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Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma

World Journal of Hepatology 2024年第3期16卷 393-404页

作者： Andrew Scott deLemos Jing Zhao Milin Patel Banks Kooken Karan Mathur Hieu Minh Nguyen Areej Mazhar Maggie Mccarter Heather Burney c.rla kettler Naga chalasani Samer Gawrieh Department of Medicine Atrium HealthCharlotteNC 28204United States center for Outcomes Research and Evaluation Atrium HealthCharlotteNC 28204United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States center for Health System Sciences(cHASSIS) Atrium HealthCharlotteNC 28204United States Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisIN 46202United States Department of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

BAcKGROUND Obesity is an independent risk factor for the development of hepatocellular carcinoma(Hcc)and may influence its ***,after diagnosis of Hcc,like other malignancies,the obesity paradox may exist where higher body mass index(BMI)may in fact confer a survival *** is frequently observed in patients with advanced Hcc and cirrhosis,who often present late with advanced tumor features and cancer related weight *** To explore the relationship between BMI and survival in patients with cirrhosis and *** This is a retrospective cohort study of over 2500 patients diagnosed with Hcc between 2009-2019 at two United States academic medical *** and tumor characteristics were extracted manually from medical records of each institutions'cancer *** were stratified according to BMI classes:30 kg/m^(2)(obese).Patient and tumor characteristics were compared according to BMI *** performed an overall survival analysis using Kaplan Meier by the three BMI classes and after adjusting for Milan criteria.A multivariable cox regression model was then used to assess known risk factors for survival in patients with cirrhosis and *** A total of 2548 patients with Hcc were included in the analysis of which 11.2%(n=286)were classified as *** three main BMI categories:Lean(n=754),overweight(n=861),and obese(n=933)represented 29.6%,33.8%,and 36.6%of the total population *** each BMI class,the non-cirrhotic patients accounted for 15%(n=100),12%(n=94),and 11%(n=92),*** patients with a BMIcluded in the lean *** the obese cohort,42%(n=396)had a BMI≥35 kg/m^(2).Out of 2262 patients with cirrhosis and Hcc,654(29%)were lean,767(34%)were overweight,and 841(37%)were *** three BMI classes did not differ by age,MELD,or child-Pugh *** hepatitis c was the dominant etiology in lea

关键词： Hepatocellular carcinoma cirrhosis Obesity Body mass index class Sarcopenia chronic hepatitis c

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Mc simulation of thermal neutron flux of large samples irradiated by 14 MeV neutrons

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Nuclear Science and Techniques 2010年第1期21卷 11-15页

作者： BAI Yunfei WANG Dezhong MAUERHOFER Eric kettler John School of Nuclear Science and Engineering Shanghai Jiao Tong University 200240 Shanghai China Institute of Energy Research IEF-6： Safety Research and Reactor Technology Forschungszentrum Jiilich GmbH 52425 Jiilich Germany

The response of a 14 MeV neutron-based prompt gamma neutron activation analysis (PGNAA) system,*** prompt gamma-rays count rate and the average thermal neutron flux,is studied with a large concrete sample and with a homogeneous large sample,which is made of polyethylene and metal with various concentrations of hydrogen and cadmium using the McNP-5 (Monte carlo N-Particle) *** average thermal neutron flux is determined by the analysis of the prompt gamma-rays using the thermal neutron activation of hydrogen in the sample,and the thermal and fast neutron activation of carbon graphite irradiation chamber of the *** results demonstrated that the graphite irradiation chamber of the PGNAA-system fairly operates,and is useful to estimate the average thermal neutron flux of large samples with various compositions irradiated by 14 MeV neutrons.

关键词：中子通量中子辐照大样本 MeV 中子活化分析 PGNAA 瞬发γ射线模拟

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Topology impacts TRAIL therapy: Differences in primary cancer growth and liver metastasis between orthotopic and subcutaneous xenotransplants of pancreatic ductal adenocarcinoma cells

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 279-284页

作者： Bastian kettler Anna Trauzold christian Röder Jan-Hendrik Egberts Holger Kalthoff clinic for General- Abdominal-and Transplant-SurgeryMedical School HannoverCarl-Neuberg-Str.130625 HannoverGermany Institute for Experimental cancer Research University of Kiel and University Clinic of Schleswig-HolsteinCampus KielHs.U30Arnold-Heller-Str.324105 KielGermany clinic for General VisceralThoracicTransplantation-and Pediatric SurgeryUniversity Clinic of Schleswig-HolsteinCampus KielHs.CArnold-Heller-Str.324105 KielGermany

Background: To study novel treatment modalities for pancreatic ductal adenocarcinoma(PDAc), we need to transfer the knowledge from in vitro to in vivo. It is important to mirror the clinical characteristics of the typically local invasive growth of pancreatic cancer and the distant spread resulting in liver metastasis. Notably, for xenotransplant studies using human specimen, two models, i.e. subcutaneous(s.c.) and orthotopic(o.t.) transplantation are widely used. Methods: The subcutaneously and orthotopically inoculated colo357 Bcl-x L cell-derived tumors were directly compared with and without TNF-related apoptosis inducing ligand(TRAIL) treatment. The size of primary tumors, number of liver metastasis and the histologic markers Ki67, M30, TNF-α and cD31 were assessed. Results: Upon TRAIL treatment, the primary tumors did not change their size, neither in the s.c. nor in the o.t. approaches. But when s.c. was compared to o.t., the size of the s.c. tumors was more than twofold bigger than that of the o.t. tumors( Pce with orthotopically inoculated PDAc cells developed liver metastasis upon TRAIL treatment much more frequently( n=13/17) than mice with subcutaneously inoculated PDAc cells( n=1/11)( Pce for this increased metastasis, a higher TNF-α staining intensity in the o.t. tumors was observed by immunohistochemistry. conclusions: These data from a direct side-by-side comparison underline the importance of the proper inoculation site of the PDAc cells. Local invasion and liver metastases are a hallmark of PDAc in the clinic;the o.t. model is clearly superior in reflecting this setting. Moreover, a serious side-effect of a possible new therapeutic compound became obvious only in the o.t. model.

关键词： Pancreatic cancer Animal models Immunohistochemistry Subcutaneous metastasis

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与金矿化共生的有机质的硫化作用——多米尼加Pueblo Viejo矿区实例

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地质科学译丛 1991年第3期8卷 68-74页

作者： Richard M.kettler 胡明安

多米尼加Pueblo Viejo是世界上最大的贵金属产地之一,年产黄金 11000kg以上。该地金矿产于下白垩统Los Ranchos组细碧岩,粗屑和具微细层理的细粒碳质沉积岩中。金矿化的同时伴生硫化作用,其证据有(1)远离矿化中心出现菱铁矿,靠近矿体黄... 详细信息

多米尼加Pueblo Viejo是世界上最大的贵金属产地之一,年产黄金 11000kg以上。该地金矿产于下白垩统Los Ranchos组细碧岩,粗屑和具微细层理的细粒碳质沉积岩中。金矿化的同时伴生硫化作用,其证据有(1)远离矿化中心出现菱铁矿,靠近矿体黄铁矿富集;(2)S/Fe比值随金矿化的强度增大而上升;(3)在矿体内部及其附近均见到自然硫;(4)含矿岩石中见硫化有机质(即有机硫化合物)。碳质沉积岩中有机质由镜质组和焦沥青组成。Rock—Eval热解数据表明这些有机质具过成熟性(HI<55)。在铁质全被硫化成黄铁矿的岩石中,有机质富含硫(硫含量高达14％)。X射线吸收近端结构分析(XANES)结果指出与碳结合的硫为噻吩型。早期浸染状金矿化被认为与二价铁发生硫化作用生成黄铁矿有关。由于矿液中H_2S的活度下降,破环了金的二硫化物络合物的平衡,导致金沉淀。富硫有机质的产生主要限于铁质全部以黄铁矿形式出现的岩石中,这就意味着有机质的硫化晚于二价铁的硫化,亦晚于金的沉淀期。

关键词：金矿矿化有机质硫化作用

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Myeloid sarcoma as a differential diagnosis of small bowel obstruction

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case Reports in clinical Medicine 2013年第2期2卷 173-176页

作者： Bastian kettler Mahmoud Abbas Bastian Ringe Lothar Hambach Jürgen Klempnauer Michael Winkler Hans-Heinrich Kreipe Nikos Emmanouilidis clinic for General- Abdominal- and Transplant-Surgery Medical School Hannover Hannover Germany clinic for Haematology Medical School Hannover Hannover Germany Institute for Pathology Medical School Hannover Hannover Germany

We are presenting the case of a 42-year-old ?male patient, who was hospitalized due to an acute small bowel obstruction caused by a tissue mass of the mesentery. The patient reported that he had a history of a testicular tumour. For therapy of intestinal obstruction as well as for diagnostic reasons we decided to perform ?an explorative laparotomy. On histopathological examination the immunohistological staining was positive for myeloperoxidase (MPO) and KP-1 (cD68). Staining was slightly positive for Bcl-2, cD117, cD34, but negative for cD3, cD4, cD5, cD8, cD20, cD30, cD79, Bcl-6 and S-100. This leads to the diagnosis of a myeloid sarcoma. After recovery from surgery and chemotherapy, allogenic bone marrow transplantation was performed. Most intestinal obstructions are caused by postoperative adhesions or hernias and only in rare cases caused by a myeloid sarcoma.

关键词： Myeloid Sarcoma Small Bowel Obstruction

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爸爸的手(英文)

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海外英语 2009年第6期 47-47页

作者： David kettler

Bedtime came, we were settling down,I was holding one of my *** I grasped him so tight, I saw a strange sight:

关键词：《爸爸的手》英语诗歌当代文学

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Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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chinese Physics c 2021年第4期45卷 198-241页

作者： H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson c.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.c.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.cai H.caines M.calderon de la Barca Sanchez D.cebra R.cendejas M.c.cervantes Z.chajecki P.chaloupka S.chattopadhyay H.F.chen J.H.chen J.Y.chen L.chen J.cheng M.cherney A.chikanian K.E.choi W.christie P.chung M.J.M.codrington R.corliss J.G.cramer H.J.crawford S.Dash A.Davila Leyva L.c.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.c.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak c.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs c.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.c.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine c.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis c.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of califomia BerkeleyCaliformnia 94720USA University of california DavisCalifornia 95616USA University of califormnia Los AngelesCalifomia 90095USA Universidade Estadual de campinas Sao PauloBrazil University of Illinois at chicago ChicagoIlinois 60607USA creighton University OmahaNebraska 68178USA czech Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS cR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of Modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA Massachusetts Institute of Technology CambridgeMA 02139-4307USA Mx-Planck-Institut fir Physik MunichGermany Michigan State University East LansingMichigan 48824USA Moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of china Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIc through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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首次除颤由急诊医生还是由急救员执行?

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德国医学 1995年第1期12卷 3-3页

作者： D.Mauer T.Schneider Ph.Diehl W.Dick F.Brehmer R.Juchems D.kettler R.Kleine-Zander H.Klingler R.Rossi H.J.Roth J.Schüttler D.Stratmann U.Strohmenger J.Zander 郝连杰 Klinik für Anasthesiologie Johannes Gutenberg-UniversitatMainz 同济医科大学附属同济医院

除颤是心室颤动唯一的病因治疗,除颤越早,病人存活的机率就越大。为缩短病人院外复苏心脏停止至首次除颤之间的间期,在美国和其他无院外急救医疗系统的国家,将除颤权授于受过相应培训的急救站人员,在医生的监督下执行。在德国柏林和慕... 详细信息

除颤是心室颤动唯一的病因治疗,除颤越早,病人存活的机率就越大。为缩短病人院外复苏心脏停止至首次除颤之间的间期,在美国和其他无院外急救医疗系统的国家,将除颤权授于受过相应培训的急救站人员,在医生的监督下执行。在德国柏林和慕尼黑已进行了急救站人员首先除颤的规范化,并已有成果报导。但尚无急救站人员除颤与目前常规治疗制度(除颤由急救医生执行)相比较的前瞻性研究。

关键词：心室颤动除颤术急症处理医生

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