来确定放牧压力水平对有机物质进食量的影响,以及进食量与饲草消失之间的关系。在四、七和九月的14天试验中所研究的放牧压力水平为每天给每个家畜单位提供10、20、40和50公斤饲草（公斤/家畜单位/天）。每次试验之前,中期以及之后都要测定饲草的现有量。有机物质进食量是用排粪量:未消化率比率技术来估计的。有机物质进食量在四月份最高;肉牛在九月份消耗的饲草比七月份多。把饲草质量与家畜生理状况结合起来可以解释试验中进食量的变化。肉牛所消耗的有机物质在试验结束时要比开始时大约要少12克/公斤代谢体重（kg体重0.75）。在10和20公斤/家畜单位/天的处理中,肉牛在试验结束时有比在开始时消耗的饲草减少的趋势。总的现存量在放牧试验中稳定地下降,饲草的可利用率在试验结束时也随之显著少于开始时和中期。三个试验平均起来,在放牧压力为10、20、40和50公斤/家畜单位/天时,饲草的消失分别为8.5、12.0、12.7和16.3公斤/家畜单位/天。然而对于所有的处理,期间和试验来说,平均每天的进食量约为9公斤/家畜单位/天。当放牧压力的水平为10公斤/家畜单位/天时,饲草的消失约等于平均的日进食量,而在放牧压力为20、40和50公斤/家畜单位/天的条件下,饲草的消失则分别超过进食量28%、48%和90%。这些数据表明,当放牧压力增加时放牧肉牛的饲草收获效率有可能增长2倍。

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Freshwater Dothideomycetes

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Fungal Diversity 2020年第6期105卷 319-575页

作者： Wei Dong Bin Wang Kevin D.Hyde Eric H.c.McKenzie Huzefa A.Raja Kazuaki Tanaka Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Mingkwan Doilom Rungtiwa Phookamsak Sinang Hongsanan Dhanushka N.Wanasinghe Xian-Dong Yu Gen-Nuo Wang Hao Yang Jing Yang Kasun M.Thambugala Qing Tian Zong-Long Luo Jian-Bo Yang Andrew N.Miller Jacques Fournier Saranyaphat Boonmee Dian-Ming Hu Sarunya Nalumpang Huang Zhang Faculty of Agriculture and Food Kunming University of Science and TechnologyKunming 650500China department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Innovative Agriculture Research center Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Mai 57100Thailand Innovative Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225China School of Environment and Resource Southwest University of Science and TechnologySichuan 621010China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Research center of Microbial Diversity and Sustainable Utilization Faculty of SciencesChiang Mai UniversityChiang Mai 50200Thailand Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand department of chemistry and Biochemistry University of North CarolinaGreensboro 27413USA Faculty of Agriculture and Life Science Hirosaki UniversityBunkyo-cho3HirosakiAomori 035-8561Japan department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt cAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina centre for Mountain Futures(cMF) Kunming Institute of BotanyKunming 650201YunnanChina East and central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731China Faculty of Environmental Science and Engineering Kunming University of Science&TechnologyKunming 650500China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Genetics and Molecular Biology Unit

Freshwater Dothideomycetes are a highly diverse group of fungi,which are mostly saprobic in freshwater habitats *** are important decomposers of submerged woody debris and leaves in *** this paper,we outline the genera of freshwater Dothideomycetes with notes and keys to *** on multigene analyses and morphology,we introduce nine new genera,***,Aquatospora,Aquihelicascus,Fusiformiseptata,Neohelicascus,Neojahnula,Pseudojahnula,Purpureofaciens,Submersispora;33 new species,*** bipolare,Aquimassariosphaeria kun-mingensis,Aquatospora cylindrica,Aquihelicascus songkhlaensis,***,Ascagilis submersa,***,Bambusicola aquatica,caryospora submersa,Dictyocheirospora thailandica,Fusiformiseptata crocea,Helicosporium thai-landense,Hongkongmyces aquaticus,Lentistoma aquaticum,Lentithecium kunmingense,Lindgomyces aquaticus,Longipedi-cellata aquatica,Neohelicascus submersus,Neohelicomyces dehongensis,***,Neohelicosporium submersum,Nigrograna aquatica,Occultibambusa kunmingensis,Parabambusicola aquatica,Pseudoasteromassaria aquatica,Pseu-doastrosphaeriella aquatica,Pseudoxylomyces aquaticus,Purpureofaciens aquatica,Roussoella aquatica,Shrungabeeja aquatica,Submersispora variabilis,Tetraploa puzheheiensis,***;16 new combinations,***-eria typhicola,Aquihelicascus thalassioideus,Ascagilis guttulaspora,***,***,***,Ernakulamia xishuangbannaensis,Neohelicascus aquaticus,***,***,***,***,***,***,Neojahnula australiensis,Pseudojahnula potamophila;17 new geographical and habitat records,*** khaoyaiensis,Aquastroma magniostiolata,caryospora aquatica,***,dendryphiella vinosa,Ernakulamia cochinensis,Fissuroma neoaggregatum,Helicotruncatum palmigenum,Jahnula rostrata,Neorous-soella bambusae,***,Occultibambusa pustula,Paramonodictys solitarius,Pleopunctum pseud

关键词： 42 new taxa Freshwater distribution Phylogeny Submerged wood Taxonomy

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Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A delphi technique-based consensus

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World Journal of Hepatology 2016年第25期8卷 1075-1086页

作者： Juan P Arab Juan c claro Juan P Arancibia Jorge contreras Fernando Gomez cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese c.rlos Benítez departamento de Gastroenterología Escuela de Medicina Pontificia Universidad Católica de Chile departamento de Medicina Interna and Programa de Salud Basada en la Evidencia Escuela de Medicina Pontificia Universidad Católica de Chile Sección de Gastroenterología Departamento de Medicina Hospital Clínico Universidad de Chile and Clínica Santa María Unidad de Gastroenterología Universidad del Desarrollo Clínica Alemana Servicio de Gastroentero-logía Unidad de Trasplante Hepático Hospital del Salvador Facultad de Medicina Universidad de Chile and Unidad de Gastroenterología Clínica Alemana de Santiago Clínica Indisa clínica las condes y Servicio de Gastroenterología Hospital Fuerza Aérea de Chile departamento de Nefrología Facultad de Medicina Pontificia Universidad Católica de Chile

AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal *** A group of eleven gastroenterologists and nephrologists performed a structured analysis of available *** expert was designated to review and answer a *** generated draft statements for evaluation by all the *** input was obtained from medical *** order to reach consensus,a modified three-round delphi technique method was *** to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was *** Nine questions were *** available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its *** generated questions were answered by the expert panel with a high level of ***,a therapeutic algorithm was *** role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of *** the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was *** role of several other options was also evaluated and the available evidence was explored and *** transplantation is considered the definitive treatment for *** present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools *** Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1.

关键词： Hepatorenal syndrome delphi consensus Evidence-based medicine Treatment

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Assessment of right ventricular afterload by pressure waveform analysis in acute pulmonary hypertension

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World Journal of cardiology 2011年第10期3卷 322-328页

作者： Juan c Grignola Enric Domingo Lucía devera Fernando Ginés department of Pathophysiology. Hospital de clínicas Facultad de Medicina. Universidad de la República Area del cor. Hospital Universitari Vall d'Hebron. Passeig Vall d'Hebron 119-129 department of Physiology Universitat Autono- ma Barcelona 08193 Bellaterra (Cerdanyola del Vallès)

AIM: To characterize hydraulic right ventricle (RV) af- terload by pulmonary arterial pressure waveform analy- sis in an acute pulmonary hypertension (PH) model. METHODS: Pulmonary artery (PA) flow and pressure were recorded in six anesthetized sheep. Acute iso- baric PH was induced by phenylephrine (active) and PA mechanical constriction (passive). We estimated the amplitude of the forward and reflected pressure waves according to the inflection point. In most cases the in- flection pressure was smooth, thus the inflection point was defined as the time at which the first derivative ofpulmonary arterial pressure reached its first minimum. We calculated the input and characteristic (Z c , time- domain Li method) impedances, the capacitance index (stroke volume/pulse pressure), the augmentation index (AI) (reflected pressure/pulse pressure), the frac- tional pulse pressure (pulse pressure/mean pressure) and the wasted energy generated by the RV due to wave reflection during ejection (E W ). RESULTS: Pulse pressure, fractional pulse pressure, AI and Z c increased and capacitance index decreased during passive PH with respect to control (P contrast, Z c and the capacitance index did not change and E W and the AI decreased during active PH. Pulse pressure correlated with E W and Z c and the AI was cor- related with E W (r > 0.6, P cONcLUSION: PA pressure waveform analysis al- lows the quantification of the dynamic RV afterload. Prospective clinical studies will be necessary to validate this time-domain approach to evaluate the dynamic RV afterload in chronic PH.

关键词： Pulmonary hypertension Time-domain analysis Augmentation index characteristic imped- ance Reflected wave

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