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Time scales and length scales in magma ?ow pathways and the origin ofmagmatic Ni-cu-PGE ore deposits

Geoscience Frontiers 2019年第1期10卷 77-87页

作者： Stephen J.barnes Jesse c.Robertson cSIRO Mineral Resources

Ore forming processes involve the redistribution of heat, mass and momentum by a wide range of processes operating at different time and length scales. The fastest process at any given length scale tends to be the dominant control. Applying this principle to the array of physical processes that operate within magma flow pathways leads to some key insights into the origins of magmatic Ni-cu-PGE sulfide ore deposits. A high proportion of mineralised systems, including those in the super-giant Noril'sk-Talnakh camp, are formed in small conduit intrusions where assimilation of country rock has played a major role. Evidence of this process is reflected in the common association of sulfides with varitextured contaminated host rocks containing xenoliths in varying stages of assimilation. Direct incorporation of S-bearing country rock xenoliths is likely to be the dominant mechanism for generating sulfide liquids in this setting. However, the processes of melting or dissolving these xenoliths is relatively slow compared with magma flow rates and, depending on xenolith lithology and the composition of the carrier magma, slow compared with settling and accumulation rates. chemical equilibration between sulfide droplets and silicate magma is slower still, as is the process of dissolving sulfide liquid into initially undersaturated silicate magmas. Much of the transport and deposition of sulfide in the carrier magmas may occur while sulfide is still incorporated in the xenoliths, accounting for the common association of magmatic sulfide-matrix ore breccias and contaminated "taxitic" host rocks. Effective upgrading of so-formed sulfide liquids would require repetitive recycling by processes such as reentrainment, back flow or gravity flow operating over the lifetime of the magma transport system as a whole. In contrast to mafic-hosted systems, komatiite-hosted ores only rarely show an association with externally-derived xenoliths, an observation which is partially due to the pre

关键词： Magmatic ore deposits Assimilation Intrusions Nickel Norilsk Komatiites

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cDc7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYc degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel colm Morrsey Sanjoy Mehta Jesse barnes Michael c.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.chan charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos college of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening core Facility Memorial Sloan Kettering cancer center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics coreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well cornell Medical college New York NYUSA Present address:Swiss Institute for Experimental cancer Research(ISREc) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase cell Division cycle 7(cDc7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the cDc7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYc Proto-Oncogen(MYc),implicated in stemness and histological *** overexpression of a degradation-resistant MYc isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate cDc7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

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Ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.carter M.Dunlop c.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.c.Fear D.G.Sibeck M.connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.barnes D.D.Billet G.chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu M.K.James L.Juusola K.Kauristie E.A.Kronberg M.Lester J.Manuel J.Matzka I.Mccrea Y.Miyoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh c.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEc European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of china Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany canadian Space Agency MontrealCanada GFZ German Research centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

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A Finite Element Method for Modelling Electromechanical Wave Propagation in Anisotropic Piezoelectric Media

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communications in computational Physics 2007年第2期2卷 271-292页

作者： S.Rahman H.P.Langtangen c.H.W.barnes cavendish Laboratory Cambridge UniversityJ J Thomson AvenueCambridgeCB3 OHEUnited Kingdom Simula Research Laboratory Martin Linges v 17Fornebu P.O.Box 1341325 LysakerNorway

We describe and evaluate a numerical solution strategy for simulating surface acoustic waves(SAWs)through semiconductor devices with complex *** multi-physics problem is of particular relevance to the design of SAW-based quantum electronic *** mathematical model consists of two coupled partial differential equations for the elastic wave propagation and the electric field,respectively,in anisotropic piezoelectric *** equations are discretized by the finite element method in space and by a finite difference method in *** latter method yields a convenient numerical decoupling of the governing *** describe how a computer implementation can utilize the decoupling and,via object-oriented programming techniques reuse independent codes for the Poisson equation and the linear time-dependent elasticity *** we apply the simulator to a simplified model problem for verifying the implementation,and thereafter we show that the methodology is capable of simulating a real-world case from nanotechnology,involving SAWs in a geometrically non-trivial device made of Gallium ***:***,***,*** Key words:Finite element method,piezoelectric surface acoustic waves,Gallium Arsenide.

关键词： Finite element method piezoelectric surface acoustic waves Gallium Arsenide.

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A Kinetic Analysis of Golf Swings Performed by Healthy Older Adult Males

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Journal of Science in Sport and Exercise 2022年第1期4卷 74-81页

作者： Anna c.Severin c.Lowry barnes Erin M.Mannen Department of Orthopaedic Surgery University of Arkansas for Medical Sciences4301 W.Markham StSlot 531Little RockAR 72205USA Department of Human Movement Science Norwegian University of Science and TechnologyTrondheimNorway

Purpose The kinetic profile of golf swings is frequently assessed in ***,most research is limited to young golfers,so the mechanical demands on older athletes are poorly *** study provides kinetic data of older golfers swinging with a driver and a *** We examined 17 older,skilled male golfers(62.2±8.8 years,handicap 8.7±4.9)using a 10-camera motion cap-ture system and two force ***-dimensional net support moments,joint moments of the hip,knee,and ankle,ground reaction forces(GRF),and the inclination angles between the centre of mass(cOM)and centre of pressure(cOP)were calculated and tested for between-club *** The 3D net support moments of the trail leg were higher when using the driver,while those of the lead leg were higher with the ***-club differences existed in the relative contribution from each joint,the cOM-cOP inclina-tion angles,and the peak *** The mechanical demands of golf swings on older adults differ between a driver and a 6-iron,which likely affects the balance and control strategies *** improved understanding of the kinetic profiles of golf swings in older adults provide clinicians and coaches better means to maintain older golfers active and healthy for longer.

关键词： center of pressure Ground reaction forces 3D net support moment Biomechanics Golf Elderly

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Fibre Optic Protection System for concrete Structures

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Journal of Materials Science & Technology 2006年第3期22卷 404-410页

作者： J.S.Leng A.Hameed D.Winter R.A.barnes G.c.Mays G.F.Fernando centre for composite Materials Harbin Institute of Technology Harbin 150001 China Engineering System Department Defence Academy of the United Kingdom Cranfield University Shrivenham Wiltshire SN6 8LA UK

The design concepts, modelling and implementation of various fibre optic sensor protection systems for development in concrete structures were investigated. Design concepts and on-site requirements for surface-mounted and embedded optical fibre sensor in concrete were addressed. Finite element （FE） modelling of selected sensor protection systems in strain-transfer efficiency from the structure to the sensing region was also studied. And experimental validation of specified sensor protection system was reported. Results obtained indicate that the protection system for the sensors performs adequately in concrete environment and there is very good correlation between results obtained by the protected fibre optic sensors and conventional electrical resistance strain gauges.

关键词： Fibre optic sensor (FOS) Sensor protection system (SPS) concrete structures Extrinsic Fabry-Perot interferometer (EFPI) sensor Smart Structures Strain transfer

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The elements of social theory

The elements of social theory

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作者： Barry barnes.

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A slow-growth high-mortality meta-analysis for insects： A comment on chen and chen

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Insect Science 2018年第2期25卷 352-354页

作者： Shannon M. Murphy Mayra c. Vidal claudia J. Hallagan Elizabeth E. barnes E. Dale Broder Department of Biological Sciences University of Denver Denver CO US

Dear Editor, Insect Science recently published a meta-analysis that tried to test support for the slow-growth high-mortality （hereafter SG-HM） hypothesis （chen＆ chen, 2018）. Meta-analysis is a powerful statistical tool used to quantitatively compare and summarize multiple studies （Arnqvist ＆ Wooster, 1995）. However, results from a meta-analysis must be carefully interpreted when only limited sample sizes are available. Many conclusions made by chen and chen （2018） are based on low sam- rile sizes and/or have small fail-safe numbers,

关键词： FILE-DRAWER PROBLEM LEAF QUALITY HYPOTHESIS PREDATION

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Reply:Is the evolution of tumors Darwinian or non-Darwinian?

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National Science Review 2018年第1期5卷 17-19页

作者： Marc J Williams Benjamin Werner chris P barnes Trevor A Graham Andrea Sottoriva Evolution and cancer Laboratory Barts CancerInstitute Queen Marry University of London Department of cell and Developmental Biology University College London centre for Mathematics and Physics in the Life Sciences and Experimental Biology (coMPLEX) University College London centre for Evolution and cancer The Institute of Cancer Research Department of Genetics Evolution and EnvironmentUniversity College London

Wu and colleagues’letter discusses the limitations of the use of a single sample per tumor to investigate neutral evolution in human *** evolution describes the situation in which there is no differential clonal selection amongst the population of cells within a cancer:all mutations thataccrue during growth are passengers and all drivers were already present in the

关键词： Reply:Is the evolution of tumors Darwinian or non-Darwinian VAF

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Solutions to coastal Disasters 2005 conference

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Episodes 2005年第4期28卷 286-287页

作者： Kelly barnes Program Director coasts Oceans Ports and Rivers Institute American Society of Civil Engineers 1801 Alexander Bell DriveReston VA 20191 USA

Last season＇s hurricanes and the recent Indian Ocean earthquake and tsunami resulted in the loss of hundreds of thousands of lives, and billions of dollars in economic damage. To help mitigate the extensive damage and tragic loss of life caused by these and other natural disasters, and to examine lessons learned and explore other vital issues in coastal engineering, coastal professionals gathered in historic charleston, S. c., a city that has withstood 29 hurricanes and tropical storms since 1871, for the Solutions to coastal Disasters 2005 conference, held May 8-11.

关键词：海洋灾难海洋工程飓风赤潮海啸

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