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contribution of Estrogen to Sex Dimorphic Expression of cardiac Natriuretic Peptide and Nitric Oxide Synthase Systems in ANP Gene-Disrupted Mice

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Open Journal of Endocrine and Metabolic Diseases 2013年第4期3卷 1-11页

作者： Philip G. Wong David W. J. Armstrong M. Yat tse Nicole M. Ventura Stephen c. Pang Department of Biomedical and Molecular Sciences Queen’s University Kingston Canada

Background: Sex dimorphism in the prevalence, onset, development and progression of cardiovascular disease (cVD) is well recognized, but the mechanisms whereby sex hormones are believed to confer cardioprotection are still not fully understood. Objective: This study more closely delineates the effect of 17β-Estradiol (E2) on the expression and signaling of the cardiac NP and NOS systems, well-known cardioprotective modulators of the cardiac hypertrophy (cH) response, that both contribute to downstream production of cyclic guanosine 3’,5’-monophosphate (cGMP). Materials and Methods: Ovariectomized (OVX) female ANP+/+ and ANP-/- mice, 6 - 7 weeks old, were subjected to a five-week treatment with E2 (100 μg/100 μL/day) or vehicle (VEH). Left ventricle from these treatment groups, along with that from age-matched male ANP+/+ and ANP-/- mice was used to assess expression of these systems by real-time quantitative PcR (qPcR). Left ventricle tissue and plasma cGMP were measured by enzyme immunoassay to assess alterations in resultant downstream signaling. Results: NP system expression was unchanged across genotype, sex and E2 treatment. Sex-specific differences in NOS system expression were observed;female mice showed an increased expression of NOS system genes that were significantly elevated in all but one of the E2 treatment groups. Left ventricle tissue cGMP remained unchanged across genotype, sex and E2 treatment. Plasma cGMP levels were unchanged in ANP+/+ treatment groups. In ANP-/- treatment groups, plasma cGMP in the female OVX-E2 mice was significantly higher compared to male and female OVX-VEH mice. conclusion: These findings demonstrate that in the absence of ANP, E2 upregulates cardiac NOS system expression to produce cGMP. This study confirms the importance of the cardiac NOS system in females;this particular system may be a promising future target for sex-specific treatments and therapies for cVD in women.

关键词： Estrogen Atrial Natriuretic Peptide Nitric Oxide Synthase Sex Dimorphism Heart

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Degradation of FBL Dye by Rare-earth doped Titanium Dioxide

Degradation of FBL Dye by Rare-earth doped Titanium Dioxide

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中国颗粒学会超微颗粒专委会2013年年会暨第八届海峡两岸超微颗粒学术研讨会

作者： Robert Liu Ruth Yu-Li Yeh S.Y.chung Y.c.Liu Yung-tse Hung Department of chemical and Materials Engineering Minghsin University of Science and Technology Graduate School of Opto-Mechatronics and Materials WuFeng University Department of civil Engineering Cleveland State University

The photocatalyst such as TiO has been widely used in environmental sanitation and wastewater *** methods improve the activity of *** research was carried out by preparing pure TiO and rare-earth doped *** adsorption and degradation treatment of simulated dye(FBL) wastewater by prepared TiO and rare-earth doped TiO were then *** earth of Nd and Gd oxides were used respectively.

关键词： Photocatalyst coprecipitation rare-earth doped TiO2 AOP(advanced oxidation process) Langmuir-Hinshelwood kinetic model

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comparison of ultrasound-measured properties of the common carotid artery to tobacco smoke exposure in a cohort of Indonesian patients

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World Journal of Emergency Medicine 2017年第3期8卷 177-183页

作者： Allen R.Yu Bima Hasjim Luke E.Yu christopher Gabriel Alexander Anshus Jonathan B.Lee Michael J. Louthan Esther c.Kim Katrina Lee c.ristina tse Thomas Keown Shadi Lahham Maili Alvarado Steven Bunch Abdulatif Gari J.christian Fox School of Medicine University of California Department of Emergency Medicine University of California

BAcKGROUND: The purpose of this study was to use point-of-care ultrasound(POcUS) to investigate the relationship between tobacco smoke exposure and the characteristics of the common carotid artery(ccA). The effect of both primary and secondary smoking on ccA properties was ***: We performed a prospective cross-sectional study across 20 primary care clinics in Bandung, West Java, Indonesia in July 2016. Point of care ultrasound was performed on a convenience sample of Indonesian patients presenting to clinic. The ccA wall stiffness and carotid intima-media thickness(cIMT) were measured during diastole and systole. These measurements were correlated with smoke exposure and cardiovascular ***: We enrolled 663 patients in the study, with 426 patients enrolled in the smoking category and 237 patients enrolled in the second-hand smoke category. There was an overall positive correlation with the measured lifestyle factors and the ultrasound-measured variables in the group of individuals who smoked. For all variables, age seemed to contribute the most out of all of the lifestyle factors for the positive changes in cIMT and ccA wall ***: Our data yielded correlations between ccA properties and cardiovascular risk, as well as between cIMT and arterial stiffness. We were also able to demonstrate an increase in thickness of the cIMT in patients who have been exposed by tobacco through the use of ultrasound. Further large scale studies comparing patients with multiple cardiac risk factors need to be performed to confi rm the utility of ultrasound fi ndings of cardiovascular disease and stroke.

关键词： carotid artery thickness Point of care ultrasound Indonesia Intimal thickness

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视觉分散和视听分散对接受结肠镜检病人焦虑和接受性的影响

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中国循证医学杂志 2006年第9期6卷 630-634页

作者：周会兰蒋晓莲 Mimi M Y tse 朱丹四川大学华西护理学院成都610041 香港理工大学护理学院

目的通过在结肠镜检查中给患者看DVD,了解视觉分散和视听联合分散对受检者焦虑和接受性的影响。方法采用随机对照的研究方法,将180例准备行结肠镜检查的患者随机分为三组,每组60例,视觉分散组检查时看DVD但不听DVD里播放的声音,视听分... 详细信息

目的通过在结肠镜检查中给患者看DVD,了解视觉分散和视听联合分散对受检者焦虑和接受性的影响。方法采用随机对照的研究方法,将180例准备行结肠镜检查的患者随机分为三组,每组60例,视觉分散组检查时看DVD但不听DVD里播放的声音,视听分散组检查时看DVD并戴着耳机听DVD里播放的声音,对照组检查时不看DVD,比较三组患者间的焦虑水平和接受性。结果视觉分散组和视听分散组检查后焦虑水平降低较对照组显著,但这种差异未达到统计学意义。视觉分散组和视听分散组的愿再检查率均较对照组高(P<0．05)。结论视觉分散和视听分散能增加结肠镜检查患者的接受性,对患者的焦虑水平无显著影响。

关键词：结肠镜检查分散注意力焦虑接受性

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虹膜黑色素瘤——是痣还是恶性肿瘤?

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国际眼科纵览 1986年第5期 286-288页

作者： Robert c Kersten ,David T tse ,宣梦铮

虹膜黑色素瘤的性质和处理是近代文献中甚为关心的问题。作者报告一例30年前因单纯性虹膜黑色素瘤作眼球摘除的74岁老年妇女,眶内复发,侵犯上颔窦。最终死于肝脾转移。原发的肿瘤很小、微隆起、局限于虹膜与邻近的房角。病理检查为梭形... 详细信息

虹膜黑色素瘤的性质和处理是近代文献中甚为关心的问题。作者报告一例30年前因单纯性虹膜黑色素瘤作眼球摘除的74岁老年妇女,眶内复发,侵犯上颔窦。最终死于肝脾转移。原发的肿瘤很小、微隆起、局限于虹膜与邻近的房角。病理检查为梭形细胞B-上皮样细胞混合型虹膜黑色素瘤。作者复习有关文献后认为近来有人主张把虹膜黑色素瘤重新分类,纳入良性肿瘤范畴是不正确的。

关键词：黑色素瘤脉络膜眼球摘除梭形细胞黑色素肿瘤虹膜葡萄膜恶性肿瘤

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu cheung Ho ching chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law chi Seng Leung chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.c.Kong Maria V.Babak Yudai Matsuda Department of chemistry City University of Hong KongHong Kong SARChina iGEM Team“Variecure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow clinical Research center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATcc *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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混合使用中心矩与累加量的电力系统概率特征根分析方法

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中国电机工程学报 2000年第5期20卷 37-41页

作者：王克文钟志勇谢志棠曾启明香港理工大学电机系

在现有电力系统概率特征根分析方法的基础上 ,依据特征根各阶矩对整体概率分布的影响程度 ,将随机变量的中心矩与累加量混合使用 ,以求达到计算精度与计算量需求之间的协调。文中所考虑的不确定因素为 :基于节点功率运行曲线的系统多运... 详细信息

在现有电力系统概率特征根分析方法的基础上 ,依据特征根各阶矩对整体概率分布的影响程度 ,将随机变量的中心矩与累加量混合使用 ,以求达到计算精度与计算量需求之间的协调。文中所考虑的不确定因素为 :基于节点功率运行曲线的系统多运行方式 ,利用不同近似程度的特征根 1阶及2阶灵敏度算式 ,从节点电压或节点注入功率的概率特性计算出特征根的各阶数字特征 ,然后由Gram charlier级数确定临界特征根的概率密度和稳定概率。在该混合算法中 ,既不限制随机变量的分布类型 ,又充分计及变量之间的相关性 ,同时也考虑了运算过程中方差对均值的修正。最后。

关键词：电力系统概率特征根中心矩累加量

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Analysis of Using Ultraviolet Light to Test color Mothball

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Journal of Textile Science and Technology 2018年第4期4卷 129-140页

作者： Shen-Kung Liao chung-tse Wu chia-chi Yang Wen-chang chen Tien-Yuan Liang Department of Fiber and composite Materials Feng Chia University Taiwan Environmental Bioengineering & chemical Analysis Section China Steel Corporation Taiwan

color mothball is a daily necessity in Southeast Asia. Mothball contained nearly 100% naphthalene or 100% p-dichlorobenzene. It was used to resist insects, mothproof and mildew with a special odor. In other words, the odor was thought unpleasant enough to drive animals away in repellent products. This research analyzed color mothball which was manufactured by c and N companies. The mothball was dyed with eight dyes and three essences of fragrance, respectively. The experiment of color fastness with UV-light test is to determine how much the color will fade, when it exposed to a known ultraviolet light source. In the last analysis, the experimental data from the spectrum of Gc/MS described all kinds of structure on color mothball after 80 hours phototherapy treatment as shown in the content. This research reveals that color mothball can have better appearance and greater performance, to meet the requirements for customs and various applications.

关键词： Naphthalene Quinoline color Fade Whiteness

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Studies on chemical composition of Anemone Altaica *** (Ⅱ)

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chemical Journal of chinese Universities 1987年第1期 104-105页

作者： Ju Yong,Jia Zhonqjian and Zhu Ziqing(chu tse-Tsing) (Organic chemistry Institute,Lanzhou University,Lanzhou)

A new dispirolactone compound,c10H12O6 m.p.224-226℃,wasisolated from the ethyl acetate extract of the roots of anemone aJ-taica ***,the chinese medicinal herb,by using Si gel column *** structure was determined as: 1,6,9,13-tetra-oxadispiro[4,2,4,2]tetradecane-2,10-dione by means of IR,NMR,MS spectra and X-ray diffraction analysis.

关键词： Studies on chemical composition of Anemone Altaica c.A.May

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Theory-directed discovery of high-temperature superconductivity in clathrate hydrides at high pressure

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The Innovation 2022年第2期3卷 9-10页

作者： Xin Zhong John S.tse Russell J.Hemley Hanyu Liu International center for computational Method&Software and State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Department of Physics and Engineering Physics University of SaskatchewanSaskatoon S7N 5E2Canada Departments of Physics Chemistryand Earth and Environmental SciencesUniversity of Illinois ChicagoChicagoIL 60607USA International center of Future Science Jilin UniversityChangchun 130012China

The search for room-temperature superconductivity has been one of the great challenges in condensedmatter physics ever since the first observation of superconductivity with a critical temperature(T_(c))of 4 K in mercury in *** recent years,we have been witness to the successful observation of superconductivity in highly compressed SH_(3)(T_(c)=203 K at 155 GPa)and classes of clathrate hydrides(e.g.,caH_(6),YH_(6),YH_(9),LaH_(10)).

关键词： hydrides superconductivity high

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