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Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

Tec.onic.modes of mantle c.nvec.ion and their implic.tions for Earth's tec.onic.evolution based on three-dimensional numeric.l simulations

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Sc.enc. c.ina Earth Sc.enc.s 2025年第1期68卷 270-296页

作者： Song XIANG Jinshui HUANG Bingc.eng wu Sc.ool of Earth and Spac. Sc.enc.s University of Science and Technology of China c.S c.nter of Exc.llenc. in c.mparative Planetary Studies

Five tec.onic.modes of mantle c.nvec.ion are obtained and analyzed with three-dimensional numeric.l models in a spheric.l shell domain. The five tec.onic.c.nvec.ive modes are non-plate mobile-lid, plate-like mobile-lid, episodic.plate-like mobile-lid, episodic.stagnant-lid, and stagnant-lid c.nvec.ive modes, respec.ively. The typic.l c.arac.eristic. of these five tec.onic.modes and their numeric.l c.assific.tion c.iteria based on plateness, mobility, and their standard deviations are presented and disc.ssed. The results show that the yield stress of the lithosphere has profound effec.s on the tec.onic.c.nvec.ive *** the gradual inc.ease of yield stress, the tec.onic.mode of mantle c.nvec.ion c.anges from one to another sequentially through the aforementioned five modes. Additionally, as the Rayleigh number inc.eases, the range of yield stress for the platelike mobile-lid c.nvec.ive mode dec.eases, and the dimensionless transition stress between different tec.onic.modes ***, the dimensional transition stress between the non-plate mobile-lid c.nvec.ive mode and plate-like mobile-lid c.nvec.ive mode inc.eases with the inc.ease of Rayleigh number, but dec.eases between other tec.onic.modes. Furthermore, we find that the transition stress between different tec.onic.modes is inversely proportional to the internal heating rate, with the transition stress dec.easing as the internal heating rate inc.eases. The fitting analysis of the transition stress between tec.onic.modes shows that Earth's c.rrent plate tec.onic. c.rrespond to a lithospheric.yield stress of 150–250 MPa, whic. aligns with the strength of serpentinized mantle roc. determined by experimental petrography. If the Arc.ean mantle was 300°c.warmer than it is today, then the Earth was in an episodic.stagnant-lid c.nvec.ive mode. The tec.onic.evolution of the Earth's surfac. is c.osely related to the lithospheric.strength and the proc.ss of thermal evolution. If the lithospheric.strength w

关键词： Tec.onic.mode of mantle c.nvec.ion Plate-like mobile-lid c.nvec.ion Episodic.plate-like mobile-lid c.nvec.ion Episodic.stagnant-lid c.nvec.ion Plate tec.onic. and tec.onic.evolution of the Earth

Ultra‑Transparent and Multifunc.ional IZVO Mesh Elec.rodes for Next‑Generation Flexible Optoelec.ronic.

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Nano-Mic.o Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot c.enjie Yao Nahyun Kim Tae Geun Kim Sc.ool of Elec.ric.l Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mec.anic.lly durable transparent elec.rodes are essential for ac.ieving long-term stability in flexible optoelec.ronic.***,they are c.uc.al for applic.tions in the fields of energy,display,healthc.re,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide c.nduc.ors due to their high elec.ric.l c.nduc.ivity,optic.l transparenc.,and enhanc.d mec.anic.l *** this paper,we present a simple method for fabric.ting an ultra-transparent c.nduc.ing metal oxide mesh elec.rode using selfc.ac.ing-assisted *** this method,we produc.d an elec.rode with ultra-transparenc.(97.39%),high c.nduc.anc.(Rs=21.24Ωsq^(−1)),elevated work func.ion(5.16 eV),and good mec.anic.l *** also evaluated the effec.iveness of the fabric.ted elec.rodes by integrating them into organic.photovoltaic.,organic.light-emitting diodes,and flexible transparent memristor devic.s for neuromorphic.c.mputing,resulting in exc.ptional devic. *** addition,the unique porous struc.ure of the vanadium-doped indium zinc.oxide mesh elec.rodes provided exc.llent flexibility,rendering them a promising option for applic.tion in flexible optoelec.ronic..

关键词： Self-c.ac.ing template Vanadium-doped indium zinc.oxide mesh Organic.solar c.lls Organic.light-emitting diodes Flexible transparent memory

Mac.ine learning empowers effic.ent design of ternary organic.solar c.lls with PM6 donor

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Journal of Energy c.emistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim Sc.ool of Elec.ric.l Engineering Korea University c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao c.avan Sc.ool of Rural Development Shivaji University

Organic.solar c.lls(OSc.) hold great potential as a photovoltaic.tec.nology for prac.ic.l ***, the traditional experimental trial-and-error method for designing and engineering OSc. c.n be c.mplex, expensive, and time-c.nsuming. Mac.ine learning(ML) tec.niques enable the profic.ent extrac.ion of information from datasets, allowing the development of realistic.models that are c.pable of predic.ing the effic.c. of materials with c.mmendable ac.urac.. The PM6 donor has great potential for high-performanc. OSc.. However, it is c.uc.al for the rational design of a ternary blend to ac.urately forec.st the power c.nversion effic.enc.(Pc.) of ternary OSc.(TOSc.) based on a PM6 ***, we c.llec.ed the devic. parameters of PM6-based TOSc. and evaluated the feature importanc. of their molec.le desc.iptors to develop predic.ive models. In this study, we used five different ML algorithms for analysis and predic.ion. For the analysis, the c.assific.tion and regression tree provided different rules, heuristic., and patterns from the heterogeneous dataset. The random forest algorithm outperforms other predic.ion ML algorithms in predic.ing the output performanc. of PM6-based TOSc.. Finally, we validated the ML outc.mes by fabric.ting PM6-based TOSc.. Our study presents a rapid strategy for assessing a high Pc. while eluc.dating the substantial influenc. of diverse desc.iptors.

关键词： Random forests

Plasmonic.tandem heterojunc.ions enable high-effic.enc. c.arge transfer for broad spec.rum photoc.talytic.hydrogen produc.ion

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Journal of Energy c.emistry 2025年第1期100卷 710-720页

作者： Wenxuan c.en Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-Sheng Li c.llege of Materials and c.emic.l Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory c.llege of c.emistry and Materials Sc.enc. and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semic.nduc.or photoc.talysts for effic.ent hydrogen produc.ion is of great signific.nc. but still c.allenging,primarily due to the limitations in c.arge transfer ***,a fasc.nating plasmonic.tandem heterojunc.ion with the hc.c.S/Mo2c.c.heterostruc.ure is aimfully prepared for effec.ively promoting the c.arge separation kinetic. of the c.S photoc.talyst via the synergistic.strategy of phase junc.ion,Sc.ottky junc.ion,and photothermal *** differenc. in atomic.c.nfiguration between c.bic.c.S （c.c.S） and hexagonal-c.S （h-c.S） leads to effec.ive c.arge separation through a typic.l Ⅱ c.arge transfer mec.anism,and plasmonic.Sc.ottky junc.ion further extrac.s the elec.rons in the hc.c.S phase junc.ion to realize gradient c.arge ***,the photothermal effec. of Mo2c.c.helps to expand the light absorption,ac.elerate c.arge transfer kinetic.,and reduc. the hydrogen evolution energy *** c.rbon layer provides a fast c.annel for c.arge transfer and protec.s the photoc.talyst from *** a result,the optimized hc.c.c.photoc.talyst exhibits a signific.ntly high photoc.talytic.H2produc.ion ac.ivity of 28.63 mmol/g/h and apparent quantum effic.enc. of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhanc. the c.arge transfer kinetic. and photoc.talytic.ac.ivity of c.S by c.nstruc.ing plasmonic.tandem heterogeneous junc.ions.

关键词： c.dmium sulfide

A func.ional c.thode sodium c.mpensation agent for stable sodium-ion batteries

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Green Energy & Environment 2025年第1期10卷 173-182页

作者： Wei wu Zhenglin Hu Zhengfei Zhao Aoxuan Wang Jiayan Luo Key Laboratory for Green c.emic.l Tec.nology of Ministry of Educ.tion School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China State Key Laboratory of Metal Matrix c.mposites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Shanghai Jiao Tong University Shaoxing Researc. Institute of Renewable Energy and Molec.lar Engineering Shaoxing312000China

Hard c.rbon(Hc.is widely used in sodium-ion batteries(SIBs),but its performanc. has always been limited by lowinitial c.ulombic.effic.enc.(Ic.)and c.c.ing *** c.mpensation agent is a favorable strategy to make up for the loss of ac.ive sodium ions c.nsumed *** it lac.s agent that effec.ively dec.mposes to inc.ease the ac.ive sodium ions as well as regulate c.rbon defec.s for dec.easing the irreversible sodium ions ***,we propose 1,2-dihydroxybenzene Na salt(NaDB)as a c.thode c.mpensation agent with high spec.fic.c.pac.ty(347.9 mAh g^(-1)),lower desodiation potential(2.4–2.8 V)and high utilization(99%).Meanwhile,its byproduc. c.uld func.ionalize Hc.with more c.O groups and promote its reversible ***,the presodiation hard c.rbon(pHc.anode exhibits highly reversible c.pac.ty of 204.7 mAh g^(-1) with 98%retention at 5 c.rate over 1000 ***,with 5 wt%NaDB initially c.ated on the Na3V2(PO4)3(NVP)c.thode,the c.pac.ty retention of NVP t NaDBjHc.c.ll c.uld inc.ease from 22%to 89%after 1000 c.c.es at 1 c.*** work provides a new avenue to improve reversible c.pac.ty and c.c.ing performanc. of SIBs through designing func.ional c.thode c.mpensation agent.

关键词： Hard c.rbon Ic. c.thode c.mpensation agent Reversible c.pac.ty Stability

Review of prec.pitation strengthening in ultrahigh-strength martensitic.steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian c.unlei Shang c.aolei Zhang Xiaoye Zhou Honghui wu Shuize Wang Guilin wu Junheng Gao Jiaming Zhu Xinping Mao Institute for c.rbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Tec.nology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Sc.enc. and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Tec.nology Liaoning Academy of MaterialsShenyang 110004China Sc.ool of c.vil Engineering Shandong UniversityJinan 250061China

Martensite is an important mic.ostruc.ure in ultrahigh-strength steels,and enhanc.ng the strength of martensitic.steels often involves the introduc.ion of prec.pitated phases within the martensitic.*** c.nsiderable researc. efforts devoted to this area,a systematic.summary of these advanc.ments is *** review foc.ses on the prec.pitates prevalent in ultrahigh-strength martensitic.steel,primarily c.rbides(e.g.,Mc.M_(2)c.and M_(3)c.and intermetallic.c.mpounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The prec.pitation-strengthening effec. of these prec.pitates on ultrahigh-strength martensitic.steel is disc.ssed from the aspec.s of heat treatment proc.sses,mic.ostruc.ure of prec.pitate-strengthened martensite matrix,and mec.anic.l ***,a perspec.ive on the development of prec.pitation-strengthened martensitic.steel is presented to c.ntribute to the advanc.ment of ultrahigh-strength martensitic.*** review highlights signific.nt findings,ongoing c.allenges,and opportunities in the development of ultrahigh-strength martensitic.steel.

关键词： ultrahigh-strength martensitic.steel prec.pitation strengthening mec.anic.l property c.rbide intermetallic.c.mpound

Estimation of c.loride Diffusivity in Hydrated Tric.lc.um Silic.te Using a Hydration-Diffusion Integrated Method

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Journal of wuhan University of Tec.nology(Materials Sc.enc.) 2025年第1期40卷 49-64页

作者： WANG Xin SHEN Dejian TAO Sijie LIU Ruixin wu Shengxing c.llege of c.vil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a c.loride diffusion simulation method that c.nsiders the hydration mic.ostruc.ure and pore solution properties during the hydration of tric.lc.um silic.te(c.S).The method c.mbines the hydration simulation,thermodynamic.c.lc.lation,and finite element analysis to examine the effec.s of pore solution,inc.uding effec. of elec.roc.emic.l potential,effec. of c.emic.l ac.ivity,and effec. of mec.anic.l interac.ions between ions,on the c.loride effec.ive diffusion c.effic.ent of hydrated c.S *** results indic.te that the effec. of elec.roc.emic.l potential on c.loride diffusion bec.mes stronger with inc.easing hydration age due to the inc.ease in the c.ntent of hydrated c.lc.um silic.te;as the hydration age inc.eases,the effec. of c.emic.l ac.ivity on c.loride diffusion weakens when the number of diffusible elements dec.eases;the effec. of mec.anic.l interac.ions between ions on c.loride diffusion dec.eases with the inc.ease of hydration age.

关键词： tric.lc.um silic.te simulation method c.loride diffusion c.effic.ent pore solution